Blog

  • Enhancing Railway Asset Management for a Resilient Future

    Enhancing Railway Asset Management for a Resilient Future

    Embracing the future: next-gen railway asset lifecycle management for a growing market

    The global rail market is expansive, and revenues are projected to grow by 19% by the year 2029. This growth brings with it an urgent demand for next-gen railway asset management systems. Now is the time for the sector to embrace the technologies that make smart railway asset management possible.

    As the rail sector continues to evolve, asset owners and operators (AOOs) face a complex landscape shaped by legacy infrastructure, sustainability pressure, and rapid digitalization. Today’s challenges demand a strategic rethink of railway asset lifecycle management.

    Currently, asset value is primarily concentrated in just a handful of countries, underlining the need for targeted investment and innovation. To address this, the industry is increasingly turning to smart asset strategies and adopting business models that prioritize modern technologies and collaborative ecosystems. These approaches are essential for building resilient, efficient, and sustainable rail networks.

    Capgemini is exploring how advanced analytics, digital twins for capital projects, and other intelligent solutions are redefining asset lifecycle management for railways – empowering the sector to meet rising expectations for safety and performance.

    What leaders need to know about smart railway asset lifecycle management

    Explore the shifting landscape of rail asset lifecycle management and why now is the time for AOOs to embrace smart asset technology.

    Laying the tracks for smarter railways report cover image

    Enhance your rail asset management system

    Railway asset management is being completely transformed to ensure a safer, more resilient future for the global rail sector. By addressing legacy challenges and climate risks with smart technologies and collaborative approaches with next-gen solutions like complex infrastructures digital twins, asset owners and operators can achieve safer, more efficient, and resilient operations – laying the foundation for long-term value and reliable mobility.

    Continue Reading

  • Singer M, Deutschman CS, Seymour CW, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). Jama. Feb 23 2016;315(8):801 – 10. https://doi.org/10.1001/jama.2016.0287

  • Peerapornratana S, Manrique-Caballero CL,…

Continue Reading

  • Researchers in Australia reveal progressive, regional brain changes in Parkinson’s disease-Xinhua

    SYDNEY, Nov. 25 (Xinhua) — Researchers in Australia have found that Parkinson’s disease causes significant and progressive changes in the brain blood vessels, changing the understanding of the disease, which may open up new treatment avenues.

    Continue Reading

  • New white paper lays groundwork for adaptation finance guide supporting ASEAN Taxonomy – United Nations Environment – Finance Initiative

    New white paper lays groundwork for adaptation finance guide supporting ASEAN Taxonomy – United Nations Environment – Finance Initiative

    Climate adaptation has emerged as one of the defining priorities of our time. Nowhere is this challenge more acute than in the ASEAN region, where climate-related risks—rising sea levels, floods, droughts, and extreme heat—threaten the foundations of economic stability, livelihoods, and ecosystems. Addressing these risks requires mobilizing enormous levels of finance—both public and private—and ensuring that investments are aligned with resilience outcomes.

    A new white paper, the first output from a collaboration among the ASEAN Capital Markets Forum (ACMF), Sustainable Finance Institute Asia (SFIA), and United Nations Environment Programme Finance Initiative (UNEP FI),* lays the groundwork for a forthcoming guide that aims to channel more finance towards building adaptation and resilience capacity in support of Environmental Objective (EO) 2 of the ASEAN Taxonomy for Sustainable Finance (ASEAN Taxonomy). The work is financially and technically supported by the European Union Sustainable Finance Advisory Hub (EUSFAH), which promotes interoperable and credible sustainable finance frameworks globally.

    The ASEAN Taxonomy is a valuable tool for governments and the private sector to identify economic activities in the region that support climate-positive outcomes and other sustainability goals—and in turn, to finance aligned activities. Taxonomies have proven instrumental in directing capital towards mitigation, but additional information to provide clear, sector-specific guidance for assessing what qualifies as an “adaptation-aligned” investment can enhance the orientation of capital towards adaptation. The additional guidance can be useful for financial institutions to identify, assess, and report on credible adaptation opportunities—promoting the flow of private finance into projects that build resilience.

    To address this, ACMF, chaired by SC Malaysia, in collaboration with UNEP FI, will develop a mitigation co-benefit and Adaptation for Resilience (mARs) Guide to serve as a companion to the ASEAN Taxonomy, providing the methodological foundation for identifying the key principles and sectoral priorities that can enhance the functionality and usability of the taxonomy to channel  adaptation finance.

    The new white paper marks the first phase of the collaboration among the EUSFAH, UNEP FI, ACMF, and SFIA to translate high-level objectives into practical guidance that financial institutions, regulators, and issuers can apply when identifying, assessing, and tracking adaptation-aligned investments, and aims to catalyze adaptation finance in the region.

    “The ACMF is committed to advancing sustainable finance in the region. The mARs Guide will complement the ASEAN Taxonomy by providing practical tools for adaptation finance, ensuring that our markets remain resilient and future-ready. This white paper outlines the key elements and considerations that will guide the development of the mARs Guide, and highlights the need to address the adaptation funding gap, through mechanisms such as blended finance, which is key to funding non-bankable but necessary projects.”

    – Dato’ Mohammad Faiz Azmi, Chairman of the Securities Commission Malaysia, the current Chair of the ACMF

    Strengthening adaptation finance in ASEAN

    The white paper highlights that adaptation finance remains significantly underfunded compared to mitigation, with current flows falling far short of the scale required to protect communities and markets. As detailed in UNEP’s latest Adaptation Gap Report, developing countries require between USD 310 billion and USD 365 billion annually by 2035 to meet climate adaptation needs, yet only approximately USD 26 billion was available from international public finance in 2023. Mobilizing both public and private capital toward resilience outcomes is therefore an urgent priority.

    Taxonomies play a critical role in mobilizing finance by providing a common language and classification system that helps investors, regulators, and issuers identify credible activities, including adaptation-aligned activities, and channel capital toward them with confidence. UNEP FI’s earlier analysis of ASEAN Member States’ sustainable finance taxonomies shows increasing alignment between domestic taxonomies and the regional ASEAN Taxonomy in areas such as climate change mitigation, adaptation, biodiversity, and circular economy priorities. The mARs Guide builds on this progress by offering the practical detail and sector-level guidance needed for financial institutions to integrate adaptation criteria into investment decisions, product design, and disclosure frameworks.

    By mapping national adaptation priorities across ASEAN Member States, the white paper identifies areas of convergence that can serve as a regional baseline for adaptation-aligned finance. It also proposes for discussion a set of key principles for the mARs Guide, which complement the existing Five Core Principles of the ASEAN Taxonomy and its Guiding Principles for EO2. The proposed principles for the mARs Guide underscore that the guide would be:

    • Science-based and evidence-led
    • Context-relevant and locally prioritized
    • Inclusive across AMS
    • Maladaptation risk management (uncertainty-aware)
    • Interoperable and comparable
    • Usable for finance and the real economy

    Together, these findings and principles establish the methodological foundation for the mARs Guide to become a key regional reference. They also highlight how it can complement the ASEAN Taxonomy and support the application of existing assessment requirements by providing more detailed information on adaptation-relevant technologies and activities, as well as additional guidance in conducting maladaptation and climate risk and vulnerability assessments.

    “This white paper is a critical step in building the foundations for adaptation finance in ASEAN. By aligning financial flows with resilience outcomes, the mARs Guide will help ensure that capital markets play their part in safeguarding communities and ecosystems against climate risks.”

    – Eric Usher, Head of UNEP FI

    A long-term, collaborative effort

    Financial institutions and market participants from across ASEAN have contributed valuable feedback throughout the process, helping to ensure that as the mARs Guide is developed, it will reflect both climate science and practical considerations. This multi-stakeholder exchange underscores the importance of dialogue between the public and private sectors in advancing a coherent, proportionate, and credible policy enabling environment for adaptation finance.

    “Our mitigation efforts need to be supported by adaptation action as climate change impacts intensify. Guided by the key principles set out in the white paper, the mARs Guide will be developed to help providers and users of finance identify the technologies and approaches that capital should support to achieve the paradigm shift needed for resilience.”

    – Eugene Wong, CEO of SFIA

    UNEP FI is supporting the ACMF’s work in partnership with SFIA and a broad community of technical experts and financial institutions, in close consultation with the ASEAN Taxonomy Board. The European Union’s Sustainable Finance Advisory Hub (EUSFAH) has provided technical and financial support to this project.

    The next phases of work—carrying through 2026 and 2027 with SEC Philippines and Monetary Authority of Singapore here as succeeding Chair of ACMF, respectively—will build on these principles to develop operational guidance and practical tools that under the mARs Guide. Stakeholders are encouraged to engage with the process and contribute to the development of the Guide. By working together, ASEAN can build a financial system that mobilizes more investments towards the decarbonization of the region, while enhancing its resilience and adaptive capacity.

     

     

     

    * About the partners involved in the collaboration

    ASEAN Capital Markets Forum (ACMF): The ACMF is a high-level grouping of capital market regulators from all 11 ASEAN jurisdictions, namely Brunei Darussalam, Cambodia, Indonesia, Lao PDR, Malaysia, Myanmar, Philippines, Singapore, Thailand, Timor-Leste and Vietnam. The ACMF’s primary goal is to develop a deep, liquid and integrated regional capital market.

    ASEAN Taxonomy Board (ATB): The ATB was set up in 2021 under the auspices of the ASEAN Finance Ministers and Central Bank Governors’ Meeting (AFMGM) and is jointly driven by the ACMF, ASEAN Insurance Regulators Meeting (AIRM), the Senior Level Committee on Financial Integration (SLC) and the Working Committee on Capital Market Development (WC-CMD). Its establishment is a response to the call at the 6th AFMGM to work towards “furthering a cohesive sustainable finance agenda cutting across banking, capital markets and insurance areas at the ASEAN Finance Ministers’ Meeting and AFMGM respectively, with greater coordination amongst the relevant ASEAN working committees.”

    Securities Commission Malaysia (SC): The SC was established on 1 March 1993 under the Securities Commission Act 1993 (SCA). It is a self-funded statutory body entrusted with the responsibility to regulate and develop the Malaysian capital market. Its mission is to promote and maintain fair, efficient, secure and transparent securities and derivatives markets; and facilitate the orderly development of an innovative and competitive capital market.

    Sustainable Finance Institute Asia (SFIA): SFIA is an independent institute established to catalyse ideas on sustainable finance at the policy level, as well as propel action in support of those policy ideas in Asia, particularly in ASEAN. It aims to provide thought leadership and act as a one stop centre for sustainable finance in ASEAN through collaborations with governments, regulators, central banks, multilateral development banks, industry, academia and non-governmental organisations.

    The EU Sustainable Finance Advisory Hub: The EU Sustainable Finance Advisory Hub is a technical assistance facility funded by the EU and BMZ. It supports low and middle income countries in developing credible and interoperable sustainable finance taxonomies tailored to their environmental, social, and economic contexts.

    UNEP Finance Initiative (UNEP FI): UNEP FI brings together a large network of banks, insurers, and investors that collectively catalyzes action across the financial system to deliver more sustainable global economies. Financial institutions work with UNEP FI on a voluntary basis, and UNEP FI helps them to apply the industry frameworks and develop practical guidance and tools to position their businesses for the transition to a sustainable and inclusive economy.

    Continue Reading

  • NetEase’s open-world wuxia game Where Winds Meet hits 250,000 concurrent players on Steam · TechNode

    NetEase’s open-world wuxia game Where Winds Meet hits 250,000 concurrent players on Steam · TechNode

    China’s NetEase has seen its open-world martial-arts title Where Winds Meet gain strong momentum on Steam since its global launch on Nov. 15. The game’s concurrent player count on the platform hit 251,000 on Nov. 24, while total…

    Continue Reading

  • Early mobilization, breathing exercises and chest wall oscillation in patients with bilateral pneumonia disease in the intensive care unit: a randomized clinical trial | BMC Pulmonary Medicine

    Early mobilization, breathing exercises and chest wall oscillation in patients with bilateral pneumonia disease in the intensive care unit: a randomized clinical trial | BMC Pulmonary Medicine

    Background

    The aim of this study was to evaluate the impact of three physiotherapy interventions on respiratory function, oxygenation, airway clearance, and hemodynamic stability in intensive care unit (ICU) patients diagnosed with bilateral…

    Continue Reading

  • Impaired sensitivity to thyroid hormones is associated with frailty in older patients with cardiometabolic disease | BMC Geriatrics

    Impaired sensitivity to thyroid hormones is associated with frailty in older patients with cardiometabolic disease | BMC Geriatrics

  • Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol Biol Sci Med Sci. 2001;56(3):M146–56.

    Google Scholar 

  • Ensrud KE, Ewing SK, Taylor BC, Fink HA, Cawthon PM, Stone KL, et al. Comparison of 2 frailty indexes for prediction of falls, disability, fractures, and death in older women. Arch Intern Med. 2008;168(4):382–9.

    Google Scholar 

  • Satake S, Senda K, Hong YJ, Miura H, Endo H, Sakurai T, et al. Validity of the kihon checklist for assessing frailty status. Geriatr Gerontol Int. 2016;16(6):709–15.

    Google Scholar 

  • Clegg A, Hassan-Smith Z. Frailty and the endocrine system. Lancet Diabetes Endocrinol. 2018;6(9):743–52.

    Google Scholar 

  • Bianco AC, Kim BW. Deiodinases: implications of the local control of thyroid hormone action. J Clin Invest. 2006;116(10):2571.

    Google Scholar 

  • Pappa T, Ferrara AM, Refetoff S. Inherited defects of thyroxine-binding protein. Best Pract Res Clin Endocrinol Metab. 2015;29(5):735–47.

    Google Scholar 

  • Nappi A, Moriello C, Morgante M, Fusco F, Crocetto F, Miro C. Effects of thyroid hormones in skeletal muscle protein turnover. J Basic Clin Physiol Pharmacol. 2024;35(4–5):253–64.

    Google Scholar 

  • Virgini VS, Rodondi N, Cawthon PM, Harrison SL, Hoffman AR, Orwoll ES, et al. Subclinical thyroid dysfunction and frailty among older men. J Clin Endocrinol Metab. 2015;100(12):4524–32.

    Google Scholar 

  • Bhalla NS, Vinales KL, Li M, Bhattarai R, Fawcett J, Harman SM. Low TSH is associated with frailty in an older veteran population independent of other thyroid function tests. Gerontol Geriatr Med. 2021;7:2333721420986028.

    Google Scholar 

  • Bertoli A, Valentini A, Cianfarani MA, Gasbarra E, Tarantino U, Federici M. Low FT3: a possible marker of frailty in the elderly. Clin Interv Aging. 2017;12:335–41.

    Google Scholar 

  • Okoye C, Arosio B, Carino S, Putrino L, Franchi R, Rogani S, et al. The free triiodothyronine/free thyroxine ratio is associated with frailty in older adults: a longitudinal multisetting study. Thyroid. 2023;33(2):169–76.

    Google Scholar 

  • Arosio B, Monti D, Mari D, Passarino G, Ostan R, Ferri E, et al. Thyroid hormones and frailty in persons experiencing extreme longevity. Exp Gerontol. 2020;138:111000.

    Google Scholar 

  • Pasqualetti G, Calsolaro V, Bernardini S, Linsalata G, Bigazzi R, Caraccio N, et al. Degree of peripheral thyroxin deiodination, frailty, and long-term survival in hospitalized older patients. J Clin Endocrinol Metab. 2018;103(5):1867–76.

    Google Scholar 

  • Yu ZW, Pu SD, Sun XT, Wang XC, Gao XY, Shan ZY. Impaired sensitivity to thyroid hormones is associated with mild cognitive impairment in euthyroid patients with type 2 diabetes. Clin Interv Aging. 2023;18:1263–74.

    Google Scholar 

  • Tamura Y, Ishikawa J, Fujiwara Y, Tanaka M, Kanazawa N, Chiba Y, et al. Prevalence of frailty, cognitive impairment, and sarcopenia in outpatients with cardiometabolic disease in a frailty clinic. BMC Geriatr. 2018;18(1):264.

    Google Scholar 

  • Oba K, Ishikawa J, Tamura Y, Fujita Y, Ito M, Iizuka A, et al. Serum growth differentiation factor 15 levels predict the incidence of frailty among patients with cardiometabolic diseases. Gerontology. 2024;70(5):517–25.

    Google Scholar 

  • Tamura Y, Shimoji K, Ishikawa J, Murao Y, Yorikawa F, Kodera R, et al. Association between white matter alterations on diffusion tensor imaging and incidence of frailty in older adults with cardiometabolic diseases. Front Aging Neurosci. 2022;14:912972.

    Google Scholar 

  • Furuto-Kato S, Araki A, Chiba Y, Nakamura M, Shintani M, Kuwahara T, et al. Relationship between the thyroid function and cognitive impairment in the elderly in Japan. Intern Med. 2022;61(20):3029–36.

    Google Scholar 

  • Laclaustra M, Moreno-Franco B, Lou-Bonafonte JM, Mateo-Gallego R, Casasnovas JA, Guallar-Castillon P, et al. Impaired sensitivity to thyroid hormones is associated with diabetes and metabolic syndrome. Diabetes Care. 2019;42(2):303–10.

    Google Scholar 

  • Craig CL, Marshall AL, Sjöström M, Bauman AE, Booth ML, Ainsworth BE, et al. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc. 2003;35(8):1381–95.

    Google Scholar 

  • Dentice M, Marsili A, Ambrosio R, Guardiola O, Sibilio A, Paik JH. The FoxO3/type 2 deiodinase pathway is required for normal mouse myogenesis and muscle regeneration. J Clin Invest. 2010;120(11):4021–30.

    Google Scholar 

  • Chopra IJ, Chopra U, Smith SR, Reza M, Solomon DH. Reciprocal changes in serum concentrations of 3,3’,5-triiodothyronine (T3) in systemic illnesses. J Clin Endocrinol Metab. 1975;41(06):1043–9.

    Google Scholar 

  • Ostan R, Monti D, Mari D, Arosio B, Gentilini D, Ferri E, et al. Heterogeneity of thyroid function and impact of peripheral thyroxine deiodination in centenarians and semi-supercentenarians: association with functional status and mortality. J Gerontol A Biol Sci Med Sci. 2019;74(6):802–10.

    Google Scholar 

  • Alonso SP, Valdés S, Maldonado-Araque C, Lago A, Ocon P, Calle A, et al. Thyroid hormone resistance index and mortality in euthyroid subjects: Di@bet.es study. Eur J Endocrinol. 2021;186(1):95–103.

    Google Scholar 

  • Barzilay JI, Blaum C, Moore T, Xue QL, Hirsch CH, Walston JD, et al. Insulin resistance and inflammation as precursors of frailty: the cardiovascular health study. Arch Intern Med. 2007;167(7):635–41.

    Google Scholar 

  • Carvalhaes-Neto N, Huayllas MK, Ramos LR, Cendoroglo MS, Kater CE, Cortisol. DHEAS and aging: resistance to cortisol suppression in frail institutionalized elderly. J Endocrinol Invest. 2003;26(1):17–22.

    Google Scholar 

  • Lv F, Cai X, Li Y, Zhang X, Zhou X, Han X, et al. Sensitivity to thyroid hormone and risk of components of metabolic syndrome in a Chinese euthyroid population. J Diabetes. 2023;15(10):900–10.

    Google Scholar 

  • Liu C, Hua L, Liu K, Xin Z. Impaired sensitivity to thyroid hormone correlates to osteoporosis and fractures in euthyroid individuals. J Endocrinol Invest. 2023;46(10):2017–29.

    Google Scholar 

  • Chen S, Sun X, Zhou G, Jin J, Li Z. Association between sensitivity to thyroid hormone indices and the risk of osteoarthritis: an NHANES study. Eur J Med Res. 2022;27(1):114.

    Google Scholar 

  • Wronski ML, Tam FI, Seidel M, Mirtschink P, Poitz DM, Bahnsen K, et al. Associations between pituitary-thyroid hormones and depressive symptoms in individuals with anorexia nervosa before and after weight-recovery. Psychoneuroendocrinology. 2022;137:105630.

    Google Scholar 

  • De Vito P, Incerpi S, Pedersen JZ, Luly P, Davis FB, Davis PJ. Thyroid hormones as modulators of immune activities at the cellular level. Thyroid. 2011;21(8):879–90.

    Google Scholar 

  • Wachowska K, Gałecki P. Inflammation and cognition in depression: a narrative review. J Clin Med. 2021;10(24):5859.

    Google Scholar 

  • Ma YC, Ju YM, Cao MY, Yang D, Zhang KX, Liang H, et al. Exploring the relationship between malnutrition and the systemic immune-inflammation index in older inpatients: a study based on comprehensive geriatric assessment. BMC Geriatr. 2024;24(1):19.

    Google Scholar 

  • Jiang L, Zhou L, Liu J, Wang Y, Wang G. Sex differences in the association between thyroid hormone sensitivity and cardiovascular-kidney-metabolic syndrome. J Clin Endocrinol Metab. 2025;4:dgaf059.

    Google Scholar 

  • Wang Q, Tao A, Zhang Y, Li X, Lin Q, Liu F, et al. Psychometric properties of the simplified Chinese version of Kihon checklist in the Chinese older people. Int J Older People Nurs. 2023;18(2):e12524.

    Google Scholar 

  • Assantachai P, Muangpaisan W, Intalapaporn S, Jongsawadipatana A, Arai H. Kihon checklist: Thai version. Geriatr Gerontol Int. 2021;21(8):749–52.

    Google Scholar 

  • Continue Reading

  • Full List of Wrestlers in Blue League, Gold League

    Full List of Wrestlers in Blue League, Gold League

    The 2025 Continental Classic is here! 

    And on Monday night, we were introduced to the 12 wrestlers who will participate in this year’s Continental Classic, beginning on the Thanksgiving Eve AEW Dynamite this Wednesday, live at 8 p.m. ET/7 p.m….

    Continue Reading

  • Pregnancy and neonatal outcomes of HIV infection in pregnant women in Iran: a systematic review and meta-analysis | BMC Infectious Diseases

    Pregnancy and neonatal outcomes of HIV infection in pregnant women in Iran: a systematic review and meta-analysis | BMC Infectious Diseases

  • Esmaeili ED, Azizi H, Dastgiri S, Kalankesh LR. Does telehealth affect the adherence to ART among patients with HIV? a systematic review and meta-analysis. BMC Infect Dis. 2023;23:169.

    Google Scholar 

  • Jahagirdar…

  • Continue Reading

  • Today’s NYT Mini Crossword Answers for Nov. 25

    Today’s NYT Mini Crossword Answers for Nov. 25

    Looking for the most recent Mini Crossword answer? Click here for today’s Mini Crossword hints, as well as our daily answers and hints for The New York Times Wordle, Strands, Connections and Connections: Sports Edition puzzles.


    Need some help…

    Continue Reading