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  • Ribo granted EMA Orphan Drug Designation for siRNA therapeutic RBD1016 for hepatitis delta Virus (HDV) Infection

    Ribo granted EMA Orphan Drug Designation for siRNA therapeutic RBD1016 for hepatitis delta Virus (HDV) Infection

    BEIJING, China & GOTHENBURG, Sweden — 2025-10-24 — Suzhou Ribo Life Science Co., Ltd. and Ribocure Pharmaceuticals AB (Ribo), today announced that the European Medicines Agency (EMA) has granted Orphan Drug Designation (ODD) to RBD1016 for…

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  • From The Killers To Role Model & More

    From The Killers To Role Model & More

    Over a year after It Ends With Us hit theaters in August 2024, the next film adaptation of a Colleen Hoover best-seller, Regretting You has arrived on the big screen.

    Starring Allison Williams, Dave Franco, Mason Thames, Mckenna…

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  • Behind the Emirates NBA Cup 2025 court designs with Victor Solomon

    Behind the Emirates NBA Cup 2025 court designs with Victor Solomon

    The Emirates NBA Cup 2025 tips off on Oct. 31 and will once again feature playing courts with a bold and distinctive style.

    The Emirates NBA Cup is back, and so are the custom designed courts for each team.

    For the past two seasons, the courts…

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  • FIA Team Principals press conference – 2025 Mexico City Grand Prix

    FIA Team Principals press conference – 2025 Mexico City Grand Prix

    QUESTIONS FROM THE FLOOR

    Q: (Scott Mitchell-Malm – The Race) To all three. Jonathan mentioned the issues in FP1. Just wanted to know how big a deal it was for your three teams. What were you missing? Was it just GPS? Was it more? And for Ayo…

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  • Max Verstappen leads Charles Leclerc and Kimi Antonelli during second practice in Mexico

    Max Verstappen leads Charles Leclerc and Kimi Antonelli during second practice in Mexico

    Red Bull driver Max Verstappen set the pace during second practice at the Mexico City Grand Prix, the Dutchman leading the way from the Ferrari of Charles Leclerc and Mercedes’ Kimi Antonelli.

    After a total of nine rookies were given an outing…

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  • Can Central Bank Digital Currencies Improve the Delivery of Social Safety Nets?

    Can Central Bank Digital Currencies Improve the Delivery of Social Safety Nets?


    Summary



    This paper explores how central bank digital currencies (CBDCs) could enhance the delivery of social safety nets (SSNs). It assesses CBDC design features and their implications for payment administration and delivery. Findings suggest that using CBDCs solely as payment delivery solutions offers limited advantages over existing systems such as faster payment systems. However, leveraging CBDCs as payment administration platforms—with peer-to-peer transfers, decentralized ledger access, and advanced programmability—could transform SSN delivery by enabling agencies to automate transfers, operate independently from private financial intermediaries, and monitor transactions directly. These benefits come with significant challenges, including privacy concerns, compliance risks, and infrastructure requirements. The paper emphasizes that realizing CBDCs’ full potential for SSNs will depend on thoughtful integration with existing systems and a clear understanding of their comparative advantages. Aimed at social protection policymakers and finance specialists, it highlights the need for collaboration between CBDC developers and SSN administrators to ensure that digital currencies effectively support inclusive and efficient benefit delivery.



    Subject:

    Blockchain and DLT,
    Central Bank digital currencies,
    Smart contracts,
    Technology



    Keywords:

    Blockchain and DLT,
    Central Bank digital currencies,
    Central Bank Digital Currencies,
    Financial Inclusion,
    Fintech,
    Government Transfers,
    Payment Systems,
    Smart contracts,
    Social Safety Nets

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  • How Investors May Respond To Expedia Group (EXPE) Wetour Integration of AI Trip Planner and B2B APIs

    How Investors May Respond To Expedia Group (EXPE) Wetour Integration of AI Trip Planner and B2B APIs

    • In recent days, Webus International Limited announced its Wetour platform will integrate Expedia Group’s newly launched AI-powered Trip Planner and B2B APIs, aiming to boost hotel booking efficiency and personalized travel experiences for global users.

    • This move highlights increasing adoption of Expedia’s AI-driven capabilities by partners, signaling expanding influence of its tools across the online travel industry.

    • We’ll examine how Wetour’s adoption of Expedia’s AI suite could enhance B2B growth and reshape Expedia Group’s investment narrative.

    Uncover the next big thing with financially sound penny stocks that balance risk and reward.

    Expedia Group’s investment story centers on the belief that artificial intelligence and deepening B2B alliances can drive sustained revenue and margin expansion, particularly as digital booking trends accelerate globally. The recent Wetour integration of Expedia’s AI-powered Trip Planner underscores technological differentiation and growing demand from partners, but does not materially offset persistent reliance on U.S. travel health and consumer spending, factors that still dominate near-term catalysts and risk. Investors may view this as a long-term growth lever rather than a near-term game-changer.

    Among recent announcements, the October rollout of Smart Trip AI™ and suite of B2B APIs is highly relevant, as it forms the technical foundation for Expedia’s new partnerships like Wetour. This aligns with analyst expectations for higher B2B and recurring revenue streams, underpinning net margin stability, but also reflects broader efforts to cushion the business from cyclical consumer softness while increasing technology-driven differentiation.

    But while these advances are promising, investors should still be mindful of increasing competition and the risk that more AI-enabled travel platforms could…

    Read the full narrative on Expedia Group (it’s free!)

    Expedia Group’s outlook forecasts $16.9 billion in revenue and $2.1 billion in earnings by 2028. This projection assumes a 6.4% annual revenue growth rate and a $1.0 billion increase in earnings from the current $1.1 billion.

    Uncover how Expedia Group’s forecasts yield a $224.30 fair value, in line with its current price.

    EXPE Community Fair Values as at Oct 2025

    Eight members of the Simply Wall St Community set fair value estimates for Expedia Group ranging from US$132.67 to US$423.46, covering multiple viewpoints. With competition rising across AI travel platforms, considering this wide spectrum of expectations may offer context for your own assessment.

    Explore 8 other fair value estimates on Expedia Group – why the stock might be worth as much as 93% more than the current price!

    Disagree with existing narratives? Create your own in under 3 minutes – extraordinary investment returns rarely come from following the herd.

    Every day counts. These free picks are already gaining attention. See them before the crowd does:

    This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.

    Companies discussed in this article include EXPE.

    Have feedback on this article? Concerned about the content? Get in touch with us directly. Alternatively, email editorial-team@simplywallst.com

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  • Margins Steady at 27.6% While Growth Slows, Reinforcing Value-Focused Narratives

    Margins Steady at 27.6% While Growth Slows, Reinforcing Value-Focused Narratives

    WSFS Financial (WSFS) posted earnings growth of 5.9% over the past year, moderating from its five-year annual average of 10%. Net profit margins edged up to 27.6% from last year’s 27.1%. The share price of $53.02 remains well below the estimated fair value of $113.94, and the company’s P/E ratio of 10.6x sits lower than peer and industry averages. With revenue and earnings projected to grow slower than the broader US market, the focus is on WSFS’s disciplined valuation and consistently healthy profits. This gives value-oriented investors reasons to stay interested even as growth prospects appear more subdued.

    See our full analysis for WSFS Financial.

    Next, we’ll put the results head-to-head with the market’s dominant narratives and see where the numbers back up or buck prevailing sentiment.

    See what the community is saying about WSFS Financial

    NasdaqGS:WSFS Earnings & Revenue History as at Oct 2025
    • Net profit margins improved to 27.6% this year, a modest increase from last year’s 27.1%, even as earnings growth slowed to 5.9% compared to the five-year annual average of 10%.

    • Analysts’ consensus view highlights management’s focus on digital modernization and operational efficiency as key factors helping to counter softer revenue growth.

      • Recent enhancements in online and mobile platforms are expected to help reduce costs, support efficiency, and maintain competitive customer experiences.

      • Stable margins set WSFS apart when compared to peers facing similar growth constraints, which could lift relative valuation over time.

    • To see how WSFS’s margin story fits into broader market expectations, read the consensus case for context. 📊 Read the full WSFS Financial Consensus Narrative.

    • Non-interest income sources such as wealth management and trust services are bolstering revenue diversity, and analysts anticipate a 4.97% annual decline in shares outstanding due to continued aggressive buybacks.

    • According to the consensus narrative, investors value WSFS’s strategic emphasis on building stable, fee-based income and pursuing opportunistic M&A.

      • Greater non-interest income can provide a cushion against rate-related margin pressure in the traditional lending business.

      • Declining share count could amplify earnings per share, offering a buffer during periods of modest organic growth.

    • Shares trade at $53.02 with a price-to-earnings ratio of 10.6x, notably below the bank industry’s 11.2x average and both the DCF fair value estimate of $113.94 and analyst target of $63.5.

    • The consensus narrative points out that WSFS’s disciplined valuation, combined with its high-quality earnings, could present value-oriented investors with upside if the firm executes on its digital and non-interest income strategies.

      • Peer and industry discount suggests the market doubts the company can return to faster growth or that risks remain underappreciated.

      • However, stable profit margins and capital discipline improve the chances that WSFS can deliver attractive returns even if growth lags the broader market.

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  • Issues and Approaches—An Application to Nowcasting China’s Real GDP

    Issues and Approaches—An Application to Nowcasting China’s Real GDP


    Summary



    This paper evaluates three approaches to address parameter proliferation issue in nowcasting: (i) variable selection using adjusted stepwise autoregressive integrated moving average with exogenous variables (AS-ARIMAX); (ii) regularization in machine learning (ML); and (iii) dimensionality reduction via principal component analysis (PCA). Utilizing 166 variables, we estimate our models from 2007Q2 to 2019Q4 using rolling-window regression, while applying these three approaches. We then conduct a pseudo out-of-sample performance comparison of various nowcasting models—including Bridge, MIDAS, U-MIDAS, dynamic factor model (DFM), and machine learning techniques including Ridge Regression, LASSO, and Elastic Net to predict China’s annualized real GDP growth rate from 2020Q1 to 2023Q1. Our findings suggest that the LASSO method outperform all other models, but only when guided by economic judgment and sign restrictions in variable selection. Notably, simpler models like Bridge with AS-ARIMAX variable selection yield reliable estimates nearly comparable to those from LASSO, underscoring the importance of effective variable selection in capturing strong signals.


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  • A Quarterly Projection Model for the Bank of Mauritius

    A Quarterly Projection Model for the Bank of Mauritius


    Summary



    This paper presents the Mauritius Quarterly Projection Model (QPM), the semi-structural analytical tool that underpins the modernized Forecasting and Policy Analysis System of the Bank of Mauritius (BOM). The model is designed to capture the salient features of the domestic economy, including key monetary policy transmission channels and the recently introduced flexible inflation targeting framework. Relative to canonical QPM structures, it also incorporates a parsimonious fiscal block and a labor market block, providing key insights on broader macroeconomic dynamics and enriching the policy advice. The model optimally balances theoretical consistency—evident in coherent shock propagation and policy responses—and empirical reliability, as reflected in its strong in-sample forecasting performance. The practical use of the Mauritius QPM in the context of the BOM’s regular forecasting cycles for the production of baseline projections, counterfactual simulations and alternative scenarios, together with the corresponding model-based economic narratives, make it a critical component of the BOM’s forward-looking monetary policy formulation.



    Subject:

    Exchange rates,
    Foreign exchange,
    Inflation,
    Labor,
    Labor markets,
    Output gap,
    Prices,
    Production,
    Real effective exchange rates,
    Real wages,
    Wages



    Keywords:

    Exchange rates,
    Forecasting and Policy Analysis,
    Global,
    Inflation,
    Labor markets,
    Mauritius,
    Monetary Policy,
    Output gap,
    Quarterly Projection Model,
    Real effective exchange rates,
    Real wages,
    Transmission Mechanism,
    Wages

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