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  • Managing Hereditary Angioedema with Normal C1 Inhibitor – European Medical Journal Managing Hereditary Angioedema with Normal C1 Inhibitor

    Managing Hereditary Angioedema with Normal C1 Inhibitor – European Medical Journal Managing Hereditary Angioedema with Normal C1 Inhibitor

    Key Findings at a Glance

    REAL-WORLD evidence indicates that hereditary angioedema with normal C1 inhibitor is frequently hormone sensitive. In HAE-FXII, withdrawal of combined oral contraceptives, often with progestins, is associated with…

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  • Airlines face $11 billion supply chain hit in 2025, IATA says

    Airlines face $11 billion supply chain hit in 2025, IATA says

    By Tim Hepher and Joanna Plucinska

    PARIS/LONDON (Reuters) -Global airlines face more than $11 billion in extra costs from supply chain disruption this year, a leading industry group said on Monday, in a report likely to rekindle debate over competition in the $250-billion aerospace industry.

    The study by the International Air Transport Association, produced with consultants Oliver Wyman, marks the first attempt to quantify the impact of a five-year supply chain crisis that has driven up fares and led to flight cancellations.

    IATA Director General Willie Walsh said he was surprised by the extent of the findings and told Reuters there may be grounds to revisit whether airlines are being subjected to anti-competitive practices by suppliers, after dropping a previous complaint in 2018.

    “Even if you halve the number, it’s still a massive drag on the industry,” Walsh said in an interview.

    REPORT DETAILS COST OF BOTTLENECKS

    Researchers found the largest impact stems from $4.2 billion in extra fuel as airlines keep older planes in service.

    Additional maintenance is expected to cost $3.1 billion, while leasing engines to replace those stuck in queues for maintenance adds another $2.6 billion.

    Holding more spare parts to cushion delays is projected to cost airlines $1.4 billion.

    Planemakers and their suppliers have waded through a mire of setbacks, from shortages of labour, materials and parts to mounting delays at repair shops, particularly for engines.

    There is also a growing tug of war with the defence industry for capacity as governments increase military spending.

    “There’s now going to be continuing competition for the limited supply that is there,” Walsh said, adding that supply chains would be an issue for the rest of the decade.

    He questioned the influence suppliers exert over parts pricing and called for “additional competition in the aftermarket, which clearly has seen significant consolidation.”

    PROFIT GAP

    IATA has previously called for greater competition in maintenance, including improved access to independent parts known as PMA.

    In 2016, it filed a complaint with the European Union against CFM International but withdrew it two years later after the engine maker agreed to maintain an open and competitive market.

    A similar agreement was reached with Rolls-Royce in 2021.

    Walsh said there were no plans to launch any new challenge, but did not rule it out.

    “We have been evaluating it, but we’d have to do a lot more work,” he said, noting that airlines have confidential agreements, so digging deeper involves teams of lawyers.

    “It’s a complex piece of work, but I think there could be merit in us looking at that again.”

    He pointed to the gap between airline operating margins, forecast at 6.7% this year, and margins of some engine makers and suppliers in the mid-20s as a source of concern.

    “How is it that they can make such massive margins from an industry that makes margins that are wafer-thin? It just doesn’t add up,” Walsh said.

    Engine makers argue they are entitled to adequate returns given the risks involved in developing new technologies and offering insurance-style contracts to cover repair costs.

    Airlines are expected to spend $120 billion on repair and maintenance this year, rising to $150 billion by 2030, IATA said.

    Walsh softened his tone towards Airbus and Boeing, saying they were becoming more transparent about jet delays. In June, he accused planemakers of “failing badly”.

    (Reporting by Tim Hepher, Editing by Louise Heavens)

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  • Campbell’s maiden century helps West Indies push India toward batting again in 2nd test – The Washington Post

    1. Campbell’s maiden century helps West Indies push India toward batting again in 2nd test  The Washington Post
    2. Live Cricket Update – IND vs WI 2nd Test – Live report – New-ball strikes take India closer to win  ESPNcricinfo
    3. Campbell leads West…

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  • TO_AITION project uncovers links between cardiovascular disease and mental health  

    ESC Press Office  

    Tel: +33 6 61 40 18 84   

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    Follow us on European Society of Cardiology News on LinkedIn

     

    About the European Society of Cardiology   

    The European Society of Cardiology brings…

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  • Quantum Relative Entropy Decay Yields Shallow K-Designs In O(log N) Depth For Random Circuits

    Quantum Relative Entropy Decay Yields Shallow K-Designs In O(log N) Depth For Random Circuits

    The pursuit of understanding how quickly complex quantum systems settle into predictable randomness drives much current research in quantum information science. Nicholas Laracuente from the University of Chicago, along with colleagues, now…

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  • ‘I cared only what Diane Keaton had to say’: Woody Allen pays tribute to late actor, co-star and former partner | Film

    ‘I cared only what Diane Keaton had to say’: Woody Allen pays tribute to late actor, co-star and former partner | Film

    Woody Allen has paid lengthy tribute to Diane Keaton after her death aged 79 on Saturday.

    In an essay published by The Free Press, Allen, 89, wrote about their time together from first meeting in 1969 during rehearsals for his play Play It Again,…

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  • Podium for Brits at FIA World Karting Championship

    Podium for Brits at FIA World Karting Championship

    British drivers Timo Jungling and Noah Wolfe delivered outstanding performances at the weekend’s FIA World Karting Championship, both standing on the podium in the KZ2 World Cup race.

    Both drivers began their motorsport journeys through…

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  • Wolves Esports PUBG Mobile Americas Champions | Wolves Esports | News

    Wolves Esports PUBG Mobile Americas Champions | Wolves Esports | News

    Wolves Esports PUBG Mobile team has been crowned PUBG Mobile Super League (PMSL) Americas champions.

    Live in Brazil the team took on the best teams Americas had to offer and came out on top with an extremely consistent performance where they…

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  • New Rules Could Force Tesla to Redesign Its Door Handles. That’s Harder Than It Sounds

    New Rules Could Force Tesla to Redesign Its Door Handles. That’s Harder Than It Sounds

    The issues could cascade beyond the design. The auto manufacturing industry operates on strict production schedules. Though it builds in time to validate and test whatever new features come in each new model, the sudden intro of a design change late in the process could throw off the delicate timetable.

    In this decade, China’s auto industry has shocked the world by racing ahead of legacy automakers, quickly developing, with government support, ever newer, cheaper, and more technologically advanced vehicles on shorter production schedules. The country is the world’s largest automotive market; it’s expected to manufacture a full third of the world’s cars by 2030. Still, quickly complying with new design regulations won’t be easy for domestic Chinese automakers either, says Broglin-Peterson. “Mechncial release requires a mechanical assembly,” she says. “It’s not just, you write some code.”

    Automaker’s door handle trouble likely won’t end in China. The new rules could lead to cascading responses from other global regulators. It’s a now-familiar pattern: China, once a place with lax protections, has forged ahead of the rest of the world in setting guidelines for electric vehicle battery safety and recycling, and autonomous vehicle tech. “This is a classic example of China setting the guardrails early: protecting consumers while quietly shaping global design standards,” Bill Russo, the CEO of Automobility, a Shanghai-based advisory firm, wrote in an email.

    A Handle on Design

    For many years, says Raphael Zammit, the chair of the transportation design department at the College for Creative Studies in Detroit, flush electronic door handles were the stuff of futuristic concept cars. “The fact that Elon Musk and Tesla put it into production was, frankly, pretty amazing,” he says. Their rise was linked with the increasing popularity of electric vehicles; tucking door handles into the doors of cars was meant to reduce their drag coefficient, leading to increased battery efficiency. Or so the theory went: Back-of-the-envelope math suggests the tweak maybe adds a mile of range. Maybe. Either way, the handles became a “demarcation of luxury,” Zammit says.

    Indeed, electronic door handles can be found on many luxury vehicles, including some made by Volkswagen, General Motors, Ford, and Mercedes-Benz. Jake Fisher, the senior director of the Consumer Reports’ Auto Test Center, tested several of those vehicles’ electronic handles. While all had emergency mechanical releases, as the Chinese regulations mandate, some were in places that could be difficult to find in an emergency—on the floor, in shadow, or, as in the rear seats of the 2021 Model Y under investigation by NHTSA, under a slot at the bottom of the rear door pocket. The best emergency mechanical releases, Consumer Reports found, were those that simply needed to be pulled a bit harder than usual to open, an intuitive reaction in an emergency.

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  • Electra Selects Evolito to Supply Electric Engines for the EL9 Ultra Short Hybrid-Electric Aircraft

    Electra Selects Evolito to Supply Electric Engines for the EL9 Ultra Short Hybrid-Electric Aircraft