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  • Spotify says it’s working to protect artists from AI abuse, but the streaming company’s track record is shaky

    Spotify says it’s working to protect artists from AI abuse, but the streaming company’s track record is shaky

    By Lukas I. Alpert

    After years of fighting scams and fraud, the music-streaming company announced it is joining forces with three major music labels to develop AI products that can help artists

    Spotify says it works hard to…

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  • Official data dramatically underestimates hedge funds’ involvement in the Treasury market, Fed paper finds

    Official data dramatically underestimates hedge funds’ involvement in the Treasury market, Fed paper finds

    By Vivien Lou Chen

    Treasury Department data does not reflect how much hedge funds domiciled in the Cayman Islands are dominating the so-called basis trade, according to a team at the Federal Reserve.

    Data from the U.S. Treasury Department is failing to capture Cayman Island hedge-fund exposures to Treasury securities.

    Key Treasury Department data is massively underreporting the amount of U.S. government debt held by hedge funds registered and incorporated in the Cayman Islands, and is failing to reflect their heavy reliance on a controversial leveraged trade that has repeatedly alarmed regulators.

    In a note released on Wednesday, a team at the Federal Reserve found that U.S. Treasury International Capital data appears to be “severely” undercounting the amount of Treasurys held by those hedge funds, to the tune of about $1.4 trillion as of the end of the 2024. In addition, the Fed team concluded that TIC data is not capturing just how much Cayman-domiciled hedge funds are dominating positions in the so-called basis trade.

    Since at least 2018, U.S. regulators have periodically expressed alarm over the possibility that the basis trade could trigger wider financial instability during market downturns. The Treasury Department’s press office did not immediately respond to a request for comment on Thursday. The U.S. government has been in a partial shutdown since Oct. 1.

    The basis trade uses leverage to arbitrage the price differences between Treasury futures and cash Treasurys. It involves simultaneously buying a Treasury cash position and selling a Treasury futures position, and financing the trade by borrowing in the repo market to provide leverage. The unwinding of the basis trade was seen as a likely contributor to Treasury-market instability in March 2020, and the risk of a possible repeat following hedge funds’ increased reliance on leverage drew scrutiny from the Fed’s board of governors and the Treasury in 2023.Read: Hedge funds’ use of leveraged Treasury trades needs ‘diligent monitoring,’ Fed paper says

    TIC data is the main source of U.S. data on cross-border securities and banking. It is used by policymakers, investors and researchers to understand the catalysts and impacts of cross-border flows and asset allocations among various countries and investor types.

    The severe underreporting of Cayman-domiciled funds’ Treasurys holdings presents “a major impediment for researchers, policymakers, and other data users seeking to analyze cross-border flows and their effects on the U.S. economy and financial markets,” according to the note written by Daniel Barth, principal economist for the Federal Reserve Board; Daniel Beltran, a deputy associate director; Maria Perozek, chief of the board’s Flow of Funds section; and others. The authors estimate that holdings of Treasury securities of Cayman-domiciled hedge funds stood at $1.85 trillion by the end of 2024, having climbed by $1 trillion since 2022.

    “Our findings suggest that Cayman Islands hedge funds are, increasingly, the marginal foreign buyers of U.S. Treasury notes and bonds,” the authors said. After factoring in an estimated underreporting of roughly $1.4 trillion, they wrote, the Cayman Islands “is in fact the largest foreign holder of U.S. Treasury securities – holding significantly more than China, Japan, and the United Kingdom,” which currently rank as the three largest holders.

    Hedge funds domiciled in the Cayman Islands held an estimated $1.85 trillion in Treasurys at the end of 2024, according to a note from the Federal Reserve.

    Meanwhile, the gap between what’s being reported in the Treasury Department’s TIC data versus what’s reported to the Securities and Exchange Commission has widened to almost $1.4 trillion as of the end of last year. “TIC data on Cayman Islands holdings of Treasuries do not appear to be picking up the Treasury transactions associated with the basis trade activity” that can be seen on the hedge funds’ filings to the SEC, according to the Fed note.

    While this roughly $1.4 trillion gap is not solely attributable to the basis trade, “the puzzling disconnect between the TIC and [SEC’s] Form PF data on Cayman Islands’ holdings of U.S. Treasuries is under active investigation,” Barth and the other authors wrote.

    The amount of Treasurys held by hedge funds domiciled in the Cayman Islands is far greater than what is being reported in the Treasury Department’s TIC data, according to a note from the Federal Reserve.

    On Thursday, U.S. government debt rallied, sending Treasury yields lower across the board, as investors digested a mix of worries about trade tensions between the U.S. and China, the partial government shutdown, and bad loans in the bank industry. Separately, U.S. stocks DJIA SPX COMP were falling in afternoon trading.

    -Vivien Lou Chen

    This content was created by MarketWatch, which is operated by Dow Jones & Co. MarketWatch is published independently from Dow Jones Newswires and The Wall Street Journal.

    (END) Dow Jones Newswires

    10-16-25 1424ET

    Copyright (c) 2025 Dow Jones & Company, Inc.

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  • Al Pacino on co-star and ex-girlfriend Diane Keaton: ‘She lived without limits’ | Diane Keaton

    Al Pacino on co-star and ex-girlfriend Diane Keaton: ‘She lived without limits’ | Diane Keaton

    Al Pacino has paid tribute to the his co-star and ex-romantic partner Diane Keaton who died last week.

    The 85-year-old actor had been filming in Paris and reportedly needed some time to put together his thoughts and feelings on Keaton, who died of…

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  • What GPU pricing can tell us about how the AI bubble will pop

    What GPU pricing can tell us about how the AI bubble will pop

    Stay informed with free updates

    One odd thing about AI equipment is that it’s very expensive to buy and very cheap to rent.

    Want an Nvidia B200 GPU…

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  • Fujifilm’s bringing instant cameras into the selfie age

    Fujifilm’s bringing instant cameras into the selfie age

    Fujifilm has announced an update to its Instax Mini LiPlay that first launched in 2019. The new Instax Mini LiPlay Plus offers similar functionality as the original with the ability to snap digital photos that can be immediately printed on the…

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  • Netanyahu ‘determined’ to pressure Hamas to find remaining dead hostages

    Netanyahu ‘determined’ to pressure Hamas to find remaining dead hostages

    EPA Benjamin Netanyahu standing behind a podium EPA

    Benjamin Netanyahu addressed a memorial ceremony at the Mount Herzl cemetery in Jerusalem

    Israel’s prime minister has told a memorial for victims of the Hamas-led attack on 7 October 2023 that he is “determined” to secure the return of the dead…

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  • Meta to shut down Messenger desktop apps for Mac and Windows

    Meta to shut down Messenger desktop apps for Mac and Windows

    Meta is shutting down Messenger’s standalone desktop apps for Windows and Mac on December 15, the company confirmed to TechCrunch on Thursday.

    Starting December 15, users will no longer be able to log into the apps and will be automatically…

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  • Earth’s magnetic field is shifting — and satellites are feeling it

    Earth’s magnetic field is shifting — and satellites are feeling it

    More than a decade of satellite monitoring has mapped Earth’s magnetic field as it subtly altered between 2014 and 2025 — and what scientists have learned is remarkable. The South Atlantic Anomaly, a weak region, is expanding, the north…

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  • Immunotherapy EO2463 Receives FDA Fast Track for Follicular Lymphoma | Targeted Oncology

    Immunotherapy EO2463 Receives FDA Fast Track for Follicular Lymphoma | Targeted Oncology

    The FDA has granted fast track designation to the novel immunotherapy EO2463 for the treatment of follicular lymphoma, backed by positive interim data from the ongoing phase 2 SIDNEY trial (NCT04669171).1

    Under this fast track designation, Enterome, the sponsor, will be eligible for more frequent opportunities for interaction with the FDA, rolling review, and potential eligibility for priority review if criteria are met, in hopes of bringing the therapy to patients sooner.2

    “The FDA’s decision is an important validation of the unique potential of Enterome’s OncoMimics™ program,” said Pierre Belichard, chief executive officer of Enterome, in a news release.1 “It will expedite the clinical development and the regulatory pathways for EO2463, which is ready to enter registrational testing as early as next year after this fast track designation and a recent positive type C meeting with the FDA.”

    What Is the Unmet Need in Follicular Lymphoma?

    Follicular lymphoma, an indolent subtype of non-Hodgkin lymphoma (NHL), is characterized by slow disease progression and few symptoms yet shortened life expectancy, in part due to lack of a cure.

    The condition exhibits potential for spontaneous remissions, suggesting the role of the immune system in such cases.3 While this invites an opportunity for treatment through immunotherapies, the disease’s high frequency of relapse necessitates immunotherapies that produce deep, durable antitumor responses.

    How Is EO2463 Addressing This Need?

    EO2463 is a novel therapeutic vaccine candidate that utilizes Enterome’s proprietary OncoMimics™ platform. Drugs that use this platform are designed using AI and machine learning to mimic tumor-associated antigens or lineage markers, drawing from a database of 23 million commensal bacteria genes to drive strong and lasting immune responses.1 Specifically, EO2463 is a combination of 4 synthetic OncoMimics™ microbial-derived peptides that correspond to 4 B cell markers: CD20, CD22, CD37, and CD268, as well as the CD4 helper-epitope UCP2.3

    The nonrandomized, open-label phase 1/2 SIDNEY trial is evaluating the safety and preliminary efficacy of EO2463 monotherapy and in combination with lenalidomide (Revlimid) and/or rituximab (Rituxan) in patients with indolent NHL, including those with follicular lymphoma and marginal zone B-cell lymphoma, with an estimated enrollment of 60 patients across 4 cohorts.4

    The primary outcome of phase 2 is objective response rate (ORR). In an early data report, the majority of patients remained on study treatment, with an observed ORR of 46% in the first 13 patients.5 Moreover, data presented at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting show that EO2463 monotherapy was well tolerated by patients, with no severe adverse events.3

    This clinical activity primes EO2463 as a promising alternative treatment option for this patient population who may otherwise go untreated in a standard “watch-and-wait” approach.

    REFERENCES:
    1. Enterome receives FDA Fast Track designation in follicular lymphoma for lead OncoMimics™ immunotherapy EO2463. News release. BioSpace. October 16, 2025. Accessed October 16, 2025. https://tinyurl.com/4ahshump
    2. Fast Track. US Food & Drug Administration. Updated August 13, 2024. Accessed October 16, 2025. https://tinyurl.com/ms2695jn
    3. Villasboas JC, Wallace D, Smith SD, et al. Phase 1/2 of EO2463 immunotherapy as monotherapy and in combination with lenalidomide and/or rituximab in indolent NHL (EONHL1-20/SIDNEY). J Clin Oncol. 2024;42(16_suppl):7058-7058. doi:https://doi.org/10.1200/jco.2024.42.16_suppl.7058
    4. A Novel Vaccine (EO2463) as Monotherapy and in Combination, for Treatment of Patients With Indolent Non-Hodgkin Lymphoma (SIDNEY). ClinicalTrials.gov. Updated December 13, 2024. Accessed October 16, 2025. https://www.clinicaltrials.gov/study/NCT04669171
    5. Enterome’s Immunotherapy EO2463 Shows Early Clinical Response in Newly Diagnosed Follicular Lymphoma Suggesting a Potential Alternative to ‘Watchful Waiting’. News release. Enterome. December 10, 2024. Accessed October 16, 2025. https://www.enterome.com/news-events/enteromes-immunotherapy-eo2463-shows-early-clinical-response-in-newly-diagnosed-follicular-lymphoma-suggesting-a-potential-alternative-to-watchful-waiting/

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  • Eye scan shows nerve damage, inflammation in Fabry patients

    Eye scan shows nerve damage, inflammation in Fabry patients

    Noninvasive in vivo confocal microscopy (IVCM) detected signs of nerve damage in the cornea — the eye’s transparent outer layer — in people with Fabry disease, who also had higher levels of inflammatory immune cells in the cornea than…

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