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  • Novel HIV combo therapy of lenacapavir and 2 bNAbs found effective, well tolerated in Phase 2 trial

    Novel HIV combo therapy of lenacapavir and 2 bNAbs found effective, well tolerated in Phase 2 trial

    Combining lenacapavir (LEN, Gilead) and two broadly neutralizing antibodies (bNAbs) could be a good option for HIV treatment in certain patients, according to results of a phase 2 trial presented at EACS 2025, in Paris.

    The investigators (abstract…

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  • ESMO 2025: A New Era in the Treatment of Muscle Invasive Bladder Cancer. Discussant of LBA2 – Perioperative (Periop) Enfortumab Vedotin plus Pembrolizumab in Participants with Muscle-Invasive Bladder Cancer Who Are Cisplatin-Ineligible: KEYNOTE-9 – U…

    1. ESMO 2025: A New Era in the Treatment of Muscle Invasive Bladder Cancer. Discussant of LBA2 – Perioperative (Periop) Enfortumab Vedotin plus Pembrolizumab in Participants with Muscle-Invasive Bladder Cancer Who Are Cisplatin-Ineligible: KEYNOTE-9  UroToday
    2. Pfizer and Astellas announce positive results from phase 3ev-303 clinical trial for Padcev in combination with Keytruda  TradingView
    3. Enfortumab Vedotin Plus Pembro Cuts Risk of Disease Progression, Death 60% for Patients With MIBC Who Can’t Have Chemo With Bladder Removal  The American Journal of Managed Care® (AJMC®)
    4. ESMO25: Padcev, Keytruda regimen given before, after surgery shines in bladder cancer  FirstWord Pharma
    5. KEYNOTE-905: EV/pembrolizumab emerges as new option for cisplatin-ineligible MIBC  Urology Times

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  • Adjuvant Nivolumab Displays Long-Term Activity in Resected Melanoma

    Adjuvant Nivolumab Displays Long-Term Activity in Resected Melanoma

    Adjuvant nivolumab (Opdivo) generated a long-term efficacy benefit compared with ipilimumab (Yervoy) for the treatment of patients with resected stage IIIB to IIIC or IV melanoma, according to final data from the phase 3 CheckMate 238 trial…

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  • Just a moment…

    Just a moment…

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  • Why Football Manager 26 has improved its graphics… with the help of VAR

    Why Football Manager 26 has improved its graphics… with the help of VAR

    Football Manager 26 launches next month, graphics greatly improved from the last release two years ago.

    But while most games will use motion capture to get the most realistic gameplay, the team behind Football Manager have gone leftfield when it…

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  • PPP decides to give PML-N ‘more time’ to fulfil demands – Dawn

    1. PPP decides to give PML-N ‘more time’ to fulfil demands  Dawn
    2. PPP gives govt one-month deadline to fulfill coalition promises  The Express Tribune
    3. PML-N, PPP agree to resolve differences via dialogue, end political bickering  Geo.tv
    4. Coalition…

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  • This top VC has bet close to 20% of his fund on teenagers — here’s why

    This top VC has bet close to 20% of his fund on teenagers — here’s why

    Image Credits:Prostock Studio / Getty Images

    Kevin Hartz tends to be first through the door. In 2001, he co-founded Xoom, back when sending money across borders meant standing in line at Western Union. In 2013, it went public, and in 2015, PayPal paid $1.1 billion for it. Four years after launching Xoom, he co-founded Eventbrite, which went public in 2018 and turned buying event tickets into something you could do without wanting to throw your laptop in the ocean.

    After a stint at Founders Fund, Hartz co-founded his own venture firm, A* Capital (a nod to a computer science algorithm), then in 2020, he spotted another trend before the masses: the SPAC boom. His blank-check company, “one,” swallowed up 3D printing outfit Markforged in a $2.1 billion reverse merger in 2021, right as every other financier in Silicon Valley suddenly decided SPACs were the future.

    Now Hartz is onto his next thing — teenage founders, not as a social experiment but as an unplanned investment thesis. His firm recently cut a check to Aaru, an AI-powered prediction engine with one founder who was too young to get his driver’s license at the time. Hartz is not alone in this by any stretch. The dropout-and-build movement, made most famous by founders like Steve Jobs, Bill Gates, and Mark Zuckerberg, is becoming a standard lifestyle choice for a certain kind of ambitious kid.

    Consider Cory Levy, who was interning at Founders Fund, Union Square Ventures, and Techstars while still in high school, then bailed on the University of Illinois after freshman year. Today he runs Z Fellows, a one-week accelerator that hands technical founders — even high schoolers — $10,000 grants. When Levy dropped out a decade ago, the Thiel Fellowship was a radical new idea. Now, the “community of dropouts is at an all-time high,” he told Business Insider last spring. “At a big group dinner of 15 or 20 people, we’ll look around the table, and no one has a college degree.”

    It’s becoming enough of a “thing” that the accelerator Y Combinator, which has quietly reinforced drop-out culture since its outset, recently rolled out a program that’s designed for students who want to start companies but don’t want to drop out. The program allows them to apply while still in school, get accepted and funded immediately, and defer their participation in YC until after they graduate. (For YC, known for being countercultural, the move is very on brand.)

    Naturally, TechCrunch has been covering the trend: see here and here and here. But to learn more, I’ll be sitting down with Hartz at the StrictlyVC event inside TechCrunch’s rollicking Disrupt show, kicking off in San Francisco on Monday, October 27. (Hartz is talking on Tuesday, October 28.)

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  • Devs working on Hearthstone and Warcraft Rumble join 1900 other Activision Blizzard staff in unionising

    Devs working on Hearthstone and Warcraft Rumble join 1900 other Activision Blizzard staff in unionising

    Workers in Blizzard’s Hearthstone and Warcraft Rumble teams have voted to unionise with the Communications Workers of America.

    Over 100 software engineers, designers, artists, quality assurance testers, and producers voted to join…

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  • 8BitDo drops an NES-inspired collection for the console’s 40th anniversary

    8BitDo drops an NES-inspired collection for the console’s 40th anniversary

    It’s been 40 years to the day since the Nintendo Entertainment System made its US debut, and to celebrate, gaming accessory maker 8BitDo has unveiled a line of NES-themed products. The includes a limited edition version of the company’s that…

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  • Gold prices soar to record highs, mark biggest weekly gain since 2020

    Gold prices soar to record highs, mark biggest weekly gain since 2020

    Gold price fell slightly on Friday, October 17, but ended the week with the biggest rise since 2020. Gold futures dropped over 1% to around $4,260 an ounce after hitting an intraday high of $4,380. Despite the dip, gold was up 7% for the week as investors bought the precious metal amid uncertainty, Yahoo Finance reported.

    Gold futures dropped more than 1% to around $4,260 an ounce after hitting an intraday high of $4,380. (Bloomberg)

    A ‘perfect storm’ lifts gold

    Kyle Rodda, senior financial market analyst, said a “perfect storm” of global factors has pushed gold prices higher. Rising trade tensions between the United States and China, expectations of another Federal Reserve rate cut, and worries about regional banks have all driven investors toward safe-haven assets like gold.

    Rodda, who is a market analyst at Capital.com, described the surge as “parabolic,” noting that prices have risen unusually fast. “Gold is sending an ominous message about the future,” he said. “It could be pointing to global instability or a sign of speculation that might burst later.”

    Central banks and ETFs fuel demand

    Gold’s year-to-date performance has been remarkable, up nearly 59%. Central banks worldwide have been buying gold at record levels, while a weaker US dollar and falling interest rates have made holding gold more attractive than cash or bonds.

    At the same time, gold-backed exchange-traded funds (ETFs) saw record inflows last quarter, highlighting strong appetite from both retail and institutional investors.

    Why investors are buying gold

    A Bank of America Fund Managers Survey recently found that gold is the most crowded trade in the market, beating out the “Magnificent Seven” tech stocks. 39% of fund managers have no gold, 35% have 2-4% of their portfolio in gold.

    Also Read: Gold, silver prices hit records on US credit fears and ‘US-China trade war’

    Wall Street raises its price forecasts

    Several major banks have lifted their gold price targets. BofA analysts reiterated their “long gold” call, predicting prices could reach $6,000 per ounce by mid-2026. Goldman Sachs raised its forecast to $4,900 by the end of next year, and JPMorgan expects prices could climb to $6,000 by 2029.

    For now, gold’s upsurge is due to global uncertainty and investor nervousness. Whether it continues or becomes a bubble will depend on how central banks and the world economies react to inflation, rate cuts and geopolitical risks in the coming months.

    Also Read: No Kings protests to sweep US as millions plan to march against Trump’s policies

    FAQs:

    Why did gold prices rise so much this week?

    Gold prices rose due to trade tensions, rate-cut expectations, and worries about banks, making investors buy gold as a safe option.

    How high did gold prices go?

    Gold futures reached an intraday high of around $4,380 an ounce before ending the week near $4,260.

    Will gold prices keep rising?

    Experts say prices may rise further if global uncertainty, inflation, and interest rate cuts continue, but some warn it could become a bubble.

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