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  • China accuses US of ‘double standards’ over tariff threat

    China accuses US of ‘double standards’ over tariff threat

    Donald Trump’s latest threat to impose an additional 100% tariff on Chinese goods is “a typical example of US double standards”, China’s government has said.

    A Commerce Ministry spokesperson also said China could introduce its own unspecified…

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  • Dancing dust devils on Mars trace raging winds

    Dancing dust devils on Mars trace raging winds

    The Colour and Stereo Surface Imaging System (CaSSIS) on board ESA’s ExoMars Trace Gas Orbiter (TGO) captured this dust devil tracking across the Martian surface on December 3, 2021. Studying dust devils on Mars helps scientists trace the red…

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  • NeurologyLive® Brain Games: October 12, 2025 | NeurologyLive

    NeurologyLive® Brain Games: October 12, 2025 | NeurologyLive

    Welcome to NeurologyLive® Brain Games! This weekly quiz series, which goes live every Sunday morning, will feature questions on a variety of clinical and historical neurology topics, written by physicians, clinicians, and experts in the fields…

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  • Subcutaneous Pembrolizumab Shows Possibility of Providing Effective and Convenient Treatment in Oncology

    Subcutaneous Pembrolizumab Shows Possibility of Providing Effective and Convenient Treatment in Oncology

    Subcutaneously administered systemic therapies are expected to reduce administration times, minimizing the time an individual treatment chair or room is needed while simultaneously giving patients the freedom to choose how to spend more of their time outside the clinic, according to J. Thaddeus Beck, MD, FACP.

    The most recent regulatory approval of subcutaneous treatment was announced on September 19, 2025, when the FDA approved pembrolizumab and berahyaluronidase alfa-pmph (Keytruda Qlex) for subcutaneous injection for use in adult and pediatric patients aged 12 years and older in all solid tumor indications approved for the intravenous (IV) formulation of pembrolizumab (Keytruda).1,2

    The agent was tested in the phase 3 Study MK-3475A-D77 (NCT05722015) in patients with untreated, metastatic non–small cell lung cancer (NSCLC) without EGFR, ALK, or ROS1 genomic tumor aberrations. Patients were randomly assigned to receive subcutaneous pembrolizumab (n = 251) or IV pembrolizumab administered every 6 weeks with platinum doublet chemotherapy.

    The results showed that the predefined acceptance margin was met for the pharmacokinetic end points with the lower boundary, 96% CI for cycle 1 area under the curve 0 to 6 weeks, and 94% CI for cycle 3 Ctrough, of the geometric mean ratios above the prespecified threshold of 0.8 for comparability. Descriptive analyses of efficacy also indicated that the confirmed objective response rate was 45% (95% CI, 39%-52%) in the subcutaneous arm vs 42% (95% CI, 33%-51%) in the IV arm. Progression-free survival and overall survival outcomes were also similar between arms.

    “I think [this approval] is the wave of the future. [I expect that] more of these monoclonal [antibodies] will be given subcutaneously,” J. Thaddeus Beck, MD, FACP, medical oncologist at Highlands Oncology in Rogers, Arkansas, said in an interview with OncLive®.

    In the interview, Beck discussed the regulatory agency’s approval of subcutaneous pembrolizumab, its significance for patients and providers, and considerations that should be made before the agent is introduced into clinical practices.

    OncLive: What makes this approval of subcutaneous pembrolizumab meaningful?

    Beck: The approval of the subcutaneous form of pembrolizumab gives us another option that we can use to tailor treatments for patients’ individual situations. The main benefit is the ease and simplicity of administration [since it allows for a] shortened administration time. It’s a 2.4 mL or 0.5 teaspoon size injection that can be given in seconds instead of [over 30 minutes].

    We’ve had very good feedback from patients who are on the trial [about] how it really changed the way they thought about treatment. They liked the fact that it was shorter and quicker, so that they could be in and out. They could have more time to do what they wanted to do before and after their treatment, [providing] much more of a pleasant experience for them.

    What will be the immediate effect of the approval?

    The patients like it better. It will save chair time, so treatment chairs or rooms will not be occupied as long. You can cut the infusion time down. If it’s being given with another IV chemotherapy, you can drop the last infusion, given that it is subcutaneous, and the patients will have a better experience.

    What is important to note about the design of the pivotal trial?

    The trial was designed with two arms that compared sequential treatment. The first arm was IV therapy for [X] cycles, followed by subcutaneous therapy. The second arm was subcutaneous therapy, followed by IV therapy. Then patients were allowed to assess how they felt with the treatment and choose which one they’d like to continue with. Most patients chose the subcutaneous version.

    There were no unique adverse effects or safety signals. Other than the administration difference, [the subcutaneous formulation] seemed to act in the same form and fashion [as the IV formulation].

    What is your advice to those looking to integrate the subcutaneous formulation into their practice?

    People have to get partially undressed [to receive the therapy], so you’ll need a private area to [allow for that]. We’re in the process of building a new facility, and we’re taking this change into account. We’re creating a whole separate fast track area where patients can [experience] the faster workflow and have more privacy, so they can take advantage of this program.

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  • ‘Useful feedback can come in very ugly packaging’: Oscar-winning actress Julia Roberts opens up on handling harsh career criticism creatively

    ‘Useful feedback can come in very ugly packaging’: Oscar-winning actress Julia Roberts opens up on handling harsh career criticism creatively

    Even an Academy Award on your shelf cannot shield you from criticism — Julia Roberts knows that better than most. The Hollywood icon, celebrated for her roles in Pretty Woman and Erin Brockovich, recently opened up about how early-career…

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  • IsDB issues another successful Green Sukuk under enhanced Sustainable Finance Framework | News

    IsDB issues another successful Green Sukuk under enhanced Sustainable Finance Framework | News

    8 October 2025 – The Islamic Development Bank (IsDB, the Bank) raised EUR 500 million through its latest Green benchmark Sukuk issuance under its enhanced 2025 Sustainable Finance Framework (the Framework).

    The Bank, rated Aaa/AAA/AAA by S&P, Moody’s and Fitch (all with Stable Outlook) priced the 5-year Trust Certificates under its US$25 billion Trust Certificate Issuance Programme.

    The Joint Lead Managers (JLMs) for this issuance were Barclays, BNP Paribas, Commerzbank, Crédit Agricole CIB, HSBC Bank plc, ING and Nomura.

    The transaction is the Bank’s first EUR benchmark issuance this year. This followed its two other successful public USD benchmark transactions that raised a total of ~USD 3.5 billion from the global capital markets earlier this year. IsDB has now completed its 2025 funding program.

    The latest Green Sukuk issuance, the Bank’s second overall, represents an important milestone for IsDB in the EUR markets, positioning the Bank as a future frequent EUR issuer.

    The issuance witnessed a record-breaking orderbook– both in terms of both volume (5 times over subscription) and number of investors – reflecting the Bank’s very active investor outreach with EUR investors over the recent months and the robust market demand for AAA-rated paper in a challenging market environment. The Bank’s active investor engagement over the months culminated in a large increment of new investors participating in this issuance.

    The proceeds of the EUR 500 million Green Sukuk issuance will be deployed to finance and re-finance (in whole or in part) eligible projects with environmental benefits under the ‘Green Project categories’ as defined in the Framework.

    This is IsDB’s first Green Sukuk under the newly‑launched Framework that was published in July 2025 and supersedes the 2019 Framework. The enhanced Framework aligns with the latest editions of the ICMA Principles and Guidelines, including the 2025 Green Bond Principles, the 2025 Social Bond Principles and the 2021 Sustainability Bond Guidelines.

    The Framework introduces more stringent eligibility criteria for green project categories and detailed criteria for social project categories. The Bank also added two new eligible categories in the Framework, namely (a) Climate Change Adaptation and (b) Food Security and Sustainable Food Systems, reinforcing their role in its overall operations strategy and reflecting the increasing project approvals in these sectors in recent years.

    The enhanced Framework was reviewed independently by S&P Global, which then published a strong Second Party Opinion (SPO) whereby most of the project categories were assigned Medium Green and Dark Green shading. S&P also noted that there are no weaknesses in the Framework and that it is fully aligned with the ICMA Principles.

    Execution Timeline

    IsDB formally announced to the market, on Wednesday 24 September 2025, a fixed income mandate for the JLMs to arrange a series of virtual calls and physical meetings in UK, France and The Netherlands, with a potential new 5-year Green EUR Sukuk issuance to follow, subject to market conditions.

    Throughout the week of 29September, the Bank met with a diverse range of investors, particularly focusing on ESG dedicated accounts. The Bank was also building upon the investor outreach that it had undertaken across Northern and Southern Europe in early September.

    Despite a volatile backdrop, market conditions were supportive for IsDB to announce a EUR 500mn Will Not Grow (WNG) 5-year Green Sukuk transaction on Tuesday, 7 October. After gathering positive interest, the Bank officially opened the orderbook the next morning, on Wednesday, 8 October, with a guidance of EUR SOFR Mid Swap (MS) plus 47 basis (bps) area.

    Investor demand quickly exceeded EUR 1.5 billion (bn), enabling the Bank to set the final spread at EUR SOFR MS plus 44 bps, i.e. three bps tighter from guidance. This translates to a profit rate of 2.793% for investors, payable on an annual basis and priced at par.

    The momentum continued even with the tighter pricing and final orderbooks closed in excess of EUR 2.6bn (incl. EUR 225mn JLM), resulting in IsDB’s most oversubscribed trade ever as well as its largest EUR book on record.

    The final distribution was very well diversified across investor types: Central Banks / Official Institutions / Sovereign Wealth Fund (42%); Asset Managers / Fund Managers (30%); Insurance and Pension Funds (22%); and Banks / Treasury (6%).

    From a geographical point of view, Europe turned out with the largest share (53%), followed by MENA (27%), Asia (13%) and the UK (7%).

    Dr. Zamir Iqbal, the Vice President (Finance) and CFO of IsDB, said: “The work on the Bank’s enhanced Sustainable Finance Framework reflects the Bank’s commitment to further scale up sustainable development in our Member Countries. The latest AAA-rated EUR Green Sukuk is a landmark achievement that showcases the Bank’s impact and capabilities. The strongest credential for the Bank is very strong interest of investors – we are grateful for their endorsement and confidence in the Bank’s mission and its sustainable finance framework.”

    Mr. Mohammed Sharaf, the IsDB Treasurer and Mr. Zakky Bantan, the Manager of the Capital Markets Division added, “The most significant takeaway from this issuance is the influx of new investors. Extensive investor outreach, together with the robust Sustainable Finance Framework, made this possible. We highly appreciate all the support from investors. We look forward to build upon this success for future issuances when we return to the EUR markets next year.”

    Jamie Stirling, the Global Head of SSA Debt Capital Markets at BNP Paribas concluded: “An impressive issuance by IsDB that underscores the growing appetite of European investors for high-quality AAA exposure in the region. Partnering with IsDB and the other lead managers, we assembled a broad, diversified investor base – many of them first-time Sukuk participants – demonstrating the confidence placed on IsDB Green Sukuk paper. Congratulations to all the team, a very well-deserved result.”

    IsDB is a AAA-rated supranational and multilateral development financial institution with 57 Member Countries (MCs) and a mandate of delivering social and economic development with a focus on sustainability in its Member countries and Muslim communities worldwide. The Bank’s operations span across four continents, touching the lives of nearly 1 in 5 of the global population. Its mission is to equip people to drive their own economic and social progress at scale, putting the infrastructure in place and enabling them to fulfil their potential. The Bank’s targeted efforts across multiple continents foster an environment where the primary focus is on human development and well-being.

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  • Starship flight 11. A look at the results of the first 10 launches.

    Starship flight 11. A look at the results of the first 10 launches.

    The 11th flight test of Starship is preparing to launch as soon as Monday, Oct. 13. The launch window opens at 7:15 p.m. ET.

    Monday’s launch is the fifth flight test in 2025. The spacecraft is expected to take astronauts to the moon and eventually…

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  • Mongolia and IUCN sign Memorandum of Understanding to enhance cooperation leading up to and beyond UNCCD COP17 – Press release

    Mongolia and IUCN sign Memorandum of Understanding to enhance cooperation leading up to and beyond UNCCD COP17 – Press release

    The Memorandum of Understanding (MoU), signed by IUCN and the Government of Mongolia, will enhance cooperation between the Parties on biodiversity conservation, rangeland restoration, and sustainable land management. The agreement was signed during the IUCN World Conservation Congress (WCC) at the Mongolia Pavilion by IUCN Director General Dr. Grethel Aguilar and H.E. Batbaatar Bat, Minister of Environment and Climate Change of Mongolia.

    This MoU provides a general and guiding framework for cooperation between the Parties, defining areas and forms of collaboration with the aim of strengthening Mongolia’s leadership in conservation and sustainable use of natural resources and enhancing IUCN’s contribution to Mongolia’s national and international environmental goals. It achieves this by establishing a foundation for cooperation on restoration opportunities mapping, capacity-building, multi-stakeholder dialogues, and joint advocacy for integrated approaches to land, biodiversity, and climate action.

    The MoU comes as Mongolia prepares to assume the Presidency of UNCCD COP17 in 2026, where rangelands, drought resilience, and integrated land management will be at the top of the global agenda. The agreement with IUCN sets a framework for collaboration, while also promoting synergies with IUCN tools as well as biodiversity and climate commitments under the Rio Conventions.

    UNCCD COP17 is set to take place in Ulaanbaatar, Mongolia, in late 2026. This major global convening will bring together UNCCD’s 197 Parties in a crucial global forum to accelerate action against desertification, land degradation and drought. As one of the most affected countries by desertification, with nearly 77 percent of its land degraded, Mongolia will leverage COP17 to drive solutions for land restoration, sustainable land management and resilience-building across the world.  

    COP17, set during the International Year of Rangelands and Pastoralists (IYRP) — declared by the United Nations General Assembly and championed by Mongolia — will build on efforts to promote the sustainable management, restoration and conservation of rangelands.

    Upon the signing of the MoU, Dr. Grethel Aguilar, the Director General of IUCN, said: “IUCN is proud to strengthen its partnership with Mongolia at this historic moment. Mongolia’s leadership on rangeland restoration, Nature-based Solutions, and sustainable dryland management is exemplary and provides inspiration for the global community. This agreement ensures that IUCN can bring its scientific expertise, policy experience, and broad membership to support Mongolia’s priorities during COP17 and beyond.” 

    H.E. Batbaatar Bat, Minister of Environment and Climate Change of Mongolia, similarly reflected on the significance of the signing: “This MoU reflects Mongolia’s deep commitment to safeguarding our rangelands, strengthening community livelihoods, and promoting international cooperation on nature and climate. By working closely with IUCN, we can advance our flagship initiatives and ensure that COP17 delivers bold, practical solutions for the challenges of desertification, drought, and biodiversity loss.

    Mongolia joined IUCN as a State Member in 2015 and has since engaged in joint efforts on protected and conserved areas, ecosystem restoration, drylands management, and global environmental governance. This MoU represents further strengthening of the relationship between IUCN and Mongolia, as well as a deepened commitment by both Parties to advance conservation in East Asia for the benefit of both people and nature. 

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  • Victoria Beckham weighs in on nepotism debate

    Victoria Beckham weighs in on nepotism debate



    Victoria Beckham weighs in on nepotism debate

    Victoria Beckham has recently weighed in on…

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  • Hubble went supernova hunting — and found something unexpected: Space photo of the week

    Hubble went supernova hunting — and found something unexpected: Space photo of the week

    QUICK FACTS

    What it is: NGC 6000, a spiral galaxy

    Where it is: 102 million light-years away in the constellation Scorpius

    When it was shared: Sept. 29, 2025

    Here’s a story for the ages — or maybe a story of the ages.

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