How have the FDA approvals of axi-cel and liso-cel affected the LBCL treatment paradigm?
Five years ago, irrespective of relapse status or primary refractoriness, the standard of care would have been salvage platinum-containing chemotherapy…
With the London sales all wrapped and Art Basel Paris kicking off earlier this week, there’s only one major art world event left on the calendar between now and Thanksgiving—and it’s a big one: the November marquee auctions.
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Size matters for a telescope’s image resolution. The bigger the viewing aperture, the more light it can collect. More light helps reveal fainter cosmic objects, as well as sharpen the images themselves.
Morning everyone. In good news for some and depressing news for others, house prices have risen at their fastest rate for four years boosted by interest rate cuts and the extension of the government’s first-home guarantee. In more money news, a Choice survey shows that rapid-delivery groceries are almost 40% more expensive.
Plus we look at Sussan Ley’s net zero dilemma, we have a maths challenge, and Australia’s women have walloped England by six wickets in the World Cup.
Australia
Uber Eats delivery riders. Photograph: Martin Berry/Alamy
Uber pricey | Shoppers are paying up to 39% more for groceries ordered through rapid delivery apps, according to a Choice survey, with items such as pasta, milk and fresh vegetables costing on average 11% more on third-party apps such as Uber Eats, DoorDash and Milkrun compared with supermarkets.
‘Acceleration mode’ | House prices are rising at their fastest rate in nearly four years, according to new research, as buyers rush to auctions and owners put off selling amid expectations of a further upswing. Brisbane has overtaken Canberra as the second-most expensive house market, after Sydney, with median prices rising nearly $40,000 to hit $1.1m.
Ban challenged | Queensland’s controversial ban on puberty blockers and other hormone therapies is unlawful because of a failure to properly consult health executives on a decision affected by political interference, a court has heard.
Keating cross | A development backed by media scion James Packer in Sydney’s Kings Cross is pitting the former prime minister Paul Keating against former NSW premier Morris Iemma.
Plus points | If, like the Morning Mail, you were unable to help kids with maths after year 7, look away now. But for those of you who like a challenge, test yourself on yesterday’s tough NSW HSC maths paper.
World
Wallace Shawn, Ilana Glazer and Jonathan Glazer were among the signatories of a call for sanctions on Israel. Composite: Getty Images
Exclusive | Prominent Jewish figures such as Naomi Klein, Jonathan Glazer and Wallace Shawn are calling on the United Nations and world leaders to impose sanctions on Israel over what they describe as “unconscionable” actions amounting to genocide in Gaza.
Senate marathon | Jeff Merkley, Oregon’s Democratic senator, has given a marathon speech on the Senate floor lasting more than 19 hours to make the case that Donald Trump is acting as an authoritarian, including by deploying the military into his home city of Portland. Meanwhile, the US president declared himself the arbiter of whether or not his own administration should pay him hundreds of millions of dollars in damages over past federal investigations.
Exclusive | A man sent back to France under Britain’s “one in, one out” scheme has returned to the UK on a small boat and claims to be a victim of modern slavery at the hands of trafficking gangs.
Ukraine ‘compromise’ | Volodymyr Zelenskyy has voiced support for Donald Trump’s proposal for Ukraine and Russia to freeze the war at the current frontlines, calling it “a good compromise”.
Quantum leap | Google has claimed a breakthrough in quantum computing after developing an algorithm that performed a task beyond the capabilities of conventional computers.
Full Story
Composite: PA
Can Ange Postecoglou stage a comeback?
Sports writer Martin Pegan speaks to Reged Ahmad about Ange Postecoglou’s sacking by Nottingham Forest and what’s next for one of the most polarising figures in football.
Full Story
Can Ange Postecoglou stage a comeback?
In-depth
Sussan Ley faces a big test over net zero policy. Photograph: Dan Himbrechts/AAP
With a crunch Coalition meeting on net zero looming, Dan Jervis-Bardy examines the challenge facing Sussan Ley as she tries to formulate a one-size-fits-all policy. As Dan writes, “it is not hyperbole to suggest that this debate threatens to tear the Coalition apart”, with Barnaby Joyce potentially beginning a wave of defections.
Not the news
The office work-out with Guardian journalist Emma Joyce. Photograph: Jessica Hromas/The Guardian
Squats, lateral flexions, wall sits and elevated incline push-ups are all exercises that you can do in your everyday clothes without interfering too much with your life. Our very own Emma Joyce gave them a try at Guardian Australia HQ. Find out she fared.
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Sport
Annabel Sutherland and Ash Gardner after beating England. Photograph: Matt Roberts-ICC/ICC/Getty Images
Cricket | Australia took up where they left off in the Ashes last summer by crushing England by six wickets in the penultimate group game of the Women’s World Cup in Indore thanks firstly to fine bowling by Alana King and brilliant batting by Annabel Sutherland and Ash Gardner.
Football | Sam Kerr’s return to the Matildas squad for the forthcoming friendlies against Wales (midnight Sunday) and England (6am Wednesday) can’t come too soon for a team that has stalled in recent months. Eintracht Frankfurt will be hoping to extend Liverpool’s losing streak to five in this morning’s Champions League game, while there’s also a meeting of European royalty as Real Madrid host Juventus.
Rugby league | The Leeds prop Mikolaj Oledzki moved from Poland 20 years ago and had no idea what rugby league was. Now he’s preparing to face Australia in the Ashes at Wembley.
Inner-city Melbourne suburbs must accept more housing development and can’t expect the west to keep doing the heavy lifting, Clare O’Neil said last night according to the Age. The Telegraph has picked up despairing social media reaction to yesterday’s HSC maths exam with one describing it as “actually impossible”. The Bureau of Meteorology’s redesigned website is dividing users with many calling for the old one to be reinstated, the Adelaide Advertiser reports.
What’s happening today
New South Wales | The leader of the opposition, Mark Speakman, and shadow ministers will make a “major 2027 election policy announcement” in Sydney.
Business | Star Entertainment holds its annual general meeting on the Gold Coast.
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Brain teaser
And finally, here are the Guardian’s crosswords to keep you entertained throughout the day. Until tomorrow.
