- Dimtirov withdraws ahead of Medvedev clash in Paris ATP Tour
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		Dimtirov withdraws ahead of Medvedev clash in Paris – ATP Tour
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		 Radiomics on Spinal Cord MRI May Offer Superior MS AssessmentRadiomics may offer a superior means to assess spinal cord pathology compared with visual assessment of MRI in patients with multiple sclerosis (MS), a new report found.The findings may make it easier for clinicians to more precisely understand… Continue Reading
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		 Timing is everything: a simple chemical method to determine the bioavailable surface concentration of insecticide for insecticide-treated net evaluation | Malaria JournalAll tests were conducted at Biolytrics Vietnam between September 2018 and June 2020. Five experiments were performed. (1) validation of the GC-FID (Gas Chromatography with Flame Ionization Detection) compared to standard CIPAC HPLC (High… Continue Reading
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		 eNAMPT/TLR4 signaling drives PAH cellular phenotypic switching and lung vascular remodeling | Cell Communication and SignalingAhmed M, Zaghloul N, Zimmerman P, Casanova NG, Sun X, Reyes Hernon V, et al. Endothelial eNAMPT drives EndMT and preclinical PH: rescue by an eNAMPT-neutralizing mAb. Pulm Circ. 2021;11(4):20458940211059712. Google Scholar Chen J, Sysol JR, Singla S, Zhao S, Yamamura A, Valdez-Jasso D, et al. Nicotinamide phosphoribosyltransferase promotes pulmonary vascular remodeling and is a therapeutic target in pulmonary arterial hypertension. Circulation. 2017;135(16):1532–46. Google Scholar Sun X, Sun BL, Babicheva A, Vanderpool R, Oita RC, Casanova N, et al. Direct extracellular NAMPT involvement in pulmonary hypertension and vascular remodeling. Transcriptional regulation by SOX and HIF-2alpha. Am J Respir Cell Mol Biol. 2020;63(1):92–103. Google Scholar Gorelova A, Berman M, Al Ghouleh I. Endothelial-to-mesenchymal transition in pulmonary arterial hypertension. 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Inflammation, immunological reaction and role of infection in pulmonary hypertension. Clin Microbiol Infect. 2011;17(1):7–14. Google Scholar Soon E, Holmes AM, Treacy CM, Doughty NJ, Southgate L, Machado RD, et al. Elevated levels of inflammatory cytokines predict survival in idiopathic and familial pulmonary arterial hypertension. Circulation. 2010;122(9):920–7. Google Scholar Wang J, Tian XT, Peng Z, Li WQ, Cao YY, Li Y, Li XH. HMGB1/TLR4 promotes hypoxic pulmonary hypertension via suppressing BMPR2 signaling. Vascul Pharmacol. 2019;117:35–44. Google Scholar Xiao G, Zhuang W, Wang T, Lian G, Luo L, Ye C, et al. Transcriptomic analysis identifies toll-like and nod-like pathways and necroptosis in pulmonary arterial hypertension. J Cell Mol Med. 2020;24(19):11409–21. Google Scholar Young KC, Hussein SM, Dadiz R, deMello D, Devia C, Hehre D, et al. Toll-like receptor 4-deficient mice are resistant to chronic hypoxia-induced pulmonary hypertension. Exp Lung Res. 2010;36(2):111–9. Google Scholar Dai Z, Li M, Wharton J, Zhu MM, Zhao YY. Prolyl-4 hydroxylase 2 (PHD2) deficiency in endothelial cells and hematopoietic cells induces obliterative vascular remodeling and severe pulmonary arterial hypertension in mice and humans through hypoxia-inducible factor-2alpha. Circulation. 2016;133(24):2447–58. Google Scholar Continue Reading
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		 His Highness the Aga Khan meets with President Macron in ParisParis, France, 29 October 2025 – His Highness the Aga Khan was received by President Emmanuel Macron at the Élysée Palace yesterday. The meeting follows the signing of an agreement with the government of France in July 2025 to work together… Continue Reading
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		 Immersive Hertfordshire horror maze goes bust before HalloweenDanny FullbrookBedfordshire, Hertfordshire and Buckinghamshire  Getty Images Getty ImagesOrganisers said it was the first time the character Leatherface had been featured in a UK scare attraction A company that ran an immersive horror attraction has gone bust… Continue Reading
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		 Phia’s founders on how AI is changing online shoppingWhen Phia‘s founders Phoebe Gates and Sophia Kianni decided to build an AI startup, they targeted an area they understood well: online shopping. The founders, who met at Stanford when they were randomly paired up as roommates, understood… Continue Reading
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		 Looking at the roles genes play in the growth and aging of tomatoesOverexpressing these receptors caused ABA hypersensitivity, dwarfism, delayed senescence, reproductive anomalies, and enhanced fruit pigmentation. The findings reveal how ABA signaling integrates hormonal crosstalk to fine-tune… Continue Reading
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		 S Korea announces lowering of tariffs as part of new US trade dealKoh Ewe,Singapore and Kathryn Armstrong,London  Getty Images Getty ImagesThe meeting comes as both countries are still trying to reach a trade deal The US and South Korea have reached a broad trade deal, both countries have said following talks between their… Continue Reading
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