Introduction
Background
In recent years, digital health interventions, particularly eHealth and mobile health (mHealth) platforms, have shown promise in promoting healthy behaviors []. eHealth refers to the use of digital technologies, such as…
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ATEEZ’s San Named Dolce & Gabbana Global Ambassador
Dolce & Gabbana has tapped San, a member of K-pop boy group ATEEZ, to be the luxury fashion house’s latest brand ambassador.
The Italian-based brand announced the news this week – it marks the first major fashion deal for the…
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Yuki Tsunoda ‘frustrated’ by costly Red Bull error as he suffers early exit in United States Grand Prix Sprint Qualifying
Yuki Tsunoda was left questioning what had happened after a timing error from Red Bull saw him drop out of the first phase of Sprint Qualifying at the Circuit of The Americas.
The closing moments of SQ1 saw chaos on the track, as numerous drivers…
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Prince William’s emotional promise to Princess Diana laid bare
Prince William’s childhood vow to Princess Diana revealed Prince William made a heartfelt promise to her mom, Princess Diana after the title of “Her Royal Highness” was taken away from her.
The Prince of Wales was…
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US FDA expands use of Amgen, AstraZeneca’s drug for chronic inflammatory sinus disease
Oct 17 (Reuters) – The U.S. Food and Drug Administration has approved Amgen (AMGN.O) and AstraZeneca’s (AZN.L) drug for a type of chronic inflammatory sinus disease, the drugmakers said on Friday.The approval expands the use of the drug, Tezspire, as an add-on maintenance treatment of inadequately controlled chronic rhinosinusitis with nasal polyps in adult and pediatric patients aged 12 years and older.
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The condition causes the sinuses to stay inflamed for 12 weeks or more and soft, noncancerous growths called polyps to form in the nose. Symptoms include facial pain, reduced sense of smell and nasal congestion.
Tezspire is already approved as a single-use pre-filled syringe in the U.S., EU and other countries for add-on maintenance treatment for severe asthma.
The approval is based on the results from a late-stage study in which the drug showed clinically meaningful reduction in the size of nasal polyps and reduced nasal congestion compared to placebo.
Tezspire also reduced the number of patients needing surgery for nasal polyps by 98% and reduced the need for oral steroids by 88%, the data showed.
Data for Tezspire shows that it might be more effective than Sanofi (SASY.PA) and Regeneron’s (REGN.O) Dupixent for patients with this condition, William Blair analyst Matt Phipps said ahead of the approval.Tezspire, chemically known as tezepelumab-ekko, is a monoclonal antibody that blocks TSLP — a key protein involved in triggering and sustaining inflammation linked to severe asthma and related conditions.
The approval “shows the versatility of TSLP inhibition beyond asthma and highlights both companies’ commitment to take a really important scientific insight and way to treat patients into broad application that can make a real difference for patients,” said Kate Chevlen, global commercial head of inflammation portfolio at Amgen.
Other approved treatments for chronic rhinosinusitis include Dupixent, GSK’s (GSK.L) Nucala as well as Roche (ROG.S) and Novartis’ (NOVN.S) Xolair.Reporting by Siddhi Mahatole and Sneha S K in Bengaluru; Editing by Sahal Muhammed and Shreya Biswas
Our Standards: The Thomson Reuters Trust Principles.
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Lamborghini swerves away from all-electric future
Theo LeggettInternational Business Correspondent
GettyThe boss of Lamborghini said enthusiasm for electric cars was declining The boss of Lamborghini has said its customers still want “the sound and the emotion” of internal combustion engines, and the company will use them in its cars for at least the next decade.
Speaking to the BBC at the Italian supercar-maker’s London showroom, chief executive Stephan Winkelmann said enthusiasm for electric cars was declining – creating an opportunity to focus on hybrid power instead.
Lamborghini will decide in the next month whether a long-planned new model, the Lanzador, will be all-electric, or merely a plug-in hybrid, he said.
Mr Winkelmann insisted the business was socially responsible, but added that as a low-volume manufacturer, its actions would have a limited impact on the environment.
Lamborghini is a luxury brand ultimately owned by the Volkswagen Group. It currently has three main models.
The Temerario and Revuelto are supercars. Both are plug-in hybrids, combining powerful petrol engines with electric motors. They can run in all-electric mode, but only for very short distances.
The Urus is a luxury SUV, currently available as a plug-in hybrid and as a conventional petrol-powered car. Less exotic and certainly less ostentatious than the supercars, it nevertheless makes up more than half of the company’s sales.
There is also a limited edition ‘super-sports’ car: the Fenomeno, which has a top speed of more than 215mph. Only 30 will be built, each costing at least €3m (£2.6m) before taxes.
Two years ago, Lamborghini announced plans for an all-electric successor to the Urus, which would have been available from 2029. However, the plan was recently shelved, with the electric model now not expected before 2035.
It had also planned to make a brand new battery-powered grand tourer (GT), to be called the Lanzador. However, the future of that project is also deeply uncertain.
Lamborghini chief executive Stephan Winkelmann “We still need to decide whether we are going full electric, the decision we took some years ago, or seeing whether in the new environment this should also be a plug-in hybrid”, said Mr Winkelmann.
The new environment he referred to is a perceived waning of interest in electric cars among high-end buyers.
“Today enthusiasm for electric cars is going down”, he explained. “We see a huge opportunity to stay with internal combustion engines and a battery system much longer than expected”.
Continuing to use internal combustion engines for another 10 years, he said, would be “paramount for the success of the company”. Customers, he insisted, still hankered after the noise and fury of a conventional motor.
“This is something they want, they still want the sound and the emotion of an internal combustion engine”, he said.
It’s an approach that contrasts with that of Lamborghini’s Italian arch-rival Ferrari, which is pushing ahead with its own plans for a first all-electric car.
The aptly-named Elettrica is due to be unveiled next year, though the company showed off some key components at its Capital Markets Day earlier this month.
It will be sold alongside conventional and hybrid models.
Ferrari chief executive Benedetto Vigna said it would have driving traits that were “unique in the heart, in the soul of our clients.”
Getty ImagesThere are questions about whether the Lanzador model – pictured here as a concept model in 2023 – will be fully electric Mr Winkelmann insisted his own company was not ignoring the ongoing pressure to cut emissions.
“We are selling 10,000 cars in a world that is producing 80 million cars a year, so our impact in terms of CO2 emissions is not that important”, he said.
“For sure, we are socially responsible, but it doesn’t really make a lot of difference”.
The sale of new petrol and diesel cars, including plug-in hybrids, is due to be banned in both the the EU and the UK from 2035.
However, in the EU, there has been intense lobbying from some manufacturers for the transition to electric cars to be given more time, in order to “acknowledge current industrial and geopolitical realities”.
If that happens, internal combustion engines could remain on the market beyond the current deadline.
Meanwhile the UK’s rules provide an exemption for “low volume” manufacturers who register fewer than 2,500 new cars each year.
This would currently cover Lamborghini, which sold just 795 cars here last year.
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Pickleball players warned of alarming rise in eye injuries – The Times
- Pickleball players warned of alarming rise in eye injuries The Times
- The Fastest Growing Sport in the US Comes With a Sharp Risk to Your Face Gizmodo
- Pickleball Eye Injuries Surge In U.S. U.S. News & World Report
- Pickleball: An ophthalmic…
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Gene Therapy Shows Lasting Benefit for Children With Rare Disorder – MedPage Today
- Gene Therapy Shows Lasting Benefit for Children With Rare Disorder MedPage Today
- 95% of kids with “bubble boy” disease cured by one-time gene therapy New Atlas
- An experimental therapy saves the lives of more than 60 children with a deadly…
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‘Made in Pakistan’ expo opens in Ethiopia
Over 100 leading Pakistani exporters and industry representatives attended the expo.
ADDIS ABABA:…
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Pakistan’s gold stash tops $9b on back of global rally
KARACHI:Pakistan’s gold holdings have emerged as a key driver of the country’s strengthening reserves, soaring in value as global bullion prices rally more than 50% in 2025.
According to data from Topline Securities and the State Bank of Pakistan (SBP), the country’s gold reserves are now valued at nearly $9 billion, up sharply from previous years. This surge has pushed Pakistan’s total reserves, including the liquid foreign exchange assets, to around $23.4 billion, placing them near all-time highs.
“On average, over the last 10 years, gold made up about one-third of Pakistan’s liquid reserves. Now, it is closer to two-thirds – a major shift, reflecting how global gold strength is reinforcing Pakistan’s external buffers,” noted Topline Securities CEO Mohammed Sohail.
Analysts attribute the rally to a combination of global factors: investor flight to safe-haven assets amid geopolitical uncertainty, central bank buying, and sustained inflationary pressures. For Pakistan, the windfall comes as a timely boost to its financial buffers following years of external stress.
While the SBP’s gains are largely valuation driven rather than cash inflows, the rising value of gold reserves is cushioning Pakistan’s economy and supporting the rupee in the backdrop of lingering fiscal and trade challenges.
Furthermore, gold prices in Pakistan skyrocketed to a new all-time high on Friday, defying the global trend, where bullion slumped amid a stronger US dollar and easing safe-haven demand.
According to data released by the All Pakistan Sarafa Gems and Jewellers Association, the price of 24-karat gold surged by Rs14,100 per tola, reaching a historic high of Rs456,900. Similarly, the 10-gram gold price rose by Rs12,089 to settle at Rs391,718.
In contrast, the international gold market witnessed a sharp pullback, where prices fell by more than 2% after touching a record high of $4,300 per ounce earlier in the session. The decline was triggered by a rebound in the US dollar and remarks by US President Donald Trump, who said that a “full-scale tariff” on China would be unsustainable, easing investor fears of a prolonged trade war.
Spot gold was down 2.6% at $4,212.99 per ounce at 12:39 pm ET (1639 GMT), after scaling an all-time high of $4,378.69 earlier in the session, according to Reuters. The metal breached $4,300/oz for the first time on Thursday, and is set for a weekly gain of about 5%. US gold futures for December delivery were down 1.8% to $4,225.80.
At the end of Friday’s trading session, the Pakistani rupee remained stable against the greenback and settled at 281.10. It has depreciated by 0.91% CYTD and appreciated by 0.95% FYTD, according to Ismail Iqbal Securities.
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