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  • Dinosaurs were thriving until asteroid struck, research suggests | Dinosaurs

    Dinosaurs were thriving until asteroid struck, research suggests | Dinosaurs

    Dinosaurs would not have become extinct had it not been for a catastrophic asteroid strike, researchers have said, challenging the idea the animals were already in decline.

    About 66m years ago, during the late Cretaceous period, a huge space rock…

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  • Things are looking up for lagging Dover as shares pop more than 6%

    Things are looking up for lagging Dover as shares pop more than 6%

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  • Calvin Klein Inc. launches Re-Calvin take-back program in the United States, making circularity more accessible

    Calvin Klein Inc. launches Re-Calvin take-back program in the United States, making circularity more accessible

    Calvin Klein Inc. today announces the U.S. launch of Re-Calvin, a new take-back program designed to make it easy for customers to responsibly part with their pre-loved items.

    Developed in partnership with Trove, the leader in branded resale and customer trade-in, and Debranda comprehensive sortation and circular logistics partner, Re-Calvin is a free service from Calvin Klein that gives U.S. customers a simple, accessible way to extend the useful life of clothing, shoes and accessories from any brand through donation, recycling, downcycling or, when necessary, responsible disposal that is converted from waste to energy. Re-Calvin also accepts intimates such as bras, swimwear and underwear – a category often excluded from circularity programs.

    “As Calvin Klein continues its sustainability journey, we are proud to introduce a program that makes circularity more accessible for our customers and delivers alternative uses for pre-loved items,” said David Savman, Global Brand President, Calvin Klein. “It was important that we partner with experts with a proven ability to build and scale programs that handle a wide range of products andcategories, making it easier than ever for customers to responsibly extend the life of their items.”

    How It Works

    Customers in the United States can visit calvinklein.us/re-calvin to print a free shipping label and send in items from any brand. Once received, each package is processed and routed according to Calvin Klein’s diligent, established standards:

    • Reuse: Items in good condition are donated or sent to secondhand distribution partners.
    • Recycle / Downcycle: Items that cannot be reused, including intimates, are recycled into new fibers whenever possible, or downcycled into materials such as insulation or padding.

    • Responsible Disposal: As a final step, if no reuse, recycling or downcycling option is available, items are to be converted from waste to energy or alternative fuel conversion.

    Only items suitable for a new owner are directed to reuse. Garments with significant wear, damage, heavy stains and all intimates are directed to end-of-use streams, including recycling, downcycling and responsible disposal. Customers receive an email update after their parcel is processed, detailing how their items were routed, ensuring transparency throughout the process.

    Powered by Trove’s Takeback Plug-In

    Re-Calvin is powered by Trove’s new Takeback Plug-In, which enables Calvin Klein to seamlessly manage item intake, routing and transparency at scale. The plug-in integrates directly into Calvin Klein’s existing U.S. website, enabling the brand to operate a multi-brand takeback program that includes complex categories such as intimates.

    The Takeback Plug-in expands Trove’s suite of circular solutions, which also includes the Resale Plug-in, Trade-in Plug-in and a range of API integration options. Together, these tools give brands the flexibility to build customized circular programs that meet their unique needs.

    “Re-Calvin marks the first implementation of Trove’s new Takeback Plug-In,” said Terry Boyle, CEO of Trove. “With this launch, Calvin Klein is showing how technology can make responsible choices simple for every customer, accepting items from any brand and across all categories, including intimates, to help keep more textiles in circulation.”

    By accepting items from any brand and across all categories, Re-Calvin reflects Calvin Klein, Trove and Debrand’s shared belief that every item should have as many chances as possible to find a second life.

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  • ChatGPT can provide trustworthy information for pregnant women seeking advice on opioid use disorder

    ChatGPT can provide trustworthy information for pregnant women seeking advice on opioid use disorder

    When trained correctly on medically accurate information, ChatGPT can provide trustworthy information for pregnant women seeking medical advice for treating opioid use disorder, according to new research in the Journal of Studies on…

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  • Effect of Non-surgical Periodontal Therapy on Levels of Ghrelin and Tumor Necrosis Factor-Alpha (TNF-α) in the Gingival Crevicular Fluid of Healthy and Periodontitis Patients With and Without Type 2 Diabetes Mellitus: A Clinico-Biochemical Study

    Effect of Non-surgical Periodontal Therapy on Levels of Ghrelin and Tumor Necrosis Factor-Alpha (TNF-α) in the Gingival Crevicular Fluid of Healthy and Periodontitis Patients With and Without Type 2 Diabetes Mellitus: A Clinico-Biochemical Study

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  • The race to launch ever-riskier leveraged ETFs in the U.S. is heating up

    The race to launch ever-riskier leveraged ETFs in the U.S. is heating up

    By Joseph Adinolfi

    A trio of issuers filed with the SEC this month for permission to launch dozens of new leveraged funds, some offering to amplify daily returns of hot stocks like Nvidia by as much as 5 times

    Over the past few weeks, at least three ETF issuers sought permission from the SEC to launch new leveraged funds. Some say the prospects push the boundaries of what might be permitted under existing regulations.

    Wall Street’s push to launch ever-riskier leveraged exchange-traded funds is picking up steam, as issuers test the boundaries of what is legally permissible in the U.S. with a recent flurry of filings.

    Over the past few weeks, at least three ETF issuers – Volatility Shares, ProShares and T-Rex – have sought permission from the Securities and Exchange Commission to launch new leveraged funds. If approved, these products would offer investors the opportunity to magnify daily swings in the Dow Jones Industrial Average DJIA; shares of artificial-intelligence darlings Nvidia Corp. (NVDA) and CoreWeave (CRWV); and cryptocurrencies, including bitcoin (BTCUSD) and XRP, by as much as 5x.

    Many of the filings pitched funds that aim to amplify daily moves by 3x. But Volatility Shares has filed for permission to launch at least 21 funds advertising 5x daily swings on a number of individual stocks, cryptocurrencies, stock-market indexes or existing ETFs.

    Representatives for Volatility Shares, ProShares and T-Rex all declined to comment on the filings when contacted by MarketWatch.

    Since the beginning of October, issuers have filed for permission to launch more than 100 funds targeting 3x or 5x leverage, according to a MarketWatch analysis of securities filings.

    Volatility Shares files for 21 5x levered ETFs

          Fund name                  Target                    Issuer        Date of filing 
       5x AMD ETF      Advanced Micro Devices Inc.       Volatility Shares  10/14/2025 
       5x AMZN ETF     Amazon.com Inc.                   Volatility Shares  10/14/2025 
       5x COIN ETF     Coinbase Global Inc.              Volatility Shares  10/14/2025 
       5x CRCL ETF     Circle Internet Group Inc.        Volatility Shares  10/14/2025 
       5x GOOGL ETF    Alphabet Inc. Class A             Volatility Shares  10/14/2025 
       5x MSTR ETF     Strategy Inc.                     Volatility Shares  10/14/2025 
       5x NVDA ETF     Nvidia Corp.                      Volatility Shares  10/14/2025 
       5x PLTR ETF     Palantir Technologies Inc.        Volatility Shares  10/14/2025 
       5x TSLA ETF     Tesla Inc.                        Volatility Shares  10/14/2025 
       5x Bitcoin ETF  Bitcoin                           Volatility Shares  10/14/2025 
       5x Ether ETF    Ethereum                          Volatility Shares  10/14/2025 
       5x Solana ETF   Solana                            Volatility Shares  10/14/2025 
       5x XRP ETF      XRP                               Volatility Shares  10/14/2025 
       5x GDX ETF      VanEck Gold Miners ETF            Volatility Shares  10/21/2025 
       5x GLD ETF      SPDR Gold Shares                  Volatility Shares  10/21/2025 
       5x MAGS ETF     Roundhill Magnificent Seven ETF   Volatility Shares  10/21/2025 
       5x SLV ETF      iShares Silver Trust              Volatility Shares  10/21/2025 
       5x SOXQ ETF     Invesco PHLX Semiconductor ETF    Volatility Shares  10/21/2025 
       5x SPY ETF      SPDR S&P 500 ETF Trust            Volatility Shares  10/16/2025 
       5x QQQ ETF      Invesco QQQ Trust Series I        Volatility Shares  10/16/2025 
       5x IWM ETF      iShares Russell 2000 ETF          Volatility Shares  10/16/2025 
       Source: SEC 

    These filings caught the attention of individuals who closely follow the ETF industry. Some questioned whether these products would comply with current SEC regulations or run afoul of the regulator’s restrictions.

    That’s because SEC regulations from 2021 include provisions that can effectively limit how much leverage a mutual fund or ETF can achieve using derivatives. The specific rule, known as 18f-4, states that firms must carefully manage how volatile their derivatives holdings might be – inclusive of swaps, futures or written options contracts.

    Derivatives holdings are subject to a common risk-management calculation that compares their risk of loss to an underlying benchmark, said Rahul Sen Sharma, president and co-CEO of Indxx, which provides benchmarking services for ETFs that uses derivatives.

    “Our understanding of 18f-4 is that it requires a designated reference portfolio to calculate a value at risk amount,” he told MarketWatch. While he called the rule “kind of long and complicated,” he figured it can be satisfied if a benchmark is provided – at least when it comes to 2x single-stock products, which have been approved in the past.

    The first single-stock leveraged ETFs to trade in the U.S. launched in 2022, according to data from Morningstar Direct.

    Dozens of funds aimed at 3x the daily move in an underlying index were grandfathered in because they launched before the 18f-4 SEC rule was finalized. That includes the ProShares UltraPro QQQ ETF TQQQ, which aims to amplify daily swings in the Nasdaq-100 index NDX. That fund consistently ranks among the most heavily traded by clients of Interactive Brokers Group Inc. (IBKR), according to data shared with MarketWatch.

    Of note, in the U.S., no ETF currently trading targets 3x the daily move on an individual stock. A spokesperson for the SEC said the agency isn’t able to respond to many press inquiries due to the ongoing government shutdown.

    The higher the targeted leverage, the greater the challenge for getting these funds to pass muster with the SEC, said Dave Nadig, president and head of research at ETF.com and co-author of book titled “A Comprehensive Guide to Exchange-Traded Funds.” However, SEC rules governing derivative-linked volatility could probably be gamed to a certain extent, he said.

    Others were more upbeat about the possibility that the SEC could permit the new batch of proposed funds to come to market, including the ones targeting 5x leverage.

    A top executive at one ETF issuer, who asked for anonymity because he was not authorized to speak publicly to the press, said he thinks these funds could be allowed under current SEC rules. Ultimately, whether or not they are approved will depend on how deeply opposed the SEC is to allowing these products to come to market, the executive said.

    “Remember what happened with spot bitcoin? It wasn’t allowed, everyone filed for it, now it’s huge,” the executive said. In 2024, after a years-long saga, the SEC finally approved ETFs that could hold bitcoin directly.

    Booming issuance

    Issuance of new ETFs has boomed over the past couple of years as companies gravitated toward increasingly complex products. Funds that use derivatives, either to supercharge daily swings or offer dividend income or downside protection, have proven particularly popular.

    Leveraged equity funds are the largest category in the leveraged-fund universe, encompassing 750 funds and $164.37 billion in total assets, according to data from EPFR, an ISI Markets company. The number of existing leveraged equity funds has increased by 40% year to date, and the vast majority of funds in the leveraged-equity category are ETFs.

    Firms have also launched 164 leveraged alternative funds, which track cryptocurrencies like bitcoin and commodities like gold. These have accumulated $46 billion in assets, while leveraged bond funds have taken in $7.6 billion across 56 funds, EPFR data showed. These figures include both ETFs and mutual funds.

    In the U.S., leveraged funds can be purchased on Robinhood Markets Inc. (HOOD) and other brokerages popular with individual investors, making them particularly popular with amateur speculators, experts said. Professional investors can trade them as well.

    European regulators, so far, have demonstrated a higher tolerance than their U.S. counterparts for allowing leveraged products that everyday investors can tap. While some products tied to individual stocks have proven popular, one such fund went bust earlier this month, offering a lesson to investors.

    On Oct. 6, the GraniteShares 3x Short AMD Daily ETP was terminated by its issuer after shares of AMD rose by more than 33% intraday, driving the value of the exchange-traded product to zero. This fund was what is known as an inverse fund. Seen as a sibling to leveraged funds, inverse funds aim to profit when the targeted asset or index declines in value. A 33% gain for a given stock would be large enough to wipe out a 3x inverse fund.

    In a statement shared with MarketWatch, GraniteShares described the liquidation as a “standard outcome.”

    “The closure of a 3x long or short ETF following an extreme price move is a standard outcome in both U.K. and U.S. markets. In this instance, a 33%+ intraday move in AMD triggered the predefined mechanism that results in a 100% loss for a 3x short position, exactly how the product is designed to operate,” a representative for GraniteShares said in a written statement to MarketWatch. Investors who owned the fund ahead of the wipeout lost their entire investment.

    Liquidations like that one could follow in the U.S. if any or all of the current crop of filings for single-stock leveraged funds are approved, according to Eric Balchunas, a senior ETF analyst at Bloomberg Intelligence.

    Balchunas crunched the numbers and found 350 instances over the past five years where one of 66 stocks included in a filing for a 3x leveraged product swung by 33% or more in a single session. Such a move could be large enough to wipe out a fund aiming to amplify a daily move by 3x in either direction. A drop of just 20% would be enough to push a fund targeting 5x leverage on a single stock to liquidate.

    Despite these risks, ETF.com’s Nadig said products targeting 5x leverage on stocks like Nvidia would probably prove popular with investors.

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  • IVF test could misjudge embryo health, Cambridge study finds

    IVF test could misjudge embryo health, Cambridge study finds

    Harriet HeywoodCambridgeshire

    PA Media Close-up of two small bare feet resting on a soft, light-colored surface, with toes slightly curled and background softly blurredPA Media

    The Cambridge study found that pre-implantation genetic testing could mislabel embryos as abnormal when the abnormalities were in the placenta

    Researchers have raised concerns about the reliability of a widely…

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  • International experts publish guidelines on the administration of gene therapy for hereditary hearing loss

    International experts publish guidelines on the administration of gene therapy for hereditary hearing loss

    Up to 60% of congenital and early-onset hearing loss is caused by genetic mutations in an inherited gene, and gene therapy has recently emerged as a potential treatment option. To provide a standardized framework for conducting…

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