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  • Development and Validation of a Caregiver-Reported Quality-of-Life Questionnaire for Pediatric Patients With Drug-Resistant Epilepsy on a Ketogenic Diet

    Development and Validation of a Caregiver-Reported Quality-of-Life Questionnaire for Pediatric Patients With Drug-Resistant Epilepsy on a Ketogenic Diet

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  • ‘Gateway to hell’: young reporter’s harrowing two years in besieged Gaza | Gaza

    ‘Gateway to hell’: young reporter’s harrowing two years in besieged Gaza | Gaza

    It is six o’clock in the morning on Saturday 7 October 2023. Half awake, I call out in a hoarse voice to my two sisters who are sleeping on their beds next to me: “Enas, Remas, wake up – you have school.”

    We were not to know it yet, but…

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  • Tim Dowling: I’m under an azure Croatian sky – fretting about the roof back home | Life and style

    Tim Dowling: I’m under an azure Croatian sky – fretting about the roof back home | Life and style

    I’m sitting on a terrace overlooking a sparkling bay. Directly in front of me fishing boats rock gently on the water and tidy white houses are piled on the hill opposite. I’m looking at my phone.

    The video I’m watching is narrated by…

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  • Programming Space Game For X86 In Assembly Without An Operating System

    Programming Space Game For X86 In Assembly Without An Operating System

    In this video our hacker [Inkbox] shows us how to create a computer game that runs directly on computer hardware, without an operating system!

    [Inkbox] briefly explains what BIOS is, then covers how UEFI replaces it. He talks about the…

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  • The Celebrity Traitors to I Swear: the week in rave reviews | Culture

    The Celebrity Traitors to I Swear: the week in rave reviews | Culture

    TV

    If you only watch one, make it …

    The Celebrity Traitors

    BBC iPlayer

    Come all ye faithful … The Celebrity Traitors, including Claire Balding, David Olusoga, Joe Wilkinson and Paloma Faith. Photograph: BBC/Studio Lambert/Cody Burridge

    Summed up…

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  • The Freak: script of Charlie Chaplin’s unfinished final film to be published | Charlie Chaplin

    The Freak: script of Charlie Chaplin’s unfinished final film to be published | Charlie Chaplin

    He rose from the slums of Victorian London to become arguably cinema’s first great comic artist, with The Great Dictator and Limelight among his masterpieces.

    Now the script of Charlie Chaplin’s unfinished final film is to be published, having…

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  • From Tron: Ares to Riot Women: your complete entertainment guide to the week ahead | Culture

    From Tron: Ares to Riot Women: your complete entertainment guide to the week ahead | Culture


    Going out: Cinema

    Tron: Ares
    Out now
    Perhaps the most exciting thing for many about this new Tron film is that it has a score from Nine Inch Nails. It also stars Jared Leto as the embodiment of a super-advanced AI program sent into the real world on…

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  • Blind date: ‘After too many tepid, app-based dates, outsourcing my love life to a paper is obviously the way to go’ | Dating

    Blind date: ‘After too many tepid, app-based dates, outsourcing my love life to a paper is obviously the way to go’ | Dating

    Hannah on Ioan

    What were you hoping for?
    A fun evening with a stranger … hopefully good chat and not painfully awkward.

    First impressions?
    Warm, friendly and charismatic.

    What did you talk about?
    What didn’t we talk about? We discussed the dating…

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  • Researchers solve mystery of how bats prey on birds in flight – Euronews.com

    1. Researchers solve mystery of how bats prey on birds in flight  Euronews.com
    2. Grisly recording reveals bat catching, killing and eating robin mid-flight  The Guardian
    3. Bats Catch Migratory Birds and Eat Them in Midair  The New York Times
    4. Bats hunt and…

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  • TikTok influencers fuelling parallel market for unlicensed weight-loss drug | Consumer affairs

    TikTok influencers fuelling parallel market for unlicensed weight-loss drug | Consumer affairs

    An online parallel market for an unlicensed weight-loss drug is being fuelled by TikTok fitness influencers and sellers on WhatsApp, a Guardian investigation can reveal.

    Retatrutide, which is still in clinical trials, is being advertised by social media influencers for its supposed fat-burning effects. Followers are urged to message the accounts privately for supplier links, as well as being provided with discount codes.

    Separately, there is a thriving trade on Telegram, where groups with thousands of members share “before and after” photos, injection guides and claims of next-day UK delivery. Sellers advertise the drug there before directing customers to WhatsApp for transactions.

    Retatrutide is an experimental injection developed by the US drugmaker Eli Lilly. The drug targets three gut hormones – GLP-1, GIP and glucagon. Early trials suggest it could help patients lose up to a quarter of their body weight. Nicknamed the “triple G”, the drug is being hailed online as the next Ozempic.

    However, doctors and pharmacists have warned that the sale of what is still an unlicensed drug in the UK is a cause for concern and could result in users injecting products of unknown origin.

    Some said the popularity of retatrutide could be linked to the rising cost of licensed weight loss products such as Mounjaro.

    Selling retatrutide on TikTok or Telegram is illegal in the UK, as it is an unlicensed drug that cannot be marketed or supplied for human use under the Human Medicines Regulations 2012.

    Some influencers try to sidestep the rules by referring to the drug as a “research chemical” or citing it as “not for human consumption”. Retatrutide is not a controlled drug, but promotion and supply can still breach medicines, advertising, and consumer laws, risking fines, prosecution or prison.

    The TikTok influencer Jon Kluth, who is based in the US and has 226,500 followers, posted on the 26 June an update on his journey taking what he called “reta” for four weeks and that said followers could use “code Jon” to purchase it. He then links to an account that sells peptides called Halfnattys. When asked for a comment, Kluth did not respond and the account was taken down.

    Another account with a UK influencer called @MappyMyGains talks about retatrutide as a “gamechanger” on 21 September, and when followers ask where he gets the drug from he says “pm me mate”. He did not respond to a request for a comment.

    Another promoter called @clairejoy86 posted videos captions “day 10 of Reta … ” to the background track of the song Manchild by Sabrina Carpenter. Those who comment are told to message her for supply information. She did not respond to a request for comment and instead the account was taken down.

    According to TikTok, the social media company has removed violative content and banned associated hashtags and search suggestions. It said it was dedicated to keeping the platform safe and invest in strengthening enforcement strategies.

    The Guardian also found groups with up to 9,000 members selling retatrutide using Telegram’s built-in discovery tool, which works like a public directory. Typing “retatrutide” instantly brings up channels with thousands of members, filled with photos of weight loss, glowing testimonials and step-by-step guides for mixing or injecting at home.

    Within minutes of joining one group, a seller posted WhatsApp details, where most transactions take place. The seller sent an instruction manual and promised delivery within 48 hours. When asked whether the product was genuine, one seller said: “You can’t be sure.” Another shared a photo of a supposed laboratory certificate. None asked about weight, medical conditions or previous experience.

    Inside these groups, posts show black plastic parcels with Royal Mail labels, claiming to contain new batches. One message read: “It took eight of us to load them this morning.”

    Buyers can choose between powder vials, mixed at home with sterile water, or pre-filled pens typically sold at £160 for 20mg. When asked how long a pen should last, sellers give conflicting answers ranging from a few weeks to “depends on your body”.

    A spokesperson for Telegram said it actively moderated harmful content on its platform including content that encouraged the “misuse of controlled medications”. It added that it removed “millions of pieces of harmful content each day”.

    Eli Lilly said retatrutide had not been reviewed or approved by any regulatory agency in the world. Photograph: Bloomberg/Getty Images

    Jason Murphy, the head of pharmacy at Chemist4U, said unregulated imports could be dangerous. “People are injecting substances they can’t verify. Even if the science behind retatrutide is sound, these online versions may not contain what they claim,” he said.

    Dr Crystal Wyllie of Asda Online Doctor linked the surge in demand to recent price rises for approved weight-loss drugs such as Mounjaro. “With costs increasing, patients are turning to social media. But counterfeit injections are extremely risky. You can’t be certain what’s inside or whether the environment they were made in was sterile,” she said.

    Her team has already seen patients harmed by self-injection from unverified sources. “We understand the frustration, but buying from Telegram or WhatsApp is gambling with your health,” said Wyllie. “These substances could be contaminated or incorrectly dosed.”

    A spokesperson from Eli Lilly said retatrutide was in phase 3 clinical trials and had not been reviewed or approved by any regulatory agency anywhere in the world. “Therefore at this time no one can sell [it] for human use,” they said, adding that any product “falsely representing itself as a Lilly investigational product not yet approved … may expose patients to potentially serious health risks”.

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