Inhibitors supercharge kinase turnover through native proteolytic circuits

Cell lines and cell culture

KBM7 cells (obtained from T. Brummelkamp) and KBM7 iCas9 cells (a gift from J. Zuber) were grown in IMDM (Thermo Fisher Scientific) supplemented with 10% heat-inactivated FBS (Sigma-Aldrich) and 1%…