Researchers Identify Key Metric in Delivering Focused Ultrasound to Treat Patients with High-Grade Gliomas

Authorship: In addition to Golby, Mass General Brigham authors include Nathan McDannold and Erickson Torio. In addition to Woodworth, other authors include Pavlos Anastasiadis, Ahmad Ozair, Chixiang Chen, Dheeraj Gandhi, Ying Meng, Agessandro Abrahao Jr., Jeffrey Carpenter, Christopher Cifarelli, Howard Eisenberg, Mary Jane Lim-Fat, Kullervo Hynynen, Ali Rezai, Arjun Sahgal, Jason Sheehan, Zhiyuan Xu, Nir Lipsman, and Costas Arvantis.

Disclosures: Abrahao reports grants from the Focused Ultrasound Foundation and clinical trial support from InSightec. Woodworth reports grants from the Focused Ultrasound Foundation, NIH, and the Maryland Stem Cell Research Foundation, as well as clinical trial support from InSightec and the Keep Punching Foundation. Lipsman reports grants from the Focused Ultrasound Foundation, clinical trial support from InSightec, and support from the Midas Touch Foundation. Gandhi reports grants from the Focused Ultrasound Foundation, NIH, Microvention, University of Calgary/NoNo Therapeutics, and University of Maryland Innovation Gateway. Eisenberg reports grants from InSightec. Hynynen reports a grant from the Weston Foundation and is an inventor on patents licensed to InSightec. McDannold reports grants from the Focused Ultrasound Foundation, NIH, and InSightec.

Funding: This study was funded in part by Insightec, Focused Ultrasound Foundation, National Center for Advancing Translational Sciences (1UM1TR004926), and the American Cancer Society (IRG-18-160-16)

Paper cited: Woodworth G et al. “Acoustic emissions dose and spatial control of blood-brain barrier opening with focused ultrasound” Device DOI: 10.1016/j.device.2025.100894

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