A new study has touted the anti-ageing and skin health-boosting effects of Bioiberica’s hyaluronic acid matrix ingredient, Dermial.
With a high concentration of hyaluronic acid (>60%), collagen and a balance of other glycosaminoglycans (GAGs) including dermatan sulfate, Dermial is the first hyaluronic acid matrix ingredient on the market, according to Bioiberica.
To assess the efficacy of Dermial as a nutricosmetic, the company performed a 12 week, randomised, double-blind, placebo-controlled clinical trial with 60 healthy female participants aged between 35 and 65 — all of which had visible signs of skin ageing.
Published in Dermatology and Therapy, results revealed that daily supplementation with 60mg of Dermial can enhance skin hydration and reduce the appearance of facial wrinkles.1
This suggests that hyaluronic acid, and specifically Dermial, could offer significant beauty from within benefits when taken daily.
Beauty isn’t skin deep
Hyaluronic acid has long been a staple of the cosmetics industry, with a vast number of topical products on the market utilising the super-ingredient to promote skin health and vitality.
However, when applied topically, the ingredient can only achieve surface-level hydration, which doesn’t address dryness at a cellular level. (For more information on the rise of beauty from within ingredients, check out this interview with Tosla Nutricosmetics’ Monika Jesenko.)
To overcome this issue, nutraceutical suppliers in both the joint health and beauty from within spaces have begun formulating with hyaluronic acid as an ingestible nutricosmetic ingredient — with promising results.
To assess the efficacy of Dermial specifically, Bioiberica conducted this clinical trial, which found that a low dose of 60mg a day could offer ‘powerful regenerative and moisturising properties’ alongside its unique glow-inducing effect, which was achieved six weeks into supplementation.
Researchers also observed:
- Significant improvements in the appearance of skin wrinkles in the Dermial group at six weeks
- Those taking Dermial experienced significant improvements in skin smoothness by six weeks
- Participants given Dermial had reduced skin roughness, while maintaining a more healthy skin pH balance (12 weeks)
- The Dermial group had brighter and more hydrated skin by the end of the study
- Those taking Dermial experienced a decrease in skin scaliness
Meanwhile, participant satisfaction was 69%, with this proportion all stating they were either very satisfied or satisfied with the product.
Beauty benefits for all ages
Alongside the measures discussed above, Bioiberica ran a sub-analysis of the study’s results, which suggest that Dermial could also offer different skin-supporting effects depending on a user’s age.
Interestingly, participants older than 55 experienced significant improvements in biomarkers of skin barrier function — including brightness, hydration, smoothness, deformability, roughness, scaliness and temperature.
Meanwhile, pH balance was also better maintained in the older group compared with the placebo, suggesting that Dermial can address age-related skin concerns, such as the appearance of wrinkles, dryness, dullness and roughness.
“We are so excited to share the full details of this ground-breaking debut clinical trial, demonstrating the incredible potential Dermial holds for nutraceutical innovation,” comments Daniel Martínez-Puig, Head of R&D Human and Animal Health at Bioiberica and one of the study’s authors.
“While overall improvements were less pronounced in volunteers younger than 55 years, they nevertheless experienced benefits in hydration, brightness and smoothness. These results point to the versatility of Dermial as a skin health supplement, able to meet consumers where they are in their skin health journey, regardless of age.”
Reference
1 Oral Supplementation with a New Hyaluronic Acid Matrix Ingredient Improves Skin Brightness, Hydration, Smoothness, and Roughness: Results from a Randomized, Double-Blinded, Placebo-Controlled Study