In 2025, Brazil remains the leading country in the Americas for reported yellow fever cases. However, the Republic of Colombia has confirmed a significant outbreak since 2024
By July 31, 2025, Colombia reported in a post on Facebook a total of 125 confirmed cases of yellow fever (YF), resulting in 53 deaths.
Most of these YF cases were concentrated in the Tolima Department, which accounted for 105 cases and 38 deaths.
In addition, YF cases have been reported in the Departments of Huila, Cauca, Nariño, Putumayo, Caldas, Meta, Vaupés, Guaviare, and Caquetá.
As of August 4, 2025, YF is a vaccine-preventable disease, and proof of vaccination is required to enter various countries, including Colombia.
In the United States, the YF-VAX vaccine is commercailly offered at travel vaccination retailers.