A study published in the NIHR’s Efficacy and Mechanism Evaluation journal looks at the mechanisms of a known rare side effect, vaccine-induced immune thrombosis (VITT) and thrombocytopenia, associated with adenoviral Covid vaccines.
Prof Adam Finn, Professor of Paediatrics, University of Bristol, said:
“This is a summary of the findings to date of several distinct pieces of research intended to increase our understanding of VITT. The work was extensive, took a number of different approaches, and provided some additional evidence around the potential pathogenetic mechanisms. However, a complete understanding of the genetic and environmental factors which drive these rare reactions remains elusive, partly because of the relatively small number of individuals affected who could be studied.”
‘Understanding mechanisms of thrombosis and thrombocytopenia with adenoviral SARS-CoV-2 vaccines: a comprehensive synopsis’ by Phillip LR Nicolson et al. was published in the NIHR’s Efficacy and Mechanism Evaluation journal.
DOI: 10.3310/FFSS9010
Declared interests
Prof Adam Finn: “Adam Finn is a member of JCVI subcommittees relating to varicella-zoster, pneumococcal and respiratory syncytial virus vaccines and of the WHO working group on COVID19 vaccines. He leads epidemiological research for the University of Bristol funded by Pfizer. He undertakes paid consultancy for multiple vaccine development and manufacturing companies. He was an investigator in trials of the Oxford-AstraZeneca COVID19 vaccine during the pandemic.”