In a new episode of the Rethinking Clinical Trials Podcast, Greg Simon and Lorella Palazzo discuss key takeaways from the new End-of-Trial Decision-Making chapter of the Living Textbook.
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The chapter provides guidance on how to navigate the hiatus between the end of an intervention and the return of effectiveness results.
“It’s especially relevant to pragmatic trials since there’s often a long period between when the trial activities officially end and when the results are known. What do you do in the meantime?” Simon said.
“And spoiler alert, life is lived in the meantime. Most decisions in healthcare are made in a time of uncertainty.”
The chapter was developed by Greg Simon, Lorella Palazzo, and Rachel Hays. Simon is a senior investigator at the Kaiser Permanente Washington Health Research Institute (KPWHRI) and a professor in the Department of Health Systems Science at the Kaiser Permanente Bernard J. Tyson School of Medicine. He is a longtime member of the Coordinating Center leadership team for the NIH Pragmatic Trials Collaboratory and the chair of the Health Care Systems Interaction Core. Palazzo is a senior collaborative scientist at KPWHRI and a research associate with the Health Care Systems Interactions Core.