Designing allosteric modulators to change GPCR G protein subtype selectivity

Cell lines

HEK293T/17 (CRL-11268, RRID: CVCL_1926) cells were obtained from the American Type Culture Collection (ATCC). G-protein-deficient HEK293 cells (ΔGNAS, ΔGNAL, ΔGNAQ, ΔGNA11, ΔGNA12 and ΔGNA13, HEK293 clone 38 (ref. 54) and…

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