Our study provides novel insights into the relationship between the IBI and the risk of 30-day readmission following elective PCI. By leveraging a comprehensive retrospective cohort, we have demonstrated that higher IBI values are significantly correlated with an increased risk of readmission, independent of traditional risk factors. This correlation was particularly pronounced in older, male patients and those with diabetes, highlighting the potential utility of IBI in risk stratification for these vulnerable populations. Our multivariate analysis revealed that a one-unit increase in IBI is associated with a 41% increase in the risk of 30-day readmission (OR 1.41, 95% CI 1.19–1.67, p < 0.001). This means that for every unit increase in IBI, the likelihood of a patient being readmitted within 30 days increases significantly. For example, a patient with an IBI of 2 compared to a patient with an IBI of 1 would have a 41% higher risk of readmission. This increased risk is likely due to the role of inflammation in promoting plaque instability, thrombus formation, and other adverse cardiovascular events that can lead to hospital readmission.
When compared to other studies, our findings are consistent with those of Li et al. [9], who demonstrated the association between inflammatory markers and the risk of hospitalization for heart failure post-myocardial infarction. However, our study extends these insights by showing that an integrated inflammatory index, rather than a single biomarker, is associated with readmission, emphasizing the complexity of inflammatory processes in cardiovascular disease [10]. The association between inflammation and cardiovascular outcomes, including post-PCI readmission, is well-established in the literature [11, 12]. Our findings are consistent with those of recent studies that have implicated inflammation in the pathogenesis of adverse cardiovascular events [13]. For instance, a study by Xie et al. [14] confirmed the predictive value of C-reactive protein, a key component of IBI, for cardiovascular events. Our study extends these insights by showing that an integrated inflammatory index, rather than a single biomarker, is associated with readmission, emphasizing the complexity of inflammatory processes in cardiovascular disease.
The potential mechanisms underlying the association between IBI and readmission are multifaceted. Inflammation is known to play a role in plaque rupture and thrombus formation, which can lead to acute coronary syndromes and potentially readmission [15]. Also, local or systemic inflammation has been proven to be a possible mechanism underlying the development of coronary slow flow phenomenon [16, 17]. Many patients experience recurrent episodes of angina due to the coronary slow flow phenomenon, leading to frequent hospitalizations [18]. Furthermore, inflammation may also contribute to the development of heart failure, a common cause of readmission following PCI [19]. By integrating multiple inflammatory biomarkers, IBI may provide a more comprehensive assessment of the inflammatory state and its impact on post-PCI outcomes.
The stronger correlation observed in older patients and those with diabetes may reflect the heightened inflammatory state often observed in these patient groups [20, 21]. Diabetes is known to induce a chronic low-grade inflammatory state, which could potentiate the association between IBI and readmission [22]. Similarly, aging is associated with an increased inflammatory burden, which may contribute to the observed association [23]. These findings underscore the importance of considering IBI in the context of patient-specific risk factors when assessing the risk of readmission. The stronger correlation observed in males may reflect sex-specific differences in inflammatory responses to PCI [24]. Emerging evidence suggests that sex hormones modulate inflammation, with males exhibiting higher levels of certain inflammatory markers compared to females [25]. This could potentially explain the enhanced association between IBI and readmission in male patients. Additionally, the higher IBI in males may also be indicative of a more aggressive inflammatory process post-PCI, which could lead to a higher likelihood of complications and subsequent readmission [26].
IL−6 is a well-established inflammatory marker that has been extensively studied in the context of cardiovascular disease. Recent studies have shown that elevated IL−6 levels are associated with increased risk of adverse outcomes following PCI. For instance, high levels of IL−6 have been linked to larger infarct sizes and higher mortality rates in patients with ST-segment elevation myocardial infarction [27]. Additionally, IL−6 has been identified as an independent predictor of non-target lesion progression in patients after coronary stenting [28]. In our study, we collected data on IL−6 levels to provide additional supporting evidence for the effectiveness of IBI. The significant difference in IL−6 levels between the readmitted and non-readmitted groups aligns with the observed trends in IBI, further validating its role as a comprehensive measure of inflammation. The inclusion of IL−6 in our data collection was intended to demonstrate that it shares a similar trend with IBI, thereby reinforcing the validity of IBI as a predictor of readmission risk.
The implications of our findings for clinical practice are significant. By identifying patients with higher IBI values as being at increased risk of readmission, clinicians may be able to target these individuals for more intensive post-discharge monitoring and intervention. This could potentially lead to a reduction in readmission rates and associated healthcare costs, as well as improved patient outcomes.
It is important to note that our study is not without limitations. As a retrospective cohort study, it is subject to the inherent biases and limitations of such designs. First, Our study is limited by the lack of standardized adjudication of readmission urgency or etiology, which precluded stratification into urgent vs. non-urgent or cardiac vs. non-cardiac categories. Future prospective studies with dedicated adjudication committees are needed to validate these findings in such contexts. Secondly, Second, geographical factors and variations in healthcare practices, as well as disparities in the availability and utilization of primary care, can significantly influence readmission rates. Our study population is drawn from a specific region, which may not be representative of other areas with different healthcare systems, patient demographics, or clinical practices. For instance, regions with limited access to primary care or specialized cardiovascular services may experience higher readmission rates due to inadequate post-discharge follow-up and management. Notably, we excluded patients who experienced major procedural complications, which were defined as complications necessitating additional interventions or treatments beyond standard PCI, such as vascular perforation, acute stent thrombosis, or significant bleeding requiring transfusion. While this exclusion was intended to focus on the elective PCI population and minimize confounding from procedures that became emergent, it may introduce selection bias. Future prospective studies are needed to validate our findings and to explore the potential of IBI as a predictive tool in a broader range of patient populations and clinical settings.