This guide offers a clear, in-depth look at the capabilities, applications, and innovations behind Wyatt Technology’s light scattering solutions, equipping you with the information needed to make confident choices in high-resolution macromolecular analysis.
Wyatt instruments measure a wide range of key parameters, including molar mass, particle size, structural conformation, charge, and binding affinity. These tools are essential for characterizing:
- Proteins, polymers, nanoparticles, viral vectors, exosomes, and more
- Gene therapy and drug delivery systems
- Complex conjugates and biotherapeutics
With advanced systems like the DAWN®, miniDAWN®, and DynaPro® instrument families, along with user-friendly software such as ASTRA® and DYNAMICS®, Wyatt gives researchers the power to explore molecular detail with clarity and precision. Whether you’re working in life sciences, pharmaceuticals, materials science, or nanotechnology, this guide will help you understand what these technologies can do—and how to choose the right solution for your needs.
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About Waters | Wyatt Technology
Wyatt Technology Corporation develops instrumentation, software and techniques for the characterization of macromolecules and nanoparticles, in solution, based on light scattering and related technologies. The physical properties determined by Wyatt’s products include absolute molar mass of proteins, polymers and other macromolecules; size and charge (zeta potential); protein-protein and other biomolecular interactions; composition of conjugated proteins and co-polymers; and macromolecular conformation.
Products and services
Wyatt’s product line includes instruments and software for:
- on-line multi-angle light scattering (MALS), used in conjunction with size-exclusion chromatography to quantify absolute molar mass, size, conformation, conjugation and aggregation
- traditional (cuvette-based) and high-throughput (microwell plate-based) dynamic light scattering (DLS) to determine size (radius) and size distributions, protein melting temperature and stability-indicating parameters
- electrophoretic mobility (PALS) to determine molecular charge/zeta potential
- composition-gradient light scattering for label-free analysis of biomolecular interactions
- field-flow fractionation for separation of macromolecules and nanoparticles from 1-1000 nm, used in conjunction with on-line light scattering and other detection technologies to quantify molar mass and size
Wyatt also offers, on a limited basis, sample analysis services utilizing its unique technologies.
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