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  • Tesla proposes trillion-dollar compensation package for CEO Elon Musk | Elon Musk News

    Tesla proposes trillion-dollar compensation package for CEO Elon Musk | Elon Musk News

    The governing board for the electric carmaker Tesla has put forward a pay package for CEO Elon Musk that could make him the world’s first trillionaire — but only if he meets a series of high-performance standards over the next 10 years.

    The proposal became public on Friday, as part of the company’s regulatory filings.

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    Musk is already considered one of the world’s wealthiest businessmen, and one of his eye-popping pay packages from 2018 continues to be the subject of a legal battle.

    But if approved, the latest proposal would likely be the largest corporate pay package in United States history.

    Tesla shareholders will vote on the compensation scheme on November 6. The regulatory filing indicated that the plan had already undergone a review from a committee of independent directors.

    “This is a ridiculously large pay package. It raises lots of questions,” Brian Quinn, a professor at Boston College Law School, told the news agency Reuters.

    Quinn added he had little doubt about how the shareholders will vote.

    “Given that Tesla’s stock price is basically all vibes and appears to have very little to do with the automaker’s actual performance, I suspect they will approve this package.”

    In the regulatory filing, Tesla leaders indicated that they felt Musk deserved the higher compensation range, despite the carmaker’s recent wobbles on Wall Street.

    “Traditional compensation packages granted to executives at other companies were determined to not be appropriate for designing Mr. Musk’s incentive compensation,” the filing explained.

    What are the terms?

    To earn the trillion-dollar pay package, Musk would have meet ambitious benchmarks for Tesla, reversing its drooping sales and increasing its total value and car production over the next decade.

    In the short term, Musk would have to boost Tesla’s valuation to $2 trillion. By the end of the plan, Tesla would have to reach a value target of $8.6 trillion.

    Currently, the company is worth about $1.03 trillion — roughly the same amount as the proposed compensation package.

    By the end of the 10-year term, Tesla would have also had to deliver 20 million vehicles in total. Last year, the company delivered just under 2 million vehicles.

    Other benchmarks include putting a million self-driving robotaxis in operation and delivering one million artificial intelligence (AI) bots.

    As part of the 10-year plan, Musk would also have to develop a long-term “framework” to name a successor as Tesla’s CEO.

    All of Musk’s compensation in the proposed pay package would come in the form of Tesla shares, given based on performance metrics. He would receive no salary or cash bonuses.

    Musk would have to stay with the company for at least seven and a half years to cash out any of the shares he earns. If he stays until 2035, for the full 10 years, he would be eligible for the full amount.

    Currently, Musk holds about 13 percent of Tesla’s shares. The plan puts an additional 12 percent in his reach. That would give him greater power in shareholder meetings.

    Tesla has faced protests over CEO Elon Musk’s close ties to the administration of US President Donald Trump [Taylor Coester/Reuters]

    This is not the first time Tesla has sought to compensate Musk handsomely for his leadership at the car company.

    In 2018, Tesla unveiled a similar 10-year plan, slated to give Musk nearly $55.8bn at the time in stocks and other awards.

    That pay scheme has been tied up in litigation, however, after a stockholder challenged the amount in a Delaware court. Twice, that compensation package was struck down over concerns that it was unfairly negotiated, with Musk allegedly putting his finger on the scale.

    Tesla has appealed the decisions to the Delaware Supreme Court, and in June 2024, company shareholders voted to reinstate the pay package.

    Its board also approved an interim compensation package for Musk this year worth about $29bn in stock, on the condition he remains as CEO until 2030.

    Last year, Tesla also moved its business incorporation from Delaware to Texas, in a move speculated to help avoid further legal hurdles.

    Musk himself has come under scrutiny in recent months for his close association with United States President Donald Trump.

    Protests in Spain show Elon Musk as a baby with an "I Heart Trump" bib.
    A protest in Seville, Spain, on June 29 shows Elon Musk as a baby with a Trump-themed bib [Claudia Greco/Reuters]

    Musk’s political ambitions

    In the wake of an assassination attempt against Trump in July 2024, Musk endorsed the Republican leader’s bid for re-election, throwing himself into campaigning and fundraising.

    Trump, in turn, embraced Musk as a close adviser. Days after his election victory in November, Trump announced that Musk would join his second administration as the head of a new government organisation called the Department of Government Efficiency or DOGE — an acronym reminiscent of a dog meme Musk is associated with.

    Trump’s re-election coincided with a record high last year for Tesla shares.

    But Musk’s brief tenure as a “special government employee” brought backlash against his technology brands, as did his efforts to back far-right parties in Europe, particularly ahead of Germany’s federal election in February.

    Protests erupted outside Tesla dealerships in the US after Musk took a leading role in mass layoffs in the federal government, as well as the apparent dismantling of several independent agencies, like the US Agency for International Aid (USAID).

    Some critics questioned whether Musk might have a conflict of interest in attacking certain agencies — like the Consumer Financial Protection Bureau — or accessing troves of government data that could be used to benefit his businesses.

    Special government employees, however, are capped at serving in the government for only 130 days per year.

    By the end of Musk’s term in the Trump administration, he and the Republican president had a falling-out over Trump’s efforts to pass a massive spending package known informally as the One Big Beautiful Bill.

    Musk denounced the bill — which passed in July — as fiscally irresponsible, and he and Trump publicly traded insults, with Musk threatening to launch his own rival political movement, the America Party.

    The tumult, as well as increased competition from rival electric vehicle makers, has been credited with contributing to a 25 percent drop in Tesla shares this year.

    In July, sales in the European Union fell by about 40 percent, while its Chinese rival BYD saw an increase in buying.

    Tesla’s most recent quarterly profits plummeted from $1.39bn to $409m. The fluctuation has concerned some observers.

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  • Bilawal asks PM to waive bills for farmers in disaster-hit districts – samaa tv

    1. Bilawal asks PM to waive bills for farmers in disaster-hit districts  samaa tv
    2. PPP chief urges Punjab to declare agricultural emergency  Dawn
    3. Bilawal donates PKR 10 million to red crescent for flood victims  ptv.com.pk
    4. Bilawal calls for unified national response to Punjab floods  The Express Tribune
    5. Hang in there: Bilawal tells Sindh over looming floods  Daily Times

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  • Baker McKenzie Recognized as Highly Recommended Firm Across Latin America in Latin Lawyer 250 Guide | Newsroom

    Baker McKenzie Recognized as Highly Recommended Firm Across Latin America in Latin Lawyer 250 Guide | Newsroom

    Baker McKenzie earned top-tier recognition in the prestigious Latin Lawyer 250 guide, which highlights the region’s leading law firms based on excellence in client service, depth of expertise, and regional reach. The Firm has been Highly Recommended in Argentina, Colombia, Mexico, Venezuela and Chile, reflecting its strong presence and capabilities across Latin America.

    Argentina | Highly Recommended

    Baker McKenzie is recognized for its outstanding work in:

    • Administrative Law
    • Anti-corruption Investigations and Compliance
    • Antitrust & Competition
    • Arbitration
    • Banking & Finance
    • Corporate and M&A
    • Energy
    • Environment
    • Intellectual Property
    • Labour
    • Litigation
    • Mining & Metals
    • Real Estate & Tourism
    • Tax
    • Telecoms & Media
    • Trade

    Colombia | Highly Recommended

    The Firm is commended for its expertise in:

    • Anti-corruption Investigations and Compliance
    • Antitrust & Competition
    • Banking & Finance
    • Corporate and M&A
    • Energy
    • Intellectual Property
    • Labour
    • Real Estate & Tourism
    • Tax
    • Telecoms & Media
    • Mexico | Highly Recommended
    • Baker McKenzie is recognized for excellence in:
    • Antitrust & Competition
    • Arbitration
    • Banking & Finance
    • Corporate and M&A
    • Energy
    • Environment
    • Intellectual Property
    • Labour
    • Litigation
    • Pro Bono
    • Real Estate & Tourism
    • Trade

    Venezuela | Highly Recommended

    The Firm is highlighted for its work in:

    • Anti-corruption Investigations and Compliance
    • Arbitration
    • Banking & Finance
    • Corporate and M&A
    • Energy
    • Intellectual Property
    • Litigation
    • Tax
    • Trade

    Chile | Highly Recommended

    Baker McKenzie is recognized for its capabilities in:

    • Antitrust & Competition
    • Arbitration
    • Banking & Finance
    • Corporate and M&A
    • Intellectual Property
    • Labour
    • Mining & Metals
    • Tax

    These accolades underscore Baker McKenzie’s commitment to delivering exceptional legal services across Latin America, combining deep local knowledge with global reach.

    Trench Rossi Watanabe*, the Brazilian firm with which Baker McKenzie has a strategic alliance, received the “Highly Recommended” firm recognition for the following practice areas:

    • Administrative Law
    • Antitrust & Competition
    • Arbitration
    • Banking & Finance
    • Corporate and M&A
    • Data, Technology and Privacy Law
    • Energy
    • Environment
    • Environmental, Social & Governance
    • Intellectual Property
    • Labour
    • Litigation
    • Pro Bono
    • Tax
    • Telecoms & Media

     

    For more information on the Latin Lawyer 250 rankings, visit this link.

    *Baker McKenzie and Trench Rossi Watanabe have executed a strategic cooperation agreement to consult on foreign law.

     

     

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  • Bevacizumab plus erlotinib is highly active in HLRCC-associated papillary renal cell carcinoma

    Bevacizumab plus erlotinib is highly active in HLRCC-associated papillary renal cell carcinoma

    The combination of bevacizumab (Avastin) plus erlotinib (Tarceva) elicited encouraging anti-tumor activity in patients with advanced hereditary leiomyomatosis and renal cell cancer (HLRCC)-associated papillary renal-cell carcinoma, according to findings from a phase 2 trial (NCT01130519)published in the New England Journal of Medicine.1

    A phase 2 trial is ongoing to assess the efficacy of bevacizumab and erlotinib in combination with atezolizumab.

    The combination also yielded durable responses in a subset of patients with sporadic papillary renal cell carcinoma.

    “Few effective options exist for other variants of renal-cell carcinoma, which is exemplified by HLRCC-associated papillary renal-cell carcinoma,” the authors explained. “This variant is typically associated with an aggressive clinical course; most patients die from progressive disease, with a median overall survival of 16 to 21 months in most retrospective series.”

    To address this unmet need, the trial enrolled 43 patients (30 male, 13 female) with HLRCC-associated papillary renal cell carcinoma and 40 patients (26 male, 14 female) with sporadic papillary renal cell carcinoma. Patients in the study received bevacizumab 10 mg per kilogram of body weight every 2 weeks plus erlotinib 150 mg once daily.

    The primary end point was overall survival (OS), with progression-free survival (PFS) as a key secondary end point. Median follow-up was 71.9 months in patients with HLRCC-associated papillary renal cell carcinoma and 63.6 months in patients with sporadic papillary renal cell carcinoma.

    Among patients with HLRCC-associated papillary renal cell carcinoma, 72% (n = 31; 95% CI, 57 to 83) achieved a confirmed response, including 2 patients (5%) with a complete response. The median time to response was 1.8 months (range, 1.7 to 18.3). Responses were observed across all IMDC risk scores, with a rate of 64% in patients with favorable risk disease, 75% among patients with intermediate risk disease, and 75% among patients with poor risk disease.

    Notably, the median OS was 44.6 months (95% CI, 32.7 to NE), and the median PFS was 21.1 months (95% CI, 15.6 to 26.6). On multivariable analysis, previous treatment was shown to be associated with worse OS (HR, 5.2; 95% CI, 2.1 to 13.1).

    Among patients with sporadic papillary renal cell carcinoma, 35% (n = 14; 95% CI, 22 to 51) achieved a confirmed response to treatment. The median time to response was 1.8 months (range, 1.7 to 7.3). Responses were observed across all IMDC risk scores, with a rate of 67% in patients with favorable risk disease, 31% among patients with intermediate risk disease, and 38% among patients with poor risk disease.

    In these patients, the median OS was 18.2 months (95% CI, 12.6 to 29.3), and the median PFS was 8.9 months (95% CI, 5.5 to 18.3). The authors noted, “In a post hoc subgroup analysis, previous radical nephrectomy, previous use of a VEGF TKI, and IMDC risk category were not correlated with overall survival.”

    Safety data in the study were consistent with the known profile for this combination. The most common treatment-related adverse events (TRAEs) were acneiform rash (93%), diarrhea (89%), and proteinuria (78%). The most common TRAEs of grade 3 or higher were hypertension (34%) and proteinuria (17%).

    Based on these data, the authors reported, “This study showed that the combination of bevacizumab and erlotinib was highly active in advanced HLRCC-associated papillary renal-cell carcinoma and was approximately half as effective in sporadic papillary renal-cell carcinoma.”

    They suggest that further research is warranted to elucidate the mechanisms fostering resistance to this regimen. Additionally, a phase 2 trial (NCT04981509) is ongoing to assess the efficacy of bevacizumab and erlotinib in combination with atezolizumab (Tecentriq).

    Overall, the authors hope to build on the findings from the current analysis.

    “The median survival now is almost 4 years with this combination treatment,” concluded W. Marston Linehan, MD, in a news release on the findings.2 “We’re thrilled about that. This has now become a standard treatment of this disorder worldwide.”

    REFERENCES

    1. Srinivasan R, Gurram S, Singer EA, et al. Bevacizumab and erlotinib in hereditary and sporadic papillary kidney cancer. N Engl J Med. 2025;392(23):2346-2356. doi:10.1056/NEJMoa2200900

    2. Combining bevacizumab with erlotinib shrinks tumors in patients with rare and aggressive kidney cancer. News release. National Cancer Institute Center for Cancer Research. July 11, 2025. Accessed September 5, 2025. https://ccr.cancer.gov/news/article/combining-bevacizumab-with-erlotinib-shrinks-tumors-in-patients-with-rare-and-aggressive-kidney-cancer

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  • Inherited Variants in 16 Genes May Double the Risk of Multiple Primary Cancers

    Inherited Variants in 16 Genes May Double the Risk of Multiple Primary Cancers

    Individuals carrying a rare pathogenic variant in one of 16 cancer-associated genes were 1.9 times more likely to develop a single cancer and 2.6 times more likely to develop multiple primary cancers, according to the results of a genetic association study published in JAMA Oncology

    These findings highlight a greater need for gene panel testing among patients with multiple primary cancer diagnoses. 

    “As more patients survive their first cancer, we’re learning that many carry inherited genetic mutations that put them at risk for developing additional cancers,” said senior study author Kathleen Cooney, MD, George Barth Geller Distinguished Professor of Medicine and Chair in the Department of Medicine at Duke University School of Medicine. “Knowing this opens the door to earlier screening, more personalized treatment, and the chance to protect family members through genetic testing.”

    Study Methods and Rationale 

    Previous explorations of rare pathogenic variants and cancer risk have been attained from family-based studies, which may have provided a degree of selection bias or limited sample sizes, explained the study authors. They wanted to look at these associations in a larger population-based study. 

    The researchers conducted a genetic association study in an unselected population of 183,627 participants from the United Kingdom. All participants were between the ages of 40 and 69 years at enrollment and had released whole-exome sequencing data of 200,000 genomes to the UK Biobank. The study only looked at White participants, as the proportions of patients belonging to other racial and ethnic groups were too small. 

    The team sequenced a set of 96 previously implicated cancer predisposition genes across 11 common solid tumors (bladder, breast, central nervous system, colorectal, lung, melanoma, ovarian, pancreatic, prostate, renal, and thyroid) and compared the results across two methods.  

    Key Study Findings 

    Of the participants, 25,824 individuals received at least one cancer diagnosis by March 2024; 91.8% of these were single-cancer diagnoses and 8.2% were two or more cancer diagnoses. 

    The median age was 57 (interquartile range [IQR] = 50–63 years) in participants who did not develop cancer vs 62 years (IQR = 56–65 years) in those with at least one cancer diagnosis. 

    Genetic variants from 16 genes (including ATM, BARD1, BRCA1, BRCA2, BRIP1, CDKN2A, CHEK2, HOXB13, MITF, MLH1, MSH2, MSH6, NF1, PALB2, RAD51C, and RAD51D) were considered significantly associated with at least one cancer of interest, which built upon established associations seen in prior research. The presence of a rare pathogenic variant among these genes was associated a greater risk for having at least one cancer diagnosis (odds ratio [OR] = 1.87; 95% confidence interval [CI] = 1.76–1.98) and for having multiple primary cancers (OR = 2.56; 95% CI = 2.18–2.99). 

    The study also confirmed that there are associations between BRCA2 and the development of bladder and lung cancers, which have not commonly been linked with this gene. 

    Carrier rates for rare pathogenic variants were 6.28% among individuals with at least one cancer diagnosis and 8.36% for individuals with multiple cancer diagnoses. 

    “We’ve now implicated some potential cancers that patients may be at risk for, which is different than what we’re seeing during family-based studies,” said first study author Jeffrey Shevach, MD, Assistant Professor in the Department of Medicine at Duke University School of Medicine, clarifying that population-based studies can help refine risk estimates raised in family-based studies. “As we uncover new gene-cancer associations, it may lead to changes in screening guidelines to reflect this broader understanding of inherited risk.”

    Disclosure: Research was funded by the National Institutes of Health. For full disclosures of the study authors, visit jamanetwork.com.  

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  • US and UN discuss Gaza reconstruction plan before general assembly | Gaza

    US and UN discuss Gaza reconstruction plan before general assembly | Gaza

    A potential UN-endorsed reconstruction plan for Gaza, including a one-year technocratic government, an international stabilisation force, disarmament of Hamas and a rejection of mass deportation of Palestinians, is being discussed with the US to prevent the UN general assembly descending into a bitter row about the symbolic recognition of Palestine as a state.

    It is almost certain that the UK, France, Canada, Belgium and Malta will recognise the state of Palestine at a UN conference on 22 September to be held on the sidelines of the general assembly, in the week when world leaders deliver major speeches.

    Britain had suggested it may not recognise Palestine if Israel and Hamas reached a ceasefire, but the Israeli government has adamantly rejected a ceasefire and announced an intention to capture Gaza City.

    However, Britain is eager for the two-state conference not to be dominated by a row about whether recognition is premature or a reward for Hamas, which is the charge mounted by the Israeli government.

    In a weekend visit to Qatar, the United Arab Emirates and Saudi Arabia, the UK foreign secretary, David Lammy, said he was focusing on the need “to turn any ceasefire into a durable peace, through a monitoring mechanism, the disarmament of Hamas and a new governance framework for Gaza”.

    Benjamin Netanyahu, Israel’s prime minister, who faces internal divisions within his coalition, has not spelled out a full vision for a postwar Gaza, but has increasingly spoken of a permanent Israeli presence in Gaza and annexation of the West Bank.

    The plans for a UN-endorsed Gaza reconstruction are being discussed in detail with Marco Rubio, the US secretary of state, who has warned that the Israeli threat to annex the West Bank is a wholly predictable reciprocal response to Europe taking the step of recognising Palestine.

    It is expected that the Palestinian Authority president, Mahmoud Abbas, will visit London before the UN conference. The US has announced it will not give visas to Abbas and the authority’s delegation for the general assembly, a decision Europeans are protesting against on the grounds that a reformed Palestinian Authority is essential to a ceasefire and the future governance of Palestine.

    Plans reportedly floated in the White House that in effect endorse Israeli annexation of Gaza and the West Bank are anathema to the European and Gulf leaders. “Displacement is not an option and it is a red line for Egypt, and we will not allow it to happen,” the Egyptian foreign minister, Badr Abdelatty, said on Friday.

    Tony Blair, close to many Gulf leaders as well as Jared Kushner, Donald Trump’s son-in-law, has been in discussion with the UK Foreign Office and met Trump last week in the White House.

    The two most controversial issues remain the disarmament of Hamas, a requirement of all European leaders, and whether candidates linked in the past to Hamas or terrorism will be able to stand in any elections for the Palestinian presidency and parliament.

    Speaking this week at the Chatham House thinktank, Dr Husam Zomlot, the Palestinian representative in the UK, said the Palestinian Authority was committed to staging elections in Gaza and the West Bank, including East Jerusalem, within a year of a ceasefire. A technocratic government would govern Palestine in the meantime.

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    On the issue of Hamas figures standing in the later elections, Zomlot said: “It will be up to internal revisions within Hamas. I assure you the Palestinian people are very clever; they will elect the people that will actually serve them best.”

    He added: “There had to be one law, one government, one police force. We will do that because the main requirement right now is to keep our unity of territorial system, but in the end Hamas is part of the Palestinian political, national and social fabric, and they will not just disappear in a second. What we are discussing is not erasure, but reform, change in direction and internal dialogue, so we avert Israel’s complete annihilation project.”

    At a preliminary two-state solution conference in New York in June, Arab and Muslim states, including Qatar, Saudi Arabia and Egypt, for the first time issued a joint call for Hamas to disarm and relinquish power in the Gaza Strip as part of efforts to end the war in the territory.

    The 22-member Arab League, the entire EU and another 17 countries backed the declaration that read: “The governance, law enforcement and security across all Palestinian territory must lie solely with the Palestinian Authority, with appropriate international support,” adding that “in the context of ending the war in Gaza, Hamas must end its rule in Gaza and hand over its weapons to the Palestinian Authority, with international engagement and support, in line with the objective of a sovereign and independent Palestinian state”.

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  • Bad oral hygiene linked to cancer, heart attacks

    Bad oral hygiene linked to cancer, heart attacks

    IT’S NORMAL to have bacteria in your mouth. But harmful bacteria have been linked to a host of health problems. Medical scientist Glenda Davison and microbiologist Yvonne Prince, who have researched the oral cavity, explain why it’s so important to practise good oral hygiene.

    Poor oral hygiene can lead to serious diseases.

    In fact, bacteria in the mouth may lead to the development of liver disease, renal failure, cancers, heart disease and hypertension.

    This is because the mouth is home to the second largest microbial community in humans, after the gut. The mouth is home to over 700 species of bacteria, fungi, viruses and protozoa. They thrive in and around the teeth, the gums, tongue, palate and saliva. Indeed, there are over 39 trillion microbes in the human body in the stomach, skin, lung, seminal and vaginal fluid, eyes, scalp and mouth and so on. They outnumber more than the 30 trillion human cells.

    They may cause other diseases when the acidity or alkalinity (pH) in the mouth changes. Or when the temperature and oxygen level encourage the abnormal growth of bacteria. An overabundance of these bacteria may lead to the development of diseases.

    The journey may start in a simple oral health issue: gum disease. When it develops into something more serious – like periodontitis, bleeding gums and tooth decay – the gum gets eroded to the bone. This is the time when inflammatory molecules called cytokines play a more dangerous role – when they enter the blood stream.

    The type II diabetes develops. Atherosclerosis or thickening of the arteries may follow.

    Over 1,000 species of bacteria may reside in the large intestine. No problem: these bacteria are important in digestion, absorption, immunity and protection against other harmful bacteria.

    However, an abnormal gut biome may cause autoimmunity, obesity, cardiovascular disease and even Alzheimer’s.

    These oral health issues may be avoided by simple measures such as going to the dentist regularly for check-ups, at least twice or once a year. Brushing the teeth religiously prevent plaque from developing. Carbohydrates and sugar should be avoided as much as possible as they encourage the growth of bacteria in the mouth.

    A balanced diet rich in fruits and vegetables is a big help. So is regular physical activity. In other words – healthy habits should be encouraged at all times.

    Here’s good advice from the Mayo Clinic:

    * Brush your teeth at least twice a day for two minutes each time. Use a brush with soft bristles and fluoride toothpaste. Brush your tongue too.

    * Clean between your teeth daily with floss, a water flosser or other products made for that purpose.

    * Eat a healthy diet and limit sugary food and drinks.

    * Replace your toothbrush every three to four months. Do it sooner if bristles are worn or flare out.

    * See a dentist at least once a year for checkups and cleanings. Your dentist may suggest visits or cleanings more often, depending on your situation. You might be sent to a gum specialist, called a periodontist, if your gums need more care.

    * Don’t use tobacco.

    ***

    Dr. Joseph D. Lim, Ed. D., is the former Associate Dean of the College of Dentistry, University of the East; former Dean, College of Dentistry, National University; Past President and Honorary Fellow of the Asian Oral Implant Academy; Honorary Fellow of the Japan College of Oral Implantologists;  Honorary Life Member of the Thai Association of Dental Implantology; and Founding Chairman of the Philippine College of Oral Implantologists. For questions on dental health, e-mail jdlim2008@gmail.com or text 0917-8591515.

    *** 

    Dr. Kenneth Lester Lim, BS-MMG, DDM, MSc-OI, graduated Doctor of Dental Medicine, University of the Philippines, College of Dentistry, Manila, 2011; Bachelor of Science in Marketing Management, De la Salle University, Manila, 2002; and Master of Science (MSc.) in Oral Implantology, Goethe University, Frankfurt, Germany, 2019. He is an Associate Professor; Fellow, International Congress of Oral Implantologists; and Fellow, Philippine College of Oral Implantologists. For questions on dental health, e-mail limdentalcenter@gmail.com/PN


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  • Could a Nasal Spray Help Protect Patients With Cancer Against COVID-19 Infection

    Could a Nasal Spray Help Protect Patients With Cancer Against COVID-19 Infection

    Use of a daily interferon-α nasal spray could significantly reduce the risk of COVID-19 infection among adult patients with cancer, according to the results of a multicenter, randomized trial published in Clinical Infectious Diseases. 

    The results suggest that the nasal spray could be a potential new tool for protecting vulnerable populations from the virus. 

    “This is the first randomized, controlled trial to show that an intranasal interferon-α spray can safely and effectively prevent COVID-19 in this group,” stated lead study author Michelle K. Yong, MBBS, PhD, FRACP, MPH, Associate Professor and Infectious Disease Researcher at Peter MacCallum Cancer Centre, Victoria, Australia. “Even with vaccination, cancer patients remain more vulnerable to COVID-19 and its complications. It’s an additional layer of defense, especially for those who can’t mount strong responses to vaccines.”

    Study Methods and Key Findings 

    A total of 433 participants were enrolled in the multicenter, randomized, double-blinded, placebo-controlled trial and randomized 1:1 to receive either daily 40,000 IU of an interferon-α nasal spray or a saline placebo. All patients with influenza-like symptoms took self-collected nasal swabs for polymerase chain reaction testing.

    Rates of COVID-19 infection were lower in the interferon-α spray arm, at 8.3%, compared with 14.4% in the placebo arm (relative risk [RR] = 0.60; 95% credible interval [CrI] = 0.33‒0.97). Other respiratory viral infections were reported at a rate of 5.1% in both groups (RR = 1.12; 95% CrI = 0.43‒2.34). 

    In the per-protocol cohort of 389 patients, the incidence rates for COVID-19 infection were 7.7% in the interferon-α nasal spray arm and 16.0% in the placebo arm (RR = 0.50; 95% CrI = 0.26‒0.84). Other respiratory viruses were reported at a rate of 4.6% in the interferon-α arm and 5.7% in the placebo arm. 

    Subgroup analyses showed that COVID-19 infection rates were lower in the interferon-α group for patients younger than age 65 years (RR = 0.48; 95% CrI = 0.20‒0.92); women (RR = 0.44; 95% CrI = 0.19‒0.85), and those that were vaccinated against COVID-19 (RR = 0.50; 95% CrI = 0.26‒0.82). No differences were observed according to underlying malignancy. 

    No differences were noted between the arms in regard to severity of COVID-19 infection, hospitalization, or mortality. 

    The nasal spray was considered safe and well tolerated. 

    “A safe, easy-to-use nasal spray with broad antiviral activity could benefit not just cancer patients, but other high-risk groups such as transplant recipients, people with chronic illnesses, and the elderly,” said senior author Monica Slavin, MBBS, FRACP, MD, FAAHMS, FECMM, Professor, Head of Infectious Diseases Department and National Centre for Infections in Cancer and Transplantation, Peter MacCallum Cancer Centre. “While it’s not a replacement for vaccination, it adds to our prevention toolkit and could help reduce illness, treatment delays, and hospitalizations.” 

    Disclosure: For full disclosures of the study authors, visit academic.oup.com. 

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  • Angela Rayner resigns after underpaying tax on Hove flat

    Angela Rayner resigns after underpaying tax on Hove flat

    Kate WhannelPolitical reporter

    Reuters Angela RaynerReuters

    Angela Rayner has resigned as deputy prime minister and housing secretary after failing to pay enough tax on her £800,000 flat in Hove.

    She has also stepped down as deputy Labour leader, a move which is expected to trigger a new deputy leadership election by party members.

    Her departure comes after the prime minister’s ethics adviser Sir Laurie Magnus said Rayner had “acted with integrity” but concluded that she had breached the ministerial code.

    He said she did get legal advice when buying the property, but failed to seek further expert tax advice as recommended.

    Writing to the PM, Rayner said she accepted she “did not meet the highest standards” when purchasing her property.

    “I deeply regret my decision to not seek additional specialist tax advice given both my position as housing secretary and my complex family arrangements.”

    Rayner said she took “full responsibility for this error”, adding: “It was never my intention to do anything other than pay the right amount.”

    Her resignation is a huge blow for the prime minister who began the week with a shake-up of his Downing Street team in the hope of putting a difficult first year in government behind him.

    It also kicked off a big reshuffle of ministers at the top of government, with David Lammy leaving his foreign secretary role to replace Rayner as deputy prime minister.

    Lammy also takes on the justice secretary role, while Shabana Mahmood moves to the Home Office and Yvette Cooper becomes foreign secretary.

    Steve Reed becomes the new housing secretary, a role which will see him responsible for delivering on one of the government’s key pledges of building 1.5 million homes by 2029.

    Other ministers to be moved include Liz Kendall from work and pensions secretary to the Department for Science, Innovation and Technology.

    Details of a deputy leadership election are expected to be announced in due course.

    The contest could create a severe political headache for the prime minister, as it has the potential to become a vehicle for MPs and members to voice their discontent at Sir Keir’s leadership.

    In a handwritten reply to Rayner, Sir Keir said: “Although I believe you have reached the right decision, it is a decision which I know is very painful for you.

    “You have given your all to making the Labour government a success and you have been a central part of our plan to make Britain fairer for working families.

    “On a personal note, I am very sad to be losing you from the government. You have been a trusted colleague and a true friend for many years. I have nothing but admiration for you and huge respect for your achievement in politics.”

    He concluded that Rayner would remain “a major figure” in the Labour Party.

    Conservative leader Kemi Badenoch said: “Angela Rayner is finally gone. But it’s only because of Keir Starmer’s weakness that she wasn’t sacked three days ago.”

    Rayner was first elected as an MP to the Greater Manchester constituency of Ashton-under-Lyne ten years ago.

    She had been on the Labour frontbenches since 2015 and took on her government jobs in July 2024, when Labour won the general election.

    As well as becoming one of the most powerful figures in government, Rayner was also popular with Labour backbenchers.

    However, her political fortunes began to turn last week when newspapers including the Daily Telegraph and Daily Mail raised questions about the amount of tax she had paid on her flat purchase.

    Rayner’s team initially insisted she had paid the correct amount but, as a result of the media scrutiny, sought advice from a senior lawyer.

    On Wednesday, after receiving the lawyer’s final opinion, Rayner acknowledged she had not paid enough tax when buying her East Sussex flat and said the “mistake” came about because she believed it was the only property she owned.

    However, due to complex arrangements surrounding a trust for her disabled son, the Hove flat should have been considered to be Rayner’s second home – meaning she should have paid an additional £40,000 in stamp duty.

    Rayner said she had sought legal advice when making the purchase but that it had failed to “properly take account” of her circumstances.

    She said she had contacted HMRC to work out the additional tax she needed to pay and referred herself for investigation by the PM’s standards adviser.

    After investigating the matter, ethics adviser Sir Laurie concluded that Rayner “cannot be considered to have met the ‘highest possible standards of proper conduct’”.

    In his letter to the prime minister, he said it was “deeply regrettable” that Rayner had not sought the correct tax advice.

    He said if such expert tax advice had been received, it would “likely” have advised her that a higher rate of stamp duty was payable.

    Sir Laurie concluded: “The responsibility of any taxpayer for reporting their tax returns and settling their liabilities rests ultimately on themselves alone.”

    In addition to paying an extra £40,000 in stamp duty, Rayner could also face a possible HMRC fine of £12,000 for a “careless” error in her tax arrangements.

    At the same time as Rayner announced her decision to quit, Reform UK’s party conference in Birmingham was getting under way.

    Moving his speech forward by several hours, party leader Nigel Farage told conference delegates: “You simply can’t get away from being the housing secretary and avoiding £40,000 of stamp duty.”

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  • Don’t look now, but there’s an AI-generated Italian teacup on your child’s phone. What does it mean?

    Don’t look now, but there’s an AI-generated Italian teacup on your child’s phone. What does it mean?

    In the first half of 2025, she racked up over 55 million views on TikTok and 4 million likes, mostly from tweens glued to their cellphones. Not bad for an AI-generated cartoon ballerina with a cappuccino teacup for a head.

    Her name is Ballerina Cappuccina. Her smiling, girlish face is accompanied by a deep, computer-generated male voice singing in Italian — or, at least, some Italian. The rest is gibberish.

    She is one of the most prominent characters in the internet phenomenon known as “Italian Brain Rot,” a series of memes that exploded in popularity this year, consisting of unrealistic AI-generated animal-object hybrids with absurdist, pseudo-Italian narration.

    The trend has baffled parents, to the delight of young people experiencing the thrill of a new, fleeting cultural signifier that is illegible to older generations.

    Experts and fans alike say the trend is worth paying attention to, and tells us something about the youngest generation of tweens.

    The first Italian brain-rot character was Tralalero Tralala, a shark with blue Nike sneakers on his elongated fins. Early Tralalero Tralala videos were scored with a curse-laden Italian song that sounds like a crude nursery rhyme.

    Other characters soon emerged: Bombardiro Crocodilo, a crocodile-headed military airplane; Lirilì Larilà, an elephant with a cactus body and slippers; and Armadillo Crocodillo, an armadillo inside a coconut, to name a few.

    Content creators around the world have created entire storylines told through intentionally ridiculous songs. These videos have proven so popular that they have launched catchphrases that have entered mainstream culture for Generation Alpha, which describes anyone born between 2010 and 2025.

    Fabian Mosele, 26, calls themselves an “Italian brain rot connoisseur.” An Italian animator who lives in Germany and works with AI by trade, Mosele created their first Italian brain-rot content in March. Shortly after, Mosele’s video of Italian brain-rot characters at an underground rave garnered about a million views overnight, they said. It has since topped 70 million.

    Even as the hysteria over the absurdist subgenre has slowed, Mosele said the characters have transcended the digital realm and become an indelible part of pop culture.

    “It feels so ephemeral,” Mosele said, “but it also feels so real.”

    This summer, one of the most popular games on Roblox, the free online platform that has approximately 111 million monthly users, was called “Steal a Brainrot.” The goal of the game, as the title would suggest, is to steal brain rot characters from other players. More popular characters, like Tralalero Tralala, are worth more in-game money.

    Sometimes, the games’ administrators — who are also players — cheat to steal the characters, a move called “admin abuse” that sent many kids and teens into a frenzy. One video of a young child hysterically crying over a stolen character has 46.8 million views on TikTok.

    In the non-virtual world, some have made physical toy replicas of the characters, while others have created real-life plays featuring them.

    The nonsensical songs have at times gestured to real-world issues: One clip of Bombardiro Crocodilo sparked outrage for seemingly mocking the war in Gaza.

    But ultimately, the majority of videos are silly and absurd.

    Mosele said Italian brain-rot consumers largely don’t care about how the images relate to what is being said or sung. They often don’t even care to translate the nonsensical Italian to English.

    “It’s funny because it’s nonsense,” Mosele said.

    “Seeing something so dark, in a way, and out of the ordinary, that breaks all the norms of what we would expect to see on TV — that’s just super appealing.”

    Italian brain rot didn’t go viral in a vacuum. “Brain rot,” the 2024 Oxford University Press word of the year, is defined as the numbing of an intellectual state resulting from the “overconsumption of trivial or unchallenging material.”

    It can also be used to describe the brain-rotting content itself.

    Lots of content falls into that category. Consider videos of the game “Subway Surfer” split-screened next to full episodes of television shows, or “Skibidi Toilet,” an animated series featuring toilets with human heads popping out of their bowls.

    Those not chronically online might instinctively recoil at the term brain rot, with its vaguely gory connotations, especially as concern about the potential harms of social media for adolescents mounts.

    When brain rot was crowned word of the year, Oxford Languages President Casper Grathwohl said the term speaks to “one of the perceived dangers of virtual life, and how we are using our free time.”

    Emilie Owens, 33, a children’s media researcher, agreed that endless scrolling poses dangers for young people. But she said that the concern about brain rot is misguided.

    It’s normal to “view the thing the newest generation is doing with fear and suspicion,” she said, pointing to how past generations have had similar concerns about the detrimental effects of comic books, television and even novels at one time.

    Concerns about brain rot — that it is unproductive and pointless — actually reveal a great deal about their appeal, Owens said. Brain rot is an acute rejection of the intense pressures on young people to self-optimize.

    “It’s very normal for everyone to need to switch their brains off now and again,” she said.

    ___

    Riddle is a corps member for The Associated Press/Report for America Statehouse News Initiative. Report for America is a nonprofit national service program that places journalists in local newsrooms to report on undercovered issues.

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