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  • Nick Heath picks his Fantasy Team of the Week

    Nick Heath picks his Fantasy Team of the Week

    Fantasy RWC 2025 is taking the tournament by storm, if you are not involved yet, get involved! It’s free, there are great prizes up for grabs and you can star on the global leaderboard or set up your own private league 

    To help calm those nerves and perhaps direct a few last-minute picks, here is fabled women’s rugby TV commentator Nick Heath to take you through his team of the week (pictured) and to look back at his RWC career so far. 

    Plus check out our top tips at the bottom! 

    Why have you picked Aseza Hele in your fantasy team?

    I’ve had the pleasure to watch Aseza (below) play with Harlequins and she has always been an abrasive carrier but not necessarily with the greatest care for the ball.

    For me, the maturity and growth for any player is knowing when not to do something and she is showing that now. I think she is a confidence player and she can feel the support of all the fans behind her and so when she is carrying into a defender from England or France she is now doing it with the confidence that she can carry through them.

    NORTHAMPTON, ENGLAND – AUGUST 24: Aseza Hele of South Africa runs with the ball before scoring her team’s second try during the Women’s Rugby World Cup 2025 Pool D match between South Africa and Brazil at Franklin’s Gardens on August 24, 2025 in Northampton, England. (Photo by Morgan Harlow – World Rugby/World Rugby via Getty Images)

    What is it about Mo Hunt that particularly shines in the England team?

    Her decision making and pass selection is the best in the World. Every team plays with patterns, particularly the more advanced teams like the Red Roses; who will be coming round the corner, how many, what position will they be in?

    But after breaks it can become fragmented and people won’t always be in the positions they are meant to be in and Mo’s ability to scan and pick-out players is like no one else I’ve really seen. That just gives you that finishing prowess in the last few metres of the pitch which means if you are facing her you’re probably going to be conceding five or seven points.

    Which of the tier two nations have most impressed you?:

    Certainly South Africa who we class in that bracket for now. They were closing the gap to Italy in the last two WXV seasons and their victory in round two was written in the stars. I was lucky enough to ask Ramsey Tomokino (Samoan Head Coach) about what it meant to be at a World Cup and his response shows why it is so important to score those three points against England.

    I was hearing from some of the Red Roses that they smiled on the field when that happened. That recognition on the field and focus on that element of sportsmanship in the fairness of battle, whilst something that rugby has always held dear, seems to have grown to an exponential level during this Rugby World Cup.

    Who will be playing in the final?

    It will all be about that likely semi-final. New Zealand haven’t beaten Canada in the last two tests. The Black Ferns in a World Cup are somehow a different animal. I have a feeling this Black Ferns team might have a little more now, with a few star players back, so I think they will get through that semi and beat England in the final. 

    What was your first Rugby World Cup match?:

    It would’ve been the 2010 World Cup Final. My sister and cousin had played so I’d been around the game when I was younger but that was when I began to engage with the game after moving to London and being more interested in socialising. But then I commentated on the Red Roses in 2012 so I was fully locked in and in 2014 I was the in-house videographer with England.

    What makes the Red Roses 2014 team wthe best of all?

    That team were looked after by Gary Street and Graham Smith. In that era, the players required their coaches to be partly their favourite teacher, partly their uncle, and in some cases a father figure. Those two men, for a big generation, got it absolutely spot on.

    There was the sort of bad cop with Graham Smith and the likeable bloke who will do some magic around the dinner table in Gary Street. I think that was very much where the evolution of women’s rugby had got to and met two guys who trusted each other and were trusted by their players to get the most out of them.

    You’ve had the insight from a bonafide expert, but just in case you are still unsure on who to pick, here are our Top Tips

    Sisilia Tuipulotu (WAL) 41pts in Round 2: Tuipulotu started in Wales’ round two defeat to Canada and made 11 tackles and bagged a turnover as well. Wales will be going home after the pool stages but they will be looking to go out on a high against Fiji. Look to see Tuipulotu with more time on the ball than she had against Canada and don’t bet against a couple of tries.

    Francesca McGhie (SCO) 82pts in Round 2: With 183 fantasy points so far, McGhie (below) is the second highest scorer this tournament behind only Jorja Miller (203pts). Round three will be her hardest challenge yet as her unstoppable pace faces the immovable Canadian defence. Her five tries are the second most of the tournament and with two turnovers won she leads outside backs. We think she can keep this extraordinary run going against one of the best sides in the game.

    Scotland v Wales - Women's Rugby World Cup 2025

    SALFORD, ENGLAND – AUGUST 23: Francesca McGhie of Scotland breaks away with the ball as she is tackled by Nel Metcalfe of Wales during the Women’s Rugby World Cup 2025 Pool B match between Scotland and Wales at the Salford Community Stadium on August 23, 2025 in Salford, England. (Photo by Molly Darlington – World Rugby/World Rugby via Getty Images)

    Keia Mae Sagapolu (USA) 56pts in Round 2: Sagapolu has the fourth highest points tally for a prop and is coming off a big week in that all-time match-up against Australia last weekend. In that game Sagapolu had 20 carries, the most in the game, and grabbed a try. She’s made 73m with ball in hand over the first two matches, the most in the tournament by a prop and she will need to be on top form as the USA chase enough points to reach the knockouts at Australia’s expense.

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  • Alcaraz leads Djokovic in US Open SF – ATP Tour

    1. Alcaraz leads Djokovic in US Open SF  ATP Tour
    2. US Open: Women’s semi-finals take centre stage live on Sky Sports on Thursday  Sky Sports
    3. Alcaraz on Djokovic US Open SF: ‘I want revenge’  ATP Tour
    4. US Open men’s semifinals: Three grand slam champions and one newcomer battle for spot in final  CNN
    5. Alcaraz vs Djokovic – US Open semifinal: Start time, stats, head-to-head  Al Jazeera

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  • Nasdaq Tightens IPO Rules to Rein In Risky Listings

    Nasdaq Tightens IPO Rules to Rein In Risky Listings

    This article first appeared on GuruFocus.

    Nasdaq (NDAQ, Financials) is tightening its listing rules after years of eye-popping rallies and crashes in little-known stocks, many tied to small Chinese companies.

    The exchange now wants firms operating in China to raise at least $25 million when they go public, and new listings under its income standard will need at least $15 million in public float, up from $5 million. Companies valued under $5 million could also face quicker suspensions and delistings.

    The changes are designed to curb the kind of trading frenzies that saw some newly listed Chinese stocks surge more than 2,000% on day one before collapsing just as fast. Nasdaq says the goal is simple: give investors more protection and improve liquidity.

    The proposal is now with the SEC, and if approved, Nasdaq plans to roll it out quickly. The timing is notable more than 100 Chinese firms already trade in the U.S., and the IPO market is heating up again heading into year-end. Tea chain Chagee, for example, pulled off one of the biggest Chinese listings this year with a $411 million raise on Nasdaq in April.

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  • New insights into how breast milk supports baby’s internal clock

    New insights into how breast milk supports baby’s internal clock

    Breast milk is the first ‘super food’ for many babies. Full of vitamins, minerals, and other bioactive compounds, it helps build the young immune system and is widely considered the optimal source of infant nutrition. Not all mothers, however, have the opportunity to directly breastfeed multiple times during the day and night, and might use expressed milk stored for later.

    Breast milk delivers a variety of cues from the mother to the infant, including signals that are thought to influence babies’ circadian rhythms. The hormones and proteins involved in circadian signaling, however, may vary in breast milk concentration over 24 hours. To learn more about these fluctuations, researchers in the US investigated expressed breast milk samples taken during different times of the day. They published their findings in Frontiers in Nutrition.

    We noted differences in the concentrations of bioactive components in breast milk based on time of day, reinforcing that breast milk is a dynamic food. Consideration should be given to the time it is fed to the infant when expressed breast milk is used.”


    Dr. Melissa Woortman, first author, a recent PhD graduate, Department of Nutritional Sciences, Rutgers University

    “The timing of these cues would be particularly critical in early life, when the infant’s internal circadian clock is still maturing,” added senior author Prof Maria Gloria Dominguez-Bello, a researcher at the Department of Biochemistry and Microbiology at Rutgers University.

    Powerful compounds

    The researchers took 10 milliliter breast milk samples from 21 participants at 6am, 12pm, 6pm, and 12am on two different days, which were about a month apart. A further 17 participants provided samples taken at the same times once, resulting in 236 samples included in the analysis. The samples were examined for levels of melatonin, cortisol, and oxytocin – all hormones – as well as immunoglobulin A (IgA), an antibody protein part of the immune system, and lactoferrin, a milk protein. Melatonin and cortisol are involved in the regulation of the circadian rhythm, whereas the other examined components influence intestinal development and gut microbiome dynamics.

    They found that some breast milk components, especially melatonin and cortisol, varied over the course of the day. Melatonin peaked at midnight, whereas cortisol was at the highest level in the early morning. “We all have circadian rhythms in our blood, and in lactating mothers, these are often reflected in breast milk,” explained Woortman. “Hormones like melatonin and cortisol follow these rhythms and enter milk from maternal circulation.” The other examined components were mostly stable throughout the day. This might be because they may not be as strongly influenced by signals dictating circadian rhythms.

    The team also found that as infants got older, the levels of different compounds in breast milk varied. For example, the levels of cortisol, IgA, and lactoferrin were highest when babies were less than one month old. Higher levels of these compounds likely support immune defense and gut colonization in very young babies.

    “When it comes to differences in day/night variations by infant age, this could reflect the stabilizing of the maternal circadian clock that occurs with time after giving birth, as well as the maturing and stabilization of the infant’s circadian rhythm,” Woortman pointed out.

    Labels for development

    The researchers said their study was not able to account for all potentially relevant demographic factors, including delivery mode and maternal diet, due to sample size. Larger and more diverse cohorts will be needed in the future to ensure the generalizability of these results. In addition, future research should examine how infants respond to the variations observed here.

    Still, the findings suggest that feeding expressed milk could be timed to maximize natural biological alignment. This way, circadian signals that support infant sleep, metabolism, and immune development – adaptations shaped through evolution – could be maintained.

    “Labeling expressed milk as ‘morning,’ ‘afternoon,’ or ‘evening’ and feeding it correspondingly could help align expressing and feeding times and preserve the natural hormonal and microbial composition of the milk, as well as circadian signals,” Dominguez-Bello pointed out.

    “In modern societies where it may not be feasible for mothers to stay with their infants throughout the day, aligning feeding times with the time of milk expression is a simple, practical step that maximizes the benefits of breast milk when feeding expressed milk,” Woortman concluded.

    Source:

    Journal reference:

    Woortman, M. A., et al. (2025) Day/night fluctuations of breast milk bioactive factors and microbiome. Frontiers in Nutrition. doi.org/10.3389/fnut.2025.1618784

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  • Kavoa relishing huge Red Roses challenge a year on from switching to front row

    Kavoa relishing huge Red Roses challenge a year on from switching to front row

    In the final week of pool stage at Women’s Rugby World Cup 2025, the pressure is on for teams to secure a place in the quarter-finals.

    Needless to say, these matches are incredibly important for all players. But for one Australian player, this match is special in more ways than one.

    Lydia Kavoa will be starting at loose-head prop in a first for her at a Rugby World Cup, in what is a second ever Test start in the position. Her road to the World Cup has been anything but conventional having only started playing prop last year.

    The 31-year old Leading Seaman was scouted by Wallaroo’s coach Jo Yapp at a Naval tri-service competition, and was convinced by Yapp to switch playing positions following a spate of injuries in Australia’s front row.

    “At first I was like, ‘no, I’m back row’ because there’s this massive stigma that you’ve gotten slower and you’ve put on weight.

    “I went away and thought about it and she [Yapp] told me, ‘I want to take you to a World Cup, but your opportunity will be in the front row’ so I said ‘OK, when do we start?’”

    Kavoa said her dad was a key factor in coming to the right decision and moving forward on it with purpose.

    “I went away and thought, ‘do I really want to do it?’ My dad said ‘if you’re going to do it, make sure all your eggs are in one basket and give it a decent crack, go all in, because you can’t half-ass it.’”

    Kavoa has certainly been giving it a ‘decent crack’. She took on three extra training sessions a week to work on her skills to ensure she would be ready to play in the front row at Rugby World Cup 2025.

    “I got in contact with a scrum coach down in Canberra. I was like, ‘you got to help me out here.’

    “He moved mountains for me and I said ‘I need to play this game’. He said ‘Well you got to see me like, twice to three times a week then.’ I was like ‘okay, let’s do it.’”

    Now at her first Rugby World Cup, Kavoa is starting a hugely crucial match for the Wallaroos, who need to secure a bonus point at the very least in order to progress to the quarter-finals at the expense of USA.

    “I’m literally still pinching myself, because one of my key goals was to try and start this World Cup and after last week’s game, I didn’t think I’d play. They caught me off guard.

    “It’s a huge honour. I just want to try and be in the moment on Saturday.”

    Australia face England’s Red Roses at 17:00 on Saturday at the Brighton and Hove Community Stadium.

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  • NASA Announces CHAPEA Crew for Year-Long Mars Mission Simulation

    NASA Announces CHAPEA Crew for Year-Long Mars Mission Simulation

    Four research volunteers will soon participate in NASA’s year-long simulation of a Mars mission inside a habitat at the agency’s Johnson Space Center in Houston. This mission will provide NASA with foundational data to inform human exploration of the Moon, Mars, and beyond.

    Ross Elder, Ellen Ellis, Matthew Montgomery, and James Spicer enter into the 1,700-square-foot Mars Dune Alpha habitat on Sunday, Oct. 19, to begin their mission. The team will live and work like astronauts for 378 days, concluding their mission on Oct. 31, 2026. Emily Phillips and Laura Marie serve as the mission’s alternate crew members.

    Through a series of Earth-based missions called CHAPEA (Crew Health and Performance Exploration Analog), carried out in the 3D-printed habitat, NASA aims to evaluate certain human health and performance factors ahead of future Mars missions. The crew will undergo realistic resource limitations, equipment failures, communication delays, isolation and confinement, and other stressors, along with simulated high-tempo extravehicular activities. These scenarios allow NASA to make informed trades between risks and interventions for long-duration exploration missions.

    “As NASA gears up for crewed Artemis missions, CHAPEA and other ground analogs are helping to determine which capabilities could best support future crews in overcoming the human health and performance challenges of living and operating beyond Earth’s resources – all before we send humans to Mars,” said Sara Whiting, project scientist with NASA’s Human Research Program at NASA Johnson.  

    Crew members will carry out scientific research and operational tasks, including simulated Mars walks, growing a vegetable garden, robotic operations, and more. Technologies specifically designed for Mars and deep space exploration will also be tested, including a potable water dispenser and diagnostic medical equipment.

    “The simulation will allow us to collect cognitive and physical performance data to give us more insight into the potential impacts of the resource restrictions and long-duration missions to Mars on crew health and performance,” said Grace Douglas, CHAPEA principal investigator. “Ultimately, this information will help NASA make informed decisions to design and plan for a successful human mission to Mars.”

    This mission, facilitated by NASA’s Human Research Program, is the second one-year Mars surface simulation conducted through CHAPEA. The first mission concluded on July 6, 2024.

    The Human Research Program pursues methods and technologies to support safe, productive human space travel. Through applied research conducted in laboratories, simulations, and aboard the International Space Station, the program investigates the effects spaceflight has on human bodies and behaviors to keep astronauts healthy and mission-ready.

    Ross Elder, Commander

    Ross Elder, from Williamstown, West Virginia, is a major and experimental test pilot in the United States Air Force. At the time of his selection, he served as the director of operations of the 461st Flight Test Squadron. He has piloted over 35 military aircraft and accumulated more than 1,800 flying hours, including 200 combat hours, primarily in the F-35, F-15E/EX, F-16, and A-10C. His flight test experience focuses on envelope expansion, crewed-uncrewed teaming, artificial intelligence, autonomy, mission systems, and weapons modernization.

    Elder earned a Bachelor of Science in astronautical engineering from the U.S. Air Force Academy in Colorado Springs, Colorado, and commissioned as an Air Force officer upon graduation. He earned a Master of Science in mechanical engineering from the University of Colorado in Colorado Springs and a master’s degree in flight test engineering from the U.S. Air Force Test Pilot School at Edwards Air Force Base in California.

    Ellen Ellis, Medical Officer

    Ellen Ellis, from North Kingstown, Rhode Island, is a colonel and an acquisitions officer in the United States Space Force. She currently serves as a senior materiel leader in the National Reconnaissance Office (NRO) Communications Systems Directorate. She is responsible for fielding commercial cloud and traditional information technology hosting solutions and building modernized data centers for the NRO. She previously served as an Intercontinental Ballistic Missile operations officer and GPS satellite engineer, and she also developed geospatial intelligence payloads and ground processing systems.  

    She earned a Bachelor of Science in aerospace engineering at Syracuse University in New York and holds four master’s degrees, including a Master of Science in systems engineering from the Naval Postgraduate School in California, and a Master of Science in emergency and disaster management from Georgetown University in Washington.

    Matthew Montgomery, Science Officer

    Matthew Montgomery, from Los Angeles, is a hardware engineering design consultant who works with technology startup companies to develop, commercialize, and scale their products. His focus areas include LED lighting, robotics, controlled environment agriculture, and embedded control systems.

    Montgomery earned a Bachelor of Science and a Master of Science in electrical engineering from the University of Central Florida. He is also a founder and co-owner of Floating Lava Studios, a film production company based in Los Angeles.

    James Spicer, Flight Engineer

    James Spicer is a technical director in the aerospace and defense industry. His experience includes building radio and optical satellite communications networks; space data relay networks for human spaceflight; position, navigation, and timing research; and hands-on spacecraft design, integration, and tests.

    Spicer earned a Bachelor of Science and Master of Science in aeronautics and astronautics, and holds a Notation in Science Communication from Stanford University in California. He also holds commercial pilot and glider pilot licenses.

    Emily Phillips

    Emily Phillips, from Waynesburg, Pennsylvania, is a captain and pilot in the United States Marine Corps. She currently serves as a forward air controller and air officer attached to an infantry battalion stationed at the Marine Corps Air Ground Combat Center in Twentynine Palms, California.

    Phillips earned a Bachelor of Science in computer science from the U.S. Naval Academy in Annapolis and commissioned as a Marine Corps officer upon graduation. She attended flight school, earning her Naval Aviator wings and qualifying as an F/A-18C Hornet pilot. Phillips has completed multiple deployments to Europe and Southeast Asia.

    Laura Marie

    Born in the United Kingdom, Laura Marie immigrated to the U.S. in 2016. She is a commercial airline pilot specializing in flight safety, currently operating passenger flights in Washington.

    Marie began her aviation career in 2019 and has amassed over 2,800 flight hours. She holds a Bachelor of Arts in philosophy and a Master of Science in aeronautics from Liberty University in Lynchburg, Virginia. In addition to her Airline Transport Pilot License, she also possesses flight instructor and advanced ground instructor licenses. Outside the flight deck, Marie dedicates her time to mentoring and supporting aspiring pilots as they navigate their careers.

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  • Benmelstobart Combo Elicits PFS Advantage in Untreated Advanced ccRCC

    Benmelstobart Combo Elicits PFS Advantage in Untreated Advanced ccRCC

    Efficacy data revealed that at a median follow-up of 22.8 months for the interim analysis, 48% of the benmelstobart arm and 21% of the sunitinib arm were still receiving treatment, with the primary reason for discontinuation being disease progression in both arms.

    The addition of benmelstobart (TQB2450) to anlotinib (Fukewei) exhibited advantageous progression-free survival (PFS) outcomes vs sunitinib (Sutent) in the treatment of patients who are Chinese with previously untreated advanced clear cell renal cell carcinoma (ccRCC), according to findings from the phase 3 ETER100 trial (NCT04523272) published in The Lancet Oncology.1

    Efficacy data revealed that at a median follow-up of 22.8 months (IQR, 15.2-29.7) for the interim analysis, 48% of the benmelstobart arm and 21% of the sunitinib arm were still receiving treatment, with the primary reason for discontinuation being disease progression in both arms. Additionally, disease progression per blinded independent review committee (BIRC) or death occurred in 48% vs 55% of the respective arms. The median PFS was 19.0 months (95% CI, 15.3-22.8) vs 9.8 months (95% CI, 8.4-12.4), respectively (HR, 0.53; 95% CI, 0.42-0.67; P <.0001).

    In a per-protocol set, the median BIRC-assessed median PFS was 19.0 months (95% CI, 16.5-22.8) vs 11.0 months (95% CI, 8.5-13.6) in the combination and control arms, respectively (HR, 0.55; 95% CI, 0.43-0.70; P < .0001). The between-group difference met the prespecified threshold for significance (P = .0153). Additionally, the Kaplan-Meier estimates for PFS at 12 months were 65% (95% CI, 59%-71%) in the combination arm vs 44% (95% CI, 37%-51%) in the control arm; a post hoc analysis of 24-month PFS showed values of 42% (95% CI, 34%-49%) vs 26% (95% CI, 18%-33%).

    Subgroup analyses generally favored the benmelstobart combination vs sunitinib, including patients with intermediate-poor International Metastatic RCC Database Consortium (IMDC) risk as well as those with a PD-L1 combined positive score (CPS) of less than 1. Overall survival (OS) data were not mature as of the interim analysis, and 24% vs 30% of patients in each arm had died as of data cut off, mostly due to disease progression.

    “The ETER100 trial showed that benmelstobart plus anlotinib resulted in a significant [PFS] benefit and higher objective response rate [ORR] compared with sunitinib in the first-line treatment of advanced [ccRCC],” Aiping Zhou, MD, a professor from the Department of Medical Oncology at the National Cancer Center/Chinese Academy of Medical Sciences and Peking Union Medical College in Beijing, China, wrote in the publication with study coinvestigators. “The safety profile of this combination was manageable without new safety signals. These findings support the use of benmelstobart plus anlotinib as an effective and safe therapeutic option for patients with advanced [ccRCC].”

    Patients 18 years to 80 years old who are Chinese with previously untreated histologically confirmed advanced ccRCC in the open-label phase 3 trial were randomly assigned 1:1 to received benmelstobart plus anlotinib (n = 264) or sunitinib (n = 263). Treatment in the combination arm consisted of 1200 mg of benmelstobart on day 1 of 3-week cycles and anlotinib given orally at 12 mg daily for the first 2 weeks of each cycle. Those in the control arm received 50 mg of daily sunitinib for the first 4 weeks of 6-week cycles.

    Across the investigational and control arms, the median age was 60 years (IQR, 54-67) vs 59 years (IQR, 54-67), with 64% and 69% of each arm being younger than 65 years. Most patients in either arm were male (77% vs 75%), Han (94% vs 94%), and had an ECOG performance score of 1 (73% vs 74%). Additionally, patients most commonly had an intermediate IMDC prognostic risk (71% vs 72%), lung metastases (63% vs 61%), and a PD-L1 CPS of less than 1 (73% vs 72%).

    The primary end point of the trial was BIRC-assessed PFS. Secondary end points included investigator-assessed PFS, OS, and ORR assessed by BIRC and investigators.

    Per BIRC assessment, the ORR was 72% (95% CI, 66%-77%) with the benmelstobart combination vs 25% (95% CI, 20%-31%) with sunitinib (P <.0001), with a median duration of response (DOR) of 17.9 months (95% CI, 13.7-29.4) vs 16.3 months (95% CI, 10.7-24.5). Based on investigator evaluation, the ORR was 68% (95% CI, 62%-74%) vs 25% (95% CI, 20%-30%) in each arm (P <.0001); the median DOR was 16.8 months (95%CI, 13.9-26.3) vs 16.6 months (95% CI, 8.3-28.8), respectively.

    In the safety population, the median duration of treatment in the combination arm was 20 cycles for benmelstobart and anlotinib (IQR; 12-28 and 12-30) vs 6 cycles (IQR, 2-10) for sunitinib. Additionally, the median time to first dose interruption or reduction was 19 weeks, 20 weeks, and 7 weeks, respectively.

    Any-grade treatment-emergent adverse effects (TEAEs) occurred in 99% vs 99% of the investigational and control arms, with 75% vs 75% experiencing grade 3 or higher TEAEs. Furthermore, treatment-related AEs (TRAEs) occurred in 98% of each arm, with grade 3 or higher TRAEs occurring in 67% vs 66% of each arm.Common grade 3 or higher TRAEs were hypertension (34% vs 21%), platelet count decreases (1% vs 23%), neutrophil count decreases (2% vs 16%), white blood cell count decreases (1% vs 11%), and anemia (1% vs 9%).

    Deaths due to treatment occurred in 3 patients in the combination arm due to cardiac-respiratory arrest, renal failure, and an unknown cause. Health-related quality of life data, particularly changes FKSI-15 scores compared with baseline, indicated more favorable outcomes with the benmelstobart-based combination vs sunitinib.

    Reference

    Zhou A, Shen P, Li J, et al.First-line benmelstobart plus anlotinib versus sunitinib in advanced renal cell carcinoma (ETER100): a multicentre, randomised, open-label, phase 3 trial. Lancet Oncol. 2025;26(9):1145-1157. doi:10.1016/S1470-2045(25)00343-2

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  • Adding progesterone to gender-affirming hormone therapy improves breast growth for transgender people

    Adding progesterone to gender-affirming hormone therapy improves breast growth for transgender people

    The addition of the hormone progesterone to gender-affirming hormone therapy leads to increased breast growth for transgender people following feminizing hormone therapy. This is demonstrated by an Amsterdam UMC-led trial among 90 participants and these results are presented today at the European Professional Association for Transgender Health (EPATH) annual congress in Hamburg.

    Our results show that progesterone is safe and effective for transgender people. We’re now able to prescribe it, in a trial setting, for those who have been taking oestradiol for at least year. We hope that our findings lead to better hormone treatments for transgender individuals.”


    Koen Dreijerink, endocrinologist at Amsterdam UMC

    Gender-affirming hormone therapy helps an individual’s body better align with their gender identity. In the case of feminizing hormone therapy this involves blocking the action of testosterone and the addition of estradiol. Traditionally, any breast growth is then limited, leading many transgender people to ultimately opt for breast augmentation surgery.

    Breast growth

    Alongside estradiol, progesterone is one of the two key female sex hormones. Progesterone is known in cis women to also cause breast growth. However, progesterone has not been prescribed in transgender people due to a lack of evidence of its effectiveness and safety. In order to gain more information of the effect on breast volume as well as the safety of progesterone, Dreijerink and his colleagues conducted a randomly controlled trail between 2021 and 2024.

    “Among our 90 participants we repeatedly used 3D-scanning techniques to measure breast volume and saw up to an increase of 37%. Crucially, we also saw that the study participants were more satisfied with the size, shape and the growth of their breasts,” adds Raya Geels, PhD candidate at Amsterdam UMC and the study’s first author.

    The largest increase was seen in the group who also increased their estradiol dosage with some frequent side effects such as short-lasting tiredness, breast and nipple sensitivity and mood swings.

    Participants in the study used progesterone for a year. “The reason we’re moving forward with prescribing this in a research setting is to learn about the long-term effects and side-effects, for example we know that progesterone causes drowsiness so we advised our participants to take it prior to sleeping” adds Dreijerink. “It’s important that we keep learning about the effects of gender affirming hormone therapy”.

    Source:

    Amsterdam University Medical Center

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  • Rory McIlroy, Tyrrell Hatton in the mix at Irish Open, where Joakim Lagergren shot 62 Friday

    Rory McIlroy, Tyrrell Hatton in the mix at Irish Open, where Joakim Lagergren shot 62 Friday

    Rory McIlroy drew the most attention from the crowd, but a 33-year-old Swede drew the most circles on his scorecard Friday at the 2025 Amgen Irish Open.

    Joakim Lagergren made nine birdies and an eagle en route to a blistering 10-under 62 at the K Club in Straffan, Ireland. He teed off on the back nine and made three straight birdies on Nos. 10-12 to kickstart his round before making another birdie on the 16th and an eagle at the par-5 18th.

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    “I just played really well out there,” Lagergren said. “My putter was obviously really hot. Holed a lot of putts today. Did yesterday as well, but didn’t really have my A-game yesterday. Working with my coach yesterday afternoon and obviously found something.”

    Joakim Lagergren of Sweden acknowledges the crowd after a birdie on the ninth green on day two of the Amgen Irish Open 2025 at The K Club on September 05, 2025 in Straffan, Ireland.

    At 9 under with four holes to play, Lagergren had an outside chance at 59, but a bogey on the eighth dashed those hopes. Still, he made birdie on No. 9 to finish on a high note.

    “I think this course is really tricky. It is tough. I can’t really dream of shooting minus 10 at K Club.”

    He’ll take the lead into the weekend at 12 under, one shot clear of France’s Adrien Saddier, who sits in solo second place after a 66 Friday.

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    Those two have a cushion ahead of a pack full of big names, including McIlroy, who bounced back with a bogey-free 66 to enter the weekend at 7 under, in a four-way tie for third with Alfredo Garcia-Heredia, Daniel Hillier and PGA Tour stalwart Thorbjorn Olesen.

    McIlroy started strong with birdies on Nos. 1 and 4, but he cooled off to the tune of eight straight pars before going nuclear down the stretch with back-to-back birdies on holes 13-14 and 17-18.

    “I felt like I hit the ball pretty similarly to yesterday, maybe gave myself a few more chances with the approach shots. Yeah, I just didn’t make a bogey, which was nice. A couple of good par saves on the back nine and finished well with a couple of birdies on the last three holes.

    “Overall, I’m really pleased with the day’s work, and it keeps me within touching distance going into the weekend,” McIlroy said. “Obviously the two boys are a little bit ahead of the rest of the pack, but I feel like I’m close enough, if I do have a good weekend, to chase them down.”

    Rory McIlroy of Northern Ireland tees off on the second hole on day two of the Amgen Irish Open 2025 at The K Club on September 05, 2025 in Straffan, Ireland.

    Rory McIlroy of Northern Ireland tees off on the second hole on day two of the Amgen Irish Open 2025 at The K Club on September 05, 2025 in Straffan, Ireland.

    It was a round more like what we’ve come to expect from the World No. 2, who was steaming mad after being put on the clock during Thursday’s first round in which he shot 1-under 71. McIlroy, 36, would obviously love to win the Irish Open, but he is also working to get his game into shape so he can live up to his billing as Europe’s heavyweight in the Ryder Cup at Bethpage Black later this month.

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    A few of his Ryder Cup teammates are enjoying good weeks, too, including Englishman Tyrrell Hatton, who is one behind McIlroy in a nine-way tie for seventh at 6 under. Hatton started on No. 10 and shot 68 on Friday, which included three birdies in four holes on Nos. 1-4.

    “Ended up being a pretty good day,” Hatton said. “It was a little bit scruffy early on. Not used to the early starts, I guess. Yeah, it took me a while to get going. Holed a nice par putt on 17, and then from there, I had a nice sort of burst of birdies. That was key to today’s round.”

    Tyrrell Hatton of England lines up a putt on the ninth green on day two of the Amgen Irish Open 2025 at The K Club on September 05, 2025 in Straffan, Ireland.

    Tyrrell Hatton of England lines up a putt on the ninth green on day two of the Amgen Irish Open 2025 at The K Club on September 05, 2025 in Straffan, Ireland.

    Shane Lowry, who will join McIlroy and Hatton on Team Europe, is in a tie for 22nd at 4 under after a 71 in Friday’s second round. He struggled to start, making bogeys on Nos. 1 and 3, but a birdie on 11 and an eagle on hole 13 put him safely back inside the even-par cutline.

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    “I feel like I hit the ball really well obviously off the tee. Then it was just weird, I don’t know, my iron play was a little poor. Then I was sloppy and I missed the green. I missed a couple early on at the start. I missed a couple of greens on the wrong side, and before you know it, you’re a couple over and you’re fighting.

    “I’m proud of the way I battled back going into the back nine. The last place you want to be is 1-under par for the tournament playing 16, 17, 18 where the trouble is waiting. So I felt like I did very well to get my round back together.”

    Other notables to make the cut at the Irish Open include Christiaan Bezuidenhout (5 under), Thomas Detry (2 under), Erik Van Rooyen (1 under) and LIV Golf star Patrick Reed (even).

    The final pairing of Lagergren and Saddier tee off at 8:10 a.m. ET for the third round, while McIlroy goes off at 7:50 a.m. and Hatton at 7:40 a.m.

    This article originally appeared on Golfweek: Rory McIlroy, Tyrrell Hatton in the mix at Amgen Irish Open 2025

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  • Gold nears record $3,600/oz level as weak US jobs data fuels rate-cut bets – Reuters

    1. Gold nears record $3,600/oz level as weak US jobs data fuels rate-cut bets  Reuters
    2. Why is the price of gold hitting record highs?  Al Jazeera
    3. Gold prices jump to fresh all-time peak after weak U.S. jobs data  Investing.com
    4. Gold price rallies to record high after downbeat U.S. jobs data  KITCO
    5. Gold (XAUUSD) & Silver Price Forecast: NFP Data in Focus as Metals Hold Bullish Trend  FXEmpire

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