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  • BBC Verify Live: Verifying video from Gaza after wave of Israeli air strikes

    BBC Verify Live: Verifying video from Gaza after wave of Israeli air strikes

    Construction activity visible at Iran’s bombed Fordo nuclear facilitypublished at 10:34 British Summer Time

    Kayleen Devlin and Benedict Garman
    BBC Verify

    Satellite imagery from Maxar Technologies shows heavy construction equipment operating at the Fordo nuclear facility in Iran – one of the sites targeted by the US military.

    Images from 29 June show an excavator and crane at the top of a newly constructed access road close to an area targeted by the American bunker-busting bombs. Further down the mountainside, a bulldozer and lorry are visible.

    Construction vehicles are also working at the entrance to the site and at a bombed building on the east side of the complex – both of which were damaged in Israeli strikes the day after the US attacks.

    According to nuclear weapons expert David Albright, who analysed imagery of the same site taken on 28 June, the construction work may include backfilling the craters, carrying out engineering damage assessments and radiological sampling.

    Following the US strikes President Donald Trump said they had “obliterated” Iran’s key nuclear enrichment facilities.

    Rafael Grossi, director general of the International Atomic Energy Agency, said on Friday that Iran could resume uranium enrichment “in a matter of months.”

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  • PCB appoints Azhar Mahmood as red-ball head coach

    PCB appoints Azhar Mahmood as red-ball head coach

    The Pakistan Cricket Board (PCB) has announced the appointment of Azhar Mahmood as the acting red-ball head coach for the Men’s cricket team.

    The former assistant coach will hold the position until the end of his current contract, according to a statement issued by the PCB on Monday.

    Azhar Mahmood, a seasoned cricket professional, brings a wealth of experience to the role. Having served as the assistant head coach of the national team, he is well-versed in the team’s strategies and operations, the statement added.

    The PCB also stated that his experience extends beyond coaching, with a distinguished career in international cricket and a successful stint in the English county circuit.

    “Mahmood’s red-ball credentials are highlighted by two County Championship titles, showcasing his leadership skills, tactical insight, and dedication to the sport,” it said.

    The PCB is confident that his expertise will contribute significantly to the team’s continued growth, performance, and discipline on the international stage.

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  • Crystal defies Pasteur’s chirality rules in breakthrough discovery

    Crystal defies Pasteur’s chirality rules in breakthrough discovery

    Expectations over optical behaviour that have been widely held since Louis Pasteur’s seminal discoveries in 1848 have been upended by a new study. Researchers observed optical behaviours linked to chirality in crystalline lithium cobalt selenium oxide (Li2Co3(SeO3)4), a centrosymmetric crystal that as such cannot be chiral. ‘Within the inorganic crystal community there’s been a strong sentiment that you cannot have chiroptical effects under centrosymmetry,’ says Roel Tempelaar, a researcher at Northwestern University’s chemistry department who led the new work.

    Chirality refers to two versions of a structure – be that light, molecules or crystals – that are almost identical but cannot be superimposed on each other, just like your left and right hand. When a structure displays centrosymmetry it has lines of symmetry in every direction from a central point, ruling out any possibility of chirality.

    Chiral materials have a chiroptical response – they rotate linearly polarised light and absorb circularly polarised light differently depending on whether it is left-or right-handed – as a result of the molecule or crystal’s shape. Pasteur was able to explain why artificially synthesised tartaric acid did not rotate linearly polarised light, while that derived from biological processes did, as life only produces one version of the molecule. Where both versions are present in equal measure in artificially synthesised tartaric acid, the chiroptical responses cancel out. As centrosymmetric crystals have no chirality in the first place, no-one expected to see chirality in their optical response at all. However, the researchers showed that centrosymmetric crystalline Li2Co3(SeO3)4 transmits more left circularly polarised light than right.

    ‘This is a really beautiful study that challenges the boundaries of conventional thinking,’ says Richard Robinson, a materials scientist at Cornell University in the US. ‘This result is sure to open exciting new avenues in chiroptic material design.’

    How a centrosymmetric crystal shows chiral behaviour

    Although, by definition, a centrosymmetric crystal structure does not meet the criteria for a chiroptical response, it turns out that the interference of two other linear polarisation phenomena also results in different absorption of left- and right-handed circularly polarised light. In fact, while the result came as a surprise, reports date back decades when it comes to chiroptical responses based on interference between linear dichroism – polarisation dependent absorption – and linear birefringence – polarisation dependent refraction.

    Crystal

    The research community has now come to recognise the effect as a physical mechanism with potentially useful features that differ to the optical activity attributed to chiral molecular or crystal structure. As such it could be exploited for engineering chiral light for quantum information applications, where qubits are encoded in spin states of photons instead of electrons or nuclei. Tempelaar was particularly intrigued by the possibility of exploiting the effect to produce compact chiral lasing. But while there are reports of the effect in organic thin films, metal-halide perovskites and nanostructures, Tempelaar and his team were unable to find any reports of the effect in inorganic crystals, where the prevailing mindset still maintains that chiral crystal structure is a prerequisite for chiroptical responses.

    Classy discovery

    Being mostly a molecular scientist, Tempelaar was lucky enough to find himself in conversation with a colleague at Northwestern University, Kenneth Poeppelmeier, who has long worked in the realm of inorganic crystals. The two eventually found themselves exploring crystal symmetries theoretically to see in which types of crystal the effect could manifest. ‘To our surprise, we found that it will survive under certain centrosymmetric classes,’ Tempelaar says.

    Even so there remained a ‘healthy dose of scepticism’ among the team as they began searching for chiroptical centrosymmetric crystals. A close collaboration between graduate students Katherine Parrish and Andrew Salij, as well as postdoctoral researcher Kendall Kamp, ultimately predicted, synthesised and characterised the candidate crystal Li2Co3(SeO3)4. To their excitement, the measured effect was very large.

    ‘The magnitude of the effect has significant technological implications,’ says Garth Simpson, who specialises in novel light–matter interactions at Purdue University in the US, but was not involved in this research. He adds that tabulation of crystal classes supporting this effect could be a ‘particularly useful practical guide’ – more so if the table includes all the relevant crystal classes.

    Haipeng Lu, whose research at the Hong Kong University of Science and Technology focuses on inorganic functional materials, also notes that the interaction is ‘not new to researchers but has been overlooked for many years’. He says that optoelectronics, photonics, spintronics and quantum information science could all benefit from this discovery. ‘It makes researchers in the field re-think the general idea that only non-centrosymmetric materials can produce circular dichroism.’

    Furthermore, Tempelaar is confident the effect is widespread. ‘I don’t think we got particularly lucky – I think this is the tell-tale that there is a whole class of centrosymmetric materials that will be extremely good chiroptical materials,’ he says.

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  • Siemens and EnPot join forces to power China’s aluminium industry using renewables – News

    Siemens and EnPot join forces to power China’s aluminium industry using renewables – News

    EnPot’s technology preserves the electrochemical process of aluminium production while allowing smelters to modulate energy by up to 30%

    SIEMENS has signed a deal with EnPot, developer of a novel heat exchange technology, to help China’s huge aluminium industry use more renewable power.

    EnPot, a New Zealand-based process development company, has developed a technology that allows aluminium smelters to modulate their power use. This would open the door for smelters to reduce their reliance on more dependable fossil fuels while contributing to grid stability.

    Traditional smelter design requires a constant power supply to sustain the electrochemical reaction that produces aluminium and to maintain the heat balance within the pots – a reduction in power can cause severe damage.

    EnPot’s technology uses a mechanical system of heat exchangers that preserve the electrochemical process while allowing smelters to modulate energy by up to 30% without disrupting the internal heat balance. This makes smelting more compatible with variable supplies of renewable power.

    Siemens Energy designs energy management systems that integrate renewable power generation into existing facilities and optimise power use. Together the partners aim to help manufacturers integrate more renewable energy, improve energy efficiency and reduce operating costs.

    China has strict targets for renewable energy to power 30% of its aluminium industry by 2027.

    Karyna Young, CEO of EnPot, said: “China boasts more than 55% of the world’s aluminium smelters and counting. Like the rest of the world, they also see an urgent need to power the process with more energy from the sun, wind and lakes.

    “This means they need to produce aluminium more flexibly by turning power consumption up or down on demand to match the availability of renewables. Numerous smelters in China have told our team they have an abundance of renewable energy that is next to impossible to take full advantage of without being able to dynamically balance the heat in the pots.”

    EnPot’s technology was commercialised at a smelter in Essen, Germany in 2014 and expanded to a full potline of 120 pots in 2019.

    For more on the technology, read a feature written by its developers.

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  • Pixalate Reveals Global Q1 2025 Ad SDK Market Share

    Pixalate Reveals Global Q1 2025 Ad SDK Market Share

    London, June 30, 2025 (GLOBE NEWSWIRE) — Pixalate, the leading ad fraud protection, privacy, and compliance analytics platform, today released the Q1 2025 Global Mobile App Ad SDK Market Share Rankings Reports for the Google Play Store and Apple App Store. The Q1 2025 reports analyze the estimated market share of third-party ad software development kits (SDKs) used across apps on the Google Play Store and Apple App Store.

    Third-party SDKs are created by companies that are different from the app developer. App developers utilize third-party advertising SDKs to perform various advertising-related functions, including mediation, measurement, attribution, and more.

    Top Android Ad SDKs Apps in the Google Play Store

    Market share estimates are based on SDK presence. Pixalate identifies ad impressions on an app and attributes them to every SDK integrated into that app. Because many apps utilize multiple SDKs, this metric reflects an SDK’s footprint and potential access to impressions, not a direct confirmation of its participation in each ad sale.

    Download the full report to explore the estimates based on the number of apps and impression volume.

    Top Android Ad SDKs by Global Estimated Market Share (March 2025):

    • IAB OM Open Measurement OMSDK (95% estimated ad market share)
    • Meta Audience Network (89%)
    • Unity Ads (86%)
    • AppLovin (85%)
    • Vungle (Liftoff) (83%)

    Top Android Ad SDKs by North America Estimated Market Share (March 2025):

    • IAB OM Open Measurement OMSDK (96%)
    • Meta Audience Network (92%)
    • AppLovin (89%)
    • Unity Ads (88%)
    • Vungle (Liftoff) (86%)

    Top Android Ad SDKs by EMEA Estimated Market Share (March 2025):

    • IAB OM Open Measurement OMSDK (95%)
    • Meta Audience (88%)
    • Unity Ads (86%)
    • AppLovin (86%)
    • Vungle (Liftoff) (82%)

    Top Android Ad SDKs by APAC Estimated Market Share (March 2025):

    • IAB OM Open Measurement OMSDK (93%)
    • Meta Audience Network (86%)
    • Unity Ads (83%)
    • Mintegral (78%)
    • AppLovin (77%)

    Top Android Ad SDKs by LATAM Estimated Market Share (March 2025):

    • IAB OM Open Measurement OMSDK (98%)
    • Vungle (Liftoff) (90%)
    • Meta Audience Network (88%)
    • Unity Ads (86%)
    • AppLovin (85%)

    Top Android Ad SDKs on ‘Video Gaming’ Apps by Estimated Market Share (March 2025):

    • IAB OM Open Measurement OMSDK (99%)
    • Unity Ads (99%)
    • AppLovin (98%)
    • Meta Audience Network (96%)
    • Vungle (Liftoff) (96%)

    Download the full Android Ad SDK Market Share Rankings for the Google Play Store here.

    Top iOS Ad SDKs Apps in the Apple App Store

    Download the full report to explore the estimates based on the number of apps and impression volume.

    Top iOS Ad SDKs by Global Estimated Market Share (March 2025):

    • AppLovin (83% estimated ad market share)
    • Amazon Ads (74%)
    • Meta Audience Network (64%)
    • Vungle (Liftoff) (62% )
    • ByteDance TikTok (60%)

    Top iOS Ad SDKs by North America Estimated Market Share (March 2025):

    • AppLovin (84%)
    • Amazon Ads (80%)
    • Meta Audience Network (68%)
    • Vungle (Liftoff) (66%)
    • Appodeal (65%)

    Top iOS Ad SDKs by EMEA Estimated Market Share (March 2025):

    • AppLovin (83%)
    • Amazon Ads (74%)
    • ByteDance (TikTok) (59%)
    • Vungle (Liftoff) (55%)
    • Meta Audience Network (54%)

    Top iOS Ad SDKs by APAC Estimated Market Share (March 2025):

    • AppLovin (75%)
    • ByteDance TikTok (71%)
    • Meta Audience Network (67%)
    • Amazon Ads (56%)
    • Vungle (Liftoff) (52%)

    Top iOS Ad SDKs by LATAM Estimated Market Share (March 2025):

    • AppLovin (79%)
    • Meta Audience Network (64%)
    • Vungle (Liftoff) (63%)
    • Amazon Ads (59%)
    • ByteDance TikTok (56%)

    Top iOS Ad SDKs on ‘Video Gaming’ Apps by Estimated Market Share (March 2025):

    • AppLovin (99%)
    • Amazon Ads (85%)
    • Vungle (Liftoff) (82%)
    • Meta Audience Network (80%)
    • Appodeal (79%)

    Download the complete iOS Ad SDK Market Share Rankings for the Apple App Store here.

    Pixalate’s data science team analyzed over 3.8M mobile apps downloadable from the Apple App Store and Google Play Store and 28 billion open programmatic advertising transactions during March 2025 (Q1 2025).
    Download the reports for a complete analysis and review of SDKs:

    About Pixalate

    Pixalate is a global platform specializing in privacy compliance, ad fraud prevention, and digital ad supply chain data intelligence. Founded in 2012, Pixalate is trusted by regulators, data researchers, advertisers, publishers, ad tech platforms, and financial analysts across the Connected TV (CTV), mobile app, and website ecosystems. Pixalate is accredited by the MRC for the detection and filtration of Sophisticated Invalid Traffic (SIVT). pixalate.com

    Disclaimer

    The content of this press release, and the Global Mobile App SDKs Market Share Rankings Report, reflect Pixalate’s opinions with respect to the factors that Pixalate believes can be useful to the digital media industry. Any data shared is grounded in Pixalate’s proprietary technology and analytics, which Pixalate is continuously evaluating and updating. Any references to outside sources should not be construed as endorsements. Pixalate’s opinions are just that, opinions, which means that they are neither facts nor guarantees. Pixalate is sharing this data not to impugn the standing or reputation of any entity, person or app, but, instead, to report findings and trends pertaining to the time period studied.

                

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  • Ambassador Kamran elected as President of 53rd session of IDB – RADIO PAKISTAN

    1. Ambassador Kamran elected as President of 53rd session of IDB  RADIO PAKISTAN
    2. Pakistan’s PR to UN in Vienna elected UNIDO president  The Express Tribune
    3. 4:00 pm Headlines on 24Digital channel  24 News HD
    4. Kamran Akhtar leads 53rd UNIDO meeting, Pakistan marks historic win  Daily Times
    5. Ambassador Kamran Akhtar elected President of UNIDO Industrial Development Board  Islamabad Post

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  • New Mierle Laderman Ukeles Documentary Looks at Art of Unseen Labor

    New Mierle Laderman Ukeles Documentary Looks at Art of Unseen Labor

    A new documentary about an artist’s decades-long dialogue with New York City government agencies premiered, at the Tribeca Film Festival earlier this month, at the perfect time. For the past several months, supposed cost-saving measures, courtesy of Elon Musk’s Department of Government Efficiency, shrunk federal agencies under the guise that workers who process new vaccines, coordinate air traffic, or protect consumers from business fraud waste money. Debates about the childcare costs, building affordable housing, and free buses dominate New York’s current mayoral race. The moment is ripe to reflect on the practice of an artist like Mierle Laderman Ukeles who encouraged city residents to “hear what New York City is like for the people who keep it alive every single day.”

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    Maintenance Artist, written and directed by Toby Perl Freilich, follows Ukeles as she develops “Maintenance Art,” a term she coined in a 1969 manifesto to describe her new approach to art, or as she put it, “doing everyday things, flushing them up to consciousness, and exhibiting them as art.” As she was raising two children, Ukeles seemed frustrated with daily house tasks (child-rearing, cleaning, cooking) that got in the way of her art-making. Likewise, she wanted to make her presence known in an art world that rendered mothers invisible. The manifesto brought those worlds together. In a contemporary art landscape focused on innovation, genius, and individualism, she asked, “After the revolution, who’s going to pick up the garbage on Monday morning?”

    A film poster showing a woman pouring water over steps outside a brownstone.

    Art: ©Mierle Laderman Ukeles. Courtesy the artist and Ronald Feldman Gallery, New York

    Telling her story chronologically, Maintenance Artist weaves in key points from Ukeles’s career—dropping out of Pratt, the manifesto, working with conservators and museum staff, interviewing janitorial staff—into moments for succinct analyses of the context that shaped them (second-wave feminist art, the city’s economic crisis, and the rise of conceptual art). The film deftly unpacks themes without letting their weight distract from the film’s main thrust, as it does when it shows her discussing plans for Landing: Cantilevered Overlook (2008), an ongoing installation at the landfill–turned–city park Freshkills in Staten Island. Difficulties securing institutional funding for the Percent for Art commission coupled with red tape from city bureaucracy have kept the work from being realized. As the artist sorts through documentation for Landing to determine what to send to the Smithsonian Archives of American Art, which holds her papers, the exhaustion and frustration show clearly on her face. But central to it all is Ukeles at work, from cleaning the sidewalk, to talking to or shaking hands with maintenance workers, to worrying about funding.

    Freilich keeps the editorializing to a minimum while still managing to expose the unconscious bias that operates within the systems that Ukeles works. The film zooms in, for example, on Ukeles’s time as an artist in residence with the NYC Department of Sanitation workers in the late ’70s and early ’80s. For her seminal Touch Sanitation Performance (1979–80), the artist documented her interactions with some 8,500 DSNY employees, or “sanmen,” across the five boroughs, as she shook their hands, interviewed them, and simply observed them. The groundbreaking partnership between an artist and a city agency helped to raise public sentiment and budgets for DSNY. But Ukeles’s footage from that era reveals the crux of her feminist concerns with the project. A veteran, explaining why DSNY staff feel undervalued, says that city residents don’t respect their work because “they think that we’re here to clean up their messes.” Debriefing that moment for the documentary, Ukeles points out the tension. She says, “If they were women would it be okay to hate them?”

    A mirror garbage truck installed outside the Queens Museum.

    Mierle Laderman Ukeles, The Social Mirror, 1983, installed at the Queens Museum in 2016.

    Photo Hai Zhang/Courtesy Maintenance Artist

    But Maintenance Artist features mostly footage from Ukeles’s own archive and the artist’s narration. Freilich wanted to highlight the overlooked artist making ecofeminist, public art decades before it was popular after seeing Ukeles’s Queens Museum career retrospective in 2016. Staying so close to the artist’s point of voice means there are only a few moments that describe the impact of her work. Her collaborators at DSNY, the gallery representing her, and her family share their experiences with the artist at the time, but few interviews interrogate the work beyond its immediate impact.

    The omission becomes evident at the end, where you would expect to see comments from contemporary artists or art administrators whom Ukeles inspired, either directly or indirectly. There would be no shortage of artists or administrators to pull. Ukeles’s unpaid work has grown into funded city programs such as NYC’s Public Artist in Residence program, established in 2015 during interviewee Tom Finkelpearl’s time as commissioner of the New York City Department of Cultural Affairs, or Los Angeles’s Creative Catalyst programs, which now intentionally pair artists with city agencies. The documentary also seems to ignore the abundance of social practice artists whose works Ukeles would have been in conversation with.

    Similarly, other than a short description of Ukeles attending Vito Acconci’s Seedbed (1972) with her children, there is little information about her relationship with her children as her practice developed. After that experience, Ukeles left her children at home, working 16-hour sanitation shifts. Her children seem understanding of that decision but they don’t elaborate. The film never resolves if Ukeles’s Maintenance Art was the best solution for the two people who inspired her career. Instead, the, at times, myopic documentary seems so overwhelmed by the mere fact that the 86-year-old artist is still alive that it forgets to step back and look around. “We are all a maintenance worker,” Ukeles reminds us.

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  • At least 12 killed in an explosion and fire at a pharmaceutical factory in southern India

    At least 12 killed in an explosion and fire at a pharmaceutical factory in southern India

    An explosion and fire at a pharmaceutical factory in Telangana, India, have killed at least 12 people and injured several others

    NEW DELHI — An explosion and fire at a pharmaceutical factory in India’s southern state of Telangana killed at least 12 people and injured several others, authorities said Monday.

    The fire department recovered the charred bodies of 10 workers in an industrial area about 50 kilometers (31 miles) from the state capital Hyderabad (31 miles), the state’s fire services director G.V. Narayana Rao told The Associated Press.

    Two other workers succumbed to burns and were pronounced dead at a hospital, Rao said, adding that debris of the gutted pharmaceutical unit of Sigachi Industries was being removed to find out if any more workers were trapped. Nearly three dozen injured workers were admitted to hospitals. he said.

    “It was an explosion in a spray dryer unit of the factory, which is used to process raw material into fine powder for making drugs,” Rao said.

    India is home to some of the world’s top pharmaceutical companies, playing a pivotal role in the global supply of generic medicines and vaccines. The country’s robust manufacturing and cost-effective production have made it a hub for pharma giants.

    Industrial accidents, particularly involving chemical reactors, aren’t uncommon in such factories, underlining the need for authorities to implement stringent safety protocols and regulatory oversight in a sector critical to public health.

    Sigachi Industries Limited is an Indian company dealing with active pharmaceutical ingredients, intermediates and vitamin-mineral blends, according to the company’s website. It has five manufacturing facilities across India, and also subsidiaries in the U.S and the United Arab Emirates.

    Prime Minister Narendra Modi in a social media post expressed his anguish over the loss of lives and announced financial support of 200,000 Indian rupees ($2,333) each to the next of kin.

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  • Review | Lorde’s ‘Virgin’ charts a journey of self-discovery – The Washington Post

    1. Review | Lorde’s ‘Virgin’ charts a journey of self-discovery  The Washington Post
    2. Lorde Is Brilliantly Reborn on ‘Virgin’  Rolling Stone
    3. Review: ‘Virgin’  dailyuw.com
    4. “Virgin”: An X-Ray of Lorde’s Sonic Arrival  The Knockturnal
    5. ‘Broken Glass’ Picks Up Where Lorde (and Charli XCX) Left Off  MSN

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  • FAU researchers secure key grants to target new gene in the fight against glioblastoma

    FAU researchers secure key grants to target new gene in the fight against glioblastoma

    Florida Atlantic University researchers have secured two key grants to investigate targeting a gene for the first time as a new approach to treat glioblastoma, a very aggressive and fast-growing type of brain cancer.

    Malignant gliomas, such as glioblastoma multiforme and astrocytomas, are the most common type of primary brain tumor in the United States. They make up about 78% of all malignant brain tumors. Although these tumors are not very common, especially in the U.S., they cause a high number of cancer deaths because they are so aggressive.

    These awards, granted by the Florida Department of Health’s Cancer Connect program for $562,000 and the Palm Health Foundation for $50,000, support a distinctive collaboration among FAU researchers that unites complementary expertise in neuroscience and cancer biology. Together, this partnership aims to advance highly innovative projects that have the potential to make a meaningful impact on cancer therapy.

    The grants will explore a promising new target – a gene called MBLAC1 – whose properties encouraged a collaboration between two FAU research labs, one focused on molecular neuroscience and the other on cancer mechanisms and treatment.

    MBLAC1 plays a key role in regulating copper levels within cells, which affects mitochondrial function and oxidative stress – both critical factors in cancer cell survival and growth. Since glioblastoma cells rely heavily on mitochondrial energy production and protection against oxidative damage, targeting MBLAC1 could disrupt these processes and slow tumor progression.

    Investigators of this grant are Randy D. Blakely, Ph.D., executive director of the FAU Stiles-Nicholson Brain Institute, the David J.S. Nicholson Distinguished Professor in Neuroscience and a professor of biomedical science within FAU’s Charles E. Schmidt College of Medicine; and Gregg B. Fields, Ph.D., FAU vice president for research and executive director of the FAU Institute for Human Health and Disease Intervention (I-Health).

    By combining our expertise in cancer biology and neuroscience, we are approaching glioblastoma with a fresh and powerful perspective. By identifying how MBLAC1 supports tumor growth and testing drugs that block its function, our team hopes to lay the groundwork for developing new, effective therapies that could improve outcomes for patients with glioblastoma and possibly other cancers.”


    Gregg B. Fields, Ph.D., FAU vice president for research and executive director of the FAU Institute for Human Health and Disease Intervention 

    The project will investigate how MBLAC1 influences glioblastoma invasion and copper homeostasis using advanced 3D tumor models and genetically engineered mice lacking the gene.

    “I’m excited to bring my background in neuroscience to explore new frontiers in cancer research,” said Blakely. “Our work centers on how a specific gene regulates copper – a vital micronutrient – in brain cells, which directly influences how these cells generate energy and manage stress. Because cancer cells depend heavily on energy to grow and spread, uncovering and interrupting this process could transform treatment. This collaboration is a perfect example of how combining different scientific perspectives can spark innovation and accelerate progress in the fight against cancer.”

    The Blakely lab discovered that MBLAC1, a previously unstudied gene, plays a crucial role in brain cell function by regulating copper, which is essential for cell energy production and protection against oxidative stress. Lower levels of MBLAC1 have been linked to better survival in patients, suggesting it could be a key target for new treatments.

    Researchers will investigate whether MBLAC1 from support brain cells or from the cancer cells themselves drives tumor invasion. Using 3D tumor models that closely mimic real tumors, they will observe how blocking MBLAC1 or copper affects tumor growth and spread. They are also developing a new test to quickly identify drugs that specifically inhibit MBLAC1 activity.

    Blakely is collaborating on this project with cancer biologists Fields and Ania Knapinska, Ph.D., principal investigator and a research professor at FAU I-Health.

    “Our project breaks new ground by uncovering a molecular pathway that actively promotes cancer through a gene linked to copper balance and glioblastoma risk,” said Knapinska. “We’re also pioneering novel genetic models to study glioblastoma in ways never done before. Our discoveries that mutations in this gene reduce mitochondrial function and increase cellular stress have driven us to explore its fundamental role in copper regulation and metabolism in living systems. Because this gene is highly targetable by drugs, our research opens promising new avenues for developing effective glioblastoma treatments.”

    Source:

    Florida Atlantic University

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