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  • Draper & Pegula oust Alcaraz & Raducanu, then storm into US Open semis – ATP Tour

    1. Draper & Pegula oust Alcaraz & Raducanu, then storm into US Open semis  ATP Tour
    2. 2025 US Open: Schedule, prize money, how to watch year’s final tennis major  USA Today
    3. Jannik Sinner and Katerina Siniakova withdraw from 2025 US Open mixed doubles  US Open Tennis
    4. US Open 2025 mixed doubles: How event featuring Carlos Alcaraz and Emma Raducanu is dividing opinion  BBC
    5. US Open mixed doubles: Draper/Pegula into semi-finals after beating Alcaraz/Raducanu – as it happened  The Guardian

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  • Plex urges users to update server after fixing a security issue

    Plex urges users to update server after fixing a security issue

    Plex, the popular app for organizing and streaming personal media collections, is warning users running certain Plex Media Server versions to update immediately due to a “potential security issue” that was recently patched. Here are the details.

    Urgent fix, no details

    As reported by BleepingComputer (via Tecnoblog), Plex is reaching out to users running server versions 1.41.7.x through 1.42.0.x, and urging them to update to Plex Media Server 1.42.1.10060 as soon as possible.

    The company’s e-mail reads:

    Update Your Plex Media Server

    Dear Plex user,

    We recently received a report via our bug bounty program that there was a potential security issue affecting Plex Media Server versions 1.41.7.x to 1.42.0.x. Thanks to that user, we were able to address the issue, release an updated version of the server, and continue to improve our security and defenses.

    You’re receiving this notice because our information indicates that a Plex Media Server owned by your Plex account is running an older version of the server. We strongly recommend that everyone update their Plex Media Server to the most recent version as soon as possible, if you have not already done so.

    The new version (1.42.1.10060 or later) is now available to update through your regular server management page or you can download the package from our downloads page (https://www.plex.tv/media-server-downloads/).

    Thank you,
    The Plex Team

    The company hasn’t disclosed any specifics about the vulnerability, and it doesn’t yet have a CVE identifier, both signs that this was a serious and urgent bug fix.

    So if you’re running Plex, double-check that your server is fully up to date, as now that the word is out there that a severe bug was fixed, it’s very likely that attackers will try to figure out the vulnerability and exploit it on users who haven’t updated yet.

    While Plex has an overall good track record, BleepingComputer notes that it has had issues in the past with remote code execution, which is about as serious as it gets.

    So even if you don’t think you’re running versions 1.41.7.x through 1.42.0.x of Plex Media Server, it’s worth double-checking that you’re on version 1.42.1.10060, just to be safe.

    Are you a Plex user? Let us know in the comments.

    Limited time Mac deals on Amazon

    • Mac mini (M4) 16GB/256GB: $499 (17% off)
    • MacBook Air, 15-inch, M4, 16GB/256GB: $999 (was $1,199) 
    • MacBook Pro, 14-inch, M4, 16GB/512GB: $1,299 (19% off)
    • Studio Display, Nano-Texture Glass, VESA Mount Adapter: $1,649 (13% off)

    FTC: We use income earning auto affiliate links. More.

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  • Study: Early Signs of Valve Failure One Year After TAVI Raises Durability Concerns in Younger Patients

    Study: Early Signs of Valve Failure One Year After TAVI Raises Durability Concerns in Younger Patients

    Aug. 18, 2025 — A new study published in The Annals of Thoracic Surgery, a journal from The Society of Thoracic Surgeons, has identified early hemodynamic valve deterioration (HVD) in more than 6% of patients just one year after undergoing transcatheter aortic valve implantation (TAVI), raising new questions about valve durability in younger, lower-risk populations.

    The retrospective study, which analyzed 10 years of procedures from 2012 to 2022, evaluated 2,123 patients who had complete echocardiographic follow-up data. Researchers found that patients with 1-year HVD were more likely to be younger and have smaller aortic annuli than those without HVD. Importantly, smaller implanted valve sizes were significantly associated with the development of HVD, while larger valves appeared to be protective.

    “As TAVI is increasingly used in younger and healthier patients, our findings suggest a need to carefully consider valve sizing and long-term durability,” said lead study author Eishan Ashwat, BS, a medical student at the University of Pittsburgh School of Medicine. “Early identification of hemodynamic deterioration may serve as a key predictor of future reintervention and patient outcomes.”

    According to the study, patients with 1-year HVD had a five-year aortic valve reintervention rate nearly four times higher than those without HVD (2.3% vs. 0.6%). Prior surgical aortic valve replacement (AVR) was also independently associated with a higher risk of early HVD.

    The findings underscore the importance of vigilant long-term follow-up and may influence future decision-making regarding valve selection, particularly in patients with smaller aortic anatomy or a history of AVR.

    The study used the updated Valve Academic Research Consortium-3 (VARC-3) definitions to assess bioprosthetic valve function and structural deterioration.

    Read the full article here. 

     

    Source: Newswise


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  • AI Captures Once-in-a-Lifetime Supernova That Glowed Twice – SciTechDaily

    1. AI Captures Once-in-a-Lifetime Supernova That Glowed Twice  SciTechDaily
    2. AI Helps Astronomers Discover a New Type of Supernova  Center for Astrophysics | Harvard & Smithsonian
    3. There’s Something Really Suspicious About the Way This Star Died  Futurism
    4. Saturday Citations: A new category of supernovas; neurons beat machine learning; depression and vitiligo  Phys.org
    5. Why the death of this star is very, very strange  The Washington Post

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  • Ariana DeBose’s mother, Gina, dead at age 57 of ovarian cancer

    Ariana DeBose’s mother, Gina, dead at age 57 of ovarian cancer

    Oscar-winner Ariana DeBose is mourning the loss of her mother, Gina Michelle DeBose, who has died at age 57 after battling Stage 3 ovarian cancer.

    The “West Side Story” actor and Broadway star announced her mother’s death Tuesday on Instagram, sharing photos of the two of them over the years — from the younger DeBose’s childhood to her historic win at the Academy Awards in 2022.

    “I couldn’t be more proud of her and how she fought this insidious disease over the past 3 years,” DeBose wrote.

    Ariana DeBose, 34, said in her tribute that her mother was her “favorite person, my biggest fan and toughest critic. My best friend.” The “Love Hurts” actor said her mother “fought like hell” to support her daughter’s ambitions, adding that her accolades — which include BAFTA, Critics’ Choice and Golden Globe awards — belong equally to her mother.

    The actor said her mother was a longtime public school teacher who devoted her life to educating young people. She was “the greatest advocate” for arts education, she said, adding that the death of the elder DeBose would deeply impact her mother’s community: “She was a force of epic proportion.”

    Actors including “Abbott Elementary” star Quinta Brunson, “Insecure” alumna Yvonne Orji, former “Dancing With the Stars” pro Julianne Hough and celebrity fitness trainer Amanda Kloots rallied around DeBose in the comments section as she broke the news. In addition to paying tribute to her mother, DeBose highlighted several charities where supporters could donate in her mother’s honor.

    “My greatest and most proud achievement will always be to have made her proud,” DeBose wrote. “I love you mommy. Now travel amongst the seas, the winds and the angels as I know you always loved to do.”


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  • Louis Vuitton Tapped a German Industrial Designer for Its Makeup Debut

    Louis Vuitton Tapped a German Industrial Designer for Its Makeup Debut

    Above: LV Rouge Complete Lipstick and LV Baume Complete Lip Balm, $160 each; LV Ombres Eyeshadow, $250.

    How does a Berlin-based designer find himself developing the look, feel, and functionality of Louis Vuitton’s entrée into beauty? In the case of Konstantin Grcic, there’s a circularity to the appointment. Louis Vuitton the man was a trunkmaker, and Grcic’s best-known works include an ergonomic work caddy for Vitra and a set of stacking stools that have been exhibited at the Museum of Modern Art in New York.

    Florence Sullivan

    LV Ombres Eyeshadow, $250.

    For La Beauté Louis Vuitton, Grcic built the collection of lipstick and eyeshadow cases around a golden ring that swivels shut with the dexterity of a lock; he got the idea from the brass fittings of the maison’s historic trunks. “It’s a nod to heritage but also a powerful marker of identity,” says Grcic, who avoided plastic, working instead with reusable aluminum and brass components. “The way it feels in your hand, the sound of the closure, the temperature of the materials—these are all part of the emotional connection.”

    Stacked lipsticks and a designer case.

    Florence Sullivan

    LV Rouge Complete Lipstick and LV Baume Complete Lip Balm, $160 each.

    Headshot of Sean Santiago

    Sean Santiago is ELLE Decor’s Deputy Editor, covering news, trends and talents in interior design, hospitality and travel, culture, and luxury shopping. Since starting his career at an interior design firm in 2011, he has gone on to cover the industry for Vogue, Architectural Digest, Sight Unseen, PIN-UP and Domino. He is the author of The Lonny Home (Weldon Owens, 2018), has produced scripted social content for brands including West Elm and Streeteasy, and is sometimes recognized on the street for his Instagram Reels series, #DanceToDecor

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  • In Xcode 26, Apple shows first signs of offering ChatGPT alternatives

    In Xcode 26, Apple shows first signs of offering ChatGPT alternatives

    The latest Xcode beta contains clear signs that Apple plans to bring Anthropic’s Claude and Opus large language models into the integrated development environment (IDE), expanding on features already available using Apple’s own models or OpenAI’s ChatGPT.

    Apple enthusiast publication 9to5Mac “found multiple references to built-in support for Anthropic accounts,” including in the “Intelligence” menu, where users can currently log into ChatGPT or enter an API key for higher message limits.

    Apple introduced a suite of features meant to compete with GitHub Copilot in Xcode at WWDC24, but first focused on its own models and a more limited set of use cases. That expanded quite a bit at this year’s developer conference, and users can converse about codebases, discuss changes, or ask for suggestions using ChatGPT. They are initially given a limited set of messages, but this can be greatly increased by logging into a ChatGPT account or entering an API key.

    This summer, Apple said it would be possible to use Anthropic’s models with an API key, too, but made no mention of support for Anthropic accounts, which are generally more cost-effective than using the API for most users.

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  • Trump says he has ended seven wars. The reality isn’t so clear cut – NBC Los Angeles

    Trump says he has ended seven wars. The reality isn’t so clear cut – NBC Los Angeles

    President Donald Trump has projected himself as a peacemaker since returning to the White House in January, touting his efforts to end global conflicts.

    In meetings with Ukrainian President Volodymyr Zelenskyy and other European leaders Monday, Trump repeated that he has been instrumental in stopping multiple wars but didn’t specify which.

    “I’ve done six wars, I’ve ended six wars, Trump said in the Oval Office with Zelenskyy. He later added: “If you look at the six deals I settled this year, they were all at war. I didn’t do any ceasefires.”

    He raised that figure Tuesday, telling “Fox & Friends” that “we ended seven wars.”

    But although Trump helped mediate relations among many of these nations, experts say his impact isn’t as clear cut as he claims.

    Here’s a closer look at the conflicts.

    Israel and Iran

    Trump is credited with ending the 12-day war.

    Israel launched attacks on the heart of Iran’s nuclear program and military leadership in June, saying it wanted to stop Iran from building a nuclear weapon — which Tehran has denied it was trying to do.

    Trump negotiated a ceasefire between Israel and Iran just after directing American warplanes to strike Iran’s Fordo, Isfahan and Natanz nuclear sites. He publicly harangued both countries into maintaining the ceasefire.

    Evelyn Farkas, executive director of Arizona State University’s McCain Institute, said Trump should get credit for ending the war.

    “There’s always a chance it could flare up again if Iran restarts its nuclear weapons program, but nonetheless, they were engaged in a hot war with one another,” she said. “And it didn’t have any real end in sight before President Trump got involved and gave them an ultimatum.”

    Lawrence Haas, a senior fellow for U.S. foreign policy at the American Foreign Policy Council who is an expert on Israel-Iran tensions, agreed the U.S. was instrumental in securing the ceasefire. But he characterized it as a “temporary respite” from the ongoing “day-to-day cold war” between the two foes that often involves flare-ups.

    President Donald Trump said on social media that Iran and Israel had agreed to a total ceasefire.

    Egypt and Ethiopia

    This could be described as tensions at best, and peace efforts — which don’t directly involve the U.S. — have stalled.

    The Grand Ethiopian Renaissance Dam on the Blue Nile River has caused friction between Ethiopia, Egypt and Sudan since the power-generating project was announced more than a decade ago. In July, Ethiopia declared the project complete, with an inauguration set for September.

    Egypt and Sudan oppose the dam. Although the vast majority of the water that flows down the Nile originates in Ethiopia, Egyptian agriculture relies on the river almost entirely. Sudan, meanwhile, fears flooding and wants to protect its own power-generating dams.

    During his first term, Trump tried to broker a deal between Ethiopia and Egypt but couldn’t get them to agree. He suspended aid to Ethiopia over the dispute. In July, he posted on Truth Social that he helped the “fight over the massive dam (and) there is peace at least for now.” However, the disagreement persists, and negotiations between Egypt, Ethiopia and Sudan have stalled.

    “It would be a gross overstatement to say that these countries are at war,” said Haas. “I mean, they’re just not.”

    India and Pakistan

    The April killing of tourists in Indian-controlled Kashmir pushed India and Pakistan closer to war than they had been in years, but a ceasefire was reached.

    Trump has claimed that the U.S. brokered the ceasefire, which he said came about in part because he offered trade concessions. Pakistan thanked Trump, recommending him for the Nobel Peace Prize. But India has denied Trump’s claims, saying there was no conversation between the U.S. and India on trade in regards to the ceasefire.

    Although India has downplayed the Trump administration’s role in the ceasefire, Haas and Farkas believe the U.S. deserves some credit for helping stop the fighting.

    “I think that President Trump played a constructive role from all accounts, but it may not have been decisive. And again, I’m not sure whether you would define that as a full-blown war,” Farkas said.

    Serbia and Kosovo

    The White House lists the conflict between these countries as one Trump resolved, but there has been no threat of a war between the two neighbors during Trump’s second term, nor any significant contribution from Trump this year to improve their relations.

    Kosovo is a former Serbian province that declared independence in 2008. Tensions have persisted ever since, but never to the point of war, mostly because NATO-led peacekeepers have been deployed in Kosovo, which has been recognized by more than 100 countries.

    During his first term, Trump negotiated a wide-ranging deal between Serbia and Kosovo, but much of what was agreed on was never carried out.

    Rwanda and the Democratic Republic of the Congo

    Trump has played a key role in peace efforts between the African neighbors, but he’s hardly alone and the conflict is far from over.

    Eastern Congo, rich in minerals, has been battered by fighting with more than 100 armed groups. The most potent is the M23 rebel group backed by neighboring Rwanda, which claims it is protecting its territorial interests and that some of those who participated in the 1994 Rwandan genocide fled to Congo and are working with the Congolese army.

    The Trump administration’s efforts paid off in June, when the Congolese and Rwandan foreign ministers signed a peace deal at the White House. The M23, however, wasn’t directly involved in the U.S.-facilitated negotiations and said it couldn’t abide by the terms of an agreement that didn’t involve it.

    The final step to peace was meant to be a separate Qatar-facilitated deal between Congo and M23 that would bring about a permanent ceasefire. But with the fighting still raging, Monday’s deadline for the Qatar-led deal was missed and there have been no public signs of major talks between Congo and M23 on the final terms.

    Armenia and Azerbaijan

    Trump this month hosted the leaders of Armenia and Azerbaijan at the White House, where they signed a deal aimed at ending a decades-long conflict between the two nations. Armenian Prime Minister Nikol Pashinyan called the signed document a “significant milestone,” and Azerbaijani President Ilham Aliyev hailed Trump for performing “a miracle.”

    The two countries signed agreements intended to reopen key transportation routes and reaffirm Armenia’s and Azerbaijan’s commitment to signing a peace treaty. The treaty’s text was initialed by the countries’ foreign ministers at that meeting, which indicates preliminary approval. But the two countries have yet to sign and ratify the deal.

    Armenia and Azerbaijan have been locked in a bitter conflict over territory since the early 1990s, when ethnic Armenian forces took control of the Karabakh province, known internationally as Nagorno-Karabakh, and nearby territories. In 2020, Azerbaijan’s military recaptured broad swaths of territory. Russia brokered a truce and deployed about 2,000 peacekeepers to the region.

    In September 2023, Azerbaijani forces launched a lightning blitz to retake remaining portions. The two countries have worked toward normalizing ties and signing a peace treaty ever since.

    Cambodia and Thailand

    Officials from Thailand and Cambodia credit Trump with pushing the Asian neighbors to agree to a ceasefire in this summer’s brief border conflict.

    Cambodia and Thailand have clashed in the past over their shared border. The latest fighting began in July after a land mine explosion along the border wounded five Thai soldiers. Tensions had been growing since May, when a Cambodian soldier was killed in a confrontation that created a diplomatic rift and roiled Thai politics.

    Both countries agreed in late July to an unconditional ceasefire during a meeting in Malaysia. Malaysian Prime Minister Anwar Ibrahim pressed for the pact, but there was little headway until Trump intervened. Trump said on social media that he warned the Thai and Cambodian leaders that the U.S. would not move forward with trade agreements if the hostilities continued. Both countries faced economic difficulties and neither had reached tariff deals with the U.S., though most of their Southeast Asian neighbors had.

    According to Ken Lohatepanont, a political analyst and University of Michigan doctoral candidate, “President Trump’s decision to condition a successful conclusion to these talks on a ceasefire likely played a significant role in ensuring that both sides came to the negotiating table when they did.” ___ Associated Press reporters Jon Gambrell, Grant Peck, Dasha Litvinova, Fay Abuelgasim, Rajesh Roy, and Dusan Stojanovic contributed.

    ___

    Find AP Fact Checks here: https://apnews.com/APFactCheck.

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  • Nina White, Isabel Keating, Melody Butiu and More Join Kristin Chenoweth in The Queen of Versailles on Broadway | Broadway Buzz

    Nina White, Isabel Keating, Melody Butiu and More Join Kristin Chenoweth in The Queen of Versailles on Broadway | Broadway Buzz

    Nina White, Isabel Keating, Melody Butiu
    (Photos c/o O&M)

    The Queen of Versailles, the Stephen Schwartz-scored musical starring Kristin Chenoweth and F. Murray Abraham as real-life couple Jackie and David Siegel, has completed casting. The production will open on Broadway this fall at the St. James Theatre, beginning previews October 8 with opening night set for November 10.

    Reprising their roles from the 2024 world premiere production at Boston’s Emerson Colonial Theatre are Melody Butiu as Sofia, Stephen DeRosa as John, Greg Hildreth as Gary, Tatum Grace Hopkins as Jonquil, Isabel Keating as Debbie and Nina White as Victoria Siegel.

    Butiu was last on Broadway with Here Lies Love. Recently seen in BOOP!, DeRosa’s Broadway credits also include Into the Woods, Hairspray and On the Town. Hildreth, seen in last season’s Encores! revival of Urinetown, also starred in the 2021 revival of Company. Keating received a Tony nomination for her performance in The Boy From Oz; her Broadway credits include Hairspray and Wicked. White originated the role of Teresa in Kimberly Akimbo.

    The company will also include Yeman Brown, David Aron Damane, Drew Elhamalawy, Christopher Gurr, KJ Hippensteel, Cassondra James, Andrew Kober, Jesse Kovarsky, Pablo David Laucerica, Travis Murad Leland, Ryah Nixon, Shea Renne, Michael McCorry Rose, Grace Slear, Anne Fraser Thomas and Jake Bentley Young.

    From computer engineer to Mrs. Florida to billionairess, Jackie Siegel sees herself as the embodiment of the American Dream. She and her husband, David “The Timeshare King” Siegel, invite you to behold their most grandiose venture yet: a $100 million house big enough for her dreams and inspired by the Palace of Versailles. But then Jackie and David’s dreams begin to crumble, along with their lavish lifestyle. The Queen of Versailles explores the true cost of fame, fortune and family.

    Based on Lauren Greenfield’s award-winning 2012 documentary film and the life stories of Jackie and David Siegel, The Queen of Versailles features a book by Olivier Award nominee Lindsey Ferrentino, music direction by Mary-Mitchell Campbell, choreography by Lauren Yalango-Grant and Christopher Cree Grant, and direction by Michael Arden (the Tony-winning director of Maybe Happy Ending and Parade). The show is a reunion for Chenoweth and Schwartz, who are coming together on Broadway for the first time since Wicked premiered in 2003.

    The show will include scenic and video design by Dane Laffrey, costume design by Christian Cowan, lighting design by Natasha Katz, sound design by Peter Hylenski, hair and wig design by Cookie Jordan, orchestrations by John Clancy and casting by Stephen Kopel, CSA and Carrie Gardner, CSA at C12 Casting. 

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  • Emotional Distress May Confer Worse Immunotherapy Outcomes in NSCLC

    Emotional Distress May Confer Worse Immunotherapy Outcomes in NSCLC

    “STRESS-LUNG-1 highlights the crucial role of addressing [emotional distress] and optimizing mental health in [patients with] cancer. This study introduces the first ‘psycho-biomarker’ to predict the efficacy of ICIs in NSCLC,” according to the editorial authors.

    Pretreatment emotional distress may significantly correlate with worse clinical efficacy following immune checkpoint inhibitor (ICI) use in patients with advanced non–small cell lung cancer (NSCLC), supporting a need for an integrative care approach in this population, according to an editorial commentary published in Translational Lung Cancer Research.1

    According to the authors of the editorial, data from the prospective observational STRESS-LUNG-1 study (NCT05477979) establish “compelling evidence” of this link between emotional distress and clinical outcomes in this population. Investigators previously published findings from STRESS-LUNG-1 in Nature Medicine.2

    With a data cutoff of November 30, 2023, and a median follow-up of 16.0 months (95% CI, 14.0-18.0), the median progression-free survival (PFS) was 9.2 months (95% CI, 7.0-11.4) following ICI therapy across the overall population, 7.9 months (95% CI, 6.2-9.7) among patients who exhibited emotional distress, and 15.5 months (95% CI, 7.8-23.2) in those without emotional distress. The median PFS was significantly shorter among patients with emotional distress (HR, 1.73; 95% CI, 1.23-2.43; P = .002), and this association persisted across various patient subgroups.

    Additional data showed an objective response (ORR) of 54.6% (95% CI, 48.1%-61.1%) across all patients, 46.8% (95% CI, 37.6%-56.1%) among those with emotional distress, and 62.1% (95% CI, 53.2%-70.9%) in those without. Those with emotional distress experienced significantly lower odds of achieving a response vs those without emotional distress (OR, 0.54; 95% CI, 0.32-0.91; P = .022).

    Regarding overall survival (OS), patients in the emotional distress cohort had a higher risk of death from any cause (HR, 1.82; 95% CI, 1.12-2.97; P = .016). In those with and without emotional distress, respectively, the OS rates were 70.4% vs 80.8% at 1 year and 46.5% vs 64.9% at 2 years.

    Quality of life (QOL) data showed that patients with emotional distress experienced lower global health scores as well as worse measures for individual functional domains related to physical functioning, role functioning, emotional functioning, cognitive functioning, and social functioning. Those with emotional distress also had worse symptoms of fatigue, pain, dyspnea, insomnia, loss of appetite, and constipation.

    “STRESS-LUNG-1 highlights the crucial role of addressing [emotional distress] and optimizing mental health in [patients with] cancer. This study introduces the first ‘psycho-biomarker’ to predict the efficacy of ICIs in NSCLC,” Shannon Zhang, a hematology and oncology fellow in the Division of Hematology/Oncology of the Department of Medicine at University of California Irvine, wrote with coauthors in the editorial.1 “Moving forward, multi-center and global studies involving diverse populations are essential.”

    In cohort 1 of the STRESS-LUNG trial, otherwise known as the STRESS-LUNG-1 cohort, investigators assessed patients with advanced NSCLC who received PD-1 and PD-L1 inhibitors, which included agents like pembrolizumab (Keytruda), atezolizumab (Tecentriq), and camrelizumab. The study’s primary end point was investigator-assessed PFS. Secondary end points included ORR, OS, and QOL.

    Eligible patients were 18 years or older; had histologically confirmed NSCLC; had unresectable, locally advanced, metastatic, or recurrent stage IIB to IV disease; had an ECOG performance of 0 or 1; had at least 1 measurable lesion per RECIST v1.1 guidelines; and underwent treatment at the Second Xiangya Hospital of Central South University in Hunan China. Investigators assessed emotional distress in patients at baseline before initiation of ICI therapy, with the Patient Health Questionnaire-9 (PHQ-9) and Generalized Anxiety Disorder 7-item (GAD-7) questionnaires used to evaluate symptoms of depression and anxiety, respectively.

    The median patient age was 63 years (IQR, 57-69) in the overall population (n = 227), 63.5 years (range, 57-68) in those without emotional distress (n = 116), and 63 years (IQR, 57-69) in those with emotional distress. In those with and without emotional distress, respectively, most patients had an ECOG performance status of 1 (83.8% vs 78.4%), current or former smoking history (83.8% vs 90.5%), stage IV disease (64.0% vs 52.6%), treatment with ICIs as part of a combination regimen (92.8% vs 96.6%), and no brain or liver metastases (84.7% vs 87.9%).

    “We urge oncologists to assess mental health from the initial evaluation and throughout treatment. Early involvement of multidisciplinary support teams, including palliative care, psychologists, psychiatrists, and social workers, is vital for improving outcomes,” the editorial authors wrote.1 “Further research is needed to determine if treating [emotional distress] can significantly enhance overall outcomes, given the potential for prolonged resolution times.”

    References

    1. Zhang S, Wang S, Arter ZL. Emotional distress: the hidden barrier to immunotherapy success in advanced non-small cell lung cancer. Transl Lung Cancer Res. 2025;14(5):1877–1881. doi:10.21037/tlcr-2025-31
    2. Zeng Y, Hu CH, Li YZ, et al. Association between pretreatment emotional distress and immune checkpoint inhibitor response in non-small-cell lung cancer. Nat Med. 2024;30(6):1680-1688. doi:10.1038/s41591-024-02929-4

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