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  • Shower gel ad gets UK ban for suggesting black skin is problematic | Advertising

    Shower gel ad gets UK ban for suggesting black skin is problematic | Advertising

    A television advert for Sanex shower gel has been banned in the UK for appearing to suggest that black skin is “problematic” and white skin is “superior”.

    The Advertising Standards Authority (ASA) acted after investigating two complaints that the Sanex fed negative stereotypes about people with darker skin tones.

    The ad, broadcast in June, included a voiceover that said: “To those who might scratch day and night. To those whose skin will feel dried out even by water,” alongside scenes of a black woman with red scratch marks and another covered with a cracked clay-like material.

    The ad then showed a white woman taking a shower with the product, and stated: “Try to take a shower with the new Sanex skin therapy and its patented amino acid complex. For 24-hour hydration feel.” It ended with text and the voiceover stating: “Relief could be as simple as a shower.”

    The UK arm of Colgate-Palmolive, the $68bn (£54.4bn) US consumer goods group that owns the Sanex brand, argued that its ad did not perpetuate negative racial stereotypes and was unlikely to cause serious or widespread offence.

    It said the ad illustrated a “before and after” effect, and that the models demonstrated the product was suitable and effective for everyone. It told the regulator that when the model with darker skin was depicted, her skin tone was not a focal point.

    Another screengrab from the Sanex advert. Photograph: ASA/PA

    Clearcast, a body that approves or rejects ads for broadcast on television, also argued that the Sanex ad did not perpetuate negative racial stereotypes but demonstrated the product’s inclusivity.

    However, the ASA said the use of different skin colours as a means of portraying a “before and after” created a negative comparison.

    The watchdog said the ad was “structured in such a way that it was the black skin … which was shown to be problematic and uncomfortable, whereas the white skin, depicted as smoother and clean after using the product, was shown successfully changed and resolved”.

    The ASA added that although it understood that message was not intended and may pass unnoticed by some viewers, it considered “the ad was likely to reinforce the negative and offensive racial stereotype that black skin was problematic and that white skin was superior.

    “We concluded that the ad included a racial stereotype and was therefore likely to cause serious offence,” it said.

    The regulator told Colgate-Palmolive that it must not show the ads again in their current form “to ensure they avoided causing serious offence on the grounds of race”. Colgate-Palmolive was approached for comment.

    Earlier this week the ASA issued a plea to advertisers to stop using “irresponsible” images of unhealthily thin-looking models. In 2024 it received 61 complaints about the size of models in adverts, and it has reported that 45% of the public are concerned about ads that include idealised body images of women.

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  • Family in fear after Tommy Robinson shares video of black man with white granddaughters | The far right

    Family in fear after Tommy Robinson shares video of black man with white granddaughters | The far right

    A family say their lives have been ruined after a video of a black man and his brother playing in the park with his white granddaughters was shared by Tommy Robinson and weaponised by the far right.

    Olajuwon Ayeni, a musician from Redcar, North Yorkshire, has been racially abused and falsely labelled a paedophile in the week since the family video was stolen from the TikTok account of his wife, Natalie, who he married five years ago, and shared by extremists online.

    On Tuesday, the couple’s local MP, Anna Turley, was forced to write a letter providing a reference of good character for Ayeni when he was suspended by his management after the online disinformation.

    “I’m devastated to receive the email from my management,” Ayeni said. “Music is my life. My social media will be damaged, my career will be tarnished … but I am determined to show the truth and hopefully clear it up.”

    He and Natalie say they have been living in fear since being threatened in the street after Robinson shared the video with his 1.4 million followers. The far-right activist wrote on his X account: “Wtf is even going on here? Where are the parents?!”

    Olajuwon and Natalie Ayeni in Redcar. Photograph: Christopher Thomond/The Guardian

    Robinson, whose real name is Stephen Yaxley-Lennon, has not removed the video despite numerous replies debunking it and calling for him to delete it.

    Ayeni and his wife have been scared to leave their house because of threats. “We haven’t gone outside at home, we just can’t,” Natalie said. “Just after it started to go viral, someone in the local pub recognised Olajuwon immediately; we couldn’t believe how quick it had spread. We were walking home from shops just streets from our house, and two lads passed us, spun round and said ‘I hope you’re not them off that video or we’re coming back to slash you up’. It’s just horrendous.

    “Someone was shouting ‘paedophile’ outside the house the other night, so I rang the police again but they say there’s little they can do. It feels a matter of time before something bad happens. We tried to go out yesterday and had to come home.”

    The impact on Ayeni has been particularly severe. “I feel I have to sleep with one eye open,” he said. “I feel unsafe, scared and sad, as mine and my brother’s lives have been threatened. Someone said they will seek revenge and I’ll never walk again, all for just being in the park with the kids I love on a family day out. It’s been twisted by haters and wicked people.”

    Natalie said: “The distress this is causing is unreal, it’s ruined our lives and there we were, getting on with things, looking after the girls minding our own business and now we are scared to do anything. It’s made me quite poorly to be honest and the shares, views and vile comments just keep going. I’ve had to stop looking.

    “We just want people to know the truth,” Natalie added. “We’re a normal family who went to the park with our grandchildren. The lies and racism have turned our lives upside down and continue to do so daily.”

    Despite reporting threats to police, the family said they had received only limited support. Officers have told them that while personal threats are criminal, sharing the video does not constitute a crime.

    Cleveland police said they were offering the family all available support and advice. The Redcar and Cleveland local policing superintendent, Emily Harrison, added: “Cleveland police would also urge social media users to refrain from further sharing either the video or any incorrect information about the people featured.”

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  • Qatar urges a Gaza ceasefire after a ‘positive response’ from Hamas

    Qatar urges a Gaza ceasefire after a ‘positive response’ from Hamas

    JERUSALEM — A key mediator on Tuesday stressed the urgency of brokering a ceasefire in the Gaza Strip after Hamas showed a “positive response” to a proposal from Arab countries, but Israel has yet to weigh in as its military prepares an offensive in some of the territory’s most populated areas.

    The prospect of an expanded assault on Gaza City and other areas sheltering hundreds of thousands of civilians has sparked international outrage. Palestinians say there is nowhere to flee after 22 months of war that has already killed tens of thousands and destroyed much of the territory.

    “They are talking about a 60-day truce, and after Israel gets its (hostages) they will strike us again,” said Huda Rishe, who has been displaced four times since the start of the war. “We will return to Gaza City and then leave again. We have lost hope.”

    AP reporters saw some families arriving in central Gaza after fleeing Gaza City.

    Many Israelis, who rallied in the hundreds of thousands on Sunday, fear the offensive will further endanger the remaining hostages in Gaza. Just 20 of the 50 remaining are thought to be alive.

    “If this (ceasefire) proposal fails, the crisis will exacerbate,” Majed al-Ansari, a spokesperson for Qatar’s Foreign Ministry, told journalists, adding they have yet to hear from Israel on it.

    Al-Ansari said Hamas had agreed to terms under discussion. He declined to provide details but said the proposal was “almost identical” to one previously advanced by U.S. envoy Steve Witkoff.

    That U.S. proposal was for a 60-day ceasefire, during which some of the remaining hostages would be released and the sides would negotiate a lasting ceasefire and the return of the rest.

    “If we get to a deal, it shouldn’t be expected that it would be instantaneously implemented,” al-Ansari said. “We’re not there yet.”

    That cautious assessment came a day after the foreign minister of Egypt, the other Arab country mediating the talks, said they were were pushing for a phased deal and noted that Qatar’s prime minister had joined the negotiations with Hamas.

    Witkoff has been invited to rejoin the talks, Egyptian Foreign Minister Badr Abdelatty told The Associated Press. Witkoff pulled out of negotiations less than a month ago, accusing Hamas of not acting in good faith. It was not clear how Witkoff has responded to the invitation.

    Abdelatty held a series of phone calls Tuesday with foreign ministers from the United Kingdom, Turkey and the European Union, seeking to put pressure on Israel to accept the ceasefire proposal.

    “The ball is now in Israel’s court,” Abdelattay said in a statement.

    An Israeli official, speaking on condition of anonymity to discuss the sensitive talks, said the government’s position has not changed. Prime Minister Benjamin Netanyahu has said he will pause the fighting to facilitate the release of hostages, but that the war will continue until all the hostages are returned and Hamas is defeated and disarmed.

    Hospitals in Gaza said they had received the bodies of 34 Palestinians killed Tuesday, including women and children, as Israeli strikes continued across the territory. Nasser Hospital said an airstrike killed a mother, father and three children in their tent overnight in Muwasi, a camp for hundreds of thousands of civilians.

    “An entire family was gone in an instant. What was their fault?” the children’s grandfather, Majed al-Mashwakhi, said, sobbing.

    Israel’s military did not immediately respond to requests for comment on the strikes.

    Nasser Hospital said nine people were killed while seeking aid in areas where U.N. convoys have been overwhelmed by looters and desperate crowds, and where people have been shot and killed while heading to sites run by the Gaza Humanitarian Foundation, or GHF, an Israeli-backed American contractor.

    Another two people were killed near a GHF site in central Gaza, according to Al-Awda Hospital. GHF said there were no violent incidents at any of its sites on Tuesday.

    Witnesses, health officials and the U.N. human rights office say Israeli forces have killed hundreds of people seeking aid from GHF sites and U.N. convoys since Israel eased a 2 1/2 month blockade on Gaza in May. The military says it has only fired warning shots at people who approached its forces.

    The overall Palestinian death toll in the war surpassed 62,000 on Monday, according to Gaza’s Health Ministry, which is part of the Hamas-run government and staffed by medical professionals. The ministry does not say how many of the dead were civilians or combatants, but says women and children make up around half of them.

    In addition to that toll, other Palestinians have died from malnutrition and starvation, including three reported in the past 24 hours, the ministry said Tuesday. It says 154 adults have died of malnutrition-related causes since late June, when it began counting such deaths, and 112 children have died of malnutrition-related causes since the war began.

    Hamas-led militants started the war when they attacked Israel on Oct. 7, 2023, killing some 1,200 people, mostly civilians, and abducting 251. Most of the hostages have been released in ceasefires or other deals. Hamas says it will only free the rest in exchange for a lasting ceasefire and an Israeli withdrawal.

    Aid groups continue to struggle to deliver supplies to Gaza, where most of the population is displaced, large swaths are in ruins and experts say the “worst-case scenario of famine is currently playing out.”

    Israel imposed a full blockade in March, then allowed limited aid to resume two and a half months later. The Israeli military body in charge of humanitarian aid to Gaza, COGAT, said 370 trucks of aid entered Tuesday — still below the 600 per day that the United Nations and partners say is needed.

    COGAT said Tuesday that 180 pallets of aid were airdropped into Gaza with help from countries including Jordan, the United Arab Emirates and France. The U.N. and partners have called airdrops expensive, inefficient and even dangerous for people on the ground.

    ___

    Magdy reported from Cairo and Gambrell from Dubai, United Arab Emirates. Melanie Lidman in Tel Aviv, Israel, and Edith M. Lederer at the United Nations contributed to this report.

    ___

    Follow AP’s war coverage at https://apnews.com/hub/israel-hamas-war

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  • Scientists Locate Universe’s Missing Sulfur

    Scientists Locate Universe’s Missing Sulfur

    For decades, astrochemists have been looking for sulfur atoms in space and finding surprisingly little of the element that is a key ingredient to life. A new study could point to where it has been hiding.

    An international team of researchers including Ryan Fortenberry, an astrochemist at the University of Mississippi, and Ralf Kaiser, professor of chemistry at the University of Hawaii at Mānoa and Samer Gozem, computational chemist at Georgia State University, published their research in the journal Nature Communications.

    “Hydrogen sulfide is everywhere: it’s a product of coal-fired power plants, it has an effect on acid rain, it changes the pH levels of oceans and it comes out of volcanoes,” Fortenberry said. “If we gain a better understanding of what the chemistry of sulfur can do, the technological commercialization that can come from that can only be realized with a foundation of fundamental knowledge.”

    Sulfur is the 10th most abundant element in the universe and is considered a vital chemical element for planets, stars and life. The lack of molecular sulfur in space has been a mystery for years.

    “The observed amount of sulfur in dense molecular clouds is less – compared to predicted gas-phase abundances- by three orders of magnitude,” Kaiser said.

    The answer might lie in interstellar ice.

    In cold regions of space, sulfur can form two distinct, stable configurations: octasulfur crowns, which are a group of eight sulfur atoms configured in ring-like crowns, and polysulfanes, chains of sulfur atoms that are bonded by hydrogen. These molecules can form on icy dust grains, locking sulfur into solid forms.

    “If you use, for instance, the James Webb Space Telescope, you get a specific signature at specific wavelengths for oxygen and carbon and nitrogen and so forth,” Fortenberry said. “But when you do that for sulfur, it’s out of whack, and we don’t know why there isn’t enough molecular sulfur.

    “What this work is showing is that the most common forms of sulfur that we already know about are probably where the sulfur is hiding.”

    Kaiser and Fortenberry’s research showed that these sulfur-rich molecules may be abundant in icy regions of interstellar space, giving astronomers a potential road map to solving the sulfur puzzle.

    “Laboratory simulations of interstellar conditions such as this study discover possible inventories of sulfur-containing molecules that can be formed on interstellar ices,” Kaiser said. “Astronomers can then utilize the results and look for these polysulfane molecules in the interstellar medium via radio telescopes once sublimed into the gas-phase in star forming regions.”

    The reason sulfur has been so difficult to find is that the bonds it forms are always changing, going from crowns to chains and a variety of other formulations.

    “It never maintains the same shape,” Fortenberry said. “It’s kind of like a virus – as it moves, it changes.”

    The researchers’ work identifies possible stable configurations that astronomers can search for in the universe.

    “The thing that I love about astrochemistry is that it forces you to ask hard questions, then forces you to come up with creative solutions,” Fortenberry said. “And those hard questions and creative solutions can have significant, unintended positive consequences.”

    /Public Release. This material from the originating organization/author(s) might be of the point-in-time nature, and edited for clarity, style and length. Mirage.News does not take institutional positions or sides, and all views, positions, and conclusions expressed herein are solely those of the author(s).View in full here.

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  • How Meghan Markle ‘controlled’ situation by ‘outing’ Prince Harry

    How Meghan Markle ‘controlled’ situation by ‘outing’ Prince Harry

    How Meghan Markle ‘controlled’ situation by ‘outing’ Prince Harry

    Meghan Markle is called out for trying to control the Royal staff during her time in the UK.

    The Duchess of Sussex, who on various occasions has been accused of bullying her staff, enjoyed ‘controlling’ situations around her.

    Royal author Tom Bower reveals: “In Meghan Markle’s life, little happened by chance. Beyond the empathetic smile was a woman who disrupted spontaneity and liked to control every aspect of her life. In late September 2016 nothing was more important than her relationship with Harry.”

    How Meghan Markle controlled situation by outing Prince Harry

    He adds in ‘Revenge: Meghan, Harry and the war between the Windsors’: “Most at the party were in no doubt that Meghan was ‘outing’ Harry. For her own good reasons she wanted the relationship to be publicised. In media hype, some would call it the ‘Greatest Story since the Abdication’.”

    This comes as Meghan previously told Ellen DeGeneres about her final incognito Halloween with Prince Harry: “He came to see me in Toronto and our friends and his cousin Eugenie and now her husband Jack, they came as well, and the four of us snuck out in Halloween costumes to just have one fun night on the town before it was out in the world that we were a couple. It was a post-apocalypse theme, so we had all this very bizarre costuming on, and we were able to just have one fun final night out.”


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  • Australia hits back at Netanyahu amid escalating diplomatic row over Gaza | Israel-Palestine conflict News

    Australia hits back at Netanyahu amid escalating diplomatic row over Gaza | Israel-Palestine conflict News

    Australia’s Home Affairs minister says ‘strength is not measured by how many people you can blow up’.

    Australia has hit back at Israel’s Benjamin Netanyahu after he branded the country’s prime minister “weak”, with an Australian minister accusing the Israeli leader of conflating strength with killing people.

    In an interview with Australia’s national broadcaster on Wednesday, Minister for Home Affairs Tony Burke said that strength was not measured “by how many people you can blow up or how many children you can leave hungry”.

    Burke’s comments come after Netanyahu on Tuesday launched a blistering attack on Australian Prime Minister Anthony Albanese on social media, claiming he would be remembered by history as a “weak politician who betrayed Israel and abandoned Australia’s Jews”.

    Speaking on the ABC’s Radio National Breakfast programme, Burke characterised Netanyahu’s broadside as part of Israel’s “lashing out” at countries that have moved to recognise a Palestinian state.

    “Strength is much better measured by exactly what Prime Minister Anthony Albanese has done, which is when there’s a decision that we know Israel won’t like, he goes straight to Benjamin Netanyahu,” Burke said.

    “He has the conversation, he says exactly what we’re intending to do, and has the chance for the objections to be made person to person. And then having heard them, makes public announcement and then does what needs to be done.”

    Relations between Australia and Israel, traditionally close allies, have progressively soured in recent months amid tensions over the war in Gaza, but ties have become especially acrimonious since Canberra’s announcement last week that it would recognise a Palestinian state.

    On Monday, Australia announced that it had cancelled a visa for Simcha Rothman, a lawmaker with Israel’s far-right Mafdal-Religious Zionism party and a member of Netanyahu’s governing coalition, amid concerns that a planned speaking tour in the country aimed to “spread division”.

    Hours after that decision, Israeli Minister of Foreign Affairs Gideon Saar said he had revoked the visas of Australian diplomats to the Palestinian Authority.

    Israel has come under growing international pressure, including from many of its traditional allies, over the level of human suffering being inflicted by its war in Gaza.

    More than 62,000 Palestinians have been killed by Israel since it launched its military offensive following Hamas’s October 7, 2023 attacks on Israeli communities, according to Gaza’s Ministry of Health.

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  • Wekerle H. Nature, nurture, and microbes: the development of multiple sclerosis. Acta Neurol Scand. 2017;136(Suppl 201):22–5.

    PubMed 

    Google Scholar 

  • Mische LJ, Mowry EM. The evidence for dietary interventions and nutritional supplements as treatment options in multiple sclerosis: a review. Curr Treat Options Neurol. 2018;20(4):8.

    PubMed 

    Google Scholar 

  • Mousavi-Shirazi-Fard Z, Mazloom Z, Izadi S, Fararouei M. The effects of modified anti-inflammatory diet on fatigue, quality of life, and inflammatory biomarkers in relapsing-remitting multiple sclerosis patients: a randomized clinical trial. Int J Neurosci. 2021;131(7):657–65.

    CAS 
    PubMed 

    Google Scholar 

  • Yadav V, Marracci G, Kim E, Spain R, Cameron M, Overs S, Riddehough A, Li DK, McDougall J, Lovera J, Murchison C, Bourdette D. Low-fat, plant-based diet in multiple sclerosis: A randomized controlled trial. Mult Scler Relat Disord. 2016;9:80–90.

    PubMed 

    Google Scholar 

  • Storoni M, Plant GT. The therapeutic potential of the ketogenic diet in treating progressive multiple sclerosis. Mult Scler Int. 2015;2015:681289.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Piccio L, Stark JL, Cross AH. Chronic calorie restriction attenuates experimental autoimmune encephalomyelitis. J Leukoc Biol. 2008;84(4):940–8.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Kafami L, Raza M, Razavi A, Mirshafiey A, Movahedian M, Khorramizadeh MR. Intermittent feeding attenuates clinical course of experimental autoimmune encephalomyelitis in C57BL/6 mice. Avicenna J Med Biotechnol. 2010;2(1):47–52.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Razeghi Jahromi S, Ghaemi A, Alizadeh A, Sabetghadam F, Moradi Tabriz H, Togha M. Effects of intermittent fasting on experimental autoimune encephalomyelitis in C57BL/6 mice. Iran J Allergy Asthma Immunol. 2016;15(3):212–9.

    PubMed 

    Google Scholar 

  • Fitzgerald KC, Vizthum D, Henry-Barron B, Schweitzer A, Cassard SD, Kossoff E, Hartman AL, Kapogiannis D, Sullivan P, Baer DJ, Mattson MP, Appel LJ, Mowry EM. Effect of intermittent vs. daily calorie restriction on changes in weight and patient-reported outcomes in people with multiple sclerosis. Mult Scler Relat Disord. 2018;23:33–9.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Winesett SP, Bessone SK, Kossoff EH. The ketogenic diet in pharmacoresistant childhood epilepsy. Expert Rev Neurother. 2015;15(6):621–8.

    CAS 
    PubMed 

    Google Scholar 

  • Kossoff EH. More fat and fewer seizures: dietary therapies for epilepsy. Lancet Neurol. 2004;3(7):415–20.

    PubMed 

    Google Scholar 

  • Reger MA, Henderson ST, Hale C, Cholerton B, Baker LD, Watson GS, Hyde K, Chapman D, Craft S. Effects of beta-hydroxybutyrate on cognition in memory-impaired adults. Neurobiol Aging. 2004;25(3):311–4.

    CAS 
    PubMed 

    Google Scholar 

  • Vanitallie TB, Nonas C, Di Rocco A, Boyar K, Hyams K, Heymsfield SB. Treatment of Parkinson disease with diet-induced hyperketonemia: a feasibility study. Neurology. 2005;64(4):728–30.

    CAS 
    PubMed 

    Google Scholar 

  • Kim DY, Hao J, Liu R, Turner G, Shi FD, Rho JM. Inflammation-mediated memory dysfunction and effects of a ketogenic diet in a murine model of multiple sclerosis. PLoS ONE. 2012;7(5):e35476.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Choi IY, Piccio L, Childress P, Bollman B, Ghosh A, Brandhorst S, Suarez J, Michalsen A, Cross AH, Morgan TE, Wei M, Paul F, Bock M, Longo VD. A diet mimicking fasting promotes regeneration and reduces autoimmunity and multiple sclerosis symptoms. Cell Rep. 2016;15(10):2136–46.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Brenton JN, Banwell B, Bergqvist AGC, Lehner-Gulotta D, Gampper L, Leytham E, Coleman R, Goldman MD. Pilot study of a ketogenic diet in relapsing-remitting MS. Neurol Neuroimmunol Neuroinflamm. 2019;6(4):e565.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Brenton JN, Lehner-Gulotta D, Woolbright E, Banwell B, Bergqvist AGC, Chen S, Coleman R, Conaway M, Goldman MD. Phase II study of ketogenic diets in relapsing multiple sclerosis: safety, tolerability and potential clinical benefits. J Neurol Neurosurg Psychiatry. 2022;93(6):637–44.

    PubMed 

    Google Scholar 

  • Bahr LS, Bock M, Liebscher D, Bellmann-Strobl J, Franz L, Pruss A, Schumann D, Piper SK, Kessler CS, Steckhan N, Michalsen A, Paul F, Mahler A. Ketogenic diet and fasting diet as nutritional approaches in multiple sclerosis (NAMS): protocol of a randomized controlled study. Trials. 2020;21(1):3.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Bahr LS. Effects of fasting and a ketogenic diet on neuropsychiatric outcomes in multiple sclerosis patients – a randomized controlled trial. Charié – Universitätsmedizin Berlin 2022.

  • Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, Comi G, Correale J, Fazekas F, Filippi M, Freedman MS, Fujihara K, Galetta SL, Hartung HP, Kappos L, Lublin FD, Marrie RA, Miller AE, Miller DH, Montalban X, Mowry EM, Sorensen PS, Tintore M, Traboulsee AL, Trojano M, Uitdehaag BMJ, Vukusic S, Waubant E, Weinshenker BG, Reingold SC, Cohen JA. Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. Lancet Neurol. 2018;17(2):162–73.

    PubMed 

    Google Scholar 

  • Wilhelmi de Toledo F, Buchinger A, Burggrabe H, Holz G, Kuhn C, Lischka E, Lischka N, Lutzner H, May W, Ritzmann-Widderich M, Stange R, Wessel A, Boschmann M, Peper E, Michalsen A. Medical association for F, nutrition. Fasting therapy – an expert panel update of the 2002 consensus guidelines. Forsch Komplementmed. 2013;20(6):434–43.

    PubMed 

    Google Scholar 

  • Hamilton GF, McDonald C, Chenier TC. Measurement of grip strength: validity and reliability of the sphygmomanometer and Jamar grip dynamometer. J Orthop Sports Phys Ther. 1992;16(5):215–9.

    CAS 
    PubMed 

    Google Scholar 

  • Goldman MD, Marrie RA, Cohen JA. Evaluation of the six-minute walk in multiple sclerosis subjects and healthy controls. Mult Scler. 2008;14(3):383–90.

    PubMed 

    Google Scholar 

  • Fischer JS, Rudick RA, Cutter GR, Reingold SC. The multiple sclerosis functional composite measure (MSFC): an integrated approach to MS clinical outcome assessment. National MS society clinical outcomes assessment task force. Mult Scler. 1999;5(4):244–50.

    CAS 
    PubMed 

    Google Scholar 

  • Smith A. Symbol digit modalities test (Revised). Western Psychological Services. 1982.

  • Aaron T, Beck RAS, Gregory K. Brown. Beck Depression Inventory – 2nd Edition (BDI-II)1996.

  • Wintjen L, Petermann F. Beck-Depressions-Inventar revision (BDI-II). Z Psychiatr Psych Ps. 2010;58(3):243–5.

    Google Scholar 

  • Krupp LB, LaRocca NG, Muir-Nash J, Steinberg AD. The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. Arch Neurol. 1989;46(10):1121–3.

    CAS 
    PubMed 

    Google Scholar 

  • Vickrey BG, Hays RD, Harooni R, Myers LW, Ellison GW. A health-related quality of life measure for multiple sclerosis. Qual Life Res. 1995;4(3):187–206.

    CAS 
    PubMed 

    Google Scholar 

  • Harris PA, Taylor R, Minor BL, Elliott V, Fernandez M, O’Neal L, McLeod L, Delacqua G, Delacqua F, Kirby J, Duda SN, Consortium RE. The REDCap consortium: Building an international community of software platform partners. J Biomed Inf. 2019;95:103208.

    Google Scholar 

  • Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG. Research electronic data capture (REDCap)–a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inf. 2009;42(2):377–81.

    Google Scholar 

  • R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. 2023 [Available from: https://www.R-project.org/

  • Saul AM, Taylor BV, Blizzard L, Simpson-Yap S, Oddy WH, Shivappa N, Hébert JR, Black LJ, Ponsonby AL, Broadley SA, Lechner-Scott J, van der Mei I, Investigators AA. A pro-inflammatory diet in people with multiple sclerosis is associated with an increased rate of relapse and increased FLAIR lesion volume on MRI in early multiple sclerosis: A prospective cohort study. Mult Scler J. 2023;29(8):1012–23.

    CAS 

    Google Scholar 

  • Rahmani F, Ghezzi L, Tosti V, Liu J, Song SK, Wu AT, Rajamanickam J, Obert KA, Benzinger TLS, Mittendorfer B, Piccio L, Raji CA. Twelve weeks of intermittent caloric restriction diet mitigates neuroinflammation in midlife individuals with multiple sclerosis: A pilot study with implications for prevention of alzheimer’s disease. J Alzheimers Dis. 2023;93(1):263–73.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Gold R, Kappos L, Arnold DL, Bar-Or A, Giovannoni G, Selmaj K, Tornatore C, Sweetser MT, Yang M, Sheikh SI, Dawson KT, Investigators DS. Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis. N Engl J Med. 2012;367(12):1098–107.

    CAS 
    PubMed 

    Google Scholar 

  • Kuhle J, Plavina T, Barro C, Disanto G, Sangurdekar D, Singh CM, de Moor C, Engle B, Kieseier BC, Fisher E, Kappos L, Rudick RA, Goyal J. Neurofilament light levels are associated with long-term outcomes in multiple sclerosis. Mult Scler. 2020;26(13):1691–9.

    CAS 
    PubMed 

    Google Scholar 

  • Harris S, Comi G, Cree BAC, Arnold DL, Steinman L, Sheffield JK, Southworth H, Kappos L, Cohen JA, Investigators OS. Plasma neurofilament light chain concentrations as a biomarker of clinical and radiologic outcomes in relapsing multiple sclerosis: post hoc analysis of phase 3 ozanimod trials. Eur J Neurol. 2021;28(11):3722–30.

    PubMed 

    Google Scholar 

  • Kuhle J, Kropshofer H, Haering DA, Kundu U, Meinert R, Barro C, Dahlke F, Tomic D, Leppert D, Kappos L. Blood neurofilament light chain as a biomarker of MS disease activity and treatment response. Neurology. 2019;92(10):E1007–15.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Oh U, Woolbright E, Lehner-Gulotta D, Coleman R, Conaway M, Goldman MD, Brenton JN. Serum neurofilament light chain in relapsing multiple sclerosis patients on a ketogenic diet. Mult Scler Relat Disord. 2023;73:104670.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Silveira C, Guedes R, Maia D, Curral R, Coelho R. Neuropsychiatric symptoms of multiple sclerosis: state of the Art. Psychiatry Investig. 2019;16(12):877–88.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Lee JE, Titcomb TJ, Bisht B, Rubenstein LM, Louison R, Wahls TL. A modified MCT-Based ketogenic diet increases plasma beta-Hydroxybutyrate but has less effect on fatigue and quality of life in people with multiple sclerosis compared to a modified paleolithic diet: A Waitlist-Controlled, randomized pilot study. J Am Coll Nutr. 2020;40:1–13.

  • Benedict RH, Cohan S, Lynch SG, Riester K, Wang P, Castro-Borrero W, Elkins J, Sabatella G. Improved cognitive outcomes in patients with relapsing-remitting multiple sclerosis treated with daclizumab beta: results from the DECIDE study. Mult Scler. 2018;24(6):795–804.

    CAS 
    PubMed 

    Google Scholar 

  • Button KS, Kounali D, Thomas L, Wiles NJ, Peters TJ, Welton NJ, Ades AE, Lewis G. Minimal clinically important difference on the Beck depression Inventory–II according to the patient’s perspective. Psychol Med. 2015;45(15):3269–79.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Fond G, Macgregor A, Leboyer M, Michalsen A. Fasting in mood disorders: neurobiology and effectiveness. A review of the literature. Psychiatry Res. 2013;209(3):253–8.

    PubMed 

    Google Scholar 

  • Gibson AA, Seimon RV, Lee CM, Ayre J, Franklin J, Markovic TP, Caterson ID, Sainsbury A. Do ketogenic diets really suppress appetite? A systematic review and meta-analysis. Obes Rev. 2015;16(1):64–76.

    CAS 
    PubMed 

    Google Scholar 

  • Michalsen A, Schlegel F, Rodenbeck A, Ludtke R, Huether G, Teschler H, Dobos GJ. Effects of short-term modified fasting on sleep patterns and daytime vigilance in non-obese subjects: results of a pilot study. Ann Nutr Metab. 2003;47(5):194–200.

    CAS 
    PubMed 

    Google Scholar 

  • Górska E, Tylicka M, Hermanowicz A, Matuszczak E, Sankiewicz A, Gorodkiewicz E, Hermanowicz J, Karpinska E, Socha K, Kochanowicz J, Jakoniuk M, Kaminska J, Homsak E, Koper-Lenkiewicz OM. UCHL1, besides leptin and fibronectin, also could be a sensitive marker of the relapsing-remitting type of multiple sclerosis. Sci Rep-Uk. 2023;13(1).

  • Moharami S, Nourazarian A, Nikanfar M, Laghousi D, Shademan B, Joodi Khanghah O, Khaki-Khatibi F. Investigation of serum levels of orexin-A, transforming growth factor beta, and leptin in patients with multiple sclerosis. J Clin Lab Anal. 2022;36(1):e24170.

    CAS 
    PubMed 

    Google Scholar 

  • Matarese G, Carrieri PB, La Cava A, Perna F, Sanna V, De Rosa V, Aufiero D, Fontana S, Zappacosta S. Leptin increase in multiple sclerosis associates with reduced number of CD4(+)CD25 + regulatory T cells. Proc Natl Acad Sci U S A. 2005;102(14):5150–5.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Loonstra FC, Falize KF, de Ruiter LRJ, Schoonheim MM, Strijbis EMM, Killestein J, de Vries HE, Uitdehaag BMJ, Rijnsburger M. Adipokines in multiple sclerosis patients are related to clinical and radiological measures. J Neurol. 2023;270(4):2018–30.

    CAS 
    PubMed 

    Google Scholar 

  • Igwe O, Sone M, Matveychuk D, Baker GB, Dursun SM. A review of effects of calorie restriction and fasting with potential relevance to depression. Prog Neuropsychopharmacol Biol Psychiatry. 2021;111:110206.

    CAS 
    PubMed 

    Google Scholar 

  • Siddiqui K, Browne RW, Benedict RHB, Jakimovski D, Weinstock-Guttman B, Zivadinov R, Ramanathan M. Cholesterol pathway biomarkers are associated with neuropsychological measures in multiple sclerosis. Mult Scler Relat Disord. 2023;69:104374.

    CAS 
    PubMed 

    Google Scholar 

  • Andaloro A, Russo M, Pastura C, Sessa E, Calatozzo P, Maggio MG, Bramanti P. Is there a correlation between dyslipidemia and cognitive impairment in patients with multiple sclerosis? Int J Neurosci. 2020;132.

  • Noori H, Gheini MR, Rezaeimanesh N, Saeedi R, Aliabadi HR, Sahraian MA, Moghadasi AN. The correlation between dyslipidemia and cognitive impairment in multiple sclerosis patients. Mult Scler Relat Dis. 2019;36.

  • Hernandez-Ledesma AL, Rodriguez-Mendez AJ, Gallardo-Vidal LS, Garcia-Gasca T, Alatorre-Cruz JM, Garcia-Solis P, Lopez Reyes J, Solis-Sainz JC. Lipid profile: causal relationship on cognitive performance in multiple sclerosis? Mol Biol Rep. 2020;47(12):9667–76.

    CAS 
    PubMed 

    Google Scholar 

  • Silva AS, Guimaraes J, Sousa C, Mendonca L, Soares-Dos-Reis R, Mendonca T, Abreu P, Sequeira L, Sa MJ. Metabolic syndrome parameters and multiple sclerosis disease outcomes: A Portuguese cross-sectional study. Mult Scler Relat Disord. 2023;69:104370.

    PubMed 

    Google Scholar 

  • Oliveira SR, Simao AN, Kallaur AP, de Almeida ER, Morimoto HK, Lopes J, Dichi I, Kaimen-Maciel DR, Reiche EM. Disability in patients with multiple sclerosis: influence of insulin resistance, adiposity, and oxidative stress. Nutrition. 2014;30(3):268–73.

    CAS 
    PubMed 

    Google Scholar 

  • Penesova A, Vlcek M, Imrich R, Vernerova L, Marko A, Meskova M, Grunnerova L, Turcani P, Jezova D, Kollar B. Hyperinsulinemia in newly diagnosed patients with multiple sclerosis. Metab Brain Dis. 2015;30(4):895–901.

    CAS 
    PubMed 

    Google Scholar 

  • Zhornitsky S, McKay KA, Metz LM, Teunissen CE, Rangachari M. Cholesterol and markers of cholesterol turnover in multiple sclerosis: relationship with disease outcomes. Mult Scler Relat Disord. 2016;5:53–65.

    PubMed 

    Google Scholar 

  • Dossi DE, Chaves H, Heck ES, Rodriguez Murua S, Ventrice F, Bakshi R, Quintana FJ, Correale J, Farez MF. Effects of systolic blood pressure on brain integrity in multiple sclerosis. Front Neurol. 2018;9:487.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Motl RW, Baird JF, Sandroff BM, Baynard T, Fernhall B. Blood pressure and cognition in older adults with multiple sclerosis: preliminary examination. Neurol Sci. 2023;44(2):677–83.

    PubMed 

    Google Scholar 

  • Marrie RA, Patel R, Figley CR, Kornelsen J, Bolton JM, Graff LA, Mazerolle EL, Helmick C, Uddin MN, Figley TD, Marriott JJ, Bernstein CN, Fisk JD. Effects of vascular comorbidity on cognition in multiple sclerosis are partially mediated by changes in brain structure. Front Neurol. 2022;13:910014.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Roman SN, Fitzgerald KC, Beier M, Mowry EM. Safety and feasibility of various fasting -mimicking diets among people with multiple sclerosis. Mult Scler Relat Dis. 2020;42.

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  • What a 30-Year Study Just Found About Your French Fries and Diabetes – SciTechDaily

    1. What a 30-Year Study Just Found About Your French Fries and Diabetes  SciTechDaily
    2. Not All Potatoes Are Equal: French Fries Fuel Diabetes, But Mashed and Baked Potatoes Don’t  ZME Science
    3. Why Putin’s Russia spooks Western Europe  Times of India
    4. Are potatoes good for you? Not french fries.  USA Today
    5. Eating French fries often raises diabetes risk, Harvard study warns  Business Standard

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  • Astronomers discover a hidden engine inside space’s “Eye of Sauron”

    Astronomers discover a hidden engine inside space’s “Eye of Sauron”

    A look into the throat of an active galaxy reveals a ring-shaped magnetic field that may explain extreme gamma radiation and neutrinos.

    Key Points

    • A look into the heart of an active galaxy: Astronomers have captured an image of the origin of a cosmic jet. The image and its artificial coloring remind of the Eye of Sauron.
    • The question of the origin of neutrinos: PKS 1424240 is the brightest neutrino-emitting object of its kind. However, the concentrated mass flow is too slow to explain the emission of neutrinos.
    • Spiral magnetic fields accelerate particles: 15 years of precise observations with the Very Long Baseline Array have enabled a detailed analysis of the jet’s origin. The radio image could solve this problem, as it shows ring-shaped magnetic fields, an environment that acts like a spring and can accelerate particles to high energies. This in turn explains neutrinos and high-energy gamma radiation.

    Located billions of light-years away, the blazar PKS 1424+240 had long baffled astronomers. It stood out as the brightest known neutrino-emitting blazar in the sky — as identified by the IceCube Neutrino Observatory — and was also glowing in very high-energy gamma rays ob-served by ground-based Cherenkov telescopes. Yet, oddly, its radio jet appeared to move sluggishly, contradicting expectations that only the fastest jets can power such intense high-energy emissions.

    Now, thanks to 15 years of ultra-precise radio observations from the Very Long Baseline Ar-ray (VLBA), researchers have stitched together a deep image of this jet at unparalleled resolution.

    “When we reconstructed the image, it looked absolutely stunning,” says Yuri Kovalev, lead author of the study and Principal Investigator of the ERC-funded MuSES project at the Max Planck Institute for Radio Astronomy (MPIfR). “We have never seen anything quite like it — a near-perfect toroidal magnetic field with a jet, pointing straight at us.”

    Because the jet is aligned almost exactly in the direction of Earth, its high-energy emission is dramatically amplified by the effects of special relativity. “This alignment causes a boost in brightness by a factor of 30 or more,” explains Jack Livingston, a co-author at MPIfR. “At the same time, the jet appears to move slowly due to projection effects — a classic optical illusion.”

    This head-on geometry allowed scientists to peer directly into the heart of the blazar’s jet — an extremely rare opportunity. Polarized radio signals helped the team map out the structure of the jet’s magnetic field, revealing its likely helical or toroidal shape. This structure plays a key role in launching and collimating the plasma flow, and may be essential for accelerating particles to extreme energies.

    “Solving this puzzle confirms that active galactic nuclei with supermassive black holes are not only powerful accelerators of electrons, but also of protons — the origin of the observed high-energy neutrinos,” concludes Kovalev.

    The discovery is a triumph for the MOJAVE program, a decades-long effort to monitor relativistic jets in active galaxies using the Very Long Baseline Array (VLBA). Scientists employ the technique of Very Long Baseline Interferometry (VLBI), which connects radio telescopes across the globe to form a virtual telescope the size of the Earth. This provides the highest resolution available in astronomy, allowing them to study the fine details of distant cosmic jets.

    “When we started MOJAVE, the idea of one day directly connecting distant black hole jets to cosmic neutrinos felt like science fiction. Today, our observations are making it real,” says Anton Zensus, Director at MPIfR and co-founder of the program.

    This result strengthens the link between relativistic jets, high-energy neutrinos, and the role of magnetic fields in shaping cosmic accelerators — marking a milestone in multimessenger astronomy.

    Background Information

    A blazar is a type of active galactic nucleus powered by a supermassive black hole that launches a jet of plasma moving at nearly the speed of light. What makes a blazar special is its orientation: one of its jets is pointed within about 10 degrees of Earth. This alignment makes blazars appear bright across the electromagnetic spectrum and allows scientists to study extreme physical processes — including the acceleration of particles to energies far beyond those achieved in human-made accelerators.

    The VLBA (Very Long Baseline Array) is an array of ten antennas, at locations across the continental United States and in Hawaii and St Croix, which operates in the very long baseline interferometry (VLBI) mode. Spacings between the antennas vary up to approximately ten thousand kilometers, providing angular resolution on the sky as fine as 50 micro-arcseconds.

    MOJAVE (Monitoring Of Jets in Active galactic nuclei with VLBA Experiments) is a long-term program to monitor radio brightness and polarization variations in jets associated with active galaxies visible in the northern sky. The observations are made with the Very Long Baseline Array, which enables us to make full polarization images with an angular resolution better than 1 milliarcsecond (the apparent separation of your car’s headlights, as seen by an astronaut on the Moon). We are using these data to better understand the complex evolution and magnetic field structures of jets on light-year scales, close to where they originate in the active nucleus, and how this activity is correlated with a high energy electromagnetic and neutrino emission.

    MuSES, which stands for Multi-messenger Studies of Energetic Sources, is a pioneering initiative in astrophysics. It is dedicated to the study of Active Galactic Nuclei, which are among the most powerful particle accelerators known in the cosmos. These celestial bodies harness the gravitational energy of matter accreted by supermassive black holes and convert it into electromagnetic and kinetic energy, resulting in the production of highly relativistic electrons and protons. The acceleration of protons and its relation to neutrino production is not well understood, posing a formidable challenge to researchers. MuSES aims to address these fundamental questions by exploiting recent advances in multi-messenger astronomy.

    The MuSES project has received funding from the European Union (ERC grant agreement No 101142396). Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or European Research Council Executive Agency (ERCEA). Neither the European Union nor the granting authority can be held responsible for them.

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  • Study clarifies how amylin receptors respond to drugs

    Study clarifies how amylin receptors respond to drugs

    Amylin, a hormone that controls appetite and blood sugar by activating three different receptors in the brain, could be the basis for the next blockbuster obesity drugs. A University of Oklahoma study published today in the journal Science Signaling reveals a new understanding of how amylin receptors react upon being activated, an advancement that will be crucial to the field of drug development.

    “This paper shows the new biochemical and pharmacological methods we developed that will enable the field, for the first time, to understand exactly what drugs in development do at each of the three amylin receptors,” said the paper’s senior author, Augen Pioszak, Ph.D., an associate professor of biochemistry and physiology at the University of Oklahoma College of Medicine. “Amylin receptors are very complicated, and each has very different and unique properties. What we have discovered has eluded researchers for many years, and we believe our findings will advance drug development.”

    Amylin is secreted from the pancreas, along with insulin, after a person eats. Amylin receptors in the brain are in the same family as GLP-1 receptors, which are targeted by pioneering drugs like semaglutide (Ozempic and Wegovy).

    “There has been a lot of interest in the pharmaceutical industry for developing new obesity drugs,” said Sandra Gostynska, a doctoral student in Pioszak’s lab who is the lead author of the paper and made the seminal findings. “What we have done is given the field new tools for understanding how a drug can affect amylin receptors.”

    Their findings are two-fold:

    • The three amylin receptors share a core component but have differing accessory subunits, as if they wear common attire but dress it up with different accessories to make each a distinct fashion. Understanding how to target that distinctiveness may be important for creating a drug that best controls appetite and brings about the most weight loss with the fewest side effects. Gostynska developed a laboratory procedure to arrive at that understanding.
    • Drugs have the potential to pull the subunits together or push them apart. This, too, could be important for drug development because the drugs may act differently depending on whether they push or pull.

    Pharmaceutical companies are already developing drugs based on amylin. Pioszak said his lab’s research provides clarity for what occurs when a drug targets a complicated set of receptors.

    “We believe our findings will further the study of drugs because what pharmaceutical and biotech companies want to know is what their drug does at each amylin receptor,” Pioszak said. “Now we have a method of answering those questions that were previously unanswerable.”

    Source:

    Journal reference:

    DOI: 10.1126/scisignal.adt8127

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