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  • MHRA to investigate links between genetics, GLP-1 drugs and pancreatitis : Clyde & Co

    MHRA to investigate links between genetics, GLP-1 drugs and pancreatitis : Clyde & Co

    The Medicines and Healthcare products Regulatory Agency (MHRA) has launched an investigation into whether an individual’s genes may increase their risk of developing acute pancreatitis when taking GLP-1 drugs for weight loss and Type 2 diabetes.

    The investigation follows reports submitted to the MHRA’s Yellow Card scheme purportedly linking GLP-1 drugs to numerous deaths, and adverse reactions, the bulk of which were comprised of gastrointestinal disorders. The reports break down as follows:

    • Semaglutides (with brand names including Ozempic and Wegovy): 18,046 adverse reactions, 1,765 serious reports and 16 fatal outcomes.
    • Tirzepatides (with brand names including Mounjaro): 20,882 adverse reactions, 3,116 serious reports and 21 fatal outcomes.
    • Liraglutide (with brand names including Saxenda and Victoza): 2,905 adverse reactions, 688 serious reports and 18 fatal outcomes.

    Extracted from Yellow Card website, 27 June 2025 – What is being reported | Making medicines and medical devices safer

    Whilst it should be stressed that these reports are unverified, reflecting suspected or potential links between GLP-1 drugs and adverse outcomes, the reports raise necessary questions in the context of the risk/benefit of GLP-1 drugs and broader risk landscape, which includes:

    • A huge increase in the use of GLP-1 drugs, with estimates suggesting that 1.5M people in the UK may be taking privately funded weight loss injections, with a further 220,000 expected to receive Mounjaro, after it recently became available via the NHS.
    • The suggestion of a causative relationship between GLP-1 drugs and pancreatitis, including:

      • A research paper published in the BMJ linking GLP-1 drugs to an increased risk of gastrointestinal events, including pancreatitis, gastroparesis, and bowel obstruction.
      • The US Food and Drug Administration’s Adverse Events Reporting System (FAERS) receiving 908 reports of Ozempic users developing pancreatitis.

    • The developing litigation in the US, which is centred around a large multi-district litigation against Eli Lilly (the manufacturer of Trulicity and Mounjaro) and Novo Nordisk (the manufacturer of Ozempic, Wegovy, and Rybelsus) in relation to alleged personal injuries. Whilst the alleged injuries include pancreas damage, the litigation is more strongly focused on other injuries, chiefly, gastroparesis, bowel blockage and vision problems. The claims comprise various causes of action, including failure to warn, negligence, misrepresentation and breaches of consumer protection legislation/unfair trade practices.
    • The extent to which, if at all, the MHRA’s investigation might impact clinical trials, including an ongoing NHS trial, which seeks to measure the “real-world” public health impact of weight loss drugs, including their impacts on prospects of employment and number of sick days taken. The trial involves around 3,000 people in the Greater Manchester area, and is set to take place over a 5 year period.

    Pending further clarification of the role (if any) that an individual’s genetics may play in the development of pancreatitis, there would be no obvious need for any or any immediate change in underwriters’ approach to GLP-1 drugs. The Market will, no doubt, be monitoring the position with interest.

    Further detail on the MHRA’s investigation is available here: If you take a GLP-1 medicine and have been hospitalised by acute pancreatitis, the Yellow Card Biobank wants to hear from you  – GOV.UK

    View all our ‘weight loss drugs’ content here

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  • The ITA Academy to Support High-Quality and Harmonised Training for Anti-Doping Workforce

    The ITA Academy to Support High-Quality and Harmonised Training for Anti-Doping Workforce

    Through its training and certification programs, the ITA Academy plays an essential role in protecting athletes and supporting their right to fair competition. By ensuring that doping control officers, blood collection officers, chaperones, educators, and other clean sport professionals are thoroughly trained and up to date with international standards and best practice, the ITA Academy helps build an environment where athletes can trust the processes that govern clean sport. Well-prepared anti-doping personnel are crucial to delivering testing, education and other clean sport activities that are reliable, respectful, and consistent across borders. 

    Over 3,300 professionals from 157 countries and 95 anti-doping and academic organisations have already completed ITA Academy training programs. As such, the ITA’s training programs are already embedded as essential training and development for the workforce of many anti-doping organisations. Through live and virtual formats, the ITA Academy supports National Anti-Doping Organisations (NADOs), Regional Anti-Doping Organisations (RADOs), International Federations (IFs), Major Event Organisers (MEOs) and individual professionals with a growing portfolio of training and certification programs. 

    “The ITA Academy is a service to the global anti-doping community, offering harmonious education and training designed to strengthen clean sport globally, as well as certification to build and uphold trust in the implementation of anti-doping programs,” said Benjamin Cohen, ITA Director General. “By recognising completion of our programs under the ITA Academy, we aim to provide even greater recognition to the achievements of our graduates and practical opportunities for them at the many sporting events under ITA’s supervision. Our training programs now cover training for all core professional roles when it comes to on-the-ground delivery of anti-doping programs, providing a trusted framework of training that can be adopted by all anti-doping organisations.” 

    The ITA Academy currently offers a range of training opportunities to individuals and organisations, including: 

    • The International Doping Control Officer (IDCO) Training Program 
    • The International Blood Collection Officer (IBCO) Training Program 
    • The Doping Control Officer (DCO) Foundation Training Program 
    • The Anti-Doping in Sport Foundation Course (ADSF) 
    • The International Clean Sport Educator Program (ICSE) 
    • The International Chaperone Training Program (ICT) 

    The ITA Academy also serves to facilitate and coordinate research projects undertaken in collaboration with the ITA in areas related to the implementation of anti-doping programs. As part of the launch, the ITA is pleased to confirm the renewal of its partnership with Berlinger Special, a leading manufacturer of doping control equipment. Berlinger becomes the Official Partner of the ITA Academy, supporting its broader mission to strengthen anti-doping training and professional development. 

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  • PM Paetongtarn Shinawatra suspended over leaked phone call

    PM Paetongtarn Shinawatra suspended over leaked phone call

    Thailand’s Constitutional Court has suspended Prime Minister Paetongtarn Shinawatra, who has come under mounting pressure to resign over her leaked phone conversation with former Cambodian leader Hun Sen.

    The clip, in which Paetongtarn called him “uncle” and criticised a Thai military commander, sparked public anger and a petition for her dismissal, which the court is now considering.

    That could make Paetongtarn the third politician in the powerful Shinawatra clan – which has dominated Thai politics for the past two decades – to lose power before completing their term.

    Her ruling coalition is already teetering with a slim majority after a key conservative ally abandoned it two weeks ago.

    The Constitutional Court voted 7-2 to suspend her while they consider the case for her dismissal and she has 15 days to present her defence.

    In the meantime the deputy PM will serve as the country’s acting leader. Paetongtarn, however, will remain in the cabinet as culture minister, a new appointment following a cabinet reshuffle that was endorsed hours before she was suspended.

    On Tuesday, Paetongtarn apologised again, adding that the purpose of her phone call with Hun Sen was “more than 100%… for the country”.

    The call was about the border dispute between the two countries – although it’s decades old, tensions have risen again since late May when a Cambodian soldier was killed.

    The leaked audio especially angered conservative lawmakers who accused her of appeasing Hun Sen and undermining Thailand’s military.

    But she defended herself on Tuesday, saying, “I had no intent to do it for my own interest. I only thought about how to avoid chaos, avoid fighting and to avoid loss of lives.

    “If you listened to it carefully, you’d understand that I didn’t have ill intentions. This is what I’ll focus and spend time on explaining thoroughly.”

    If she is eventually dismissed, Paetongtarn will be the second prime minister from the Pheu Thai party to be removed from premiership since August last year.

    At that time, her predecessor Srettha Thavisin was dismissed, also by the constitutional court, for appointing to his cabinet a former lawyer who was once jailed.

    Days later, Paetongtarn – whose father is Thailand’s deposed leader Thaksin Shinawatra – was sworn in as prime minister.

    Tuesday’s decision once again underscores the constitutional court’s power to unmake governments, which critics say can be weaponised to target political opponents.

    This court has dissolved 34 parties since 2006, including the reformist Move Forward, which won the most seats and votes in the 2023 election but was blocked from forming the government.

    “This has become a pattern in Thai politics… a part of the Thai political culture, which is not what a true political process is supposed to be,” said Titipol Phakdeewanich, a political science lecturer at Ubon Ratchathani University.

    “The suspension by court order shouldn’t have happened but most people could see its legitimacy because the leaked conversation really made people question if the PM was genuinely defending the interest of the country.”

    Paetongtarn, 38, remains the country’s youngest leader and only the second woman to be PM after her aunt, Yingluck Shinawatra.

    Already struggling to revive a weak economy, Paetongtarn saw her approval rating fall to 9.2% last weekend, down from 30.9% in March.

    The court’s decision comes on the same day as Paetongtarn’s father, who was seen as the driving force behind her government, battles his own political troubles.

    Thaksin is fighting charges of insulting the monarchy over an interview he gave to a South Korean newspaper nine years ago. His trial started on Tuesday.

    The controversial political leader, who returned to Thailand in 2023 after 15 years in exile, is the most high-profile figure to face charges under the country’s notorious lese majeste law.

    Thaksin’s return was part of a grand compromise between Pheu Thai and its former conservative foes.

    They include the military, which deposed two Shinawatra governments in coups, and groups close to the monarchy.

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  • Atos successfully supported UEFA Under21 Championship 2025™

    Atos successfully supported UEFA Under21 Championship 2025™

    Next-Gen technologies for Next-Gen players

     

    Paris, France – July 1st, 2025

    Atos, the Official Information Technology Partner of UEFA National Team Football, has delivered key IT services and applications support for the UEFA Under21 Championship 2025, that took place from June 11 to June 28, 2025, in Slovakia. This championship, which brings together 16 European teams, is the tournament where countless football legends started their journey on the global stage.

    Atos supported a total of 31 matches in 17 days, taking place across 8 cities Slovakia. The services provided included:

    • Event Management systems including accreditation, access control solutions, competitions solutions, radio communication and service desk services.
    • Diffusion system like the football service platform, the mobile app, the website including some embedded gaming functionalities such as match predictor and quiz about competitions.
    • End-to-end cybersecurity services, from compliance and threat intelligence to on-the-ground and hybrid-cloud security.

    This year’s championship has proven to be an immense popular success, establishing new records regarding physical attendance with a total of 244,866 spectators, as illustrated by Atos employees that enthusiastically attended the games. The final broke the record for stadium attendance at over 18,000 fans watching in Bratislava. TV audiences set a new standard for the competition, with a cumulated audience of over 100 million.  Ahead of the final, across all competing markets domestic match audiences have seen a 7% increase, and across the Top 6 markets domestic audiences have increased by 55%, thanks to strong audiences in Germany and UK. Digital audience, page views and applications visits, are also expected to establish new heights for the tournament.

    In addition to the key services provided, Atos is proudly supporting the next generation of players and rising stars of European Football with advanced technologies that can be used by coaches to further develop their players and teams’ skills and abilities. The data collected during the tournament are, for example, consolidated through AI to extract and define main strategies and new trends that appeared during the competition, allowing for a deeper understanding of the players and game’s evolution.

     

    We feel privileged to have witnessed first-hand the emergence of the next football stars at the UEFA Under21 Championship in Slovakia. We made sure to deliver best-in-class IT services during the tournament to allow these young players to enter the global stage and express their incredible potential in the best possible conditions” said Nacho Moros, Head of Atos Major Events.

     

    In addition to marking a coming-of-age moment for some of the most exceptional playing careers, the Under21 championship is also the gateway to the Olympic Games men’s tournament.

    Since the beginning of their collaboration in 2022, Atos and UEFA have established a strong partnership. Atos has been supporting UEFA daily in managing, enhancing, and optimizing its complex technology ecosystem while helping it navigate emerging technological challenges. Atos has also been instrumental in making the UEFA EURO 2024™ a tremendous success, as well as most recently in successfully delivering IT services for the UEFA Nations League Finals™ 2025 in Germany.

     

    Atos has been serving its partners and customers through a dedicated in-house sports and major events division (“Major Events”) for over 3 decades, giving it an unmatched experience and the experience and flexibility to serve its customers regardless of their exposure, size and scale. From global events to local competitions, Atos consistently strives to deliver technology excellence to its entire customer base. 

    Atos has been involved with the Olympic Movement since 1992 and the Paralympic Movement since 2002 and is the official Digital partner for Special Olympics International. Most recently, Atos has been instrumental in delivering successful leading-edge IT services for iconic events such as the Olympic and Paralympic Games Paris 2024 or inspiring events such as the Invictus Games Vancouver 2025 or the Special Olympics Torino Winter Games 2025. 

    To learn more about Atos solutions for sporting events and major events, visit  Atos Major events. 

    Download the PDF document

    ***

    About Atos Group

    Atos Group is a global leader in digital transformation with c. 72,000 employees and annual revenue of c. € 10 billion, operating in 68 countries under two brands — Atos for services and Eviden for products. European number one in cybersecurity, cloud and high-performance computing, Atos Group is committed to a secure and decarbonized future and provides tailored AI-powered, end-to-end solutions for all industries. Atos is a SE (Societas Europaea) and listed on Euronext Paris.

    The purpose of Atos is to help design the future of the information space. Its expertise and services support the development of knowledge, education and research in a multicultural approach and contribute to the development of scientific and technological excellence. Across the world, the Group enables its customers and employees, and members of societies at large to live, work and develop sustainably, in a safe and secure information space.

     

    Press contact

    Laurent Massicot – laurent.massicot@atos.net – 33 (0)7 69 48 01 80

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  • Govt unveils plan to expand Gwadar Port’s capacity, introduce ferry service to GCC countries

    Govt unveils plan to expand Gwadar Port’s capacity, introduce ferry service to GCC countries

    The Ministry of Maritime Affairs on Tuesday revealed a strategic initiative to expand Gwadar Port’s operational capacity by introducing additional shipping lines and launching a ferry service connecting Pakistan with Gulf Cooperation Council (GCC) countries.

    The announcement was made during a meeting chaired by Federal Minister for Maritime Affairs, Muhammad Junaid Anwar Chaudhry, in Islamabad. The minister stated that this initiative is part of the government’s broader strategy to enhance regional connectivity and position Gwadar as a key transshipment and logistics hub in the Arabian Sea.

    Chaudhry emphasized that with Gwadar Port now fully operational, the government is focused on accelerating its integration into international maritime networks to increase its commercial activity. “The goal is to facilitate trade with Central Asia and the Middle East, reduce pressure on existing ports, and improve cargo handling efficiency,” he said.

    The plan includes the introduction of new shipping routes aimed at enhancing the movement of goods through Gwadar, thereby bolstering Pakistan’s position in regional trade. Furthermore, the government has proposed a ferry service that will provide direct maritime links to GCC countries, offering an affordable and efficient transport option for both passengers and cargo. This service is expected to benefit expatriate communities and traders while contributing to tourism and local economic growth in Balochistan.

    Chaudhry also highlighted the importance of improving supporting infrastructure and attracting private sector participation, especially in areas like ship services, hospitality, and transportation.

    The maritime ministry is currently in discussions with shipping companies, maritime authorities, and port operators to finalize the technical, legal, and logistical frameworks for these initiatives. The government has reaffirmed its commitment to unlocking the full potential of Gwadar Port as a strategic asset for Pakistan and the region.


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  • Trump’s aid cut risks causing 14 million deaths, report finds

    Trump’s aid cut risks causing 14 million deaths, report finds

    President Donald Trump’s move to cut most of the US funding towards foreign humanitarian aid could cause more than 14 million additional deaths by 2030, according to research published in The Lancet medical journal.

    A third of those at risk of premature deaths were children, researchers projected.

    Low- and middle-income countries were facing a shock “comparable in scale to a global pandemic or a major armed conflict,” said Davide Rasella, who co-authored the report.

    US Secretary of State Marco Rubio said in March that over 80% of all programmes at the US Agency for International Development (USAID) had been cancelled. The Trump administration has taken aim at what it sees as wasteful spending.

    The controversial cutbacks – which were condemned around the world by humanitarian organisations – were overseen by Elon Musk. The billionaire was then leading an initiative to shrink the federal workforce.

    During his second term, Trump has repeatedly said he wants overseas spending to be closely aligned with his “America First” approach.

    The USAID funding cuts “risk abruptly halting – and even reversing – two decades of progress in health among vulnerable populations,” said the statement from Rasella, a researcher at the Barcelona Institute for Global Health.

    In their report, Rasella and his fellow researchers estimated that USAID funding had prevented more than 90 million deaths in developing countries between 2001 and 2021.

    They modelled the potential impact on death rates with an assumption that funding would be cut by 83% – the figure provided by Rubio in March.

    The researchers suggested that the cuts could lead to a “staggering” number of more than 14 million avoidable deaths by 2030.

    That would include the deaths of more than 4.5 million children under the age of five, they added.

    The Lancet report was published as dozens of world leaders meet in the Spanish city of Seville this week for a United Nations-led aid conference, the biggest of its kind in a decade. The US is not expected to attend.

    The US, by far the world’s largest humanitarian aid provider, has operated in more than 60 countries, largely through contractors. According to government data, it spent $68bn (£55bn) on international aid in 2023.

    USAID was seen as integral to the global aid system. After Trump’s cuts were announced, other countries followed suit with their own reductions – including the UK, France and Germany.

    The moves have been widely condemned by humanitarian organisations. Last month, the United Nations said it was dealing with “the deepest funding cuts ever to hit the international humanitarian sector”.

    According to Rubio’s statements in March, there were still approximately 1,000 remaining US programmes that would be administered “more effectively” under the US State Department and in consultation with Congress.

    Still, the situation on the ground has not been improving, according to UN workers.

    Last month, a UN official told the BBC that hundreds of thousands of people were “slowly starving” in Kenyan refugee camps after US funding cuts reduced food rations to their lowest ever levels.

    At a hospital in Kakuma, in northwestern Kenya, the BBC witnessed a baby who could barely move and was showing signs of malnutrition, including having parts of her skin wrinkled and peeling.

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  • Canyon overhauls the Grizl gravel bike and gives it a crazy new handlebar

    Canyon overhauls the Grizl gravel bike and gives it a crazy new handlebar

    Canyon has released a brand new version of its Grizl gravel bike today, and it has received quite an update.

    The Grizl, Canyon’s more relaxed, adventure-focused gravel bike, which sits alongside the racier Grail model, was first launched in 2021. This marks its third iteration.

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  • meet Maeving’s cool new motorbike

    meet Maeving’s cool new motorbike

    Challenger brands have become the norm these days, with the disruptor playgrounds of fintech, artificial intelligence and computing fuelling significant changes in traditional industries. Transport is a perfect example, and while the electric car world is grabbing all the headlines, especially with Elon Musk’s Tesla and his ill-fated bromance with the president of the United States, there is also a more dignified, quiet revolution occurring in the electric motorcycle market.

    This article contains affiliate links that can earn us revenue

    It’s an industry filled with several well-established brands that date back over a century. T en years ago no motorcycle aficionado would have even heard the name Maeving. Today, however, this small British firm founded by a couple of university friends is at the forefront of electric motorcycle sales in the UK and is expanding its reach globally.

    The Maeving philosophy appears relatively straightforward but is undoubtedly challenging to execute, especially when competing against industry titans. The product proposition is clearly electric-only, emissions-free power first. Yet right behind that is a handsome design aesthetic that nods to traditional motorcycle building while embracing the future optimism of the new tech. The Maeving RM1 that came out a few years ago epitomises this approach. Within a year of its launch it was the bestselling electric motorcycle in the UK. Maeving’s latest creation, the RM1S, leverages the company’s early learnings and public goodwill to create a bike that retains all the charm of the RM1 but with some notable upgrades.

    First, power and, inevitably, performance have been increased, given the RM1S a top speed of 70mph, compared to the 45mph of the RM1. Second, the batteries have been placed lower down in the engine casing, which is crucial for a low centre of gravity. This also handily frees up space in the faux fuel tank, which is very useful for storing mobile phones, gloves or that essential pack of Haribos for a longer road trip.

    Removable batteries make charging simple on a charging pad wired to a standard three-pin plug — or, new to the RM1S, the ability to charge in situ while still on the bike, allowing you to take advantage of public charging points en route. The heightened top speed should be as fast as you’d ever need to go, and a full charge will get you 80 miles of range — again, enough for a bike that will mostly appeal to commuters or weekend pleasure seekers. The RM1S also provides an accessible entry point into motorcycle riding, requiring only a Compulsory Basic Training (CBT) certificate. However, it is worth noting that to ride on a motorway in the UK you will need at least an A1 license.

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    Electric power has undergone significant development over the past few years. Apart from the all-important zero emissions, the silent delivery of clean power offers a unique contrast to the time-honoured image of a roaring motorbike. The liberty of a motorbike ride becomes more of a peaceful freedom on an electric version, which has often been seen as an expression of rebellion or a symbol of the free spirit. The Maeving brand ambassador Ashley Walters is a passionate exponent of these virtues. The actor and director talks enthusiastically about being “drawn to the silence” on his Maeving — something you wouldn’t always have associated with motorcycle riding. He describes how this adds a refreshing dimension to the joy of riding and escaping the daily grind. In his Maeving “rider story” he reflects on his motorbike journeys, stating, “I’m riding for peace in the moment.”

    The Maeving RM1S is a handsome, convenient, emissions-free commuting tool, but more than that, and of interest to most potential purchasers, it achieves all this in a stylish and silent manner.

    Discover Maeving’s full range and Ashley Walters’s rider story at maeving.com

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  • Circular economy investment has surged since 2018, but high-impact solutions remain underfunded

    Circular economy investment has surged since 2018, but high-impact solutions remain underfunded

    The Circularity Gap Report Finance is the first empirical global study that quantifies and explains the global financial streams to circular business models, such as resale and repair, which allows for estimating the ‘gap’ in finance for a circular economy. It was authored by the Amsterdam-based impact organisation Circle Economy in collaboration with KPMG International, with support from the International Finance Corporation (IFC).

    The report highlights that circular economy investments can deliver risk-adjusted returns. Circular business models generate additional revenue, unlock new markets, and deliver greater value from fewer resources. In addition, circularity is emerging as a key strategy for the financial sector to manage resource risks from supply chain disruptions and material scarcity—risks that are now more relevant than ever, considering trade wars and geopolitical instability.

    The sector increasingly recognises these benefits: investment in the circular economy has grown from US$ 10 billion in 2018 to US$ 28 billion in 2023, peaking at US$ 42 billion in 2021. While this upward trend signals a strengthening business case for circularity, the failure to surpass the 2021 peak suggests waning momentum. Banks account for the majority of these investments in the form of debt. Nevertheless, circular investments still represent just 2% of all tracked capital (in the scope of this report), suggesting a vast unrealised potential.

    Investments mainly go to conventional applications of circularity, like rental and repair, which have existed for decades. High-impact solutions and innovations in design and production received just 4.7% of all investment, despite their potential to eliminate waste and pollution at the source.

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  • Europe swelters under a punishing heat wave with Paris forecast to hit 104 F

    Europe swelters under a punishing heat wave with Paris forecast to hit 104 F

    PARIS — France and the rest of Europe were still in the grips of the first major heat wave this summer with health warnings in effect Tuesday, even as conditions began to improve in some parts of the region.

    Punishing temperatures were forecast to reach 40 degrees Celsius (104 degrees Fahrenheit) in Paris and to stay unusually high in Belgium and the Netherlands. In contrast, temperatures were falling in Portugal, where no red heat warnings were issued.

    In France, the national weather agency Météo-France placed several departments under the highest red alert, with the Paris region particularly hard hit. The heat wave — defined as consecutive days of very high temperature — is expected to intensify Tuesday and more than 1,300 schools were expected to be partially or fully closed, the Education Ministry said.

    Visitors to the Eiffel Tower without tickets were told to postpone their visits, and the summit of the city’s landmark was closed until Thursday.

    Farther south, 17 of Italy’s 27 major cities were experiencing a heat wave, according to the Health Ministry.

    Météo-France also warned of the heightened risk of wildfires due to the drought-stricken soil, compounded by a lack of rain in June and the recent surge in temperature.

    Climate experts warn that future summers are likely to be hotter than any recorded to date. By 2100, France could be up to 4 C (39 F) warmer, with temperatures exceeding 40 C expected every year and extreme heat spikes potentially reaching 50 C (122 F). According to Météo-France, the country may face a tenfold increase in the number of heat wave days by 2100.

    In Portugal, Lisbon was forecast to reach 33 C (91 F), typical for this time of the year, though some inland areas could still see peaks of 43 C (109 F), according to the national weather agency. June temperature records were broken in two locations in Portugal on June 29.

    ___

    Associated Press writers Barry Hatton in Lisbon, Portugal, and David Billier contributed to this report.

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