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  • Railways signs phase-I of dedicated freight corridor

    Railways signs phase-I of dedicated freight corridor

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    ISLAMABAD, Sep 08 (APP):The Ministry of Railways on Monday inked Phase-I of the Dedicated Freight Corridor (DFC), a flagship project set to boost freight capacity, speed up cargo movement to and from Karachi Port, and ease congestion on roads and terminals.

    Addressing the ceremony, Federal Minister for Railways Muhammad Hanif Abbasi said the project will prove to be a milestone for Pakistan Railways. He added that it will not only modernize freight transportation but also strengthen Pakistan Railways’ revenue base through freight charges, track access fees, and revenue-sharing mechanisms.

    The Minister emphasized that the government is fully committed to launching Phase-II of the DFC at the earliest, reflecting the prime minister’s vision of transforming Pakistan Railways into a key driver of trade facilitation and modernization.

    He expressed deep gratitude to DP World and the Government of the UAE for their valuable support, stating that their collaboration marks the beginning of a new era for Pakistan Railways.

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  • Monte dei Paschi secures 62% of Mediobanca, paving way for CEO Nagel’s exit

    Monte dei Paschi secures 62% of Mediobanca, paving way for CEO Nagel’s exit

    MILAN (Reuters) -Monte dei Paschi di Siena has secured 62% of Mediobanca, bourse data showed on Monday, paving the way for a shake-up at the helm of the bid target where long-standing CEO Alberto Nagel is preparing to step down.

    Reuters reported last week Nagel would leave his post at the head of the merchant bank, which he has held since 2008, if Monte dei Paschi (MPS) secured a majority of Mediobanca’s capital.

    The offer will run for a further week from September 16, giving MPS a chance to get closer to the two-thirds majority targeted by its Chief Executive Luigi Lovaglio.

    (Reporting by Valentina Za and Gianluca SemeraroEditing by Keith Weir)

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  • Siemens highlights early lung cancer diagnosis CT technology at WCLC

    Siemens highlights early lung cancer diagnosis CT technology at WCLC

    Siemens Healthineers is highlighting technology that increases early lung cancer diagnoses at the World Conference on Lung Cancer (WCLC) being held in Barcelona, Spain.

    The technology was developed in collaboration with Intuitive Imaging Informatics and combines Ion robotic bronchoscopy with Cios Spin, a mobile C-arm that uses conebeam CT (CBCT) to generate three-dimensional CT-like images, the company said. 

    It is being used at the University Hospital of Zurich in Switzerland and has led to a 291% increase in stage 1A lung cancer diagnoses, as well as a 69% increase in overall diagnoses of the disease and a diagnostic performance rate of 89%, according to Siemens.

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  • UAE investors explore major projects in Islamabad, CDA assures full support

    UAE investors explore major projects in Islamabad, CDA assures full support

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    ISLAMABAD, Sep 08 (APP):A high-level delegation of investors from the United Arab Emirates (UAE) met with Chairman Capital Development Authority (CDA) and Chief Commissioner Islamabad, Muhammad Ali Randhawa, on Monday to explore investment opportunities in the federal capital.

    During the discussions, CDA officials briefed the UAE delegation on potential projects across key sectors, including hotels and hospitality, commercial real estate, and tourism.

    Officials underscored that Islamabad’s growing demand in the hospitality and real estate industries offers “excellent investment opportunities.”

    Feasibility studies for major tourism projects, including a proposed theme park and a cable car system, have already been completed, officials informed the delegation.

    They also assured that “robust financial and operational models” have been developed to secure investor capital in commercial ventures.

    Chairman CDA Muhammad Ali Randhawa emphasized that the authority is committed to facilitating foreign investment.

    “CDA is creating uniform and excellent opportunities for investors,” Randhawa said. “We are taking comprehensive measures to provide maximum incentives and facilitation. Gaining the confidence of investors in Islamabad is our top priority.”

    He further noted that renowned consultancy firms have conducted studies to ensure the financial viability of the proposed projects.

    The UAE investors expressed strong interest in Islamabad’s real estate, hotel, and tourism sectors.

    According to CDA, the primary aim of the meeting was to promote foreign investment and attract international-standard projects to boost the city’s development.

    The meeting, held at CDA Headquarters, was attended by senior CDA officials, including Member Administration and Estate Talat Mahmood, Member Engineering Syed Nafasat Raza, and Member Planning and Design Dr. Khalid Hafiz.

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  • Aggression Is Contagious: Observing Violence Primes the Brain for Aggression

    Aggression Is Contagious: Observing Violence Primes the Brain for Aggression

    Summary: A new study shows that observing violence can make individuals more likely to act aggressively later, but the effect depends on familiarity. Male mice who watched familiar peers attack others became more violent afterward, driven by amygdala neurons that “prime” aggression.

    When these neurons were inhibited, the learned aggression disappeared, while activating them heightened violent responses. These findings highlight how social context and brain circuits combine to shape the spread of violence.

    Key Facts:

    • Familiarity Matters: Only observing aggression by familiar peers—not strangers—led to later violence.
    • Amygdala Link: Aggression-priming neurons in the amygdala activated during familiar attacks.
    • Intervention Potential: Manipulating these neurons suppressed or promoted later aggressive behavior.

    Source: SfN

    People who repeatedly observe aggression have a higher likelihood of engaging in violent behavior later in life.

    In a new Journal of Neuroscience paper, Jacob Nordman and colleagues, from Southern University of Illinois School of Medicine, used mice to explore the environmental factors and neural mechanisms that lead to the aggression that witnesses later acquire. 

    In a behavioral paradigm created by this research group, mice observed known peers or unfamiliar strangers attack intruder mice.

    Only male witnesses later displayed increased aggression themselves, and this happened only after watching familiar peers attack intruders. 

    What neural mechanism might be driving this behavior in the bystander males? As male mice behaved in the paradigm, the researchers recorded activity from neurons in a part of the amygdala that is implicated in aggression priming.

    Elaborating on this, says Nordman, “We previously found that these neurons are involved in an ‘aggression priming’ effect, meaning that being a perpetrator of an attack increases the likelihood of attacking again. For example, imagine getting in an argument with a coworker or family member.

    “Afterwords, your agitation and frustration make you more likely to have another outburst.”

    The researchers theorized that these neurons might be active in male witnesses observing violent peers because the familiarity makes them mirror their friends’ own aggression priming. Indeed, these neurons were active in males as they saw familiar—but not unfamiliar—attacks.

    Notably, artificially inhibiting these neurons suppressed later aggression after witnessing peers, and activating these neurons while males watched violent strangers promoted attacking behavior in observers later.  

    These findings shed light on aggression learned via observation, suggesting that not only proximity, but also familiarity of attackers may be risk factors for behaving violently later, at least in males.

    According to the authors, this neural mechanism could inform the development of neural and behavioral treatment interventions for learned violence.

    About this neuroscience and aggression research news

    Author: SfN Media
    Source: SfN
    Contact: SfN Media – SfN
    Image: The image is credited to Neuroscience News

    Original Research: The findings will appear in Journal of Neuroscience

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  • Hamnet review – Jessie Buckley and Paul Mescal excel in stately Shakespeare drama with overwhelming finale | Toronto film festival 2025

    Hamnet review – Jessie Buckley and Paul Mescal excel in stately Shakespeare drama with overwhelming finale | Toronto film festival 2025

    Maggie O’Farrell’s lauded 2020 novel Hamnet is a dense and lyrical imagining of the lives of William Shakespeare’s family, full of interior thought and lush descriptions of the physical world. It would seem, upon reading, near impossible to adapt into a film. Or, at least, a film worthy of O’Farrell’s so finely woven sensory spell. Film-maker Chloé Zhao has attempted to do so anyway, and the result is a stately, occasionally lugubrious drama whose closing minutes are among the most poignant in recent memory.

    Zhao is a good fit for the material. She, too, is a close observer of nature and of the many aching, yearning people passing through it. But she has previously not made anything as traditionally tailored and refined as this. The humbler dimensions of her films The Rider and Nomadland are missed here; Hamnet too often gives off the effortful hum of prestige awards-bait.

    But Zhao’s hallmark compassion and curiosity remains, qualities necessary to Hamnet, which could easily tilt into the realm of manipulative tearjerkers. Hamnet was, records tell us, Shakespeare’s son, who died at a young age and is thought to have inspired, at the very least, the title of Hamlet, the story of a young prince who meets a tragic end. What O’Farrell and now Zhao imagine is that the writing of Hamlet was an exercise in grieving, a way for Shakespeare to honor his son and bid him adieu.

    It’s a persuasive idea, even if it takes some literary contortions to really buy into it. While Zhao sometimes strains to sell the notion – a scene in which a weeping Shakespeare stands on the banks of the Thames and speaks a snippet of the “to be or not to be” soliloquy is perhaps a bit over-egged – she has mostly convinced us by the end. Or, at least, Hamnet has justified the bold speculation, using a leapt-to conclusion to illuminate a fundamental aspect of living. Ultimately, what does it really matter if it actually happened this way?

    Hamnet invents many other facets of Shakespeare’s history. It dreams up the courtship of young William (Paul Mescal), then a Latin tutor, and slightly older Agnes Hathaway (Jessie Buckley), an oddball loner about whom the villagers whisper in fearful tones. William is drawn to exactly that strangeness, the individuality that will come to inform so much of the family’s domestic routine. Zhao spends a fair amount of time on these early days, maybe too much. Some of it could be better spent on the years in which Hamnet (Jacobi Jupe) occupied the house alongside his twin, Judith (Olivia Lynes), and their older sister, Susanna (Bodhi Rae Breathnach). One longs to truly know Hamnet before he is so wrenchingly lost to the world, to feel the agony of his absence that much more acutely.

    Whatever Zhao doesn’t supply, though, is mostly made up for by the richly felt performances of the film’s two leads. Mescal is able to be far more expressive than he’s been allowed in quieter films such as Aftersun and The History of Sound. It is a pleasure to see the full breadth of his range, from seductive to shattered. It’s Buckley, though, who wholly envelops the film, giving staggering breath and body to Hamnet’s portrait of loss. She is nothing short of a wonder. (She also recorded a new version of the audiobook and does a terrific job at that.) It is on her shoulders that the film’s knockout climax rests. As she rises to the task, it is as if she is no longer acting but instead channeling a whole history of human lamentation.

    That may all sound rather grandiose. But the final five minutes of Hamnet really are that striking. So much much so that one can totally forgive the use of composer Max Richter’s On the Nature of Daylight, already used to embody grief over a child so effectively in the film Arrival. In these final moments, Zhao finally makes clear the whole purpose of the film. It has not been merely to show us a prettily shot sad thing, as the film can too often seem. It has, it turns out, been building toward a grand meditation on art’s great capacity. We watch in awe as something so personal to Agnes and her husband becomes, in a transformative instant, universal. It is the power of creation made manifest, a private sorrow blossoming into one of the most enduring works of art the world has ever known.

    This sublime finale does not completely absolve the film of all of its problems. There is still its lopsided storytelling, still the persistent feeling that this is all strong-arming us into doleful submission, still the ever so slightly cloying quality of Agnes’s woodsy mysticism. But that Zhao manages even a few minutes of such transcendent catharsis may tip Hamnet into greatness anyway. In that closing, as Agnes both reaches for and says goodbye to the son who slipped away, the tears flow naturally, they need no effortful wringing out. It proves a lovely experience, to sob in a movie theater alongside strangers, mourning for Agnes and William’s loss and for our own, amazed and relieved that a faraway, unknowable person has made something to connect us all.

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  • 'He’ll take his time' – Argentina manager Lionel Scaloni says Lionel Messi’s decision on 2026 World Cup still unclear – Goal.com

    'He’ll take his time' – Argentina manager Lionel Scaloni says Lionel Messi’s decision on 2026 World Cup still unclear – Goal.com

    1. ‘He’ll take his time’ – Argentina manager Lionel Scaloni says Lionel Messi’s decision on 2026 World Cup still unclear  Goal.com
    2. Messi signs off in style as Argentina wrap up World Cup qualifiers | Daily Sabah  Daily Sabah
    3. Lionel Messi breaks silence on retirement; hints at playing 2026 FIFA World Cup  Sports Tiger
    4. Argentina national team coach Lionel Scaloni comments on Lionel Messi playing at the World Cup  Mundo Albiceleste
    5. Messi hits emotional brace as Uruguay, Colombia, Paraguay seal World Cup spots  The Express Tribune

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  • Nicotine pouches may offer path to reduced tobacco harm, Rutgers study finds

    As lawmakers and public health experts debate the safety of nicotine pouches, researchers from Rutgers Health found that for now, most adults that use these products also have a history of tobacco use and may be choosing these products as a possible step toward reducing or quitting more dangerous forms of nicotine delivery.

    The findings – believed to be the first national estimates of daily nicotine pouch use in the U.S. – were published in JAMA Network Open.

    Faced with declining cigarette sales, tobacco manufacturers in the U.S. are turning to tobacco-free nicotine pouches, such as Velo and Zyn, which are among the few segments of the industry that’s growing.

    In January 2025, the U.S. Food and Drug Administration authorized the marketing of ZYN, the first nicotine pouch to receive such authorization. Importantly, pouches cannot be marketed as smoking cessation aids – such as patches, gums and lozenges approved for therapeutic use – even if some people appear to be turning to them for that reason.

    Against this backdrop, Cristine D. Delnevo, director of the Rutgers Institute for Nicotine and Tobacco Studies, set out to assess how widely nicotine pouches are being used among U.S. adults, and to establish a baseline for monitoring future changes in user habits.

    By analyzing data from the U.S. Census Bureau’s 2022-2023 Tobacco Use Supplement, which surveyed more than 110,000 adults across the country on their use of nicotine pouches and traditional tobacco products, the researchers painted a picture of nicotine pouch uptake in the U.S. They examined quitting behavior of other tobacco products before and after 2019, when the product became widely available nationally.

    They found that overall, the percentage of adults using the product remains low – just 2.5% non-Hispanic white men were the most likely to have used the product. Use among tobacco-naïve adults – those who had never used tobacco products – was virtually non-existent.

    Most compelling, Delnevo said, the highest prevalence of current and daily nicotine pouch use was among adults with a history of tobacco use who had recently quit, suggesting that nicotine pouches may have played a role in their cessation.

    “Our results suggest that adults may be using nicotine pouches for harm reduction given that use is highest among those that have recently quit another tobacco product or e-cigarettes,” said Delnevo, who is also a distinguished professor at the Rutgers School of Public Health.

    But questions remain. Researchers continue to study the long-term health effects of oral nicotine pouches. While nicotine itself does not cause cancer, nicotine is highly addictive and its use can impact cardiovascular health, such as by increasing blood pressure, among other concerns.

    Evidence also suggests that the popularity of pouches may be increasing among young people, albeit slowly. The Centers for Disease Control and Prevention’s 2024 National Youth Tobacco Survey found that 1.8% of U.S. middle and high school students reported using nicotine pouches, up from 1.1% in 2022.

    That trend has added urgency to warnings from Delnevo and her colleagues, who in a previous JAMA commentary, urged the FDA to ensure the oral nicotine marketplace did not proliferate as uncontrollably as e-cigarettes.

    “We should always keep a watchful eye on youth tobacco-use behaviors, including use of multiple products, substitution with other products or alternative methods of finding and using flavored tobacco and nicotine products,” she said.

    Yet, when used by established tobacco users, pouches may offer a health benefit, she added.

    “People who have never used tobacco products should not suddenly be using nicotine pouches,” she said. “But for people who smoke or use other nicotine products and don’t want to stop using nicotine, switching completely from the more harmful product and moving down the risk continuum with nicotine pouches is a likely good for public health.”

    Mary Hrywna, an associate professor in the Department of Health Behavior, Society and Policy at the Rutgers School of Public Health, and a study co-author, agreed.

    “As nicotine pouches gain increased attention in the U.S., many agree that we need to better understand who is using these products and how,” Hrywna said. “This study offers a snapshot of use patterns that is informative and, at least for now, somewhat reassuring.”


    Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

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  • County Championship: Bowlers dominate between Sussex and Hampshire

    County Championship: Bowlers dominate between Sussex and Hampshire

    Hampshire were bowled out for 226 in just 71.3 overs after being asked to bat first on a challenging Hove pitch on the opening day of their County Championship match against Sussex.

    That left Sussex to face 22 overs and by the close they had reached 42-3 as Hampshire fought their way back into the match.

    Not for the first time the Hampshire innings was held together by their captain and former Sussex wicketkeeper Ben Brown.

    But even Brown needed some good fortune on his way to a 129-ball 71, and he was dropped behind by opposite number John Simpson off the bowling of Sean Hunt when he had scored just 18.

    At the start of the day just 15 points separated the teams between fifth and ninth places. And both Hampshire, in fifth position, and Sussex, just two points behind, started the match in search of reassuring, anti-relegation points.

    Hampshire, who made four changes, bringing in Ali Orr, Toby Albert, Bjorn Fortuin and Keith Barker, reached a diffident 81-3 at lunch against a rejigged Sussex seam attack which welcomed back Ollie Robinson, Jaydev Unadkat and Sean Hunt.

    Sussex, who had lost their two most recent Championship games by an innings, broke through in the sixth over when Fletcha Middleton, driving at a wide delivery from Unadkat, edged behind.

    It was 47-2 in the 14th over when former Sussex opener Orr clipped Hunt to short leg where Oli Carter took a very sharp catch, low down.

    And Robinson picked up his first wicket in his livelier second spell when, bowling over the wicket to the left-handed Nick Gubbins, he straightened one to have the batsman lbw.

    After the break the Hampshire batsmen found the going no easier on a rather sticky surface.

    The pitch – being used for the first time this season for a Championship match – did not encourage strokeplay. Albert pulled left-armer Hunt through midwicket to bring up the hundred in the 35th over but when he attempted a similar stroke against Robinson he gloved the ball to slip.

    Tom Prest also perished as he attempted to be positive, clipping Fynn Hudson-Prentice to Daniel Hughes at midwicket.

    Fortuin played himself in but when he jumped down the wicket to drive Jack Carson through the on-side he was through the stroke too soon and chipped it back to the bowler.

    Hampshire put all their eggs in Brown’s basket, and the batsman gathered his runs with sweeps and nudges, mostly on the leg-side.

    But when he swept Carson for a single to reach his half-century it had taken him 105 deliveries. From 119-5 Brown led his side to partial recovery, but once he was eighth out at 215, sweeping Carson to square-leg, Hampshire’s resistance was broken.

    Conditions were no easier when Sussex batted. Tom Haines edged Kyle Abbott waist-high to second slip and Carter was bowled by a nip-backer from Keith Barker. Shortly before the close, James Coles, driving loosely, dragged a delivery from James Fuller onto his stumps.

    Report supplied by ECB Reporters’ Network, supported by Rothesay

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  • Silver Bear Winner ‘The Blue Trail’ Turns Box Office Hit, Eyes Oscars

    Silver Bear Winner ‘The Blue Trail’ Turns Box Office Hit, Eyes Oscars

    Gabriel Mascaro’s “The Blue Trail” has had quite a stellar run: the winner of the Silver Bear at this year’s Berlin Film Festival, the film continued to rack up awards in its festival journey well into the fall season as it arrives in Toronto this week.

    The film also has much to celebrate domestically, having just become the biggest national arthouse release of the year in Brazil with 57,000 admissions on the first weekend and having just hit a landmark 100,000 this week as it expands nationwide from 71 to 89 cities. 

    Lucky Number handles sales on “The Blue Trail,” which has sold to 66 territories so far. The film arrives in Toronto having just landed Canadian distribution by Films We Like. The president of the distribution label, Ron Mann, told Variety they are “proud to bring this award-winning film to Canadian audiences,” highlighting the film as a “powerful protest against ageism.”

    “The trajectory since Berlin has been incredible,” producer Rachel Daisy Ellis of Desvia told Variety. “It was the most sold film out of the festival, and we have continued to have many sales since, working with distributors committed to screening the film in cinemas.”

    “The Blue Trail” takes place in a near-future Brazil where the government relocates the elderly to senior housing colonies so the younger generations can fully focus on productivity and growth. Tereza (Denise Weinberg), nearing 80, refuses to accept her fate, embarking instead on a journey through the Amazon to realize one last wish before losing her freedom. 

    The producer attributed part of the film’s success to its messaging: “It’s a film that speaks to ageism and resilience. It’s a super important story at a time when our global population is getting older, and we still believe that happiness and adventure are reserved only for the young. Coming-of-age stories are always tied to the young, but in this film, we watch the coming-of-age of a 72-year-old woman. The film brings with it a much-needed hope, and it has been received with such warmth by audiences.”

    “The Blue Trail” had its Brazilian premiere at the prestigious Gramado Film Festival in August, going on to sell out preview screenings, including a special screening for cast and crew in the Northern city of Manaus. Ellis highlighted the importance of having a film establish such a strong alliance between the North and Northeast of Brazil, especially considering the longstanding focus on the Southeast and cities like Rio de Janeiro and São Paulo. Brazil’s Northeastern cinema comes with a great tradition, and its exports such as Mascaro, Kleber Mendonça Filho, and Karim Aïnouz have become prominent staples in prestigious festivals such as Cannes and Berlin. 

    “‘The Blue Trail’ builds a very strategic bridge between two regions, mixing the cinema of the North with that of the Northeast, Pernambuco and Amazonas,” Mascaro told Variety. “The beautiful thing about it is to realize we have made a Brazilian film, set in the Amazon, that also speaks to the universal in its approach of freedom, dreams, and desires, all embodied by an elderly character.” 

    For Ellis, it is “super important” to see a film like “The Blue Trail” do well box-office-wise because “it proves Brazilian arthouse cinema can reach larger audiences and is not only for cinephiles. Longtime fans of Gabriel’s work are going to the cinemas, but also new audiences who are becoming acquainted with his work through the film, which we think is beautiful.” 

    “We are undergoing a beautiful moment for Brazilian cinema, with films like ‘I’m Still Here’ and ‘Baby’ performing so well, and upcoming films like ‘The Secret Agent’ getting audiences interested,” adds the producer. “We were also moved to be able to show ‘The Blue Trail’ to President Lula, a highlight of the film’s trajectory as it reinforced the role of cinema as a vital element of Brazil’s cultural output.”

    “I think it’s a beautiful year for Brazilian cinema,” echoed Mascaro. “We had a history-making moment with ‘I’m Still Here’ earning Brazil its first Oscar, a much-awaited event for our national cinema. Within the same year, we had ‘The Blue Trail’ winning the Silver Bear in Berlin and ‘The Secret Agent’ winning two awards in Cannes. I think it’s beautiful to know it wasn’t an isolated episode. We’re living in a moment where Brazil is reaping the fruits of public policies, realizing the strength of its talent and promoting a decentralization of public resources, allowing other regions in the country to build their very own cinematographic legacy, like Pernambuco.”

    Ellis also pointed out how “The Blue Trail” still has a strong journey ahead, especially as it eyes possible selection as Brazil’s Oscar contender, though Filho’s Cannes-winner “The Secret Agent” is the favorite to land the nomination.

    “We are a strong candidate to represent Brazil at the Oscars, as well as possibly landing Goya and Golden Globes nominations within the next few months,” she says. “Again, it’s a unique moment for Brazil, having two very strong films as possible Oscar contenders. It would be beautiful to see two Brazilian films represented at the Oscars in different categories.”

    Chilean producer Giancarlo Nasi of Quijote Films also highlighted how Mascaro has recently become a member of the Academy of Motion Picture Arts and Sciences, calling him “one of the most influential filmmakers of our generation.” “The Blue Trail’ confirms his standing — a work as urgent as it is moving, as relevant for audiences as it is for professionals and critics, and unquestionably one of the films to watch this Awards season.”

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