- CDT Europe Responds to the European Commission Public Consultation on High-Risk AI Systems – Center for Democracy and Technology
- Europe’s quiet AI advantage: Why specialisation is outpacing scale EU-Startups
- Can the EU’s Act protect jobs without stifling innovation? The Next Web
- AI In The Workplace: European Parliament’s Draft Report Calls For Stronger Worker Protections – But Is It Necessary? Mondaq
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CDT Europe Responds to the European Commission Public Consultation on High-Risk AI Systems – – Center for Democracy and Technology
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Living in rural areas early in life may increase risk of type 1 diabetes
New research to be presented at this year’s Annual Meeting of the European Association for the Study of Diabetes (EASD) in Vienna, Austria (15-19 September) suggests that living in a rural environment in the first five years of life could increase the risk of developing type 1 diabetes compared with living in urban environments. The study is by Samy Sebraoui and Professor Soffia Gudbjornsdottir, University of Gothenburg, Sweden, and colleagues.
Type 1 diabetes (T1D) is a chronic autoimmune disease where the body’s immune system mistakenly attacks and destroys insulin-producing cells in the pancreas, called beta cells. This leads to little to no insulin production, a hormone crucial for regulating blood sugar levels. Without sufficient insulin, glucose (sugar) builds up in the bloodstream, causing hyperglycaemia (high blood sugar). T1D is typically diagnosed in childhood, adolescence, or young adulthood, but can occur at any age. Most people with the condition quickly progress to needing insulin replacement therapy for the rest of their lives.
Sweden has the second highest global incidence of T1D, with geographical variation suggesting environmental risk factors. Previous studies have focused on patient location at diagnosis, and only very few at the time of birth or before clinical diagnoses. This new study explores T1D incidence in Sweden based on where people have lived over time, following patients from birth to diagnosis to identify high- and low-risk clusters over different life periods.
All patients diagnosed with T1D during 2005-2022 (ages 0-30 years) were identified in the Swedish National Diabetes Register. All residential addresses from birth to diagnosis were then identified by Statistics Sweden. Statistical analysis was used to identify significant high- and low-risk clusters (see figure). A technique known as zonal statistics analysis was used to identify the land use / land cover characteristics of all identified clusters for the first five years of life exposure window.
The researchers found that 21,774 patients aged 0 to 30 years were diagnosed with T1D 2005-2022, 58 % were male; and 15,426 (around three quarters) were under 18 years old at diagnosis. The mean age at diagnosis was 13.6 yrs (males 14.1, females 12.9). 24 % of patients had relocated to a different municipality from birth to diagnosis.
Based on the residential location of all patients at the diagnosis of type 1 diabetes, 4 significant high-risk clusters were identified, all located centrally in the country (all in the countryside, away from urban centres), where the relative risk of developing T1D was between 30% and 80% higher compared to what would be expected from national averages (Fig 1a). No high-risk clusters were observed in people in major cities.
On the contrary, significant low-risk clusters were found in the largest cities, where the risk of developing T1D was found to be 20% to 50% lower (within the largest cities such as Stockholm, Gothenburg and Malmö). The authors say: “This finding was unexpected and highlights the need for environmental studies to investigate potential risk factors in rural areas, as well as possible protective factors in urban settings. In Sweden, we have access to highly detailed environmental data covering the entire country, providing a unique opportunity to better understand the development of type 1 diabetes.”
Then a second analysis, based on the main residential location during the first 5 years of life (regardless of age of diagnosis), 11 high-risk clusters were identified, all rural, with an increased risk of developing T1D of between 20% and 2.7 times higher compared with national averages. The northern regions had the highest relative risks. For the same time period, 15 low-risk clusters were observed, all in cities across the country, where risk of developing T1D was 20% to 88% lower than national averages – the very lowest risk being found in middle-sized cities in southern Sweden – (Fig 2b) – the cities with the lowest risk being Växjö (88% lower); Norrköping (64% lower) and Halmstad (61% lower).
The land use / land cover analysis conducted by the authors revealed notable differences between high- and low-risk clusters for the first 5 years of life. High-risk clusters are characterised by land covered by forest or used in agriculture, whereas low-risk clusters are dominated by urban and open land.
The authors say: “There is a clear geographical variation in the incidence of type 1 diabetes in Sweden. The first 5 years of life exhibited the strongest association with high- and low-risk clustering. Our findings facilitate further research into environmental factors potentially influencing development of type 1 diabetes. We hypothesise that the exposure of environmental factors, predominantly in rural areas and primarily during the first five years of life, elevates the risk for developing type 1 diabetes.“
They discuss some possible theories that can be explored in future studies, saying: “Viral infections are more common in early life in urban areas and that could protect a person from future autoimmune diseases including type 1 diabetes. Living in rural areas could be associated with more exposure, for example, to pesticides and allergens. This is only speculation, but we have very good data to be able to investigate this in detail in future studies.”
They conclude: “These findings were previously unknown and unexpected – it was a surprise that that living in larger cities came with a lower future risk of type 1 diabetes. We will study in detail different environmental factors that might be protective or increase risk. We will also look into different lifestyles in urban versus rural areas.“
Source:
European Association for the Study of Diabetes
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It’s not an AI-bubble; it’s a longer-term bull market, says this Wall St firm
By Jules Rimmer
Just 84 stocks, classified as AI-related, account for 35% of the S&P 500 SPX index earnings and make up 50% of its market capitalization. But after the steepling rally of recent months, investors have been trying to judge whether this is truly a structural bull market (one based on more fundamental, longer-term drivers rather than short-term or tactical factors) or simply an AI-bubble.
The call, set out in a U.S. equity strategy note published by Citi on Friday, is that this is no bubble, some valuation metrics are compelling and so to ride the AI-enablers (those companies developing AI technologies) for now.
In the medium term, though, a team led by Scott Chronert predicts there’ll be a handoff in market leadership to the AI-adopters (those companies actually using the technologies in their operations) who will be the beneficiaries of this huge boost in productivity and profitability.
Since the end of 2022, AI-related stocks have significantly outperformed other tech stocks (25% of the S&P 500) and the 25% of the index (some 269 stocks) that isn’t categorized as tech or AI-related. One surprising observation that Citi’s research team makes is that in aggregate, the AI names trade at lower PEG ratios (price-to-earnings growth, a valuation metric often used to assess fast-growing companies) compared to other sectors.
Moreover, the report examines the Sharpe ratio (a risk-adjusted measurement of an investment’s return, wherein the higher the score the better) for AI-related earnings and discovers it is notably higher than other sectors. This reinforces the preference Citi maintains for “growth as defensive” in terms of its approach to portfolio construction.
Chronert and his colleagues, Drew Pettit and Patrick Galvin, also point out that AI-related stocks stand out for metrics such as operating leverage, return-on-equity trends, sales per employee and gross margin improvement.
For Citi, most of this leads to a more structural case for large-cap stocks to outperform – the AI infrastructure build-out has more room to run. Investors have articulated concerns about current equity valuations as the S&P 500 trades on a price-earnings ratio of 24-26 times roughly – relatively stretched in historical terms.
Citi strategists maintain that “the evolution of S&P 500 construction is such that concentration in a relatively small number of stocks with exceptional fundamental trends is impacting our view of historical compares.” They are “steadfast” that longer-term fundamentals ultimately determine U.S. equity market direction.
So, while mindful that the market is at or near all-time highs, Citi insists the AI build-out will remain a key market driver over the next year or two. Thereafter, the transition will be towards those stocks who can actually adopt, implement and benefit from the AI technological innovation.
-Jules Rimmer
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Basketball: FIBA Asia Cup 2025 full schedule, all results, scores & standings
The FIBA Asia Cup 2025 is taking place in Jeddah, Saudi Arabia, from 5-17 August.
The tournament, now in its 31st edition, represents the top men’s continental basketball championship in Asia and Oceania, and features 16 teams, including defending champions Australia.
Action starts with a series of pool games, where the 16 finalists are seeded into four groups of four.
The winner of each group will advance straight to the quarter-finals, while the second- and third-place teams from each group will play off for a quarter-final berth.
From there, the competition follow a knockout format, with losers in each round eliminated until two teams are left to contest the final.
Discover all the results from each game below.
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England vs India: Tourists win one of all-time great Tests at The Oval to draw series
If the fourth day of this Test was astonishing for its fluctuations and high emotion, the fifth day provided drama that was barely believable.
England’s target of 374 represented their second highest successful chase in Tests and the highest ever on this ground. They began Monday on 339-6, 35 adrift.
Jamie Smith and Jamie Overton were being given a torrid time on Sunday before the weather ended play early. England’s task instantly looked easier on Monday when Overton pulled Krishna’s first ball of the day for four and followed by inside-edging the next delivery past his stumps to the fine-leg fence.
The runs required were down to 27, then the pendulum swung once more.
Smith looked all at sea. He played and missed at his first two balls from Siraj and edged his third. There was a wait to see if Jurel had pouched the catch, but there was no doubt.
Atkinson edged the first ball he faced, inches short of KL Rahul at second slip. India’s fans, comfortably outnumbering the England support, surrounded the ground with noise.
Siraj charged in again. Overton played all around his pad. Umpire Kumar Dharmasena took so long to raise his finger, Overton had completed a run. The England man was so sure the review would save him, he began to mark his guard, only for the replay to show umpire’s call for shaving the leg stump. India were delirious.
Atkinson was unsure whether to farm the strike or trust Josh Tongue. The sky got darker and floodlights took hold. Tongue was given leg before to Krishna, but the review showed the ball missing leg stump. England still needed 19.
England had added two more when Tongue was bowled by Krishna. There was confusion as to whether Woakes would bat, then came the sight of the 36-year-old walking down the dressing-room stairs with his left arm covered by his England sweater.
Woakes ultimately never faced a ball, but his bravery will not be forgotten.
Atkinson’s mighty blow off Siraj was parried over the ropes by Akash Deep and left England with 11 to win. India captain Shubman Gill had the decision over bringing in the field to prevent the single, or to protect the boundary. He chose the latter. Woakes was in obvious pain when he shuffled the bye off the final ball of Siraj’s over.
Atkinson dug out Krishna for two to long-on, at the beginning of the next over. India kept the field back. England took another single. They needed seven when Siraj set off once more.
Atkinson cleared his front leg again, attempting another heave to the leg side, but Siraj’s yorker was pinpoint. He ended with 5-104, his effort every bit as heroic as the lion-hearted Woakes.
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Little Tikes Unleashes Unlimited Imagination with the Dr.
LOS ANGELES and HUDSON, Ohio, Aug. 04, 2025 (GLOBE NEWSWIRE) — Get ready for playtime, reimagined! The Little Tikes Company, a subsidiary of MGA Entertainment (MGA) and legacy brand shaping childhoods for nearly six decades, is leveling up its licensing game with the launch of the Little Tikes® Dr. Seuss® Edition Story Dream Machine™ in partnership with Dr. Seuss Enterprises, L.P.
The move signals a major step forward in the brand’s licensing strategy — one that blends timeless kid’s entertainment franchises with the proven magic of Little Tikes’ immersive, multi-sensory play. With the power of Little Tikes licensing, kids can take their favorite characters and worlds along with them on their next big adventure, making every moment more memorable.
Launched on July 20, 2025, the Little Tikes Dr. Seuss Edition Story Dream Machine transforms story time into an immersive world of lights, sounds and colorful projections, uniting two beloved brands that have defined how children play and learn for decades. The Story Dream Machine is a three-in-one device — an early reading aid, engaging toy, and sleep solution. It works as a portable projector for read-along stories, a white noise machine, and a nightlight. With a sprinkle of Seussian magic, kids can follow along as tales unfold before their eyes — sparking imagination and building reading confidence in the most fun way possible.
The new Dr. Seuss lineup includes:
- The Dr. Seuss Edition Starter Pack featuring the Story Dream Machine with three story cartridges and a Cat in the Hat character topper, available now.
- A Grinch Story Collection featuring three spirited story cartridges and a Grinch character topper – available now and perfect for the holidays!
- A cuddly, interactive Cat in the Hat plush that lights up, narrates and reacts with the Story Dream Machine as the stories play for added sensory fun, launching October 5, 2025.
“At Little Tikes, we believe the best kind of play brings generations together,” said Josh Hackbarth, Chief Marketing Officer at MGA Entertainment. “With the Dr. Seuss Edition Story Dream Machine, we’re blending stories with beloved Dr. Seuss characters many of us grew up with and turning them into magical, hands-on moments for today’s kids. It’s more than just play; it’s a way for parents and grandparents to share beloved memories while inspiring imagination and early learning in the next generation.”
Join the Little Tikes universe where every kid can dream, play and create. The Little Tikes Dr. Seuss Edition Story Dream Machine is available now at major retailers worldwide and on Littletikes.com. The starter pack retails for $54.99 USD and the story collections are $16.99 USD. To learn more about Little Tikes, visit LittleTikes.com or follow us on YouTube, Instagram, TikTok and Facebook.
About Little Tikes
The Little Tikes Company, founded in 1969 in Hudson, Ohio, U.S., is a manufacturer and marketer of durable, high-quality, and engaging children’s products, continually manufacturing toys in the U.S.A. for more than 60 years. Since becoming a part of the MGA Entertainment family in November 2006, Little Tikes has been taken to new heights through exciting product innovation, strategic marketing, and licensed partnerships. Little Tikes believes that every day is an opportunity for new adventures, with more and more for a child to experience and discover. Active and imaginative play are essential to learning and early development skills, so they make toys that spark curiosity, wonder and creativity for kids of all ages. To find out more about Little Tikes visit littletikes.com and follow YouTube, Instagram, TikTok and Facebook.About MGA Entertainment
MGA Entertainment is on a mission to inspire imagination and creativity through innovative toys, entertainment, and experiences that transform play into limitless possibilities. As the largest privately held toy and entertainment company in the U.S., MGA is a global leader in designing and delivering world-class consumer products that spark wonder and drive play forward. Headquartered in Los Angeles with offices worldwide, MGA’s portfolio spans a dynamic range of original and licensed brands — from toys, dolls, games, and electronics to fashion, home décor, and entertainment content including hit movies and TV series. The company is recognized for its bold approach to storytelling, trendsetting design, and deep commitment to quality. The award-winning MGA family includes fan-favorite brands such as L.O.L. Surprise!™, Little Tikes®, Rainbow High™, Bratz®, MGA’s Miniverse™, Yummiland™, CarTuned™, Wonder Factory™, BABY born®, and Zapf Creation®. To learn more, visit www.mgae.com and follow MGA on LinkedIn, TikTok, Instagram and Facebook.About Dr. Seuss Enterprises, L.P.
Founded in 1993, Dr. Seuss Enterprises is a global entertainment company. Our mission is to educate and entertain generations around the world by promoting and protecting the literary and artistic works of Dr. Seuss. We provide world-class content that drives joyful learning and creates hopeful futures. All Dr. Seuss Enterprises’ profits benefit charitable organizations that focus on causes such as education, science, health, animal conservation, and the arts. For more information, subscribe to our YouTube channel, visit DrSeussEnterprises.com, or follow us on Instagram.Contact:
Hailey Peterson
FINN Partners on behalf of MGA Entertainment
mga@finnpartners.comPhotos accompanying this announcement are available at https://www.globenewswire.com/NewsRoom/AttachmentNg/a0adf9cb-9292-4253-87ef-ca4641710fa4
https://www.globenewswire.com/NewsRoom/AttachmentNg/fe3086c5-2e35-4346-8e8c-bcddced21ca1
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‘It was an absolute blast!’ – red carpet Unlocked winners reflect on an epic night at the New York and London premieres of F1 The Movie
Lights, camera, action! This Summer, F1 Unlocked was able to offer two groups of fans access to the premieres of F1 The Movie in New York and London. The arrival of this epic narrative, brought to life by star Brad Pitt and director Joseph Kosinski, was celebrated with an event full of glitz, glamour, and on-screen action. With Hollywood stars and current F1 drivers in attendance, it was a night that these fans will never forget.
JACK, NEW YORK
“It was an absolute blast! Super awesome to see the drivers and the cast. The screening was excellent and we loved the film. Rachel, who wasn’t particularly into F1, said she can’t wait to watch the Austrian GP. The only issue is I have to wait a week to discuss the movie with friends! Thanks so much again for the opportunity, will certainly be a memory I cherish for life.”
JASON, NEW YORK
“It was an amazing day and evening. Thank you so much for making this happen.
“This event was incredible. I hope to attend an actual Grand Prix one day and now I really want to go to one.”
KASSIDY, NEW YORK
“We enjoyed the premiere very much, and we were so thankful for the opportunity to be present for such a once-in-a-lifetime event. The movie was great – it exceeded our expectations – and we have already recommended the film to our friends and family.”
Watch the highlights of their experience in the video above.
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Sabrina Carpenter, A$AP Rocky, More Reviews
Lollapalooza 2025 wrapped on Sunday and it was one for the books. Women and international artists absolutely dominated the four-day festival held in Chicago at Grant Park. The representation was a welcome one as evidenced by the tens of thousands of fans who bought tickets; four-day passes sold-out in less than an hour after the lineup was announced in March.
Among the big draws were Sabrina Carpenter, who closed out the festival with surprise guests Earth, Wind & Fire, and A$AP Rocky, who performed from a life-sized helicopter onstage. The Marías, Dominic Fike, and Finneas were among the highlights from the Chicago fest’s final day on Sunday at Grant Park.
Sabrina Carpenter Sunday Finally Arrives
The summer Rolling Stone cover star Sabrina Carpenter last performed at Lolla a couple of years back, where she told us about the naughty freestyle outro of “Nonsense” and opening for Taylor Swift. “Two years ago I was at that stage,” Carpenter gestured toward one of the smaller side stages during her set. “Now we get to play this one,” she said from the headlining main stage at Lollapalooza. She catapulted to the top of the bill on the strength of Short n’ Sweet, making friends and more fans and angering zealots along the way. No matter, the singer can hold her own and held it well as she closed out the 2025 edition of Lollapalooza.Carpenter showed up first onscreen as a Chicago news anchor to welcome the massive crowd to the retro-themed party that matched her music influences, signaling the winking humor that was to come before she arrived onstage to perform “Busy Woman” and “Taste.” The show featured a dance competition and nostalgic television ads, and a bed where she performed the steamy “Bed Chem” — all part of her polished recent tour, but she did have a few new tricks up her clever sleeve. She brought out Earth, Wind & Fire with whom she traded verses for rousing performances of “Let’s Groove” and “September.” During the “Juno” skit where she arrests people with fuzzy pink handcuffs for being too hot, she proposed marriage to members of fellow fest headliners Twice, and later she ascended on a crane in the middle of the audience to perform “Don’t Smile” from above. After set closer “Espresso,” she dropped the trailer for her highly-anticipated Man’s Best Friend to close out the night. As with all great performances, she left the crowd wanting more. —A.L.
A$AP Rocky Makes a Rushed Job Fly By
Yes he was late, but at least A$AP Rocky looked the part in the most unexpected way. Sporting a head full of pink hair curlers and an oversized flannel atop a bulletproof vest, the rapper dangled from a life-sized helicopter like a civilian kidnapped in an action movie. Fans manifesting a Don’t Be Dumb drop after nearly three years of waiting had to hold on a little longer. As consolation, Rocky performed “Highjack” and “Tailor Swift” from the unreleased album, and tacked on a live rarity for good measure: Long.Live.ASAP’s “LVL,” which he hasn’t performed in more than a decade.“I know rap is real competitive right now, but I wanna spread love,” said Rocky. Expressing gratitude was only natural; his ascent from blog-era rapper to high-profile trendsetter and luxury fashion model is now a blueprint, which doesn’t even include wooing Rihanna and raising three children together. Performed in rapid-fire succession before Chicago’s noise ordinance kicked in were “LSD,” “Sundress,” and “Goldie,” a career-spanning set list of highlights that flaunted not just how skilled Rocky is as a rapper, but how varied his music remains in the passing years. Now, he just wanted to take it slow, even as the clock was ticking. “They’re trying to kick us out,” he yelled to his DJ. “Play the next one! Go go go!” —N.C.
The Marías Soundtrack Lucid Dreams at Dusk
The Marías are inside your head and they know what your dreams look like. Under the hypnotic spell of singer María Zardoya, whose breathy delivery is part comforting whisper, part secretive rasp, the jazzy dream-pop band used a dusk timeslot to seamlessly soundtrack different visions: hiding in a room alone, running into an ex, lusting after a lover. From the seductive “Hush” to the explosive burst of drums in “Vicious Sensitive Robot,” or even their cover of the Cardigans’ “Lovefool,” the Marías swirled through a set list of woozy emotions and hazier sounds. Maybe it was a lucid dream. —N.C.Dominic Fike Brings His Baby on Board
Dominic Fike, who pulled out of last year’s fest due to “health reasons,” made up for lost time, but he made sure to soak it in. “I want to slow down,” he said. “I want to sit in it with all you folks. I just want to connect.” And that he did, sharing tales behind songs such as early “demoey” track “One Glass” and his love for Coldplay’s “Yellow” before he covered it. Standouts included “Phone Numbers,” “Hi Grace” from his 14 Minutes EP, and “7 Hours” from Sunburn — songs that touch on connection. To close, he delivered the ultimate mic drop: in a heartwarming moment, he brought out his baby (he offhandedly referenced being a father during his set and on his recent collab with Jennie) and sang to his child on a toy mic. Then, mid-song, he picked the baby up and walked off into the night. —A.L.Finneas Makes His Solo(ish) Lolla Debut
“Back in 2018, I played with my sister Billie [Eilish] for the first time,” Finneas said of Lollapalooza. On Sunday, he made his solo(ish) debut at the fest. His set showcased that his songwriting chops extend beyond the Grammy-winning work he creates with his sister, like during “Little Window” and “Break My Heart Again.” Finneas also brought out surprise guest Ashe, whom he formed a band with called the Favors. Together they performed “The Little Mess You Made” as well as Ashe’s Finneas-featuring “Till Forever Falls Apart.” —A.L.Mariah the Scientist Showcases Chemistry
Mariah the Scientist was smoldering — from the heat and with her R&B songs. She took care of the former by shedding her furry jacket partway through her set, which included throwback tracks such as “Beetlejuice,” and “Is It a Crime,” her freshly released collab with Kali Uchis. “Now you gotta be my other half,” she said before delivering “Always n Forever.” Speaking of partners, she surprised fans by bringing out her beau Young Thug to perform “Walked In,” which displayed their chemistry. “I waited two-and-a-half years to be able to do that,” she said afterward, referencing his serving time after pleading out in the YSL racketeering case. “My man is free now!” —A.L.Everything’s a Hit in Remi Wolf’s Hands
“We need your hips so loose, so limber,” Remi Wolf told the crowd. She demonstrated by doing a dance-off with two guitarists, hopping behind the drum kit, and enacting a Jack Black-style vocal warmup routine. The California indie-pop star has big ideas and bigger hooks, and those earworms made her a quintessential festival artist. Of course, that applied to her biggest hits — set bookenders “Cinderella” and “Photo ID” — but she also did the stagework for other songs like “Sexy Villain” and “Liz” that felt like they should’ve charted, too. —N.C.The View Is ‘Fucking Gnarly’ for Katseye
One word could’ve summarized Katseye’s anticipated set: “Gnarly.” But the internationally procured girl group didn’t go through the competition show ringer — singing auditions, dance rehearsals, charisma buffing — just to be a one-hit wonder. Despite their breakout single becoming a song of the summer contender, Katseye used their performance to reintroduce their range, from mellow pop ballad “Mean Girls” to the clomping dance of “M.I.A.” They really hit their stride venturing beyond the K-pop machine they were modeled after — most notably with the sextet’s live debut of “Gabriela,” a Latin-inspired dub-pop song, complete with an outfit change into red flamenco skirts. —N.C.Rebecca Black Doesn’t Care What You Think
Less than 15 minutes into her set, Rebecca Black was already screaming “Do you even think about me?” like a threat. Maybe it was, and the answer is irrelevant to the broader point. Ridiculed in 2011 for “Friday” and ridiculed a decade later for continuing to pursue music, Black knows firsthand there’s no pleasing haters. Instead, she courted camp and queers and impulsive electro-pop. The latest — and best — product of that combination is Salvation, which she performed as it should be: karaoke-style, with two beefy dancers flanking her side in miniskirts. “One thing I know: we’re all gay,” she said to cheers. —N.C.BoyNextDoor Court an Evening Time Slot With K-pop Rock
Backed by a rock band that drew out the punches of their music, BoyNextDoor came prepared with special live arrangements to impress fans and those previously unfamiliar. Gathered around a blue prop door pinned with plushies, the K-pop six-piece danced their way through “If I Say, I Love You” and “I Feel Good” — even opting to sing English versions. During “123-78,” BoyNextDoor partnered up with each other for ballroom dance moves. “Those are very romantic songs. I kinda wish we were doing this at night right now,” said Jaehyun. With how smitten their screaming fans were, the feeling was mutual. —N.C.Continue Reading
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Regional differences found in newborn antibiotic use for suspected sepsis in Sweden
There are relatively large regional differences in Sweden in the proportion of newborns receiving antibiotics for suspected sepsis, according to a study at the University of Gothenburg. The researchers want to call attention to overuse as well as highlight good examples.
When newborns receive antibiotics, it is almost always for suspected sepsis. Despite Sweden’s low antibiotic use compared to other countries, last year researchers found unjustifiably high usage levels in newborns. The gradual decline in sepsis prevalence over time has not affected antibiotic use.
This new study provides an overview of antibiotic use in six major regions in Sweden. The dataset also includes the corresponding data from individual hospitals with neonatal units where newborns are treated, a total of 37 hospitals, from Gällivare in the north to Ystad in the south.
The study is based on data from more than one million infants born in Sweden between 2012 and 2020. The infants encompassed were born at 34 weeks’ gestation or later. The results are presented in the journal Archives of Disease in Childhood: Fetal & Neonatal Edition.
Considerable differences
The study presents the proportion of newborns receiving antibiotics during the first week of life, an internationally dominant metric. In the western world, where sepsis rates are low, the goal is to treat no more than one percent of infants while maintaining low sepsis prevalence and mortality rates.
In the study, western Sweden ranked highest in antibiotic use, followed by northern Sweden, south-eastern Sweden, southern Sweden, central Sweden, and eastern Sweden. The figures for western Sweden and eastern Sweden were 3.0 percent and 1.3 percent, respectively. Sepsis prevalence in all Swedish regions was below one per thousand live births.
At hospital level, the lowest antibiotic use of newborns during the first week of life was 0.9 percent, and the highest 4.3 percent.
One of the driving forces behind the study is Johan Gyllensvärd, a PhD student in pediatrics at Sahlgrenska Academy at the University of Gothenburg and a practicing pediatrician at Ryhov County Hospital in Jönköping.
“The threshold for antibiotic intervention varies, explained in part by prevalence levels, but it’s also down to local practices. It’s very much a matter of the policies and traditions seen at the different hospitals,” he says.
Greater awareness key
Sepsis is a potentially life-threatening condition caused by the immune system’s reaction to an infection. Treatment must be started immediately. At the same time, antibiotics disrupt the bacterial flora, which is sensitive in newborns. Overuse also increases the risk of becoming a carrier of antibiotic-resistant bacteria.
Antibiotics are essential in the treatment of sepsis in newborns, and if you have a sicker population, then it’s reasonable for antibiotic use to be higher. However, we need to increase awareness of the overuse of antibiotics and improve at distinguishing infected and uninfected infants. This study helps highlight good examples and demonstrates that it’s possible to have a treatment rate of one percent or less of all newborns while maintaining low sepsis and mortality rates.”
Johan Gyllensvärd, PhD student in pediatrics at Sahlgrenska Academy, University of Gothenburg
Source:
Journal reference:
Gyllensvärd, J., et al. (2025). Variations in antibiotic use in late preterm and term newborns from 2012 to 2020: a nationwide population-based observational study. Archives of Disease in Childhood – Fetal and Neonatal Edition. doi.org/10.1136/archdischild-2025-328944.
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Elvis Presley wasn’t fond of ‘Burning Love.’ Then it became a hit.
By all objective measures, Elvis Presley was a hunk, a hunk of burning love. But he clearly wasn’t feeling it when he heard a demo of “Burning Love” at RCA Hollywood Studios in March 1972.
The song, a slightly shocking blend of the spiritual and sexual, seemed like a hit to those in the room, with its reverent, raunchy intro:
Lord Almighty, I feel my temperature rising, mmm.Higher, higher, it’s burning through to my soul.Girl, girl, girl, girl, you’re gonna set me on fire.My brain is flaming, I don’t know which way to go, yeah.
“Elvis didn’t hate the song, he just wasn’t in the mood for it,” Jerry Schilling, Elvis’ longtime friend who attended the session, tells USA TODAY.
In the end, Presley reluctantly recorded the gospel-rock track, giving it his high-octane all: “He knew everyone felt that he should do it, he was a reasonable man,” Schilling says. It became Elvis’ final Top 10 hit, peaking at No. 2 on the Billboard Hot 100 that fall.
“I don’t think Elvis was ever too thrilled about singing lyrics like ‘Flames are now licking my body,’ but he loved having a hit record,” Schilling, 83, writes in the introduction to “Sunset Boulevard,” a new five-disc, 89-track collection that spans Presley’s Los Angeles studio sessions from 1970 to 1975. (Schilling can be glimpsed in the set’s archival images: “I’m very proud to be standing behind Elvis on the cover.”)
The set includes rare alternate takes − half of which have never been released in the U.S. − rehearsals for his Las Vegas residency, and new stripped-down mixes of classic Elvis cuts, including “For the Good Times,” “Tiger Man,” “T-R-O-U-B-L-E,” “Green, Green Grass of Home,” “Pieces of My Life,” “Memories” and “Softly As I Leave You.”
“I’m kind of a purist, you know: Don’t mess with Michelangelo’s paintings or change the clouds. Don’t mess with the artist,” says Schilling, talking from his home in California, which Elvis gifted him in 1974. “There’s a tremendous responsibility. When the big questions come up, I go, what would I do if Elvis was sitting next to me? That’s how I judge it. I know my friend.”
The singer never shied away from the provocation of songs like “Burning Love,” Schilling adds. But in the early ‘70s, as Elvis privately struggled with his disintegrating marriage to Priscilla Presley, he gravitated toward expressions of heartbreak and regret such as the autobiographical “Separate Ways” and “Always on My Mind” (both included in the set).
Over time, he came to embrace the lusty song as part of his live repertoire, breaking it out months later for an epic “Aloha From Hawaii” performance.
“There’s a part of Elvis that wanted to be sexy,” Schilling says. “And there’s a part of him that wanted to be a great gospel singer.”
In “Burning Love,” he got to be both.
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