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  • Shingles — But Also RSV — Vaccination Associated With Lower Dementia Risk

    Shingles — But Also RSV — Vaccination Associated With Lower Dementia Risk

    A new report is adding to the growing body of evidence that vaccination against shingles may also curb the risk of dementia.

    The authors of the study, published in npj Vaccines, say it may actually be the adjuvant system used to create the vaccine that provides the protective benefit.

    Paul Harrison, M.A., B.M.B.Ch., D.M.

    Last year, corresponding author Paul J. Harrison, M.A., B.M.B.Ch., D.M., of the University of Oxford, and colleagues published data showing that the recombinant shingles vaccine lowered the risk of dementia. They also found that it had a larger impact than the live version of the vaccine. The live vaccine is no longer in use in many countries, including the United States, due to data showing its efficacy is inferior to the recombinant one.

    Harrison and colleagues said the findings from last year’s report led to two nonmutually exclusive hypotheses. One is that shingles itself leads to a higher risk of dementia, so the recombinant vaccine does a better job of preventing dementia because it does a better job of preventing shingles. The second is that the AS01 adjuvant vaccine system provides protection against dementia. They said previous research in mouse models has offered evidence for the latter possibility. Adjuvants are substances used in conjunction with vaccines to spur a stronger immune response.

    “Understanding the relative contributions of these possibilities would be important for translating findings into potential strategies for the prevention of Alzheimer’s disease and other neurodegenerative disorders,” they said.

    In their new report, the investigators wanted to better understand the potential impact of the AS01 adjuvant system by looking at dementia rates in people who were given different types of AS01 adjuvant vaccines. They used electronic health records from more than 400,000 patients to explore dementia risk in people who received the AS01 adjuvant shingles vaccine, as well as those who received the AS01 vaccine for respiratory syncytial virus (RSV).

    The team constructed three cohorts based on vaccination status: those who received only the shingles vaccine, those who received only the RSV vaccine, and those who received both. Those patients were then compared with matched controls who received the flu vaccine but not the shingles or RSV vaccines. The three RSV and shingles vaccine cohorts had mean ages ranging from 69.2 to 72.8 years, and each had a higher percentage of females than males.

    Individuals were followed for up to 18 months or their last contact with their healthcare organization. Dementia diagnoses within three months of vaccination were excluded, as such patients may have already had undiagnosed dementia at the time of vaccination.

    Protection from adjuvants

    The findings showed that patients who received an AS101 vaccine had a significantly lower risk of being diagnosed with dementia compared to those who had only the flu vaccine.

    The investigators used a metric called ratio of restricted mean time lost (RMTL) to mark risk of dementia, with scores below 1.0 indicating a lower risk. They found that patients who received both the RSV and shingles vaccines had a ratio of RMTL of 0.63.

    Patients who had only the shingles or RSV vaccines had RMTLs of 0.82 and 0.71, respectively.

    Harrison and his co-authors said the fact that patients receiving either the AS01 vaccine seemed to benefit suggests that it is the AS01 system that lowers dementia risk, though they said it is not clear how it achieves this effect.

    “One possibility is that they independently reduce dementia risk by preventing respiratory infections, shingles, and RSV,” they wrote, noting that growing evidence suggests infections can heighten the risk of dementia. However, the authors said the fact that the benefit of vaccination seems to appear quickly argues against that hypothesis.

    Another possibility, they said, is that AS01 protects against dementia via specific immunological pathways, such as via toll-like receptor 4 stimulation with monophosphoryl lipid A (MPL). MPL is a component of the AS01 system and has been linked with improvement in Alzheimer’s pathology in mice, they said.

    Although the exact reasons for the apparent protection against dementia remain unclear, Harrison and colleagues said their findings underscore the need for more investigation to better understand the possible explanations.

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  • US firm agrees $500 million investment deal with Pakistan for critical minerals

    US firm agrees $500 million investment deal with Pakistan for critical minerals

    ISLAMABAD (AP) — A U.S. metals company signed a $500 million investment deal with Pakistan on Monday.

    Pakistan’s Frontier Works Organization — which is the country’s largest miner of critical minerals — signed a memorandum of understanding with Missouri-based U.S. Strategic Metals for collaboration plans that include setting up a poly-metallic refinery in Pakistan.

    The deal comes after Washington and Islamabad last month reached a trade agreement that Pakistan hoped would attract American investment in its minerals and oil reserves.

    U.S. Strategic Metals is focused on producing and recycling critical minerals, which the U.S. Department of Energy has defined as essential in a variety of technologies related to advanced manufacturing and energy production.

    A second agreement was signed between the National Logistics Corp of Pakistan and Mota-Engil Group, a Portuguese engineering and construction company.

    A statement from Prime Minister Shehbaz Sharif’s office said he held talks with the delegation from U.S. Strategic Metals and Mota-Engil over Pakistan’s copper, gold, rare earths, and other mineral resources.

    The sides expressed readiness to develop value-added facilities, enhance mineral processing capacity, and undertake large-scale projects tied to mining, the statement said.

    “The partnership will begin immediately with the export of readily available minerals from Pakistan, including antimony, copper, gold, tungsten, and rare earth elements,” it added.

    The U.S. embassy in Pakistan said in a statement: “This signing is yet another example of the strength of the U.S.-Pakistan bilateral relationship that will benefit both countries.”

    Earlier this year, Sharif claimed that Pakistan possesses mineral reserves worth trillions of dollars, and foreign investment in the mineral sector could help the country overcome its prolonged financial crisis and free itself from the burden of massive foreign loans.

    Most of Pakistan’s mineral wealth is located in the insurgency-hit southwestern Balochistan province, where separatists have opposed the extraction of resources by Pakistani and foreign firms.

    In August, the U.S. State Department had designated the Balochistan National Army separatist group and its fighting wing, the Majeed Brigade, as a foreign terrorist organization.

    Oil and minerals reserves have also been found in the southern Sindh, eastern Punjab and northwestern Khyber Pakhtunkhwa bordering Afghanistan.

    Several companies have already signed agreements with Pakistan in the mining sector. They included the Canadian firm Barrick Gold, which already owns a 50% stake in the Reko Diq gold mine in Balochistan.


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  • Murdoch Family Settles Succession Dispute, Lachlan to Take ontrol

    Murdoch Family Settles Succession Dispute, Lachlan to Take ontrol

    In a stunning development straight out of the HBO series Succession, the Murdoch family has settled its long-simmering dispute over the family trust, a settlement that will see Lachlan Murdoch walk away with the keys to the kingdom.

    The family announced the settlement Monday afternoon, adding that Lachlan’s siblings, Prudence MacLeod, Elisabeth Murdoch and James Murdoch, will each become beneficiaries of new trusts funded in part by the sale of 14.2 million shares of News Corp Class B common stock and approximately 16.9 million shares of Fox Corporation Class B common stock, that were previously held by the Murdoch family trust.

    The sale will dilute the Murdoch families votes in both Fox and News Corp. to approximately 33.1 percent of News Corp’s Class B common stock and less than 0.1 percent of News Corp’s Class A common stock and approximately 36.2 percent of Fox Corporation’s Class B common stock and less than 0.1 percent of Fox Corporation’s Class A common stock.

    New trusts will be formed for Lachlan Murdoch, Grace Murdoch and Chloe Murdoch, with Lachlan controlling the votes. Rupert Murdoch will continue in his role as Chairman Emeritus of the Company.

    “News Corp’s board of directors welcomes these developments and believes that the leadership, vision and management by the Company’s Chair, Lachlan Murdoch, will continue to be important to guiding the Company’s strategy and success,” News Corp. said in a statement.

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  • Gigi Hadid Auditioned for ‘Tangled’ Live-Action Remake

    Gigi Hadid Auditioned for ‘Tangled’ Live-Action Remake

    Gigi Hadid was ready to take on the role of Rapunzel.

    In her Vogue cover story alongside Kendall Jenner, the supermodel reflected on auditioning for the role of Rapunzel in the live-action remake of the animated film Tangled.

    “What do we do in this job anymore that scares us?” Hadid posed the question to Jenner during their interview. Though Hadid did not get the part, she said, “I was really proud of my scene.”

    Despite taking singing lessons during fashion month to prepare, Hadid said, “I knew they were going to go with a real singer.” She also told Jenner that she’d show her her audition scene.

    Disney’s live-action reimagining of its 2010 animated film focused on the Brothers Grimm fairy tale heroine, has been put on pause, according to studio insiders. The project had been in active development, with The Greatest Showman helmer Michael Gracey on board to direct and Jennifer Kaytin Robinson penning the script.

    However the decision to pause the film followed Disney’s underwhelming release of their live-action adaptation Snow White at the box office, from critics and followed by a myriad of controversies. It continues to remain uncertain whether the film will eventually move forward or be rethought creatively. Meanwhile, a live-action Moana is set to release on July 10, 2026.

    In addition to Hadid, My Oxford Year star Corey Mylchreest revealed that he too had auditioned for the Tangled live-action for the role of Flynn Rider. In an interview with Seventeen, the actor seemed to not share the same sentiments Hadid did about the audition.

    “We don’t have the footage anymore. I deleted it and then I burnt it and then I burnt the phone that I filmed on. And then I burnt the room that I did it in. And then I burnt myself,” he quipped of his audition. “No, it wasn’t very good. They then told me that they wanted someone with singing experience.”

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  • Rodent adapted marburg viruses are lethal in ferrets

    Rodent adapted marburg viruses are lethal in ferrets

    GPA-MARV is uniformly lethal in ferrets

    To determine whether GPA-MARV or MA-MARV caused disease in ferrets, groups of six male and female ferrets were inoculated with 1000 TCID50 of each virus. A third group of ferrets was inoculated with GPA-EBOV as a control. Remarkably, GPA-MARV resulted in uniform lethality, with all animals succumbing to disease at 10 dpi (Fig. 1a). These animals began manifesting clinical signs of FVD at 7-8 dpi, which coincided with weight loss and an increase in body temperature (Fig. 1b, c). Beyond 8 dpi, disease progressed rapidly, with the most notable signs of disease being significantly decreased activity, inappetence, and a hunched posture with ruffled fur. Two of the six ferrets challenged with GPA-MARV demonstrated a petechial rash observable roughly 24–48 h prior to the time of euthanasia (Fig. 2a). Additionally, a few animals showed signs of hemorrhage other than a rash, including blood in the stool as well as some orifices, including nose and eyes.

    Fig. 1: Clinical parameters of ferrets inoculated with rodent-adapted Marburg viruses.

    Clinical parameters of ferrets (n = 6 per group) inoculated with GPA-MARV (ac) or MA-MARV (d–f). Kaplan-Meier survival curves (a, d), percent weight change (b, e), microchip scan temperature (c, f). Data from each animal are depicted as dots with individual animal IDs and sex (Female, F and Male, M) indicated in the key.

    Fig. 2: Rash observed among ferrets infected with rodent-adapted Marburg viruses.
    figure 2

    Representative images of rashes observed at the terminal timepoint. Petechial rash among GPA-MARV-challenged ferrets (a) and no rash among MA-MARV-challenged ferrets (b).

    MA-MARV resulted in partial lethality among infected ferrets, with two of the six animals (33%) euthanized on 8 and 9 dpi (Fig. 1d). These two animals exhibited signs of disease that appeared less severe than those observed for GPA-MARV, with weight loss progressing gradually from 3 dpi until euthanasia and temperatures staying within normal range or mildly elevated (Fig. 1e, f). Neither of the animals that succumbed developed a rash at any point (Fig. 2b). The other four MA-MARV-challenged animals did not exhibit any signs of disease (Fig. 1d–f).

    By comparison, all ferrets challenged with GPA-EBOV succumbed to disease by 5 dpi (Supplementary Fig. 1a). These animals manifested clinical signs of disease that closely paralleled what has been observed previously for EBOV4,7 (Supplementary Fig. 1a–c). In contrast to GPA-MARV-challenged ferrets, among which only two animals developed a petechial rash, all GPA-EBOV-challenged ferrets exhibited a maculopapular rash (Supplementary Fig. 1d). Notably, the rash observed among GPA-MARV-challenged animals differed from that observed among GPA-EBOV-challenged animals, with the latter displaying a maculopapular rash that blanched upon applying pressure.

    GPA-MARV replicates to high levels in ferrets

    All animals infected with GPA-MARV were viremic on 5 dpi, with low levels of viral RNA detectable in the blood (mean 3.40 Log10 GEQ/mL). Levels of viral RNA increased moderately by 7 dpi with a mean terminal level of 9.07 Log10 GEQ/mL (Fig. 3a). Oral, rectal and nasal swabs were weakly positive from 5-7 dpi, and mean viral RNA levels increased to 5.97, 7.78, 6.38 Log10 GEQ/mL, respectively, at the time of euthanasia (Supplementary Fig. 2a–c). Tissues were uniformly positive for viral RNA at the time of euthanasia, with liver, spleen and lymph nodes having the highest mean levels of viral RNA, at 7.73, 7.14 and 7.03 Log10 GEQ/g, respectively (Fig. 3b). Levels of infectious virus in the blood and tissues paralleled the levels of viral RNA (Fig. 3c, d), while the swabs were weakly positive for infectious virus (data not shown).

    Fig. 3: Viral load in blood and tissues of ferrets infected with rodent-adapted Marburg viruses.
    figure 3

    Whole blood (a, c, e) was collected from each animal at 3, 5, 7, 10, 14 and 21 days post-infection (dpi) and at the time of euthanasia, while tissues (liver, spleen, kidney, heart, lung, gonadal white adipose tissue (GWAT), testes, ovaries, brown adipose tissue (BAT), eye, brain, and lymph node (LN)) were collected upon necropsy to evaluate viral loads among animals challenged with GPA-MARV (a–d) and MA-MARV (e–g). Virus RNA was quantified by RT-qPCR (a, b, e, f, g), and infectious virus was quantified by TCID50 (c, d). Results are depicted in genome equivalents per mL (GEQ/mL) for each animal (indicated by a square for males and a circle for females) or mean tissue culture infectious dose per mL (TCID50/mL) or per g (TCID50/g) depicted as histograms, with data from each animal depicted as dots. Individual animal IDs and sex (Female, F and Male, M) are indicated in the key. Note: virus isolation was only performed on samples positive by RT-qPCR with a CT cutoff of ≤34.

    In contrast, all MA-MARV-challenged animals were viremic at 5 dpi, with mean levels of viral RNA in the blood of 4.85 Log10 GEQ/mL (Fig. 3e). Levels of viral RNA in the blood increased slightly at 7 dpi, with mean levels of 5.61 Log10 GEQ/mL, and began to decrease thereafter in all surviving animals (Fig. 3e). The two animals that succumbed to disease had mean viral RNA levels of 6.03 Log10 GEQ/mL in the blood at the time of euthanasia (Fig. 3e). Swabs were mostly negative throughout the duration of the study, with the most positives being found in oral swabs at 7 dpi (Supplementary Fig. 2g–i). The two animals that succumbed to disease at 8 and 9 dpi were uniformly positive for viral RNA across all tested tissues; however, levels were considerably lower than those observed for GPA-MARV (Fig. 3f). Among the surviving animals at 21 dpi, the spleen was weakly positive for viral RNA, while a single animal showed low levels of viral RNA in the BAT and LN (Fig. 3g).

    Viral replication kinetics for GPA-EBOV-challenged animals closely paralleled what has been observed previously7, with mean peak levels of 10.95 Log10 GEQ/mL in the blood at time of euthanasia on 4 dpi (Supplementary Fig. 3a). Likewise, all tissues and swabs were uniformly positive for viral RNA and infectious virus at time of euthanasia (Supplementary Fig. 2d–f and Supplementary Fig. 3b). Overall, levels of viral RNA at the time of euthanasia were ~2 Log10 GEQ/mL greater among GPA-EBOV-challenged animals compared to GPA-MARV-challenged animals.

    GPA-MARV causes deviations in hematological parameters

    GPA-MARV-challenged animals demonstrated deviations in blood biochemistry characteristic of FVD. ALT levels were elevated in most animals as early as 3 dpi, reaching the upper limit of quantification (2000 U/L) in three animals (450 M, 854 F and 184 F) at the time of euthanasia (Fig. 4a). Because the remaining three animals (484 M, 492 M and 125 F) were found dead on 10 dpi, no hematology data were available at this timepoint. ALP, TBIL and BUN levels were relatively stable throughout 7 dpi but were elevated at 10 dpi for 450 M, 854 F and 184 F (Fig. 4b–d). The remaining analytes, namely, ALB, AMY, Ca2+, PHOS, CRE, GLU, Na+, K+, TP and GLOB, were mostly unremarkable, except AMY, PHOS and K+, which was elevated for a single animal (184 F) at the time of euthanasia (Supplementary Fig. 4).

    Fig. 4: Select biochemistries and blood cell counts in ferrets infected with rodent-adapted Marburg viruses.
    figure 4

    Whole blood was collected from each animal on days 0, 3, 5, 7, 10, 14 and 21 days post-infection (dpi) as well as at the time of euthanasia to evaluate serum biochemistry (a–h) and blood cell counts (i–p). Biochemistry analytes measured are as follows: alanine aminotransferase [ALT]; alkaline phosphatase [ALP]; total bilirubin [TBIL], and blood urea nitrogen [BUN]. Complete blood count analytes measured are as follows: white blood cells [WBC]; lymphocytes [LYM]; neutrophils [NEU]; platelets [PLT]. Individual animal IDs and sex (Female, F and Male, M) are indicated in the key. Gray shaded regions represent the mean baseline values ± 2 standard deviations, calculated from historical pre-challenge serum samples. Note: Partial timepoint sampling was performed for animals that succumbed to disease or met humane endpoint criteria prior to the scheduled end of the study. This includes all animals in the GPA-MARV group, as well as animals 761 F and 841 F in the MA-MARV group.

    With respect to MA-MARV, ALT levels for the non-surviving animals (761 F and 841 F) were elevated as early as 3 dpi and continued to increase until reaching the upper limit of quantification (ULOQ) at the time of euthanasia (Fig. 4e). ALT levels for the surviving animals peaked at 7 dpi, after which they gradually decreased (Fig. 4e). Levels of ALP and BUN remained mostly within the normal range throughout 21 dpi (Fig. 4f, h). Interestingly, TBIL levels were within normal range for males but elevated for females throughout the study (Fig. 4g). Also of note, GLOB levels increased for all animals as early as 3 dpi and peaked at 7 dpi before returning to baseline at 21 dpi (Supplementary Fig. 4).

    In GPA-EBOV-challenged animals, ALT, ALP, TBIL and BUN were elevated at the time of euthanasia, consistent with what is seen among ferrets challenged with EBOV4 (Supplementary Fig. 4). Unlike GPA-MARV, levels of PHOS, CRE, K+ and GLOB were also elevated among GPA-EBOV-challenged animals at euthanasia (Supplementary Fig. 4).

    GPA-MARV and MA-MARV challenged animals all demonstrated lymphopenia and thrombocytopenia at the time of euthanasia (Fig. 4j, l, n, p). In the case of MA-MARV platelets reached their lowest levels at 7 dpi and gradually returned to normal levels among survivors by the study end (Fig. 4p). No discernable trend among white blood cell levels could be observed for GPA-MARV challenged animals (Fig. 4i). In contrast, MA-MARV-challenged animals 915 M and 538 F demonstrated elevated white blood cell levels at 10 dpi, which returned to baseline levels by study end (Fig. 4m). Interestingly, neutrophils were elevated at 5 dpi among GPA-MARV-challenged animals and returned to baseline prior to the time of euthanasia (Fig. 4k). In contrast, MA-MARV-challenged animals demonstrated elevated levels of neutrophils at 3 dpi, which decreased at 7 dpi followed by and increase thereafter among surviving animals (Fig. 4o). Lastly, GPA-EBOV-challenged animals demonstrated trends consistent with what has been shown previously among ferrets infected with EBOV (Supplementary Fig. 5).

    Infected ferrets demonstrate a dysregulated immune response

    Ferret serum samples were subjected to a 12-plex ferret cytokine panel to investigate changes in the cytokine profile that occurred following infection. In GPA-MARV-challenged animals, the proinflammatory cytokines IFN-α, IL-6, IL-8, IP-10 and MCP-1 all increased following infection, with levels peaking in most animals at the time of euthanasia (Fig. 5a–e). Notably, these cytokines were all substantially elevated relative to historical control animals challenged with wild type MARV (Fig. 5a–e). Interestingly, animal 492 M showed consistently elevated levels of TNF-α, IL-12P70, IL-12p40, IL-17 and IL-2 compared to all other animals challenged with GPA-MARV (Fig. 5 and Supplementary Fig. 7). Cytokine levels for TNF-α, IL-12P70, IL-12p40, IL-17, IL-2, IL-4 and MIP-1β showed considerable fluctuation throughout the course of disease with no discernable trends (Fig. 5 and Supplementary Fig. 7).

    Fig. 5: The cytokine/chemokine response in ferrets challenged with rodent-adapted Marburg viruses.
    figure 5

    Serum was collected from each animal challenged with GPA-MARV (a–e) or MA-MARV (f–j) at 0, 3, 5, 7, 10, 14 and 21 days post-infection (dpi) as well as at the time of euthanasia to evaluate cytokine/chemokine profiles using a 12-plex ferret Luminex assay. Analytes measured are as follows: Interferon-alpha [IFNα]; interleukin-6 [IL-6]; interleukin-8 [IL-8]; Interferon gamma-induced protein 10 [IP-10]; monocyte chemoattractant protein-1 [MCP-1]. Individual animal IDs and sex (Female, F and Male, M) are indicated in the key. Animals 561 M and 423D, denoted by hashed lines, reflect historical control sera from ferrets challenged with wild type and MARV (n = 2) from a previously published study7.

    Trends observed for MA-MARV-challenged animals deviated from those observed among GPA-MARV-challenged animals. The dramatically elevated levels of IFN-α, IL-6, and MCP-1 observed among GPA-MARV-challenged animals were absent among MA-MARV-challenged animals (Fig. 5f, g, j). Nonetheless, slight increases were seen among these analytes around 5-7 dpi; however, these levels normalized by 10 dpi in the survivors (Fig. 5f, g, j). Interestingly, levels of IL-8 increased in all animals around 7 dpi, coinciding with disease onset and clinical scoring among the two animals that succumbed. Among the surviving animals, IL-8 levels decreased at 14 dpi only to increase again at the time of euthanasia (Fig. 5h). For unknown reasons, levels of IL-17 and IL-4 were elevated throughout the study for 841 F and 538 F compared to animals of the same challenge group (Supplementary Fig. 7). The levels of the remaining analytes, TNF-α, IP-10, IL-12p70, IL-12p40, IL-2, MCP-1 and MIP-1β, fluctuated, with peaks observed around 7 dpi followed by decreases thereafter (Fig. 5 and Supplementary Fig. 7).

    In general, trends observed among GPA-EBOV-challenged animals were similar to those observed among GPA-MARV-challenged animals, and they closely paralleled those observed among historical control animals challenged with wild type EBOV (Fig. 5 and Supplementary Fig. 6). In particular, IL-6 and IL-8 levels in GPA-EBOV-challenged animals at the terminal timepoint far exceeded those observed at the terminal timepoints in GPA-MARV-challenged animals (Supplementary Fig. 6). IP-10 was also elevated at the terminal timepoint among GPA-EBOV-challenged animals, although to levels lower than those observed for GPA-MARV (Supplementary Fig. 6). Levels of IFNα, TNFα, IL-12p70, IL-17, IL-2, IL-4 and MIP-1β showed fluctuations throughout the disease course with no discernable trends (Supplementary Fig. 6).

    GPA-MARV acquired several mutations following challenge

    To track changes in the virus genome throughout the course of infection, whole blood collected at 3, 5, and 7 dpi and at the time of euthanasia, along with tissues, were subjected to NGS. In total, 28 mutations were identified within GPA-MARV, of which eight were located within coding regions (Table 1 and Supplementary Figs. 8, 9). All of these mutations were found in each GPA-MARV-challenged animal in all tissues and blood samples. All mutations within the coding regions—except a single mutation in VP35 were non-synonymous, including one in NP (F287L), two in VP35 (L30S and Y34H), three in VP40 (K56N, G79S and D184N) and one in VP24 (I66V). Each of these non-synonymous mutations was present within the virus challenge stock at frequencies below 25% except K56N in VP40 which was present at a frequency of 34.01% (Table 1); however, all reached the consensus threshold frequency of ≥50%, with the majority present at a frequency of ≥75%. The remaining 20 mutations were silent and located either within UTRs or intergenic regions (Table 1). In addition to these 28 mutations, several additional mutations were present; however, most were unique to a single animal or tissue and demonstrated no discernible trends of interest. Unfortunately, given the low viral load among MA-MARV-challenged animals NGS was not feasible.

    Table 1 Summary of mutations present in blood and tissues of GPA-MARV challenged ferrets

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  • Trump reversed policies supporting electric vehicles − it will affect the road to clean electricity, too

    Trump reversed policies supporting electric vehicles − it will affect the road to clean electricity, too

    When Congress passed the Inflation Reduction Act in 2022, it was the largest climate bill in U.S. history, with major incentives for electric vehicle production and adoption. In its wake, investment in the U.S. electric vehicle industry accelerated. But in 2025, President Donald Trump’s so-called One Big Beautiful Bill Act eliminated most of the incentives, and U.S. investment collapsed.

    Hitting the brakes on electric vehicles will clearly mean less progress in reducing transportation emissions and less strategic U.S. leadership in a key technology of the future. But in a new study, my colleagues at Carnegie Mellon University and I find that fewer electric vehicles will also mean less investment to clean up the electricity sector.

    How we got here

    U.S. electric vehicle adoption lags behind the rest of the world – especially China, which has invested heavily and strategically to dominate electric vehicle markets and supply chains and to leapfrog the historical dominance of American, European and Japanese manufacturers of vehicles powered by internal combustion engines.

    Electric vehicles are much simpler to engineer, and this opened a window for China to bet big on EVs with investment, incentives and experimentation. As battery prices dropped dramatically, electric cars became real competition for gasoline cars – especially for the massive Chinese market, where buyers don’t have strong prior preferences for gasoline. China now dominates the supply chain for battery materials, such as lithium, nickel, cobalt and manganese, as well as the rare earth minerals used in electric motors.

    In 2022, the U.S. took action to change this trend when Congress passed the Inflation Reduction Act. The law encouraged EV adoption by lowering costs to manufacturers and consumers. But it also encouraged automakers to find ways to build EVs without Chinese materials by making the largest incentives conditional on avoiding China entirely.

    After the law passed, investment soared across hundreds of new battery manufacturing and material processing facilities in the U.S.

    But in 2025, Congress passed and Trump signed the One Big Beautiful Bill Act, which eliminated most of the incentives. U.S. investment in EV-related production has collapsed.

    Electric vehicles are cleaner

    As a scholar of electric vehicle technology, economics, environment and policy, I have conducted numerous peer-reviewed scientific studies characterizing benefits and costs of electric vehicles over their life cycle, from production through use and end of life. When charged with clean electricity, electric vehicles are one of the few technologies in existence that can provide transportation with near-zero emissions.

    With today’s electricity grid, EV emissions can vary, depending on the mix of electricity generators used in the region where they are charged, driving conditions such as weather or traffic, the specific vehicles being compared, and even the timing of charging. But EVs are generally better for the climate over their life cycle today than most gasoline vehicles, even if the most efficient gas-electric hybrids are still cleaner in some locations. EVs become cleaner as the electricity grid becomes cleaner, and, importantly, it turns out that EVs can even help make the electricity grid cleaner.

    This matters because transportation and electricity together make up the majority of U.S. greenhouse gas emissions, and the passenger cars and light trucks that we all drive produce the majority of our transportation emissions.

    In its efforts to prevent the government from regulating greenhouse gas emissions, the Trump administration is now claiming that emissions from cars and trucks are “not meaningful” contributors to climate change. But in reality, a technology that cleans up both transportation and electricity at the same time is a big deal.

    Across most of the U.S., adding electricity demand, such as from increasing the use of electric vehicles, would spark development of clean-energy power plants to meet that rising need.
    Michalek et al.

    An opportunity for cleaner electricity

    Our research has found that turning away from electric vehicles does more than miss a chance to curb transportation emissions – it also misses an opportunity to make the nation’s electricity supply cleaner.

    In our paper, my co-authors Lily Hanig, Corey Harper and Destenie Nock and I looked at potential scenarios for electric vehicle adoption across the U.S. from now until 2050. We considered situations ranging from cases with no government policies supporting electric vehicles to cases with enough electric vehicle adoption to be on track with road maps targeting overall net-zero greenhouse gas emissions by 2050.

    In each of these scenarios, we calculated how the nation’s power grid and electricity generators would respond to electric vehicle charging load.

    We found that when there are more electric vehicles charging, more power plants would need to be built – and because of cost competitiveness, most of those new power plants would be solar, wind, battery storage and natural gas plants, depending on the region.

    Once wind and solar plants are built, they are cheaper to operate than fossil fuel plants, because utilities don’t need to buy more fuel to burn to make more electricity. That cost advantage means wind and solar energy gets used first, so it can displace fossil-fuel generation even when EVs aren’t charging.

    A virtuous – or vicious – cycle

    Our analysis reveals that what’s good for climate in the transportation sector – eliminating emissions from vehicle tailpipes – is also good for climate in the power sector, supporting more investment in clean power and displacing more fossil fuel-powered generation.

    As a result, encouraging electric vehicle adoption is even better for the climate than many people expected because EV charging can actually cause lower-emitting power plants to be built.

    Gasoline vehicles can’t last forever. The cheap oil will eventually run out. And EV batteries have gotten so cheap, with ranges now comparable to gas cars, that the global transition is already well underway. Even in the U.S., consumers are adopting more EVs as the technology improves and offers consumers more for less. The U.S. government can’t single-handedly stop this transition – it can only decide how much to lead, lag or resist. Rolling back electric vehicle incentives now means higher emissions, less clean energy investment and weaker U.S. competitiveness in a crucial industry of the future.

    Our findings show that slowing electric vehicle adoption doesn’t just affect emissions from transportation. It also misses opportunities to help build a cleaner power sector, potentially locking the U.S. into higher emissions from its top two highest-emitting sectors – power generation and transportation – while the window to avoid the worst effects of climate change is closing.

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  • Europe’s Dashboard Reveals Upcoming Scientific Outputs — Vax-Before-Travel

    Europe’s Dashboard Reveals Upcoming Scientific Outputs — Vax-Before-Travel

    Europe (Vax-Before-Travel News)

    The European Centre for Disease Prevention and Control (ECDC) has announced the launch of a new public dashboard titled ‘Upcoming Scientific Outputs.’

    As of September 8, 2025, this interactive dashboard enables users to search and view all major scientific outputs currently under development by the Centre.

    One goal is to enhance surveillance of communicable diseases such as chikungunya and dengue.

    The dashboard presents a list of the main scientific outputs planned for publication during the coming 12 months, with weekly updates to ensure near-real-time information that accurately reflects the current situation.

    For each planned scientific output, the platform provides details on the output type (e.g., public health guidance, scientific manuscript, etc.), current working title, anticipated release date (by quarter), and status (in progress/completed/discontinued).

    It replaces the previous static list of planned outputs that was typically published each spring.

    In a media statement, ECDC Chief Scientist, Piotr Kramarz, stressed ECDC’s commitment to transparency, ‘The new searchable dashboard of ECDC’s scientific outputs will further improve our scientific transparency and credibility by ensuring that stakeholders and citizens can get a clear picture of the ECDC content in the pipeline and when key documents will be released.”

    “This will reduce the risk of duplication and promote synergies between ECDC and external partners, thereby strengthening the usefulness of ECDC’s scientific work.”

    The ECDC is based in Stockholm, Sweden, with a mission to identify, assess, and communicate current and emerging threats to human health posed by infectious diseases.

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  • The Works on Water Triennial Puts Commitment Over Spectacle

    The Works on Water Triennial Puts Commitment Over Spectacle

    A group show on an island a boat ride away from Manhattan is unlikely to attract the same attention as flashier happenings on the city’s busy fall art calendar, yet their work is no less deserving of it. The Works on Water (WoW) Triennial at the Arts Center at Governors Island, now in its third iteration, has been led since 2017 by a resourceful group of artists and curators (Emily Blumenfeld, Carolyn Hall, sTo Len, Clarinda Mac Low, Nancy Nowacek, and Sarah Cameron Sunde, at present). The collective remains oriented toward humble grassroots projects, such as performance artist Nora Almeida’s and videographer iki nakagawa’s collaborative multimedia explorations of Brooklyn’s Coney Island Creek.

    This and other projects are compelling in their own right, but what stands out about their 2025 triennial is how many artists, and even artworks, have returned from the first two editions. This apparent repetitiveness may seem strange given that many bi- and triennials aspire to be cultural status updates. But WoW’s willingness to revisit projects indicates that it values art for its depth and persistence rather than how it sets or fits trends.

    That commendable commitment is evident in “Walking the Edge” (2020–25), a preliminary version of which appeared in the previous WoW triennial and which here appears as a dense grid of shoreline photographs. The photos document an ambitious durational feat: From May to October 2025, in collaboration with Culture Push and NYC’s Department of City Planning, WoW members are leading walks covering the city’s entire 520 miles of coastline.

    Installation view of Elizabeth Velazquez, “Calling Forth The Waters that Surround Us” (2025)

    Video documentation of Sarah Cameron Sunde’s “36.5 / A Durational Performance with the Sea” (2013–22) — in which the artist and local participants stand in coastal waters for one full tidal cycle at sites around the world — also makes a repeat appearance. Sunde’s performance, oriented toward deep time, patiently bears witness to the accelerating rate of sea level rise. The horizon-long Great Lakes vistas in Jana Harper’s short video, “Song for Water” (2025), likewise operate in a pensive, almost oracular, register.

    It’s not surprising that Water Art, as WoW calls it, would take the long view of things, given the philosophical depth associated with its subject. But this triennial’s design emphasizes contemplative aesthetic gestures over the nitty-gritty logistics of its community projects, from sTo Len’s 30-foot-long gomitaku — a Japanese portmanteau meaning “trash impression” — mono print that undulates across the gallery like an elegant serpent (“Impressions for Coastal Constellation Alignment: Potomac River, Virginia,” 2020), to the floor-to-ceiling netting and cotton saris that Elizabeth Velazquez and Monica Jahan Bose use, respectively, to demarcate circular spaces (“Calling Forth The Waters That Surround Us” and “Darchira River,” both 2025).

    However counterintuitive emphasizing aesthetics over logistics might sound, it constitutes an effective solution to the problem of how to translate public and social practice art into a gallery setting. The triennial — especially the moody basement gallery suffused with a scent by perfume maker Frank Bloem (“Zeelucht (A Perfume from Forty Smells of the North Sea),” 2021) — reminded me of the dramatic installation environments in this summer’s inaugural Sky High Farm biennial, an eco-minded Hudson Valley show. But whereas the Sky High installations evince showmanship, WoW’s installations evince introspection. Nobody in the group has given up on doing the work — quite the contrary — but there’s an ambient sense that, given what has and hasn’t changed in the world since 2017, progress’s horizon might be further off than one would hope.

    The Works on Water 2025 Triennial continues at the Arts Center of Governors Island (110 Andes Road, Manhattan) through October 26. The exhibition was curated by Emily Blumenfeld and Kendal Henry with the Works on Water team (Carolyn Hall, sTo Len, Clarinda Mac Low, Nancy Nowacek, and Sarah Cameron Sunde).

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  • Body Burden: Hope for Deeper Healing Documentary Review 2025 – Free Screening Reveals Hidden Health Crisis

    Body Burden: Hope for Deeper Healing Documentary Review 2025 – Free Screening Reveals Hidden Health Crisis

    Body Burden: Hope For Deeper Healing Documentary Review 2025

    Watch the Official Body Burden Documentary Here

    TL;DR Summary: Body Burden: Hope For Deeper Healing is a groundbreaking 2025 health documentary by Nicolas Pineault. The film reveals how invisible toxins accumulate in the human body, fueling fatigue, brain fog, anxiety, and chronic illness. Featuring world-leading doctors, deeply personal patient stories, and proven detoxification strategies, this film positions itself as one of the most important wellness documentaries of the decade. It will be available to stream free online from September 15-22, 2025.

    In This Article, You’ll Discover

    Why “body burden” is considered the hidden epidemic of 2025

    The shocking science behind toxic exposure and chronic illness

    Nicolas Pineault’s personal journey and test results that sparked the film

    How pioneering doctors at Deeper Healing are transforming environmental medicine

    Real-life patient recoveries that show hope for deeper healing is possible

    What sets Body Burden apart from other wellness films

    Practical steps for reducing toxic load at home and in daily life

    Why health documentaries are more trusted than ever before

    Frequently asked questions about the film, registration, and impact

    Strategic ways to maximize your viewing experience

    Why Body Burden Is the Hidden Health Epidemic of 2025

    Across the globe, researchers are ringing alarm bells: toxic exposure is no longer a side issue – it is a defining health crisis of our time. The concept of “body burden” refers to the total load of chemicals, metals, mold toxins, and environmental pollutants stored in the human body. This burden accumulates silently, often for years, until symptoms of chronic illness emerge.

    Babies are born pre-polluted. Studies from the Environmental Working Group detected more than 200 industrial chemicals in umbilical cord blood, including dioxins, mercury, and PCBs.

    Toxins are multiplying at record pace. Worldwide, more than 10 million new chemicals are synthesized every year, many with no long-term human safety studies.

    Indoor air and water contribute significantly. EPA data reveals that nearly half of U.S. homes show signs of mold or dampness – major drivers of mycotoxin exposure.

    EMF radiation adds an invisible layer. Wi-Fi routers, cell towers, and satellites contribute to “electro-pollution,” with researchers investigating how EMF stress amplifies vulnerability to other toxins.

    Symptoms linked to body burden include fatigue, digestive issues, brain fog, headaches, hormonal imbalances, sleep disruption, anxiety, and in severe cases, autoimmune and chronic illness. Yet these symptoms are often dismissed as “normal aging.”

    Body Burden: Hope For Deeper Healing brings this overlooked epidemic into sharp focus, presenting credible science, expert insight, and deeply personal stories that reveal both the dangers and the hope.

    Register for the Free Body Burden Screening

    The Story Behind Body Burden: Nicolas Pineault’s Personal Journey

    For more than 16 years, Nicolas Pineault – widely known as “The EMF Guy” – has investigated environmental health risks. His early work focused on electromagnetic fields (EMFs), but his research soon led him into the broader, interconnected world of environmental toxins.

    In 2024, Pineault traveled to Deeper Healing, a medical center in South Carolina. The clinic was gaining attention for its work with patients suffering conditions mainstream medicine labeled as “incurable.” Instead of offering prescriptions to mask symptoms, the physicians at Deeper Healing focused on dramatically lowering each patient’s toxic load.

    Pineault decided to test himself. The results shocked him:

    Lead levels 34 times above normal

    Mercury levels 29 times above normal

    Three different doctors told him these were levels typically found in welders or lifelong industrial workers. Yet Pineault was a healthy, active 37-year-old athlete. His ongoing brain fog, fatigue, and digestive issues suddenly had an explanation.

    The turning point came when he began applying the detoxification strategies used at the clinic: sauna therapy, targeted supplementation, air and water filtration, and lifestyle shifts. Within weeks, his energy improved. His focus returned. For Pineault, this was not simply a professional investigation – it was a personal transformation.

    That experience became the foundation of Body Burden: Hope For Deeper Healing.

    Inside the Deeper Healing Clinic: Doctors Leading a Movement

    The film introduces viewers to pioneering doctors who represent the front line of environmental medicine.

    Dr. Michael Bauerschmidt: Board-certified in environmental medicine, former ER doctor. His journey from conventional emergency care to root-cause detoxification reflects the growing shift in medicine. Bauerschmidt emphasizes how reducing toxic load can help patients regain vitality without relying on endless prescriptions.

    Dr. Stephanie McCarter: Specialist in electro sensitivity and mold-related illness. McCarter has worked with patients suffering from EMF-triggered migraines, anxiety, and neurological symptoms, demonstrating the link between modern technology and toxic stress.

    Dr. William Rea (in memoriam): Founder of the Environmental Health Center in Dallas. Rea was one of the first to recognize chemical sensitivity as a legitimate condition, decades before it entered mainstream conversation.

    Dr. Walter Crinnion (in memoriam): A pioneer in naturopathic medicine and detoxification strategies. His research laid the groundwork for many protocols now in use worldwide.

    Together, their message is unified: health is not restored by masking symptoms, but by lowering toxic exposure and supporting the body’s natural resilience.

    Patient Success Stories Featured in Body Burden

    Brandon: Recovery from Heavy Metal Exposure

    Brandon’s life began unraveling in his early 40s. His once sharp memory and quick cognition dulled. Brain fog became so severe he struggled to type an email or remember the names of close friends. Years of work-related exposure to lead, asbestos, and mercury had taken a toll.

    At Deeper Healing, Brandon was introduced to protocols designed to lower toxic burden: targeted chelation therapy, sauna-based detox, nutritional support, and environmental adjustments at home. Within three months, Brandon’s cognition and vitality improved dramatically. Several years later, he continues to apply these strategies, maintaining his health and avoiding relapse.

    Ava: A Teenager’s Battle with Mold Illness

    Ashley’s daughter, Ava, was a vibrant teenager until unexplained symptoms began to appear. She developed anxiety, unusual skin discoloration, and fainting spells. Testing revealed her body was under immense stress from mold illness. Her bedroom contained 400% higher mycotoxin levels than any other room in the house.

    Specialists prescribed targeted detoxification: binding agents to capture mold toxins, immune support, and environmental remediation. Air filtration systems were installed, and the mold was removed. Over time, Ava’s symptoms resolved. She regained her health, and her family learned how environmental factors could silently erode wellness.

    Catherine: From Despair to Renewal

    Catherine’s story is one of near collapse. She developed dizziness, numbness on one side of her body, and severe insomnia. Panic attacks followed, leaving her unable to care for her four children. Multiple neurologists told her nothing was wrong.

    At Deeper Healing, testing revealed high levels of accumulated toxins, compounded by household exposures. By cleaning her home environment, installing water and air filtration, and following a personalized detox plan, Catherine recovered. Within weeks, her children’s eczema cleared as well. Today, the entire family thrives.

    These stories illustrate a powerful truth: body burden is real, measurable, and reversible.

    What Sets Body Burden Apart from Other Health Documentaries

    The wellness film genre has grown rapidly in recent years, but Body Burden stands apart for three key reasons:

    Comprehensive Scope: While many films focus on diet or fitness, Body Burden tackles the overlooked spectrum of toxins – chemicals, heavy metals, mold, and EMFs.

    Personal Connection: By sharing his own shocking test results, Nicolas Pineault adds credibility and relatability to the story.

    Actionable Strategies: Viewers leave with not just awareness, but practical steps to lower their own toxic load.

    Compared to quick online videos or fragmented social media content, Body Burden uses the documentary format to explore issues in depth. Its 61 minutes provide both the science and the human stories necessary to inspire meaningful change.

    Practical Lessons Viewers Can Apply from Body Burden

    The documentary is not entertainment alone – it is a call to action. Practical strategies highlighted include:

    Filter Indoor Air and Water: Reduce exposure to mold spores, VOCs, heavy metals, and chemical residues.

    Replace Household Cleaning Products: Swap chemical-based cleaners for non-toxic alternatives.

    Choose Safe Cookware: Avoid Teflon and aluminum pans that leach chemicals and metals into food.

    Remediate Mold: Address water damage promptly and use air filtration to prevent mycotoxin buildup.

    Reduce EMF Exposure: Limit device use before bed, move Wi-Fi routers away from sleeping areas, and consider shielding strategies.

    Support Natural Detoxification: Explore sauna therapy, nutrient support, hydration, and dietary changes under professional guidance.

    These steps empower individuals to take control of their health environment, one choice at a time.

    Learn More About Body Burden: Hope For Deeper Healing

    Why Documentaries Matter More Than Ever in 2025

    Misinformation is rampant. Social media offers snippets without context. Medical journals provide rigor, but are inaccessible to most readers. In this gap, documentaries have become one of the most trusted formats for health education.

    Studies in public health communication show that long-form storytelling combined with expert interviews increases knowledge retention and inspires behavior change. Viewers of health documentaries often report adopting new habits within weeks – a stronger impact than traditional advertising.

    Body Burden embodies this trend, offering both credibility and relatability. It shows how the combination of science, expert testimony, and human experience can create lasting change.

    Frequently Asked Questions

    What is the Body Burden documentary about?

    It explores how toxins accumulate in the body, driving chronic illness, and how reducing toxic load supports healing.

    Who should watch it?

    Anyone concerned about fatigue, brain fog, or chronic illness; families wanting safer homes; health professionals seeking educational resources.

    How long is the documentary?

    61 minutes.

    When is the free screening?

    September 15-22, 2025.

    Where can I register?

    At the official site: Register for the Free Body Burden Screening.

    Is this film medical advice?

    No. It is an educational documentary intended for informational purposes.

    Will there be a cost after the free screening?

    Yes, paid access options will be available after the free event.

    Final Verdict: Why Body Burden Is a Must-Watch in 2025

    Body Burden: Hope For Deeper Healing is not a casual documentary. It is a wake-up call about the hidden toxins silently undermining global health. By weaving together credible science, pioneering doctors, and personal transformations, it provides both knowledge and hope.

    For anyone experiencing unexplained fatigue, digestive issues, anxiety, or chronic illness, this film delivers essential insights. For families, it offers a roadmap to healthier living. For professionals, it is a resource to spark conversation and education.

    Watch the Official Body Burden Documentary Here

    Bonus Section: Strategic Ways to Maximize the Value of Body Burden in 2025

    Take Notes During Viewing: Write down detox strategies, environmental tips, or expert quotes that resonate.

    Watch as a Family: Shared viewing creates alignment on healthier practices.

    Host Group Screenings: Community health groups, workplaces, and schools can use the film to spark dialogue.

    Act Immediately: Implement one change after watching – replace a product, filter water, or reduce EMF exposure.

    Rewatch Key Segments: Expert interviews and scientific explanations often yield new insights on repeat viewings.

    Use as a Springboard: Explore referenced studies and continue your learning journey.

    Contact Information

    Company: Body Burden: Hope For Deeper Healing

    Email:support@theemfguy.com

    Disclaimer: This press release contains affiliate links. The publisher may earn a commission if you purchase through them at no additional cost to you. Body Burden: Hope For Deeper Healing is an educational documentary and not medical advice. Individual results vary. Always consult a licensed healthcare provider before making changes to diet, lifestyle, or medical care. Prices and promotions may change without notice. Only registrations through the official site guarantee access.

    Sources

    Environmental Working Group (EWG)

    Smithsonian Magazine

    EPA Indoor Environment Division

    NIEHS (National Institute of Environmental Health Sciences)

    ScienceDirect

    Contact Information

    Body Burden Customer Support
    support@theemfguy.com

    Source: Body Burden: Hope For Deeper Healing

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  • Nabors Announces Partial Redemption of 7.375% Senior Priority Guaranteed Notes Due in 2027

    Nabors Announces Partial Redemption of 7.375% Senior Priority Guaranteed Notes Due in 2027

    HAMILTON, Bermuda, Sept. 8, 2025 /PRNewswire/ — Nabors Industries, Inc (“Nabors” or the “Company”), a wholly-owned subsidiary of Nabors Industries Ltd. (“Parent”) (NYSE: NBR) today announced that it has given notice of redemption of $150 million face value of its 7.375% Senior Priority Guaranteed Notes due in 2027. The redemption date is September 30, 2025 and the redemption price is 101.844% of the principal amount of securities to be redeemed, plus accrued and unpaid interest.

    Anthony G. Petrello, Nabors Chairman, President and CEO, commented, “The reduction of debt is one of our key value drivers. We are committed to using the proceeds from the sale of Quail Tools in our business to help accomplish that reduction. This redemption comes after we already repaid the outstanding balance on our revolving credit facility, which was drawn earlier to repay the term loan assumed from Parker Wellbore. The redemption marks another concrete step in this process.”   

    About Nabors Industries

    Nabors Industries (NYSE: NBR) is a leading provider of advanced technology for the energy industry. With presence in more than 20 countries, Nabors has established a global network of people, technology and equipment to deploy solutions that deliver safe, efficient and responsible energy production. By leveraging its core competencies, particularly in drilling, engineering, automation, data science and manufacturing, Nabors aims to innovate the future of energy and enable the transition to a lower-carbon world. Learn more about Nabors and its energy technology leadership: www.nabors.com.

    Forward-looking Statements

    The information included in this press release includes forward-looking statements within the meaning of the Securities Act of 1933 and the Securities Exchange Act of 1934. Such forward-looking statements are subject to a number of risks and uncertainties, as disclosed by Nabors from time to time in its filings with the Securities and Exchange Commission. As a result of these factors, Nabors’ actual results may differ materially from those indicated or implied by such forward-looking statements. The forward-looking statements contained in this press release reflect management’s estimates and beliefs as of the date of this press release. Nabors does not undertake to update these forward-looking statements. 

    Investor Contacts:  William C. Conroy, CFA, Vice President of Corporate Development & Investor Relations, +1 281-775-2423 or via e-mail [email protected], or Kara K. Peak, Director of Corporate Development & Investor Relations, +1 281-775-4954 or via email [email protected]. To request investor materials, contact Nabors’ corporate headquarters in Hamilton, Bermuda at +441-292-1510 or via e-mail [email protected]

    SOURCE Nabors Industries Ltd.

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