Exposure to high concentrations of air pollution may worsen Alzheimer’s disease (AD) by accelerating the buildup of toxic proteins in the brain and speeding up cognitive decline. For the first time, post-mortem tissue from people with AD revealed that those who lived in areas with higher concentrations of fine particulate matter in the air even just one year had more severe accumulation of amyloid plaques and tau tangles — hallmarks of Alzheimer’s pathology — compared to those with less exposure. These individuals also experienced faster cognitive and functional decline, including memory loss, impaired judgment, and difficulty with personal care, according to research published today (September 8) in JAMA Neurologyfrom the Perelman School of Medicine at the University of Pennsylvania.
“This study shows that air pollution doesn’t just increase the risk of dementia — it actually makes Alzheimer’s disease worse,” said Edward Lee, MD, PhD, co-director of Penn’s Institute on Aging. “As researchers continue to search for new treatments, it’s important to uncover all of the factors that contribute to the disease, including the influence of the environment in which they live.”
Health risks from tiny air particles
Air pollution is made up of fine particulate matter, or the tiny, inhalable particles, ranging from 10 micrometers to less than 2.5 micrometers wide, about half the width of a single strand of spider web. It can come from wildfire smoke, car exhaust, construction site debris, or combustion from factories. Particulate matter 2.5 micrometers and smaller (PM2.5) is so small that when inhaled, the particles can be absorbed into the blood stream and cause health concerns. Previous research has linked air pollution containing PM2.5 with dementia, loss of cognitive function, and accelerated cognitive decline.
The researchers examined brain samples from over 600 autopsies from the Penn Medicine Brain Bank. Using data from satellites and local air quality monitors, the researchers modeled the amount of PM2.5 in the air based on where each person lived. They found that for every increase of 1 microgram per cubic meter of PM2.5, the risk for worse Alzheimer’s disease amyloid and tau buildup increased by 19 percent.
Further, when they examined the clinical records of these individuals, researchers found that those who lived in areas with high concentrations of PM2.5 with advanced pathology also had greater cognitive impairment and more rapid onset of symptoms, including memory loss, difficulty with speech, and diminished judgement, compared to people who lived in areas with lower concentrations of air pollution.
While this study focused on exposures to PM2.5 based on geographic location, researchers acknowledgethat they could not account for individual-specific exposures to air pollution, such as exposure to second-hand smoke in the home, or working with potentially dangerous chemicals.
“In the United States, air pollution is at the lowest levels in decades, but even just a year living in an area with high levels of pollution can have a big impact on a person’s risk for developing Alzheimer’s disease,” said Lee. “It underscores the value of environmental justice efforts that focus on reducing air pollution to improve public health.”
This research is funded by the National Institutes of Health and the National Institute of Environmental Health Sciences (P30AG072979, P01AG066597, U19AG062418, P01AG084497, and P30ES013508).
Sphere Entertainment spent an estimated $2.3B on a huge, state-of-the-art venue in Las Vegas, 366 feet tall and 516 feet wide, and launched it in 2023 with a U2 performance.
IN the summer of 1982, there was talk of a new medical college coming up in Karachi. It was to be Pakistan’s first such institution in the private sector and was being launched by a highly reputed enterprise, the Aga Khan Development Network. An imposing boundary wall along Stadium Road testified to this emerging reality. For prospective medical students like me, this was electrifying news. In those days Pakistan’s medical education landscape was in disarray because of politicised campuses, and the five-year MBBS programme was taking much longer.
Although there had been no official announcement, I made enquiries and came upon the name of a certain Dr Camer Vellani as the project’s central figure. The phone directory listed a number for his clinic, which I dialled one evening with apprehension and anticipation. When Dr Vellani came on the line and took me through the basics of the project, I was hooked. The following year, I was fortunate to be admitted to the Aga Khan University Medical College’s inaugural class, a group of 50 selected from an applicant pool of over 5,000.
The opening week included an orientation by Dr Vellani, who was associate dean. The moment he walked in, the room filled up with his quiet and dignified presence. A slender frame adorned with a scholarly bespectacled bearing, he spoke with a soft but commanding eloquence. After introductory remarks, he scribbled a searching question on the blackboard: “What am I doing here?” — emphasising each word one by one. A fundamental query was thus transformed into several, prodding us to self-reflect. You can judge the impact of that moment from the fact that it has stayed with my classmates and me ever since.
In 1985, when our clinical years began, we encountered Dr Vellani more often. He was founding chairman of the department of medicine and a decorated professor of medicine and cardiology. He taught us how to extract a systematic medical history and conduct an orderly physical examination. I happened to be one of the more excitable students in our class and would try Dr Vellani’s patience from time to time, but he never betrayed any irritation or annoyance. His method was steady gentlemanly persuasion conveyed with calmness and composure.
‘He made us want to be like him.’
Before long, we were all looking up to him not just as a teacher or mentor, but also as a father figure and a role model. We watched with rapt attention while he conducted his outpatient clinics, being unfailingly generous with his time and wisdom to both patients and students alike. We stood mesmerised at the bedside as he elicited challenging physical signs, such as a third or fourth heart sound or an abnormally robust pulsation in the jugular vein. We sat captivated as he elaborated on the biological aspects of heart failure or, his particular favourite, the physics of electrocardiography. The long and short of it is that we outright idolised him.
Our class graduated in 1988 and scattered to pursue advanced specialisation in our chosen fields. I spent a decade in the US and returned in 2000 to join the Aga Khan faculty as assistant professor of neurology. During this time Dr Vellani had served in a series of leadership roles, including a term as rector (equivalent to vice chancellor). He was revered as a medical statesman, combining the qualities of a master clinician, an impactful academic and a seasoned administrator in one inspiring and edifying persona. I went to his office to pay my respects and to apologise for having been rather a boisterous student. Dr Vellani would have none of it. He laughed a soft, gentle laugh and said “Saad, you never gave me any trouble.” Then, with a twinkle and an affectionate smile he added, “Well, perhaps just a little.” I was quickly reminded of the many reasons we had admired and adored him.
For the last few months, the word got out that Dr Vellani was unwell, triggering widespread concern across the institution. Early on the morning of Sept 4, he breathed his last; he was 88. His body may have weakened, but his mind remained sharp. A colleague who was with him in the final hours heard him express gratitude at having been granted a blessed life; perhaps he had a premonition that his time had come. Dr Vellani had exited with the same dignified elegance that had marked him throughout his long and rewarding life, a life of unmatched dedication and exemplary service. He helped and healed generations of sick patients, and motivated and inspired legions of medical students towards clinical excellence. He made us want to be like him. If the most consequential measure of a life is the sum of your good deeds, then Dr Vellani rests most comfortably and the rest of us stand enriched.
The writer is professor of neurology at Aga Khan University.
X: @_saadshafqat
Published in Dawn, September 9th, 2025
Chennai (Tamil Nadu) [India] September 9 (ANI): In a major development for the upcoming Men’s FIH Hockey Junior World Cup, Hockey India Secretary General Bhola Nath Singh has confirmed that Pakistan will participate in the event.
The event will be hosted across Chennai and Madurai.
Hockey India Secretary General Bhola Nath Singh confirmed to ANI that there is “no problem” and that Pakistan “will be coming” to India for the tournament.
He also affirmed that preparations are in their final stages and assured that the Junior World Cup will be organised on a grand scale.
“The World Cup is being held in Chennai and Madurai, with 24 countries participating. We are at the last stage of preparations, and this will be organised in a grand manner that will send a unique message across the world,” he said.
On Monday, the highly anticipated match schedule for the FIH Hockey Men’s Junior World Cup Tamil Nadu 2025 was announced in a ceremony that took place in Chennai.
The World Cup, which, for the very first time, will see participation from 24 teams from around the world, will be played in the cities of Chennai and Madurai in Tamil Nadu, India, from November 28 to December 10.
The ceremonytook place in the presence of FIH President Tayyab Ikram, Deputy Chief Minister of Tamil Nadu, Udhayanidhi Stalin; Atulya Misra (IAS), Additional Chief Secretary to the Government of Tamil Nadu, J. Meghanatha Reddy (IAS), Chief Executive Officer/Member Secretary of the Sports Development Authority of Tamil Nadu (SDAT); Hockey India President Dilip Tirkey; Hockey India Secretary General Bholanath Singh; and Hockey India Treasurer Sekar J Manoharan.
Title holders Germany will take on South Africa for an opening match in Madurai.
The hosts, India, will start their Junior World Cup campaign against Chile in Chennai.
The pools for the competition were revealed earlier this year on 28 June as follows:
Pool A: Germany, South Africa, Canada, Ireland
Pool B: India, Pakistan, Chile, Switzerland
Pool C: Argentina, New Zealand, Japan, China
Pool D: Spain, Belgium, Egypt, Namibia
Pool E: Netherlands, Malaysia, England, Austria
Pool F: France, Australia, Korea, Bangladesh. (ANI)
(This content is sourced from a syndicated feed and is published as received. The Tribune assumes no responsibility or liability for its accuracy, completeness, or content.)
Scientists have discovered why older people are more likely to suffer severely from the flu, and can now use their findings to address this risk.
In a new study, which is published in PNAS, experts discovered that older people produce a glycosylated protein called apoplipoprotein D (ApoD), which is involved in lipid metabolism and inflammation, at much higher levels than in younger people. This has the effect of reducing the patient’s ability to resist virus infection, resulting in a more serious disease outcome.
The team established that highly elevated ApoD production with age in the lung drives extensive tissue damage during infection to reduce the protective antiviral type I interferon response.
The research was an international collaboration led by scientists from the China Agricultural University, University of Notttingham, Institute of Microbiology (Chinese Academy of Sciences), National Institute for Viral Disease Control and Prevention (Chinese Centre for Disease Control and Prevention) and the University of Edinburgh.
Aging is a leading risk factor in influenza-related deaths. Furthermore, the global population is aging at an unprecedented rate in human history, posing major issues for healthcare and the economy. So we need to find out why older patients often suffer more severely from influenza virus infection.”
Professor Kin-Chow Chang, School of Veterinary Medicine and Science, University of Nottingham, and co-author on the paper
In this new study, the team investigated the mechanisms behind increased severity of influenza virus infection with age using an aging-mouse model and appropriate donor human tissue sections.
They identified ApoD as an age-related cell factor that impairs the activation of the immune system’s antiviral response to influenza virus infection by causing extensive breakdown of mitochondria (mitophagy) resulting in greater production of virus and lung damage during infection. Mitochondria are essential for cellular production of energy and for induction of protective interferons.
ApoD is therefore a target for therapeutic intervention to protect against severe influenza virus infection in the elderly which would have a major impact on reducing morbidity and mortality in the aging population.
Professor Chang, added: “There is now an exciting opportunity to therapeutically ameliorate disease severity of the elderly from influenza virus infection by the inhibitory targeting of ApoD.”
Exposure to high concentrations of air pollution may worsen Alzheimer’s disease (AD) by accelerating the buildup of toxic proteins in the brain and speeding up cognitive decline. For the first time, post-mortem tissue from people with AD revealed that those who lived in areas with higher concentrations of fine particulate matter in the air even just one year had more severe accumulation of amyloid plaques and tau tangles-hallmarks of Alzheimer’s pathology-compared to those with less exposure. These individuals also experienced faster cognitive and functional decline, including memory loss, impaired judgment, and difficulty with personal care, according to research published today in JAMA Neurology from the Perelman School of Medicine at the University of Pennsylvania.
This study shows that air pollution doesn’t just increase the risk of dementia-it actually makes Alzheimer’s disease worse. As researchers continue to search for new treatments, it’s important to uncover all of the factors that contribute to the disease, including the influence of the environment in which they live.”
Edward Lee, MD, PhD, co-director of Penn’s Institute on Aging
Air pollution is made up of fine particulate matter, or the tiny, inhalable particles, ranging from 10 micrometers to less than 2.5 micrometers wide, about half the width of a single strand of spider web. It can come from wildfire smoke, car exhaust, construction site debris, or combustion from factories. Particulate matter 2.5 micrometers and smaller (PM2.5) is so small that when inhaled, the particles can be absorbed into the blood stream and cause health concerns. Previous research has linked air pollution containing PM2.5 with dementia, loss of cognitive function, and accelerated cognitive decline.
The researchers examined brain samples from over 600 autopsies from the Penn Medicine Brain Bank. Using data from satellites and local air quality monitors, the researchers modeled the amount of PM2.5 in the air based on where each person lived. They found that for every increase of 1 microgram per cubic meter of PM2.5, the risk for worse Alzheimer’s disease amyloid and tau buildup increased by 19 percent.
Further, when they examined the clinical records of these individuals, researchers found that those who lived in areas with high concentrations of PM2.5 with advanced pathology also had greater cognitive impairment and more rapid onset of symptoms, including memory loss, difficulty with speech, and diminished judgement, compared to people who lived in areas with lower concentrations of air pollution.
While this study focused on exposures to PM2.5 based on geographic location, researchers acknowledge that they could not account for individual-specific exposures to air pollution, such as exposure to second-hand smoke in the home, or working with potentially dangerous chemicals.
“In the United States, air pollution is at the lowest levels in decades, but even just a year living in an area with high levels of pollution can have a big impact on a person’s risk for developing Alzheimer’s disease,” said Lee. “It underscores the value of environmental justice efforts that focus on reducing air pollution to improve public health.”
This research is funded by the National Institutes of Health and the National Institute of Environmental Health Sciences (P30AG072979, P01AG066597, U19AG062418, P01AG084497, and P30ES013508).
Source:
University of Pennsylvania School of Medicine
Journal reference:
Kim, B., et al. (2025). Ambient Air Pollution and the Severity of Alzheimer Disease Neuropathology. JAMA Neurology. doi.org/10.1001/jamaneurol.2025.3316
ISLAMABAD: The divide among judges is widening by the day as four senior judges stayed away from the 156th full court conclave — convened by Chief Justice of Pakistan Yahya Afridi to approve the Supreme Court Rules, 2025 — and wrote a letter objecting to the ‘cosmetic role’ of the Monday exercise.
As the scheduled meeting of the full court commenced, senior puisne judge Justice Syed Mansoor Ali Shah, Justice Munib Akhtar, Justice Ayesha A. Malik and Justice Athar Minallah informed CJP Afridi through a letter that there was no point in attending the meeting.
“The convening of the full court at this stage is not only puzzling but also fallacious,” they wrote.
Soon after the full court meeting, the SC issued a statement about the meeting, but it did not make any mention of the letter or the absence of the four senior judges while naming all the other judges who were in attendance.
The full court meeting was called by the CJP with a single-point agenda of according an approval to the new rules, which substitute the 1980 rules.
In letter to CJP, Justices Shah, Akhtar, Malik and Minallah say people must know how rules governing apex court could be ‘notified without discussion’
In their letter, the four judges highlighted that the CJP had on Aug 12 informed the SC judges that the rules had already been approved by circulation and duly notified in the gazette on Aug 9 and yet sought suggestions for further amendments to the rules, which were to be placed before the full court meeting.
By seeking its views only after notifying the rules, the exercise reduces the full court to a cosmetic role, a forum for ratifying what had already been done rather than discharging its true function under Article 191 of the Constitution, the judges noted.
“In effect, the meeting is being used to give a veneer of legitimacy to an otherwise invalid process,” the letter pointed out.
According to them, the constitutionally consistent and institutionally honest course would be to place the rules, in their entirety, before the full court, permit genuine discussion and deliberation, and only thereafter seek formal approval.
The deficiencies identified in this letter cannot be remedied by the expedient of convening a meeting that is designed merely to serve as a stamp of approval for the existing position. Such a meeting is, in fact, a contradiction in terms and ought therefore to be abandoned.
To proceed otherwise is to reduce the full court to an afterthought, convened not for decision-making but for damage control, the letter said. “It is a fallacious purpose, one that undermines the collective authority of this court,” it added.
The judges claimed that they did not see any point in attending a meeting that was premised on amending rules which, according to their opinion, had already suffered from illegality both in substance and in process. They said the working paper also recorded that some initial input had been received from the legal community, which was yet to be considered by the committee. “At the outset, we must reiterate the objection we have consistently raised that the present rules were never placed before, nor approved by, the full court in the first instance,” they emphasised.
“This omission is not merely procedural but goes to the very root of legality as Article 191 of the Constitution vests the Supreme Court with the power to make rules regulating its practice and procedure, but this power is exercised collectively by the court as an institution,” the letter stated. It added that the rules framed without prior deliberations and approval of the full court lacked the imprimatur of the court itself and could not acquire binding legal status.
The judges said what compounded this infirmity was the method adopted for “approval”.
The rules were processed through circulation, an administrative convenience to deal with routine or minor procedural matters; it is not, and cannot be, the vehicle for laying down the constitutional architecture of this court’s governance.
Unless the full court itself had expressly resolved to adopt circulation for this purpose, the CJP alone could not unilaterally resort to it, the judges argued.
The judges demanded that their “objections be fully recorded in the minutes of the meeting and that the minutes of the full court be made public”.
People are entitled to know how rules governing the internal life of the court came to be notified without discussion or deliberation amongst its judges, and how a post-facto meeting was being used to cloak that process in a semblance of legitimacy, they remarked.
Full court proceedings
At the outset of the full court meeting, the CJP welcomed the participants and commended the efforts of the committee constituted to review the SC Rules, 1980 and appreciated the four-judge committee’s exhaustive work, undertaken with input from judges and the legal fraternity, resulting in a comprehensive draft of the rules.
Justice Shahid Waheed, chairman of the committee, briefed the full court on the rules and after detailed deliberations, the full court agreed that the new rules were a “living document”, and would be subject to review and amendment as required from time to time.
After considering different aspects and deliberating upon some of the critical provisions, the full court decided to postpone the implementation of amendments to the extent of enhancement of court fees and securities for the time being. The committee will consider the suggestions from judges, the bar representatives or other stakeholders in this regard for placement before the full court for a decision in light of recommendations.
The CJP termed this development a significant milestone, reflecting the judiciary’s commitment to strengthening institutional frameworks and ensuring that the rules remain dynamic, responsive, and in line with contemporary needs.
Published in Dawn, September 9th, 2025
KARACHI: At least eight people — including two attackers — were killed after a deadly shooting attack in occupied East Jerusalem, Israeli authorities said, as the occupied West Bank braced itself for a possible reprisal.
Al Jazeera quoted paramedics as saying that at least 12 people were injured and six were in “serious condition” after the shooting on Monday morning at Ramot Junction.
Israeli police described the shooting as a suspected “terror attack”, Al Jazeera reported, adding that a security officer and an armed civilian shot and killed the perpetrators soon after the shooting began.
The police said the perpetrators arrived in a vehicle and opened fire at a bus station.
Four of the dead were ultra-Orthodox Israeli men, according to local media, while another was a recent immigrant from Spain.
Israeli forces closed all checkpoints between East Jerusalem and the occupied West Bank after the attack, sources told Al Jazeera.
After police said the perpetrators had come from the occupied West Bank, Israeli Army Radio reported Israeli forces imposed a military cordon on four villages in the Jerusalem governorate in the territory — Qatana, Biddu, Beit Inan and Beit Duqu — and conducted raids there.
The Israeli military said it had reinforced its forces in the wider Jerusalem area and was conducting a wide-ranging search for what it described as “accomplices” in the shooting.
Palestinians in the West Bank are preparing themselves to face collective punishment from Israel in retaliation for the attack, a Palestinian journalist said.
According to an Al Jazeera journalist, Israeli authorities said the two perpetrators came from an area in the occupied West Bank that is just west of East Jerusalem.
They claimed the two worked in tandem; both gunmen boarded a bus — witnesses say one of them was dressed as a ticket inspector — and opened fire.
Israeli officials are now trying to wrap their heads around how exactly this happened, saying that they haven’t seen something like this happen in years, saying that the last shooting like this in greater Jerusalem was back in November 2023, Al Jazeera reported.
Israel’s far-right Finance Minister Bezalel Smotrich blamed the attack on the Palestinian Authority, which he claimed “raises and educates its children to murder Jews”.
But the Palestinian presidency in Ramallah said it “firmly rejected and condemned any targeting of Palestinian and Israeli civilians,” the official Palestinian news agency Wafa reported.
The PA is a civilian ruling authority in areas of the West Bank, where about three million Palestinians live — as well as around half a million Israelis occupying settlements considered illegal under international law.
Published in Dawn, September 9th, 2025