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  • Successful Transition From Covert, Involuntary Oral Medication to Consensual, Long-Acting, Injectable Antipsychotic Therapy in a Patient With Schizophrenia: A Case Report From Japan

    Successful Transition From Covert, Involuntary Oral Medication to Consensual, Long-Acting, Injectable Antipsychotic Therapy in a Patient With Schizophrenia: A Case Report From Japan


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  • Brad Pitt stars in ad from Taika Waititi for espresso machine that costs nearly $1,500

    Brad Pitt stars in ad from Taika Waititi for espresso machine that costs nearly $1,500

    If you love the smell of commercialism in the morning, here’s something to drink up.

    Brad Pitt – everyone’s favorite 61-year-old actor, producer and beard-grower – is the star of a new espresso machine ad for De’Longhi from Oscar-winning director Taika Waititi.

    The gig is not new for Pitt, who’s been a spokesperson for the company since 2021, but it is for Waititi, who won the Academy Award for best adapted screenplay for his film “Jojo Rabbit” in 2019. (Another Oscar-winner, Damien Chazelle, directed Pitt’s first ad for the company.)

    In the advertising spot, which debuted at the Venice Film Festival and widely on Monday, Pitt makes himself an espresso drink while a humorous voiceover from Italian actor Riccardo Scamarcio guides him through the seemingly easy process and critiques his Italian as Pitt struggles to say “Perfetto” to the narrator’s satisfaction.

    Even Pitt’s furry, four-legged co-star seems to be judging his accent a little, but if you believe a dog that gorgeous does anything but judge everyone around it, you haven’t been paying attention.

    Speaking of judgement, the machine used by Pitt in the spot retails for $1,499.95 – a quaint deal compared to the one flashed at the end of the commercial, which goes for $1,999.95. Perfetto for the average person? Probably not. Good thing is we normal folks don’t need a fancy machine for the perfect poor-over.

    Pour. I mean pour.


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  • Neurolief Announces Publication of Groundbreaking MOOD Study Demonstrating Efficacy of Home or Clinic-Based Neuromodulation Therapy for Major Depressive Disorder

    Neurolief Announces Publication of Groundbreaking MOOD Study Demonstrating Efficacy of Home or Clinic-Based Neuromodulation Therapy for Major Depressive Disorder

    CORAL SPRINGS, Fla., Sept. 9, 2025 /PRNewswire/ — Neurolief, a neurotechnology company, is proud to announce the publication of the MOOD study. This trial is the first pivotal multicenter randomized sham-controlled clinical trial evaluating the safety and efficacy of Proliv™Rx, for Major Depressive Disorder (MDD). The study evaluated this novel neuromodulation therapy for MDD that had not responded well to prior treatment.

    The study, recently accepted by the Journal, Brain Stimulation, was conducted by a distinguished team of researchers including Dr. Linda L. Carpenter (Butler Hospital, Brown University), Dr. Mark S. George (Medical University of South Carolina), and Dr. Andrew F. Leuchter (UCLA), among others. It involved 160 patients battling severe and chronic depression across 13 US and international clinical sites. The independent investigators assessed the impact of the technology, classified as “external Combined Occipital and Trigeminal Afferent Stimulation “(eCOT-AS) on hard-to-treat-depression.

    Key Findings:

    • Significant improvement in depressive symptoms among patients using Proliv™Rx compared to sham controls.
    • Favorable safety profile with minimal adverse events.
    • High patient adherence and satisfaction with the home-based treatment protocol.

    “This publication marks a major milestone for both Neurolief and for the field of mental health,” said Scott Drees, Chief Executive Officer at Neurolief. “The MOOD study validates our vision of delivering effective, accessible, and personalized neuromodulation therapy to patients suffering from MDD. We are now one step closer to making Proliv™Rx available to millions in need.”

    Dr. Linda Carpenter, Principal Investigator of the MOOD study, added:

    “The need for new treatment options for those battling treatment-resistant depression is urgent and unmet. Proliv™Rx offers an accessible and effective solution for patients whose depression is unresponsive to medications, many of whom have endured years of persistent symptoms. This therapy has the potential to become an essential tool in the mental health treatment landscape.”

    The MOOD study builds on Neurolief’s commitment to advancing non-invasive brain therapies. The Proliv™Rx system, which received FDA Breakthrough Device Designation, integrates adaptive stimulation with remote monitoring via a dedicated app and cloud-based analytics platform.

    The full manuscript, titled “A Novel Home-Based Neuromodulation Therapy for Major Depressive Disorder: Efficacy and Safety Results from a Multicenter Randomized Sham-Controlled Study,” is in press at Brain Stimulation: https://doi.org/10.1016/j.brs.2025.08.022 

    About Neurolief
    Neurolief is a pioneering neuromodulation company committed to developing breakthrough therapies for mental health and neurological disorders. The company has developed the world’s first wearable, non-invasive, multi-channel brain neuromodulation system, that is designed for home use, engineered to simultaneously stimulate key neural pathways in the head to modulate brain regions involved in the regulation of mood and pain. Neurolief’s technology is currently FDA-cleared and CE-marked for the treatment of migraine, and the company is actively seeking regulatory approvals for Proliv™Rx, its flagship product for the treatment of Major Depressive Disorder. If granted, Neurolief will be the first medical device company to offer an FDA-approved MDD treatment that can be delivered outside of the clinic. Learn more at: www.neurolief.com

    Logo – https://mma.prnewswire.com/media/2754768/Neurolief_Logo.jpg

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  • Thales Survey Reveals Growing Interest in Mobile IDs, Digital Driver Services Across US, Canada – Thales

    1. Thales Survey Reveals Growing Interest in Mobile IDs, Digital Driver Services Across US, Canada  Thales
    2. Does digital ID have risks even if it’s ZK-wrapped?  CryptoSlate
    3. Are the non-tech savvy facing an identity crisis?  InYourArea
    4. Montana residents can use digital driver’s licenses starting Sept. 1  NonStop Local Montana
    5. Digital Identity: Global Roundup  THINK Digital Partners

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  • Will there be a ‘September surge’ in hiring this year? Experts weigh in

    Will there be a ‘September surge’ in hiring this year? Experts weigh in

    After this summer’s weak job market performance, some career experts are hoping that fall will bring more opportunities for job seekers.

    There’s a popular belief that the job market kicks into high gear in early autumn, commonly known as the “September surge.”

    According to Katie Martocchio, senior talent acquisition manager at software company Prompt, the month of September brings a spike in productivity for employers and job seekers alike.

    Coasting off of fall’s “back-to-school energy,” companies start “getting back into the groove” after Labor Day, she says, and year-end goals become top of mind.

    “Now is the time that we can onboard someone, and they can help support and drive those goals to that finish line,” Martocchio says.

    Here’s what Martocchio and other career experts say about this year’s “September surge,” and how job seekers can prepare to take advantage of the fall boost.

    Why the ‘September surge’ happens

    According to Maribel Valencia, a corporate and technical recruiter based in Las Vegas, Nevada, timing is a major factor in the September surge.

    By September, most vacationers have returned to the office, kids are back in school “and everyone just seems to get back into the rhythm of things,” Valencia says.

    Hiring is typically slow during the summer, she says, but it peaks in fall between Labor Day and the end of October.

    Additionally, she points out that September lands toward the end of Q3, right when many companies are beginning to plan for the next year. Hiring teams are often trying to spend the rest of their budgets before the end of the fiscal year, too.

    Posting open positions in September gives companies plenty of time to “hire, train, acclimate and get everybody ready” ahead of the new year, Valencia says.

    According to career coach Colleen Paulson, the beginning of fall is “just naturally an easier time to start thinking about goals and objectives.”

    “They’re starting to hire folks to get ready to solve next year’s problems,” she says.

    Will the surge happen this year?

    After this summer’s hiring slowdown, Valencia is uncertain that the labor market will bounce back this fall.

    “I think this is the first year that I’m kind of like, is it going to happen?” she says. “Obtaining a job right now is probably the hardest I’ve seen.”

    Amid recession fears, many companies are being particularly cautious about hiring, Paulson says.

    “A lot of companies are trying to figure out where they can cut costs in order to maintain profitability, especially with where this market is,” she says.

    Paulson predicts that the job market will “improve somewhat” in the fall, but she doesn’t anticipate a dramatic change.

    “I think that hiring will certainly pick up compared to where it’s been in the summer,” she says. “Will it be what we’ve seen in the past? I don’t know that we’re going to get there.”

    “In 18 years of doing this work, I feel like this is probably the worst market that I’ve seen,” Paulson continues. “This market is so much more challenging than we see on the surface.”

    Martocchio has a more optimistic view — in her experience, the “September surge” is still happening in 2025, albeit a little earlier than usual. This year, Martocchio says that she posted “a ton” of roles in August so that she could get a head start on hiring timelines.

    “The goal is to have people in seats for September and October, and sometimes you have to do that work ahead of time,” she says.

    How job seekers can prepare for a surge

    Valencia, Paulson and Martocchio all recommend that job seekers update their LinkedIn profiles ahead of a potential hiring surge.

    Having a strong LinkedIn profile can help job seekers with what Paulson calls the “passive job search”: even when you’re not actively looking, “you have this profile set up that’s attracting attention to you,” she says.

    “If you’re not set up with a strong profile there, you’re just missing out,” she adds.

    In Martocchio’s experience, job seekers often put plenty of effort into improving their resumes, but neglect to update their LinkedIn profiles.

    “From a recruiter standpoint, we look at that and we say, ‘I don’t know which one to rely on,’” she says.

    She advises job seekers to ensure that their LinkedIn profiles match the depth of their resumes.

    “It’s great to have them both updated, but making them cohesive, making them match, is something that I think is really important,” Martocchio says.

    Even if more jobs do become available this month, Martocchio cautions job seekers to be strategic about their job search.

    “Especially in the surge, it’s so tempting to just hit apply, apply, apply,” she says.

    Instead, Martocchio recommends investing the majority of your energy into your top jobs. Researching the company and messaging the hiring manager will demonstrate your genuine interest in the role, she says.

    “It’s just about getting your name out there and trying to stand out, because it’s hard nowadays,” she says.

    Last chance to save: Want to stand out, grow your network, and get more job opportunities? Sign up for Smarter by CNBC Make It’s new online course, How to Build a Standout Personal Brand: Online, In Person, and At Work. Learn how to showcase your skills, build a stellar reputation, and create a digital presence that AI can’t replicate.

    Plus, sign up for CNBC Make It’s newsletter to get tips and tricks for success at work, with money and in life, and request to join our exclusive community on LinkedIn to connect with experts and peers.

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  • The ESAs note greater effort from financial market participants in their disclosure of principal adverse impacts

    Similar to previous years, the ESAs surveyed National Competent Authorities and conducted staff-level analysis of publicly available PAI statements from the asset management, insurance and occupational pension sectors and of a sample of financial products’ PAI disclosures. 

    The 2025 Report notes an effort from financial market participants to publish more complete information in compliance with SFDR disclosure requirements, with a general improvement in the quality of information provided.

    In line with previous years, the findings also confirm that financial market participants within larger multinational groups tend to provide more detailed disclosure, while smaller entities often combine general ESG or marketing information with their SFDR disclosures.

    Surveyed National Competent Authorities affirmed that some financial market participants have taken onboard the good practices included in the previous reports and have improved their disclosures.

    Additionally, the 2025 Report also includes recommendations for National Competent Authorities to support their supervision of PAI disclosures and for the European Commission to consider ahead of the forthcoming review of the SFDR.

    Background and legal basis

    PAIs are the most significant negative impacts of investments on the environment and people. When a financial market participant considers principal adverse impacts, it means that it should seek to reduce the negative impact of the companies they invest in.

    Under Article 18 of the SFDR, the ESAs must take stock of the extent of voluntary disclosures at entity and product level and publish a Report on an annual basis by 10 September.

     

    Further information:

    Cristina Bonillo

    Senior Communications Officer
    press@esma.europa.eu

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  • Nepali PM Oli resigns amid protests: Why are ‘nepo kids’ angering youth? | Corruption News

    Nepali PM Oli resigns amid protests: Why are ‘nepo kids’ angering youth? | Corruption News

    Nepal’s Prime Minister Khadga Prasad Sharma Oli resigned on Tuesday amid surging protests that began as a movement against corruption and inequality but exploded into broader calls for change after 19 youths were shot dead by security forces during clashes on Monday.

    Protests continued on Tuesday morning, with agitators torching several buildings seen as associated with Nepal’s elite, even as ministers resigned and pressure built on Oli to follow suit.

    However, despite Oli’s resignation, Nepal remains on edge, with protesters seeking sweeping changes to the country’s political landscape. Kathmandu’s international airport cancelled all flights scheduled for Tuesday.

    Here’s the latest on the churn in Nepal, and the triggers driving the anger that has fuelled these protests:

    What happened during the protests on Monday?

    Protests began at 9am (03:15 GMT) on Monday in Kathmandu’s Maitighar neighbourhood. Thousands of young protesters, including high school students in their uniforms, took to the streets.

    Dubbed the “Gen Z protest”, it was organised by the nonprofit organisation Hami Nepal, meaning “We are Nepal”. According to the Kathmandu District Administration Office, the NGO had secured approval for it. The protest spread to other cities.

    Within hours, some protesters broke barricades set up by the police and entered the parliament premises in New Baneshwor. This resulted in clashes with the police, who opened fire on the protesters. Authorities imposed a curfew in the area until the evening.

    At least 17 people were killed in Kathmandu, while two were killed in the eastern city of Itahari after protests turned violent, according to the police.

    More than 100 people, including 28 police officers, were being treated for their injuries, according to police officer Shekhar Khanal, the Reuters news agency reported.

    In a statement released late on Monday night, Oli said he was “deeply saddened” by the protesters’ deaths and called for an investigation into the violence.

    What’s the latest on the ground in Nepal?

    Authorities have imposed an indefinite curfew, which now covers Kathmandu, Lalitpur and Bhaktapur districts. The curfew order bars public gatherings, sit-ins and protests.

    Oli resigned from his position on Tuesday, his secretariat confirmed.

    However, on Tuesday, young protesters continued to rally on the streets of Kathmandu. They gathered near the parliament building, but did not carry any posters, local media reported.

    They burned tyres while demonstrating in Kathmandu’s Kalanki area.

    They also set fire to the Nepali Congress (NC) party’s central office in Sanepa, a neighbourhood in Lalitpur, about 5km (3 miles) from Kathmandu. Since last year, the NC — one of Nepal’s largest political parties — has been a coalition partner of Oli’s governing Communist Party of Nepal (Unified Marxist-Leninist).

    Oli’s resignation came after some of his ministers stepped down in the aftermath of Monday’s deaths. On Monday, Home Minister Ramesh Lekhak resigned. Agriculture Minister Ramnath Adhikari quit his post on Tuesday.

    Who are ‘nepo kids’ and why are they upsetting Nepali youth?

    A key trigger for the protests, say activists and experts, has been a growing perception that the families of the ruling elite live lives of relative luxury in an otherwise poor nation, exposing deep inequalities.

    On Nepali social media, the term “nepo kids” — a play on nepotism — was viral in the weeks leading up to Monday’s protests. The term is commonly used to refer to the children of top government officials and ministers.

    Nepal’s government officials and politicians have long faced accusations of widespread corruption, opacity over how public money is spent, and whether parts of it are used to fund the lavish lifestyles that their families appear to enjoy, despite modest official salaries.

    Several videos on social media platforms such as TikTok and Instagram show the relatives of government officials and ministers travelling in or posing next to expensive cars and wearing designer brands.

    “The anger over ‘nepo kids’ in Nepal reflects deep public frustration,” said Yog Raj Lamichhane, an assistant professor at the School of Business in Nepal’s Pokhara University. What strikes ordinary Nepalis is how political leaders — the parents of the so-called nepo kids — who once lived modestly as party workers “now flaunt extravagant lifestyles as established figures,” Lamichhane told Al Jazeera.

    That is why protesters are demanding the formation of a special investigation commission to “thoroughly investigate the sources of their [politicians’] property, highlighting broader concerns about corruption and economic disparity in the country”, he said.

    Nepal has traditionally been a deeply feudal society, with a monarchy in place until less than two decades ago, pointed out Dipesh Karki, an assistant professor at Kathmandu University’s School of Management.

    Throughout the country’s history, “those who came into power have wielded their control over the resources and the wealth of the nation, resulting in what we can dub as an elite capture”, Karki told Al Jazeera.

    Earlier this week, a video on TikTok showed images of Sayuj Parajuli, the son of former Nepali Supreme Court Chief Justice Gopal Parajuli, posing next to cars and in fancy restaurants. “Openly flexing luxury cars and watches on social media. Aren’t we tired of them by now?” the caption read.

    Another video showed similar images of Saugat Thapa, son of Bindu Kumar Thapa, the law and parliamentary affairs minister in Oli’s government.

    Karki said urban wealth and businesses, as well as educational opportunities, are largely concentrated among elite families, particularly those with political connections.

    “The children of politicians are living off the political dividend.”

    How unequal is Nepal?

    Nepal’s per capita annual income of approximately $1,400 is the lowest in South Asia. Its poverty rate has consistently hovered over 20 percent in recent years.

    The country’s youth unemployment has been a big challenge, while the percentage of unemployed Nepali youth also not pursuing education stood at 32.6 percent in 2024, compared with 23.5 percent for neighbouring India, according to World Bank data.

    As a result, about 7.5 percent of the country’s population was living abroad in 2021. By comparison, about 1 percent of Indians live outside their country. In 2022, about 3.2 percent of Pakistan’s population was abroad.

    Nepal’s economy heavily relies on remittances from its citizens working abroad. “It’s really a harsh reality that most of the poor are outside Nepal, sending remittances to Nepal,” Karki said.

    As of 2024, personal remittances received comprised 33.1 percent of the country’s gross domestic product (GDP) — among the highest in the world, after Tonga, for which the percentage was 50 percent; Tajikistan at 47.9 percent; and Lebanon at 33.3 percent.

    For India, this percentage was 3.5 percent and for Pakistan, 9.4 percent, in the same year.

    Karki said land ownership remains unequal despite land reform efforts. “The top 10 percent of households own over 40 percent of land, while a large share of the rural poor are landless or we can say near landless.”

    “What is transpiring in Nepal today can be considered a … total of prevalent inequality that has plagued the nation since time immemorial,” Karki said.


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  • Protesters torch Nepal parliament as PM resigns amid turmoil | Protests News

    Protesters torch Nepal parliament as PM resigns amid turmoil | Protests News

    Demonstrators in Kathmandu have defied a curfew and broken into and set fire to the parliament building. They had earlier stormed the office of the Nepali Congress, the country’s largest party, and several prominent politicians’ residences.

    Nepalese Prime Minister KP Sharma Oli stepped down on Tuesday amid escalating anticorruption protests. The resignation came a day after 19 people were killed by security forces in violent demonstrations sparked by a social media ban.

    Exuberant young people flooded the parliament complex upon hearing the news, waving their hands and shouting slogans as smoke billowed from parts of the building.

    Oli’s government had lifted the social media ban after protests intensified on Monday when police used live ammunition and deployed tear gas and rubber bullets against demonstrators trying to storm parliament. The confrontation killed 19 people and injured more than 100.

    “We won,” one protester wrote in large orange letters on a beige wall of the parliament building while another nearby flashed a “V” sign for victory with his fingers.

    Although protesters remained on the streets after Oli’s resignation, witnesses reported no clashes or violence as security forces neither intervened nor tried to use force.

    This unrest marks the worst in years for the Himalayan nation situated between India and China. The violence was worse than a 2006 uprising that forced Nepal’s last king to surrender executive powers and killed 18 people. Two years later, parliament abolished the monarchy.

    Many Nepalis have grown increasingly dissatisfied with the republic, claiming it has failed to deliver political stability. In March, two people died when supporters of Nepal’s former king clashed with police during a Kathmandu rally demanding the restoration of the monarchy.

    Despite Oli’s resignation, it remains unclear whether protests will subside as many demonstrators are demanding a complete government dissolution – a move that could further destabilise Nepal, which has seen 13 governments since 2008.

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  • Meghan Markle’s ultimatum from half-sister amid ‘campaign’ message – Royals – News

    Meghan Markle’s ultimatum from half-sister amid ‘campaign’ message – Royals – News

    Meghan Markle faces a nail-biting day as her half-sister Samantha Markle launches a final bid to resurrect her defamation lawsuit. The Duchess was sued by her sibling in 2022 following statements made during the Sussexes’ bombshell Oprah Winfrey sit-down and their Netflix series, though the case was dismissed in March 2024.

    This crucial hearing is scheduled to unfold in Jacksonville, Florida, at 9am local time. Should Samantha emerge victorious, she could compel Meghan to face a full trial and potentially fork over monetary compensation. However, if she suffers defeat, no appellate court remains available to her, signaling the definitive conclusion of her three-year legal battle against her half-sister.

    Though Meghan, who is married to Prince Harry of the British Royal Family, isn’t anticipated to appear in the courtroom, Samantha’s legal representative Peter Ticktin declared the Duchess would be held “accountable for harming the people she harms.”

    He added: “If I were to give advice to Meghan, it would be to wake up and smell the coffee. She keeps trying, but she’s not coming across the way she wants to to the American public.”, reports the Express.

    “Now she’s going to be facing something where she has to be accountable for harming the people she harms, including her sister.”

    In contrast, speaking in 2022, Meghan’s attorney Michael J. Kump stated they would dedicate “the minimum attention necessary, which is all it deserves.”

    Following the launch of the couple’s docuseries, Harry & Meghan, Samantha’s legal team argued that several remarks made by the Duchess and a program participant on the Netflix show – when considered collectively – constituted an effort to unjustly damage Samantha’s reputation.

    During her 2021 interview with Oprah Winfrey, Meghan shared that she “grew up as an only child” and expressed her wish to have had siblings during her upbringing – noting that Samantha and Thomas Markle Jr. had already left their father’s household.

    Samantha’s representatives previously contended that the program led audiences to believe that Meghan’s half-sister was involved in organizing the harassment campaign directed at the Duchess. They also maintained this portrayal was unjust.

    Meghan never directly named Samantha while discussing the hostile messages she received, and the episode segment focusing on that subject concerned trolling conducted by multiple accounts.

    The Duchess’ legal representatives stated in their previous court document: “An implicit or express statement that [Samantha] belongs to a hate group spreading disinformation about Meghan is an opinion protected by the First Amendment.”

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  • Israeli carries out strike against Hamas leadership in Qatar

    Israeli carries out strike against Hamas leadership in Qatar

    Israel carried out an attack targeting Hamas leadership in Qatar on Tuesday, two Israeli sources told CNN, in what appeared to be the first known Israeli military strike against the militant group in the Gulf nation.

    One of the sources, a senior Israeli official, said among those targeted was Hamas’ chief negotiator Khalil Al-Hayya.

    “We are awaiting the results of the strike,” the official said.

    The Qatari foreign ministry’s spokesperson Majed Al Ansari called the attack “cowardly” and “criminal assault” that constitutes a “blatant violation of international laws and norms.”

    “While strongly condemning this attack, the State of Qatar emphasizes that it will not tolerate this reckless and irresponsible Israeli behavior,” Al Ansari said on X.

    A senior Hamas official confirmed to CNN that the group’s negotiators were targeted in Doha.

    Shortly after the explosion, the Israel Defense Forces (IDF) issued a statement saying it had targeted “senior leadership” of Hamas with “a precise strike” in a joint operation with the Shin Bet security agency. The statement didn’t specify where the operation was carried out, but suggested that it was outside Gaza.

    “For years, these members of the Hamas leadership have led the terrorist organization’s operations, are directly responsible for the brutal October 7th massacre, and have been orchestrating and managing the war against the State of Israel.”

    On Monday, Khalil Al-Hayya met with Qatari Prime Minister Sheikh Mohammed bin Abdulrahman Al-Thani in Doha.

    This is a developing story and will be updated.


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