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  • Bhachar slams speaker, vows legal battle, protests – Newspaper

    Bhachar slams speaker, vows legal battle, protests – Newspaper

    LAHORE: Chiding the speaker for acting like a dictator under pressure, Opposition Leader in Punjab Assembly Malik Ahmad Khan Bhachar said the opposition would continue fighting for the cause of the people of Punjab.

    “Our patron-in-chief has appreciated PTI’s 26 MPAs for challenging the pharaohs and instructed them to hold assembly outside the [assembly] premises and continue giving tough time to the fake-mandated government,” Mr Bhachar said while speaking at a news conference at Lahore Press Club on Wednesday. He said the PTI would suggest amendments to the proposed Punjab Local Government Act.

    He said the PTI would continue protesting ‘irregular’ payments of Rs10 trillion as reported by the Auditor General of Pakistan and added that this ‘Form-47’ government also got Rs509 billion supplementary budget with less than 23 members in the House.

    “PML-N MPAs came in droves to listen to CM Maryam Nawaz’ speech but their number reduced to less than 25, when supplementary budget was passed,” he said.

    Says PTI to suggest amendments to proposed LG law

    Bhachar said the speaker suspended 26 opposition MPAs for protesting during CM’s speech but he had conveniently ignored the treasury MPAs’ protest and cheap slogans, when opposition women MPAs were speaking in the assembly. He said the speaker had neither notified the opposition parliamentary leader nor gave floor to the opposition leader despite repeated requests.

    He said he had written a letter to the speaker to provide evidence explaining that the opposition members broke down microphones.

    He said the opposition would approach courts despite knowing that the courts were not giving justice to the opposition.

    The opposition leader condemned the federal government for increasing petroleum prices and added that this increase would instantly shoot up the cost of daily-use items.

    Acknowledging the negligence in death of 17 persons in Swat River, Opposition Leader in Punjab Assembly Malik Ahmad Khan Bhachar said Punjab Chief Minister Maryam Nawaz should also be punished for the death of 20 children in a Pakpattan hospital.

    “Those negligent in Khyber Pakhtunkhwa and in Punjab should be punished,” Mr Bhachar said.

    Answering a question, the opposition leader said the political parties do keep their doors open for negotiations. He said party President Chaudhry Parvez Elahi was holding meetings and issuing instructions to them.

    Published in Dawn, July 3rd, 2025

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  • TikToker held with 13 guards for ‘public display of arms’ in Lahore – Pakistan

    TikToker held with 13 guards for ‘public display of arms’ in Lahore – Pakistan

    LAHORE: The Crime Control Department (CCD) of Lahore police on Wednesday arrested a known TikToker and his 13 security guards for “public display of weapons”.

    The police acted when the suspects blatantly violated the Section 144 imposed by the Punjab government to ensure peace in the city during Muharram.

    As per CCD sources, TikToker Kashif Zamir, along with his armed bodyguards, traveled on a city road in a double-cabin vehicle. His team recorded video clips showing the weapons displayed by his guards and uploaded the same on social media.

    The police say such conduct causes harassment to the public.

    A CCD official says the police arrested the TikToker in a raid and recovered firearms from him and his guards, lodging cases against them.

    He says the police also recovered videos of the TikToker showing him traveling on different city roads, along with his heavily-armed security guards. The CCD official says that Kashif Zameer is a habitual offender as he was also arrested in the past on the same charges.

    Later, a video statement of the TikToker, recorded in police custody, appeared on social media wherein he apologised for taking law into his hands.

    Published in Dawn, July 3rd, 2025

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  • Capgemini unveils strategic AI framework to turn enterprise ambition into measurable business impact

    Capgemini unveils strategic AI framework to turn enterprise ambition into measurable business impact





    Capgemini unveils strategic AI framework to turn enterprise ambition into measurable business impact – Capgemini


























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  • Indonesia, Saudi Arabia agree on strategic cooperation worth 27 bln USD-Xinhua

    JAKARTA, July 3 (Xinhua) — Indonesia and Saudi Arabia have agreed on business cooperation worth some 27 billion U.S. dollars in various sectors, including clean energy, petrochemical industries, aviation fuel services, healthcare, pharmaceuticals, and health technology.

    According to a press release by the Indonesian Presidential Secretariat on Thursday, the agreements were signed by private sector entities from both countries and welcomed by President Prabowo Subianto and Saudi Crown Prince Mohammed bin Salman during a bilateral meeting at Al-Salam Palace in Jeddah on Wednesday.

    In a joint statement, both leaders expressed their commitment to strengthening and expanding bilateral cooperation, particularly in investment, trade, and the digital economy, including enhanced private sector collaboration.

    They also welcomed the strengthening of defense and security cooperation, including counterterrorism, the fight against extremism, cybersecurity, and cooperation in information exchange and training.

    Both leaders affirmed the importance of enhancing cooperation in multilateral mechanisms such as the G20, the Organization of Islamic Cooperation, the International Monetary Fund, and the Non-Aligned Movement, to address global challenges.

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  • A Challenging Case of Wild-Type Transthyretin Amyloidosis (ATTR) Amyloidosis Treated With Cardiac Resynchronization Therapy

    A Challenging Case of Wild-Type Transthyretin Amyloidosis (ATTR) Amyloidosis Treated With Cardiac Resynchronization Therapy


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  • Dubai’s booming restaurant scene is feeling the heat of high costs and high failure rates

    Dubai’s booming restaurant scene is feeling the heat of high costs and high failure rates

    DUBAI, United Arab Emirates — From suspended tables to underwater lounges, some 13,000 food and drink establishments in Dubai pull out all the stops to attract customers in one of the world’s most saturated dining markets.

    They cater to all tastes and budgets. Some spots ladle out inexpensive biryani while others offer dishes dusted with edible gold.

    These are some of the ways the emirate is competing with its neighbors Saudi Arabia and Qatar for tourist dollars and, so far, it’s beating them handily. Dubai has more restaurants per capita than any major city except Paris.

    But the city-state’s booming restaurant scene is testing the limits of its growth-at-all-costs model, raising questions about how long Dubai can keep feeding its own ambitions.

    The competition is cutthroat, so presentation is key.

    “Gone are the days when it just tastes good,” said Kym Barter, the general manager of Atlantis The Palm, a resort perched on a manmade archipelago that boasts more Michelin stars than any other venue in the Middle East.

    But dazzling Dubai’s food bloggers — the most popular of whom have millions of social media followers — isn’t enough. Staying afloat means battling high rents and winning over a diverse and demanding group of consumers.

    Dubai has roughly nine expatriate residents for every Emirati citizen. Most of its private sector workers are migrants on temporary contracts, and only Vatican City has a higher share of foreign-born residents.

    Tourists, in turn, outnumber locals about five to one by some estimates, and they spend lavishly. Visitors to Dubai drop an average of over five times more than those traveling to nearby Saudi Arabia or even the U.S., according to global restaurant consultant Aaron Allen.

    Dubai is “on the right path” to becoming the world’s food capital, said Torsten Vildgaard, executive chef at FZN by Björn Frantzén. The restaurant, which runs at more than $540 a head, was one of two in Dubai to nab three Michelin stars in May.

    “We’re only seeing the tip of the iceberg of what’s to come in terms of gastronomy here,” Vildgaard added.

    With each new set of illuminated high-rises and hotels, another crop of eateries emerge, vying for patrons. The legions of construction workers powering Dubai’s progress also need affordable options.

    That growth, propped up in part by investor pressure on some of the world’s biggest chains to expand in Dubai, has created what some analysts warn is a bubble.

    “If you’re a publicly traded company like Americana, what are you supposed to do — just stop opening restaurants?” restaurant consultant Allen said, referring to the Gulf-based operator of KFC, Pizza Hut and other big franchises.

    The frenetic expansion of Dubai’s restaurant industry is part of a regional shift that has seen Gulf Arab states pour hundreds of billions of dollars into building out tourist destinations as they move away from hydrocarbons to diversify their economies. Saudi Arabia has a high-stakes, $500 billion project: a straight-line futuristic city called Neom.

    But, in a Muslim-majority region, the United Arab Emirates has gone to lengths that some consider too much of a compromise, including relaxing restrictions on alcohol that fuel its pubs and nightlife and other social reforms.

    The rapid development comes at a price. Dubai’s restaurants have a high failure rate, industry veterans say, though local authorities don’t say what the rate of closures is. In the downtown district and other prime areas, annual rents for restaurants can top $100 per square foot. That’s on a par with some of the world’s most expensive cities.

    Still, the emirate issued almost 1,200 new restaurant licenses last year, according to Dubai’s Department of Economy and Tourism. The department declined to respond to questions.

    Empty tables during peak hours are common, even in top locations. Part of the problem, managers say, is that traffic congestion is so severe that convincing diners to drive out can be a tall task.

    “I sometimes go, ‘Do I go into the restaurant right now, because I’m going to get into traffic?’’’ said Waseem Abdul Hameed, operations manager at Ravi, a Pakistani family-owned eatery famous for its official Adidas shoe line and a 2010 TV feature from Anthony Bourdain.

    He knows restaurateurs who have had to shut up shop and others who are squeezed by slim margins and increasingly reliant on delivery apps, Hameed said.

    The demand sends fleets of migrant workers racing through gridlock on motorbikes, with few protections and tight delivery windows. Emirati newspaper Khaleej Times reported the accidental deaths of 17 Dubai food couriers last year.

    The math of Dubai’s restaurant scene doesn’t add up, delivery apps and wealthy tourists notwithstanding, restaurant consultant Allen said. He cited operating expenses that have more than doubled relative to sales since 2009, when a financial crisis almost hobbled the emirate.

    Too many Dubai entrepreneurs, he put it simply, have “too much money, and they don’t know what to do besides open restaurants.”

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  • Study unveils powerful strategy to rejuvenate effectiveness of CAR T cell therapy against glioblastoma

    Study unveils powerful strategy to rejuvenate effectiveness of CAR T cell therapy against glioblastoma

    A team of researchers from the San Raffaele-Telethon Institute for Gene Therapy (SR-TIGET, Milan), led by Nadia Coltella and Luigi Naldini, has unveiled a powerful strategy to rejuvenate the effectiveness of chimeric antigen receptor (CAR) T cell therapy against glioblastoma, one of the most lethal and treatment-resistant brain tumors. The findings, published in Science Translational Medicine, highlight how gene therapy targeting immune stimulating cytokines to the tumor microenvironment (TME) and enabling their private cross-talk with CAR-T cells not only restores CAR-T killer activity but also boost a broader immune response that inhibits tumor growth and extends host survival in a preclinical glioblastoma models.

    The study builds on the prior development by the Naldini’s laboratory of a gene therapy strategy that exploit genetic engineering of hematopoietic progenitors to generate a progeny of monocyte/macrophages that selectively release their immune stimulating payload upon infiltrating a tumor. This strategy has been taken to its first-in-human clinical testing as stand-alone treatment of glioblastoma by the biotech company Genenta Science, a spin-off from the San Raffaele Institute now listed on the NASDAQ.

    “Solid tumors like glioblastoma have been notoriously difficult for CAR-T cells to penetrate and control,” explains Dr. Rossari, first author of the work, “By reprogramming a population of tumor-infiltrating macrophages to deliver cytokines directly into the tumor, we’ve morphed the immunosuppressive TME into one supportive of immune cells, thus allowing CAR T cells to better persist, become activated and attack tumor cells.”

    CAR-T cells have shown transformative results in blood cancers but have struggled in solid tumors due to the hostile, immunosuppressive TME. The team’s strategy leads to selective release of two cytokines within the TME: interferon-α (IFN-α), a pleiotropic immune stimulator that counteracts local immune suppressive cues and enforces antigen presentation and immune effectors’ activity, and an engineered mutant of interleukin-2 that can only activate a cognate mutant receptor co-introduced with the CAR into T cells, thus boosting the proliferation specifically of the administered effector engaged in fighting the tumor.

    “The private ‘cross-talk’ between genetically engineered macrophages and CAR T cells established in the TME ensures that the immune stimulants act only where needed, sparing the rest of the body from systemic toxicity, and specifically on the relevant target cells involved in the tumor attack, again preventing collateral damage and aberrant effects,” says Dr. Alvisi, co-first author of the study.

    In a mouse model of glioblastoma that mimics the pathology and immunological barriers seen in human patients, the targeted cytokines rescued the activity of CAR-T cells that, given alone, were ineffective – as mostly seen in clinical trials. In turn, the rescued CAR T cells now synergized with cytokine delivery, significantly enhancing their effect on delaying tumor growth and extending mouse survival. Strikingly, even tumors with only a fraction of cells expressing the CAR-targeted antigen B7-H3 were effectively controlled, indicating engagement of endogenous T cells on top of the CAR-T to fight the tumor.

    “We observed not only reactivation of the CAR-T cells but also the recruitment of the host’s own T cells against a wider range of tumor antigens,” says Dr. Nadia Coltella, senior co-corresponding author. “This phenomenon, known as antigenic spreading, was mostly dependent on IFN-α activity in the TME and is a key feature for creating effective immunity as it may overcome immune evasion by tumors targeted only through a single antigen by the CAR-T cells.”

    “This work represents another important step forward in our decade-long commitment to develop a novel gene and cell therapy strategy effective against tumors, as we have been able to do for several genetic diseases along the life of our institute” adds Luigi Naldini, Director of SR-TIGET and Professor at Università Vita-Salute San Raffaele. “The tumor-targeted IFN-α delivery strategy is already being evaluated as stand-alone treatment in a first-in-human phase 1/2a trial on the most aggressive type of glioblastoma (Temferon trial) led by the biotech company Genenta Science. The study has shown feasibility, safety, biological activity in reprogramming the TME and early but promising indication of therapeutic benefit, albeit limited by the small number of treated patients and the design of a phase 1 study. A combination of Temferon with CAR-T cells administration, as prompted by our new study, could in future further enhance the benefit of the treatment and broaden its efficacy to a larger fraction of patients.”

    This study was supported also by the Italian Association for Cancer Research (AIRC), the Louis-Jeantet Foundation through the Jeantet-Collen Prize for Translational Medicine to Luigi Naldini, and a research contract from Genenta Sciences.

    Source:

    Journal reference:

    Rossari, F., et al. (2025) A cross-talk established by tumor-targeted cytokines rescues CAR T cell activity and engages host T cells against glioblastoma in mice. Science Translational Medicine. doi.org/10.1126/scitranslmed.ado9511.

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  • Mercedes AMG CLA 45 S Final Edition Release Info

    Mercedes AMG CLA 45 S Final Edition Release Info

    Summary

    • Limited 2026 model features exclusive grey/yellow design and aero upgrades
    • 416 hp turbo engine, 0–60 mph in 4.0 seconds with drift mode
    • Launches early 2026 in the U.S. with enhanced interior and standard equipment

    Mercedes-AMG has announced the CLA 45 S “Final Edition”, a high-performance sendoff for the compact sport sedan, arriving in limited numbers to U.S. dealerships in early 2026. Finished in MANUFAKTUR Mountain Grey Magno, the Final Edition features bold black and yellow graphics, 19-inch matte black forged wheels with yellow accents and exclusive aerodynamic enhancements from AMG’s wind tunnel testing.

    Under the hood, the hand-built 2L turbocharged AMG engine delivers 416 hp and 369 lb-ft of torque, launching the car from 0–60 mph in 4.0 seconds. Power is distributed via an 8-speed dual-clutch transmission and AMG Performance 4MATIC+ all-wheel drive with torque vectoring and drift mode capability.

    Inside, the Final Edition sports AMG Performance seats wrapped in black MB-Tex and microfiber with yellow contrast stitching, matching details on the dashboard, doors and AMG Performance steering wheel. Unique badging, yellow-stitched floor mats and illuminated yellow AMG door sills round out the design.

    With extensive standard equipment including the AMG Night Package Plus and Aerodynamics Package Plus, the CLA 45 S “Final Edition” aims to offer both track-ready performance and refined exclusivity, marking the end of an era for AMG’s compact powerhouse.

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  • "He will be able to sleep well," says Sean 'Diddy' Comb's lawyer after rapper acquitted of sex trafficking charges – ANI News

    1. “He will be able to sleep well,” says Sean ‘Diddy’ Comb’s lawyer after rapper acquitted of sex trafficking charges  ANI News
    2. Diddy’s secret world revealed in videos and his voice notes  BBC
    3. Sean ‘Diddy’ Combs Trial Live Updates: Combs Found Not Guilty of Sex Trafficking and Convicted on Lesser Charges  The New York Times
    4. Sean ‘Diddy’ Combs convicted on prostitution counts by US jury, cleared of more serious charges  Dawn
    5. Sean ‘Diddy’ Combs trial updates: Bail denied due to ‘propensity for violence’  ABC News – Breaking News, Latest News and Videos

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  • KRK launches Kreate Series Studio Monitors — a versatile solution for producers, podcasters, and content creators alike

    KRK launches Kreate Series Studio Monitors — a versatile solution for producers, podcasters, and content creators alike

    KRK introduces the Kreate Series Studio Monitors, the newest addition to the brand’s wide range of audio offerings. The Kreate monitors bring extraordinary value and legendary KRK monitoring performance to emerging musicians, engineers, producers, and content creators. These best-in-class two-way studio monitors are designed specifically to meet the diverse needs of creatives, providing the tools necessary to reproduce every nuance of a production with astonishing clarity and accuracy. From casual playback to professional music and content production, the Kreate Series is designed to perform. The Kreate line is available through select dealers and online at krkmusic.com.

    As the brand’s newest studio monitor line, the KRK Kreate Series represents KRK’s continued commitment to innovation, accessibility, and excellence, supporting a wide range of setups and needs. Great for mixing, producing, and content creation, the Kreate monitors have a variety of key features that stand out among other monitors in their class. This includes wireless audio streaming capabilities with a pairable Bluetooth® audio input alongside balanced and unbalanced analog inputs for flexible connectivity. The monitors also have a universal voltage, switch-mode power supply for seamless global operations.

    Available in three sizes — three, five, and eight-inch — these entry-level active, two-way studio reference monitors feature a wide bandwidth, boundary and tuning EQs, new transducer designs, and Class D amplification. The Kreate Series also features useful acoustic boundary correction and tuning EQ combinations to help minimize and correct acoustic environment problems and dial in the voicing to meet specific application needs.

    “The Kreate Series offers professional-grade sound and flexible functionality that empowers emerging artists, producers, podcasters, and all creators to embrace high-quality audio at an affordable price point,” says Sterling Doak, Senior Director of Marketing for Gibson. “The monitors fill a vital space in the KRK lineup and are ideal for those who demand quality without compromise. As the new introductory solution within the portfolio, the Kreate Series will enable users to begin their creative journey with confidence.”

    With KRK Kreate, composite woven glass fiber cone woofers provide amazing dynamics with good damping and modal control to deliver tight and punchy mid and low-frequency response that’s perfect for casual and professional playback environments. The glass fiber structure is heat-resistant and features a high strength-to-weight ratio, ensuring the monitors are highly adaptable and sonically accurate.

    Additionally, high-frequency reproduction emanates from a carefully designed woven-textile dome tweeter with a neodymium motor, which accurately extends the frequency range up to 40 kHz in the KRK Kreate 8 and 5 options, and up to 33 kHz in the 3 option, for a smoother, more detailed sound profile. The textile dome tweeters are used to create a smooth accurate response.

    Furthermore, the system-tuning level control and low-frequency and high-frequency shelving filters allow for easy adjustment in various acoustic conditions. Hybrid Class D and Class AB amplification delivers power and headroom with excellent dynamics reproduction. The high-performance transducers are optimized for improved response and accuracy. For maximum transient response and dynamics reproduction, the amplifiers drive the transducers efficiently at reduced operating temperatures to ensure audio integrity during long work sessions.

    The monitors are launching in KRK’s signature black/yellow and latte/black color scheme, with the Kreate 3 models sold as a pair and the Kreate 5 and Kreate 8 options priced individually. The series also continues KRK’s visual branding evolution, with packaging and stylization that closely align with other monitors from the brand’s product portfolio.

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