Author: admin

  • Crowds line Saint-Tropez streets for Brigitte Bardot funeral

    Crowds line Saint-Tropez streets for Brigitte Bardot funeral

    Crowds lined the streets of Saint-Tropez for the funeral of French film legend Brigitte Bardot on Wednesday.

    Some of those gathered were seen applauding as her coffin was driven through the French Riviera town after a service in a local church.

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  • Syria: Aleppo fighting leaves civilians dead, displaces thousands – UN News

    1. Syria: Aleppo fighting leaves civilians dead, displaces thousands  UN News
    2. Updates: Syria to launch military operation against SDF in Aleppo  Al Jazeera
    3. Syria suspends flights at Aleppo airport after YPG terror group-led SDF attacks  TRT World
    4. Flash…

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  • Alumnae Kuoppala, Enzler, Vanišová, Pribylová named to 2026 Olympic Rosters

    Alumnae Kuoppala, Enzler, Vanišová, Pribylová named to 2026 Olympic Rosters

    ORONO, Maine – Four alumnae of the Maine women’s ice hockey program have been named to Olympic rosters ahead of…

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  • Ottawa author brings a rag-era family story to life in ‘Almost English’

    Ottawa author brings a rag-era family story to life in ‘Almost English’

    By Blaine Marchand  

    There is a popular saying that every family has a story. And for this we should be thankful that Ottawa writer (and a former long-term resident of Kitchissippi), Barbara Sibbald, skillfully recaptures for us her…

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  • Council to trial mobile enforcement system to tackle parking compliance challenge

    Council to trial mobile enforcement system to tackle parking compliance challenge

    Thursday 8 January 2026

    Wollongong City Council is embarking on a 12-month trial of new camera technology that will allow compliance officers to electronically monitor timed parking zones and ensure fair public access to parking hotspots around the city.

    The electronic monitoring system captures license plate data via in-vehicle cameras, allowing officers to patrol timed areas more widely and efficiently than the current manual practice of chalking tyres. The technology is currently utilised by more than 20 NSW councils, including City of Sydney, Sutherland Shire and Bayside Councils,

    Commencing in February 2026, all timed parking zones in Wollongong, Keiraville, Gwynneville, and parts of Fairy Meadow and North Wollongong will be monitored as part of the trial, including high-trafficked areas along the Blue Mile, CBD carparks, and streets surrounding UOW.

    “We all know parking is a hot-button issue and we’ve seen that again through the Christmas-New Year period,” Lord Mayor of Wollongong Councillor Tania Brown said.

    “We have various plans and strategies aimed at bringing people into our CBD and town centres, be it for work or leisure. Timed parking zones play a vital role in ensuring efficient and fair access to parking in those high-demand locations like the city centre and around UOW.

    “We’ve heard from many residents and business owners in our community that people overstaying in timed parking zones is a major source of frustration, particularly in the locations where we’ll be trialling the technology.

    “There are around 7,700 parking spaces in our City Centre available for public use and convenient, time-restricted parking near retail areas supports high turnover, helping shoppers park, shop and free up space for the next person.

    “While it is just a trial at this stage, if it can provide more consistent and efficient monitoring of parking zones, and allow our staff to do their jobs safely and effectively, it’s certainly something we should be looking at.

    “The technology is already used by multiple other local councils, and we need to ensure all our systems utilise the best technologies available and are best practice.”

    Where possible, fines or notifications issued via the electronic management system will continue to be issued in paper form and placed on the offending vehicles. If it’s not possible to place the fine on the vehicle at the time, the fine will be posted.

    While the trial will capture valuable data regarding driver behaviour and use of timed parking zones, it does not include or propose changes to currently signposted time limits.

    The monitoring uses face-blurring technology and will not capture any personal identifiers other than vehicle license plate numbers.

    For more information on the trial and its locations you can visit Council’s website here.

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  • Cooler bedroom temperatures help the heart recover during sleep

    Cooler bedroom temperatures help the heart recover during sleep

    Maintaining a bedroom temperature of 24°C at night while sleeping reduces stress responses in older adults, according to new Griffith University research.

    Dr Fergus O’Connor

    Dr Fergus O’Connor from Griffith’s School of Allied Health,…

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  • Inspection Data for U.S. Global Network Firms

    Inspection Data for U.S. Global Network Firms

    These graphs are based on inspection results included in the public portion of PCAOB inspection reports on the six largest U.S. annual firms: Deloitte & Touche LLP (DT); Ernst & Young LLP (EY); KPMG LLP (KPMG); PricewaterhouseCoopers LLP (PwC); BDO USA, P.C. (BDO); and Grant Thornton LLP (GT).

    The “annual” category  includes firms that have more than 100 issuer clients for which they provide audit reports (firms that the Board inspects every year as long as the firm continues to provide audit reports for more than 100 issuers each year).

    The inspection data below is readily ascertainable from the public portion of the inspection report, but the data should be understood in light of contextualizing information provided with each report, including (1) it relates only to the audits selected for review, which does not constitute a representative sample of the firm’s total population of issuer audits, and only to the particular portions of the issuer audits reviewed; (2) for various reasons, inspection results are not necessarily comparable over time or among firms; (3) inspection results are not an assessment of all of the firm’s audit work nor of all of the audit procedures performed for the audits reviewed; and (4) inspection reports are not intended to serve as overall rating tools.

    2024 Inspection Results

    2024 Inspection Part I.A Deficiency Rate

    An audit deficiency is cited and described in Part I.A of an inspection report if it is of such significance that we believe the firm, at the time it issued its audit report(s), had not obtained sufficient appropriate audit evidence to support its opinion(s) on the issuer’s financial statements and/or internal control over financial reporting (ICFR).

    Part I.A Deficiency Rate by Group

    Part I.A Deficiency Rate by Firm

    Percentage of issuer audits reviewed that have at least one Part I.A deficiency in the inspection report for all six firms.

    Part I.A Deficiency Rate by Selection Method

    Percentage of issuer audits reviewed, by selection method, that have at least one Part I.A deficiency in the inspection report for all firms.

    Audits Affected by the Deficiencies Identified in Part I.A

    Number of issuer audits, by type of opinions, affected by the identified Part I.A deficiency(ies).

    Classification of Audits Reviewed

    In our inspection reports, we classify each issuer audit reviewed in one of the categories shown in the graph based on the Part I.A deficiency or deficiencies identified in our review. The purpose of this classification system is to group and present issuer audits by the number of Part I.A deficiencies we identified within the audit as well as to highlight audits with an incorrect opinion on the financial statements and/or ICFR when applicable.

    Audits Selected for Review

    Audits Selected for Review by Audit Type

    We select both integrated audits of financial statements and ICFR and audits of financial statement only.

    Audits Selected for Review by Selection Method

    We use a combination of risk-based and random methods to select issuer audits for review. Because our inspection process evolves over time, it can, and often does, focus on a different mix of issuer audits and audit areas from year to year and firm to firm. In addition, we utilize a target team of inspectors to perform inspection procedures in areas of current risk and emerging topics. More information on the focus of the target team procedures in each year can be found in the relevant inspection report.

    Deficiencies by Audit Areas and Auditing Standards

    Audit Areas Most Frequently Reviewed

    These are the audit areas we have selected most frequently for review across all six firms and the number of issuer audits by focus area with and without Part I.A deficiencies. For the issuer audits selected for review, we selected these areas because they were generally significant to the issuer’s financial statements, may have included complex issues for auditors, and/or involved complex judgments in (1) estimating and auditing the reported value of related accounts and disclosures and (2) implementing and auditing the related controls.

    Auditing Standards With Frequent Part I.A Deficiencies by
    Audit Area

    This graph reflects the auditing standards most frequently referenced in Part I.A by audit area in the most recent inspection year, with the corresponding results for the other two years presented.

    Deficiencies by Issuer Characteristics

    Inspection Results by Issuer Industry Sector

    This graph depicts the number of issuer audits reviewed, by each industry sector with and without Part I.A deficiencies for all six firms. We select issuer audits for review in sectors and specific industries experiencing particularly significant disruptions or financial reporting risks.

    Inspection Results by Issuer Revenue

    This graph depicts the number of issuer audits reviewed, by the issuer’s revenue range, with and without Part I.A deficiencies for all six firms.

    Deficiencies by Tenure

    Part I.A Deficiencies by the Firm’s Tenure on the Issuer

    The percentage in this graph represents the number of issuer audits reviewed for that tenure range with at least one Part I.A deficiency divided by total issuer audits reviewed for that tenure range. This information is for all six firms.

    Part I.A Deficiencies by the Engagement Partner’s Tenure With the Issuer

    The percentage in this graph represents the number of issuer audits reviewed for that partner tenure with at least one Part I.A deficiency divided by total issuer audits reviewed for that partner tenure. This information is for all six firms.

    Part I.B Deficiencies

    Part I.B Deficiencies by Type

    This graph depicts the number of issuer audits identified for each firm by Part I.B deficiency type. Part I.B deficiencies are certain deficiencies that relate to instances of non-compliance with PCAOB standards or rules other than those where the firm had not obtained sufficient appropriate audit evidence to support its opinions.

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  • LENZ Therapeutics Reports Fourth Quarter 2025 Preliminary Unaudited Financial Results and Recent Corporate Updates :: LENZ Therapeutics, Inc. (LENZ)

    LENZ Therapeutics Reports Fourth Quarter 2025 Preliminary Unaudited Financial Results and Recent Corporate Updates :: LENZ Therapeutics, Inc. (LENZ)





    Launched VIZZ™ (aceclidine ophthalmic solution) 1.44% in October 2025 for the treatment of presbyopia, with broad product availability in mid-November 2025

    Achieved approximately $1.6 million in net product revenue with over 20,000 prescriptions filled in Q4 2025

    Over 6,500 unique ECPs prescribed VIZZ; more than 55% have prescribed multiple times in Q4 2025

    SAN DIEGO, Jan. 07, 2026 (GLOBE NEWSWIRE) — LENZ Therapeutics, Inc. (Nasdaq: LENZ or “LENZ” or the “Company”), a pharmaceutical company focused on the commercialization of VIZZ™ (aceclidine ophthalmic solution) 1.44%, the first and only aceclidine-based eye drop for the treatment of presbyopia, today reported certain preliminary unaudited financial results for the fourth quarter ended December 31, 2025 and recent corporate updates.

    “We are proud of the strong execution delivered in our first quarter of launch, as the team established a solid foundation of awareness, confidence, and willingness to prescribe VIZZ across the eye care professional community,” said Eef Schimmelpennink, President and Chief Executive Officer of LENZ Therapeutics. “More than 6,500 eye care professionals have already written a prescription for VIZZ, the majority of whom prescribed multiple times, signaling early confidence in VIZZ as a convenient and effective alternative to reading glasses. At the same time, over 20,000 prescriptions were filled during our first quarter of launch, exceeding our expectations and reinforcing the early momentum behind VIZZ. Building on this progress, and together with our campaign spokesperson Sarah Jessica Parker, we look forward to launching the VIZZ DTC campaign this quarter.”

    Fourth Quarter 2025 Commercial Highlights

    • First commercial product sale of VIZZ in October 2025, the first and only aceclidine-based eye drop for the treatment of presbyopia
    • Full multi-channel access established through epharmacy and substantially all retail pharmacies by mid-November 2025
    • VIZZ net product revenue of approximately $1.6 million in Q4 2025
    • Over 20,000 prescriptions filled through Q4 2025
    • Rapid uptake by prescribing ECPs with over 6,500 unique prescribing ECPs; more than 55% prescribed multiple times in Q4 2025

    Additional Recent Corporate Updates

    • In January 2026, the Company announced an exclusive commercialization partnership for VIZZ with Lunatus in the Middle East. Under the terms of the agreement, LENZ will receive upfront, regulatory and commercial milestone payments, in addition to a significant share of revenue generated in the region through a pre-determined minimum product supply price. This agreement represents the fourth commercialization partnership for VIZZ outside the United States.

    About LENZ Therapeutics

    LENZ Therapeutics is a pharmaceutical company focused on the commercialization of VIZZTM (aceclidine ophthalmic solution) 1.44%, the first and only FDA-approved aceclidine-based eye drop for the treatment of presbyopia, a condition impacting an estimated 1.8 billion people globally and 128 million people in the United States. LENZ is commercializing VIZZ in the United States and continues to establish licensing partnerships internationally to provide access to VIZZ globally. LENZ is headquartered in San Diego, California. For more information, visit www.VIZZ.com and www.LENZ-tx.com.

    About Presbyopia

    Presbyopia is the inevitable loss of near vision associated with aging, impacting the daily lives of nearly all people over the age of 45. As people age, the crystalline lens in their eyes gradually hardens and becomes less able to change shape. This loss of elasticity of the lens reduces the ability of the lens to focus incoming light from near objects onto the retina. Adults over 50 years of age lose, on average, 1.5 lines of near vision every six years. Although the progression of presbyopia is gradual, presbyopes often experience an abrupt change in their daily life as the symptoms become more pronounced starting in their mid-40s, when reading glasses or other corrective aids are suddenly necessary to read text or conduct close-up work. Presbyopia is typically self-diagnosed and self-managed with over-the-counter reading glasses, or managed, after evaluation by an ECP, with prescription reading or bifocal glasses or multifocal contact lenses.

    About VIZZ (aceclidine ophthalmic solution) 1.44%

    VIZZ (aceclidine ophthalmic solution) 1.44% is a once-daily eye drop developed to restore clear near vision for up to 10 hours. Aceclidine is the sole active ingredient in VIZZ and provides rapid and durable near vision improvement. VIZZ is preservative-free and provided in single-dose vials. VIZZ is a predominantly pupil selective miotic that interacts with the iris with minimal ciliary muscle stimulation. VIZZ causes contraction of the iris sphincter muscle, resulting in a pinhole effect that extends depth of focus to improve vision. For more information, please visit www.VIZZ.com.

    VIZZ Indication and Important Safety Information

    INDICATION

    VIZZ (aceclidine ophthalmic solution) 1.44% is a prescription eye drop used to treat age-related blurry near vision (presbyopia) in adults.

    IMPORTANT SAFETY INFORMATION

    • Do not use VIZZ if allergic to any of the ingredients.
    • To help avoid potential eye injury or contamination of the product, do not allow the vial tip to touch the eye or any surfaces. Discard the opened vial immediately after use.
    • Contact lenses should be removed before using VIZZ. After dosing, contact lenses can be reinserted after 10 minutes.
    • If using more than one topical eye medication, the medicines should be administered at least 5 minutes apart.
    • Temporary dim or dark vision may be experienced after using VIZZ. Do not drive or operate machinery if vision is not clear.
    • Seek immediate medical care if sudden onset of flashing lights, floaters, or vision loss is experienced.

    ADVERSE REACTIONS

    The most common reported adverse reactions of participants were instillation site irritation (20%), dim vision (16%), and headache (13%). Adverse reactions reported in >5% of participants were conjunctival hyperemia (8%) and ocular hyperemia (7%). The majority of adverse reactions were mild, transient, and self-resolving.

    For additional information, please see the full Prescribing Information available at www.VIZZ.com/full-prescribing-information.pdf.

    Forward-Looking Statements

    This press release contains forward-looking statements within the meaning of federal securities laws. You can identify forward-looking statements by words such as “may,” “will,” “could,” “can,” “would,” “should,” “expect,” “intend,” “plan,” “anticipate,” “believe,” “estimate,” “predict,” “project,” “potential,” “poised,” “continue,” “ongoing” or the negative of these terms or other comparable terminology, but not all forward-looking statements will contain these words. ” Forward-looking statements in this press release include statements regarding the timing and availability of VIZZ, including the VIZZ DTC campaign; potential market size for VIZZ; its ability to meet patient needs and become standard of care; LENZ commercialization plans, including international partnering plans, and the quotations of LENZ management. These statements are based on numerous assumptions concerning VIZZ, target markets and involve substantial risks, uncertainties and other factors that may cause actual results, levels of activity, performance or achievement to be materially different from the information expressed or implied by these forward-looking statements, including those risk factors described in the section titled “Risk Factors” in our Quarterly Report on Form 10-Q filed for the quarter ended September 30, 2025 and our subsequent filings with the SEC. The unaudited results in this press release, including Q4 2025 net product revenue, are preliminary and subject to the completion of accounting and annual audit procedures and are therefore subject to adjustment. We cannot assure you that the forward-looking statements in this press release or the assumptions upon which they are based will prove to be accurate. The forward-looking statements in this press release are as of the date of this press release. Except as otherwise required by applicable law, LENZ disclaims any duty to update any forward-looking statements. You should, therefore, not rely on these forward-looking statements as representing our views as of any date subsequent to the date of this press release. 

    Contact:
    Dan Chevallard
    LENZ Therapeutics
    IR@LENZ-Tx.com 

    Source: LENZ Therapeutics, Inc.

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  • Wall Street investors return to AI as Trump plans to ban corporate home buying

    Wall Street investors return to AI as Trump plans to ban corporate home buying

    The S&P 500 has ended lower, pulled down by declines in JPMorgan, Blackstone and other financials, while Nvidia and Alphabet lifted the Nasdaq as investors shifted towards AI-related stocks.

    The drop in the S&P 500 followed an intraday record high earlier in the session on Wednesday.

    Shares of housing acquisition companies tumbled after President Donald Trump said he was moving to ⁠ban Wall Street investors from buying single-family homes in a bid to reduce home prices. Real estate platform Zillow moved higher.

    Fed rate cut on the cards

    The Dow Jones Industrial Average fell 472.60 points, or 0.96 per cent, to 48,999.39. Data on Wednesday showed US job openings fell more than expected in November after rising marginally in October, while a separate ADP report showed that private payrolls increased less than expected in December.

    While the latest labour market datasets mark a return to the standard release of economic data disrupted by the US government shutdown, they did little to change expectations of interest rate cuts from the Federal Reserve ahead of Friday’s key government payrolls report.

    Investors were also monitoring geopolitical developments after the US said it seized a Russian-flagged, Venezuela-linked tanker as part of Trump’s aggressive push to dictate oil flows in the Americas and force Caracas’ socialist government to become its ally.

    Investors return to AI stocks, defence sector under scrutiny

    Major defence groups Northrop Grumman and Lockheed Martin lost ground after Trump said he would not permit dividends or stock buybacks for defence companies until they fixed problems with the production of military equipment.

    Nvidia, Microsoft and Alphabet rose as investors shifted back into AI stocks following recent worries they were overvalued. Underscoring investor appetite for heavyweight AI players, Anthropic is planning a multibillion-dollar fundraising that would value the Claude chatbot maker at $US350 billion.

    That would make the privately held company more valuable than the vast majority of corporations, including Advanced Micro Devices, Chevron and Wells Fargo.

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  • X-Ray Spectra Could Help Reveal Dark Matter in Galaxy Clusters

    X-Ray Spectra Could Help Reveal Dark Matter in Galaxy Clusters

    Dark Matter (DM) remains one of the most daunting mysteries for astronomers, astrophysicists, and cosmologists. Six decades ago, the theory that the Universe was filled with mass that did not interact with normal matter in visible light…

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