Author: admin

  • Respiratory Infections Can Awaken Breast Cancer Metastases – NEJM Journal Watch

    1. Respiratory Infections Can Awaken Breast Cancer Metastases  NEJM Journal Watch
    2. A viral wakeup call  Nature
    3. Respiratory viruses like the flu and COVID can trigger dormant cancers, research suggests  KPTV
    4. New Research Suggests An Alarming Relationship Between COVID And Breast Cancer  HuffPost
    5. Study: COVID and Flu May Activate Dormant Breast Cancer Cells  Breast Cancer.org

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  • How Justin Bieber’s new music ‘put strain’ on his bond with Hailey

    How Justin Bieber’s new music ‘put strain’ on his bond with Hailey

    How Justin Bieber’s new album ‘strained’ marriage with Hailey?

    Justin Bieber and Hailey Baldwin’s marriage has been under scrutiny since they tied the knot just two months after the Baby singer’s highly publicized breakup from Selena Gomez.

    The marriage woes rumor began circling again last year before welcoming their son, baby Blue Jack, in 2024, and recently, after Justin’s new music lyrics briefly hinted at trouble in paradise.

    However, a source privy to US Weekly revealed that the love birds are “in a much better place” after Justin released his album first since 2021.

    The insider told the outlet that the rumored rift between the couple was due to Justin putting all his energy into recording his new album, Swag.

    Now, since the album is out, the “tension” between the couple “has settled.”

    “The intense focus and emotional toll of creating new music had put a strain on their marriage,” the tipster claimed. “When Justin is in the studio making new music, he gets completely consumed and shuts everything else out.”

    Since the album’s release in July, Hailey and Justin’s bond is improving, and the pop singer is also “in a better mental headspace” and “very happy” over the success of it.

    They “have been able to finally reconnect more” while on the getaway to Idaho, and “there’s a sense of relief on both sides.”

    Moreover, Hailey is “very patient” with her husband.

    But, “there’s still work to be done in their marriage.”

    “They’re in a much better place,” The bird chirped.


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  • Hrithik Roshan’s ‘War 2’ faces downward trend in first week

    Hrithik Roshan’s ‘War 2’ faces downward trend in first week



    ‘War 2’ faces major setback at box office by the end of first week

    Hrithik Roshan’s War 2 is set to wrap its extended first week on a disappointing note, nearing ₹150 crore at the box office.

    The newly released action-thriller has taken the internet by storm with its latest box office update.

    According to Pinkvilla, War 2 earned ₹3.75 crore on Thursday, August 21, closing its first week with a total of ₹147.75 crore.

    Meanwhile, Ayan Mukerji’s directorial kicked off its theatrical run with ₹28 crore and collected around ₹125 crore net over its opening weekend.

    War 2, starring Roshan, 51, Jr NTR, and Kiara Advani, is expected to conclude its theatrical run with collections comparable to Ek Tha Tiger.

    This comes after the film took the lead over Rajinikanth’s Coolie at the box office on its second day of release.

    As per Pinkvilla, War 2 collected ₹67 crore on its second day, Friday, August 15, while Coolie earned ₹63.50 crore.

    However, both projects witnessed a significant drop in collections on Saturday, August 16.

    Meanwhile, the Zindagi Na Milegi Dobara star is set to reprise his role as Major Kabir Dhaliwal in the sequel to the 2019 War.

    For the unversed, War 2 was released on Thursday, August 14. 

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  • Canada v Fiji match preview

    Canada v Fiji match preview

    The Canadians are yet to win a Rugby World Cup, but those in the know say this year could be their time. A wealth of experience – on the international stage as well as with some of the best clubs around the world – is coupled with a high degree of youthful injection in their ranks.

    For Fiji, Saturday’s game presents an exciting opportunity to showcase their credentials on the biggest stage, ably led by their young captain Alfreda Fisher.

    Kick-off: 17:30 BST, Saturday, 23 August 

    Venue: York Community Stadium, York

    From where to go before kick-off, to must-visit local attractions, check out England superstar Ellie Kildunne’s Rugby World Cup 2025 Guide to York.

    How to watch: Grab some of the few remaining tickets here.

    Or check out our global guide to the TV options in your region.

    Canada team

    Canada key player: Sophie de Goede (pictured) is about as versatile as rugby players come; despite playing in the second row and being a supreme operator in the lineout, she’s also a reliable goal kicker from the tee. One of the stalwarts of a highly experienced Canadian team, De Goede is likely to be key to her side’s ambitions of winning their first Rugby World Cup.

    Fiji team

    Fiji key player: Fiji have two players who have bucked the trend in terms of experience on this stage. They are captained by 21-year-old Fisher, while fly-half Salanieta Kinita is only 23 years old. Though some teams have a wealth of experience to lean on, these two are planning to show the world what the next generation can do.

    What they said

    Canada head coach, Kevin Rouet:

    “It’s an unpredictable team, and that’s what we love with Fiji. You can’t be too prepared because it’s very unpredictable. It’s fun to see that kind of style of play. A lot of them play in England, so it’s kind of a different style of play. So you have to prepare for that a little bit, to make sure this is not the same picture they see every weekend in PWR (Premiership Women’s Rugby). It’s fun to analyse our style of play and it’s fun to make your strategy and just show them (the team) the strengths and weakness of Fiji.

    “We have a couple of key players who don’t play this game, and we have players who haven’t played in the past two games. So everybody’s engaged, everybody knows the team is bigger than the individual, and I think it’s important to recognise that. And during the past three years, I think they show that they are like working for the team. So there is not much pushback… That I know.”

    Canada co-captain, Alexandra Tessier:

    “We’re very eager to get started, to get the first game in. We’ve had an amazing prep up to here – the two last game I think were quality and some of their respective halves. But yeah, I think everybody’s excited and we’re a very one-team kind of mindset. It’s always team first across the board. Excitement is the big word right now.

    “We also have like an underlying mission to grow the sports in our country. Big competitions like the World Cup allow us naturally to get ourselves out there as well and inspire some of the young girls, younger boys to play rugby. We want to show what rugby is and, to the world as well, what we’re capable of, with our unique style, because I think we love how we play and we want to show the rest of the world too.”

    Fiji head coach, Ioan Cunningham:

    “It’s a pleasure to be here. We’ve had a great four- or five-day prep in anticipation of our first Rugby World Cup game. An exciting opportunity for us as a team to showcase our talents and our gifts on the world stage and what a way to start against the number two team in the world, Canada. We can’t wait to get going.

    “We’ve settled in pretty well at world-class facilities, where we’re training over at Queen Ethelburga’s College. We had some good days on Monday and Tuesday and sharp day today. One captain’s run and then we start.”

    Fiji captain, Alfreda Fisher:

    “We are excited, we’ve been training really hard. We are trying to adjust to the weather and have been trying to do our best for months and now. We are really grateful for all of the small things that our management and our coaches are doing to make us get better.

    “To our Fijian community in the UK, come out in numbers, bring your flags with you and come and support us. To our family, friends and fans back home, keep on praying for us and please just support us until the very end of our campaign in England.”

     

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  • YouTube Music introduces new social features for fans

    YouTube Music introduces new social features for fans

    Just yesterday, we reported on a leak suggesting that YouTube Music could soon extend the comment functionality to public playlists, and today, with YouTube kicking off festivities connected to the platform turning 10, the feature has officially been announced.

    Yep, YouTube Music has been in existence for ten years now, even though it doesn’t feel that way. What started out as a barebones music streaming app has since matured, boasting a huge library of not just music, but also videos, podcasts, AI features, personalized playlists, and more. Now, with the app turning 10, Google is looking to add more to the feature-packed experience.

    As mentioned above, YouTube Music users will soon be able to leave comments directly on albums and playlists. In addition, they’ll also be able to access a new feature called taste match playlists, which, as its name suggests, will curate and add new music to a shared playlist based on the listening habits of everyone in a group.

    Elsewhere, the music streaming giant has also partnered with Bandsintown to bring nearby concert listings directly to the app. These will reportedly show up when you’re browsing through specific artists’ catalog on the platform. “We’re also adding new notifications to let you know when upcoming releases from your favorite artists are announced, new merch is dropping, or event dates are added – so fans never miss a beat,” added the music streaming giant.

    Whether you’ll be redirected to a website where you can actually buy tickets for said listings remains to be seen.

    YouTube Music has new badges

    But not for you

    Lastly, YouTube Music is expanding its recent ‘badges’ feature, but instead of giving users a bigger variety of badges, it is giving new ones to creators in the form of “view” milestones.

    Aimed at giving creators a helping hand, said badges will appear on music videos that are quickly approaching a major ‘view milestone.’ These include 100,000, 1 million, and even 1 billion views. According to the tech giant, these badges will motivate true fans to help their favorite artists hit major milestones.

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  • Singer-songwriter Kathleen Edwards on new album and her definition of ‘Billionaire’

    MARY LOUISE KELLY, HOST:

    Who wants to be a billionaire? If you ask hit singer-songwriter Kathleen Edwards, she’d raise a hand. But it’s probably not the kind of billionaire you’re thinking of.

    (SOUNDBITE OF SONG, “BILLIONAIRE”)

    KATHLEEN EDWARDS: (Singing) If this feeling were a currency, I would be a billionaire.

    KELLY: That’s the title track of her new album – the first from Edwards in five years, and her second since she walked away from a grueling schedule of touring and recording and left the industry for a while. She told NPR back in 2020…

    (SOUNDBITE OF ARCHIVED NPR CONTENT)

    EDWARDS: I think I just felt a huge sense of relief when I said, I’m done, and I’m done with music.

    KELLY: But now, after rediscovering the joy and the vulnerability in performing, she’s back on tour, and she has collaborated with other celebrated names in Americana music along the way. Well, I asked Kathleen Edwards about this moment in her career, starting with an explanation of that title track.

    (SOUNDBITE OF SONG, “BILLIONAIRE”)

    EDWARDS: (Singing) A billionaire.

    One of my worst traits is that I sometimes like to poke the bear a little bit. And by calling it “Billionaire,” I’m kind of highlighting an interesting social moment where the word is considered to be – like, the only people who are billionaires are people who have too much in this world. And I would argue that we should all aspire to be billionaires. And the song is actually about somebody that I lost who was very dear to me, who was very young when she passed away and still had her whole life ahead of her.

    (SOUNDBITE OF SONG, “BILLIONAIRE”)

    EDWARDS: (Singing) Grief is love. That makes sense, except for those of us still left to figure out what to do.

    And I think the song is kind of about the idea that, you know, life is meant to be lived to its fullest and without apology. And if all of your life’s adventures enrich your life to become a billionaire in experience, then that’s what you should be if that’s what you want.

    KELLY: I want to ask about another song on the album, “Little Pink Door,” which I read y’all did one take and that was it. You walked away. Is that right?

    EDWARDS: Well, you know, in the studio, a lot of times you’ll do one take and then you’ll add overdubs, or you’ll redo a vocal, or add drums. This was – everyone played live off the floor.

    KELLY: Wow.

    EDWARDS: And it’s Jason playing live, and Jen Gunderman playing live on keyboards, and…

    KELLY: Jason Isbell, for people taking note. Yeah, the Jason Isbell. Go on.

    EDWARDS: The Jason Isbell, the great Jason Isbell – and yeah, it was one live, off-the-floor pass, the three of us, start to finish.

    KELLY: Wow. Let’s hear a little bit.

    (SOUNDBITE OF SONG, “LITTLE PINK DOOR”)

    EDWARDS: (Singing) I’ll see you later in a thought (ph) for sure. You were wrapping me up at that little pink door. You were wrapping me up.

    KELLY: I got to ask, is there a real little pink door? Is this a real place?

    EDWARDS: (Laughter) There is a little pink door. There’s a place in St. Petersburg, Florida, that I pass almost every morning on my little adventure to walk my dogs. And it’s just this house that sort of – you know when you pass a beautiful, little quaint home that you just think is charming to look at, and it captures your imagination, and you wonder who lives there and how lucky they are (laughter)?

    KELLY: Yeah. And, like, I could live there, and then what would my life be if that were my front door?

    EDWARDS: You got it. And I kind of touched on an old love story that inspired it, but the house is in St. Petersburg, Florida. It’s not mine, but I look forward to handing a copy of my new record off to whoever the owners are who live there.

    KELLY: It’s not yours yet.

    EDWARDS: (Laughter).

    KELLY: Owners of little pink door house, you’ve been warned. I was looking back at the last time we spoke with you, and you talked about how you out-and-out quit the music business at one point. You opened a cafe outside Ottawa, and you named it Quitters, which I love.

    (LAUGHTER)

    KELLY: I just love that because everyone is so anti-quitting. It’s all, oh, you can’t quit now. Keep going, can’t quit. And I love that you were like, oh, yeah, buddy? Try me (laughter).

    EDWARDS: I sold the cafe in early 2022.

    KELLY: OK.

    EDWARDS: I opened it in the fall of 2014 on a shoestring budget, in a building that needed a ton of work. And I kind of, you know, imagined, after touring the world and loving coffee shops, and them being a real staple in a touring musician’s life, or in, you know, many people’s lives, this place that always made me feel like I had one little tether every day that was, you know, a bit of a constant. And I thought, well, if I’m going to not do music, I’d better find something else to do. And sure enough, I did.

    KELLY: Well, as you and I are speaking right now, Kathleen Edwards, you have been – you’ve been touring all this summer. We’re talking to you ’cause you’ve got this new album coming out. You have most definitely unquit (ph). I wonder, is there a song on here that speaks to that – that momentum in your life?

    EDWARDS: Oh, gosh. You know, “Say Goodbye, Tell No One” was a little bit of a kiss-off song from the coffee shop.

    (SOUNDBITE OF SONG, “SAY GOODBYE, TELL NO ONE”)

    EDWARDS: (Singing) People change, people grow. You can take it in stride or slam a door.

    One of the things that owning my own business I had to learn – which I’m slightly embarrassed but also proud to say it – I had to put my big girl pants on. When my first record came out, I was 22. I had a manager, an agent, and I’d sort of been scooped out of Ottawa and thrust on to “The David Letterman Show” the day my record came out.

    KELLY: Wow. Yeah.

    EDWARDS: And so for years, I had this incredible group of people supporting me, but they were the ones having difficult conversations on my behalf. And one of the things that I realized, coming through being a small business owner, is you have to confront hard truths, whether they’re about you or the people that work for you or the fact that your business has to close – all those things. And I think the joy of playing music is such a new – a renewed gift to me. But also, I’m no longer nervous about what people are going to think of me.

    (SOUNDBITE OF SONG, “SAY GOODBYE, TELL NO ONE”)

    EDWARDS: (Singing) The hardest part about the truth, saying something that might hurt you. The hardest part about a lie, you can’t outrun it if you try.

    And just ’cause you have to tell somebody something that’s really hard and might hurt their feelings doesn’t mean that you’re a bad person. And I think that’s what sometimes the record is about.

    KELLY: I love that. Well, that, I guess, brings us full circle. I was going to ask you what counts as success to you at this point, at this moment. And it sounds like it circles back to the billionaire idea and what really matters.

    EDWARDS: It is – that’s all that life is about. And I think the song that – called “Billionaire” that I wrote for my beautiful friend, Amanda – she was the most living and optimistic person. She came into the coffee shop as a customer, and she ended up running the place. And losing her reminded me that life is really just about having great people in your life and wanting to tell them that they are – they’re a gift to you.

    KELLY: Well, amen to all of that. Kathleen Edwards, thank you.

    EDWARDS: Thank you. I appreciate so much you being interested in talking to me. I’m humbled. I’m really humbled.

    KELLY: We’ve been talking about her new album – her first album in five years. It is titled “Billionaire.”

    (SOUNDBITE OF SONG, “SAVE YOUR SOUL”)

    EDWARDS: (Singing) Who’s going to save your soul? Transcript provided by NPR, Copyright NPR.

    NPR transcripts are created on a rush deadline by an NPR contractor. This text may not be in its final form and may be updated or revised in the future. Accuracy and availability may vary. The authoritative record of NPR’s programming is the audio record.

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  • NASA’s SpaceX CRS-33 to Advance Tissue Engineering, Stem Cell Research, and Space Computing

    NASA’s SpaceX CRS-33 to Advance Tissue Engineering, Stem Cell Research, and Space Computing

    ISS National Lab-sponsored investigations seek to accelerate therapeutic innovations, advance computing technologies, and prepare the future workforce

    KENNEDY SPACE CENTER, Fla., Aug. 21, 2025 /PRNewswire/ — SpaceX’s 33rd commercial resupply services (CRS) mission, funded by NASA, is slated to launch no earlier than 2:45 a.m. EDT on Sunday, August 24, from Cape Canaveral Space Force Station in Florida. The mission will carry critical research and supplies, including a diverse array of investigations sponsored by the International Space Station (ISS) National Laboratory®.

    During this mission, the ISS National Lab continues its commitment to enabling space-based research that brings value to humanity and supports the development of a robust and sustainable economy in low Earth orbit. The investigations launching include biomedical and physical science research, technology demonstrations, and student-led projects, showcasing the breadth of innovation made possible through access to the orbiting laboratory.

    ISS National Lab-sponsored investigations on this mission include the following:

    • Wake Forest Institute for Regenerative Medicine will study engineered liver tissue containing blood vessels in microgravity. Originating from NASA’s Vascular Tissue Challenge, this project could advance tissue engineering in space to support future organ replacement for patients on Earth and beyond.
    • Cedars-Sinai Medical Center will evaluate whether induced pluripotent stem cells divide faster in space, which could accelerate regenerative medicine breakthroughs. This project builds on multiple investigations from this research team over the years and could further in-space manufacturing capabilities to produce stem cell-based therapies for heart disease, neurodegenerative conditions, and more.
    • ISS National Lab Commercial Service Provider Axiom Space is partnering with Red Hat, a leading provider of open-source solutions, to validate edge computing technologies through the Red Hat Device Edge platform. Real-time data processing capabilities in orbit will be paramount to scaling R&D and manufacturing on future space platforms.
    • Multiple student-led projects aim to prepare the space workforce of tomorrow. One project is from the annual Genes in Space competition, in which students in grades 7-12 propose genetics-related investigations to be done on the space station. The project aims to use bacteriophages as therapeutic agents to combat potential microbial infections in space. Additionally, the Higher Orbits Go For Launch! program will send multiple experiments from students in Florida, Michigan, Pennsylvania, Texas, and Virginia.

    These investigations reflect the growing demand for space-based R&D and the expanding role of the space station as a platform for innovation. The ISS National Lab is proud to support these efforts, pushing the limits of science and technology in space to benefit life on Earth.

    To learn more about the science launching on this mission, visit our launch page.

    Download a high-resolution image for this release: Space Station Resupply Mission

    About the International Space Station (ISS) National Laboratory:
    The International Space Station (ISS) is a one-of-a-kind laboratory that enables research and technology development not possible on Earth. As a public service enterprise, the ISS National Laboratory® allows researchers to leverage this multiuser facility to improve quality of life on Earth, mature space-based business models, advance science literacy in the future workforce, and expand a sustainable and scalable market in low Earth orbit. Through this orbiting national laboratory, research resources on the ISS are available to support non-NASA science, technology, and education initiatives from U.S. government agencies, academic institutions, and the private sector. The Center for the Advancement of Science in Space® (CASIS®) manages the ISS National Lab, under Cooperative Agreement with NASA, facilitating access to its permanent microgravity research environment, a powerful vantage point in low Earth orbit, and the extreme and varied conditions of space. To learn more about the ISS National Lab, visit our website.

    As a 501(c)(3) nonprofit organization, CASIS accepts corporate and individual donations to help advance science in space for the benefit of humanity. For more information, visit our donations page.


    International Space Station (ISS) National Laboratory
    Managed by the Center for the Advancement of Science in Space® (CASIS®)


    1005 Viera Blvd., Suite 101, Rockledge, FL 32955 321.253.5101 www.ISSNationalLab.org

    SOURCE International Space Station National Lab

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  • Powell’s Jackson Hole speech could be make-or-break moment for the summer stock-market rally

    Powell’s Jackson Hole speech could be make-or-break moment for the summer stock-market rally

    By Isabel Wang

    The Fed chair’s annual speech could trigger a significant repricing in bond yields and risk assets in the U.S. financial market

    All eyes will be on Federal Reserve Chair Jerome Powell when he speaks in Jackson Hole, Wyo., on Friday.

    Friday brings what’s become an annual rite of summer for U.S. financial markets, in the form of Federal Reserve Chair Jerome Powell’s address to monetary-policy mavens in Jackson Hole, Wyo.

    Investors have their eyes fixed on the annual economic symposium hosted by the Kansas City Fed, as the central bank charts the future direction of its monetary policy in what could be a defining moment for the market’s summer story.

    Powell speaks at 10 a.m. Eastern time Friday. This year, investors are hoping for confirmation that the Federal Reserve will resume cutting interest rates in September – a move largely priced into markets. Yet analysts warn that Powell could fail to do so, leaving the stock rally hanging by a thread or even sending markets into turmoil. The potential hang-up is that a number of policymakers appear worried that inflation from President Donald Trump’s tariffs is just around the corner.

    “If Powell uses his Jackson Hole speech to draw a line in the sand – refusing to precommit to cuts or hinting that the market’s pricing has run ahead of reality – it could trigger a significant repricing in bond yields BX:TMUBMUSD02Y BX:TMUBMUSD10Y and risk assets,” said Daniela Sabin Hathorn, senior market analyst at Capital.com.

    “Investors should tread carefully because what’s expected to be a calm, consensus-driven event could instead become the Fed’s rebuttal to market exuberance in months,” she told MarketWatch in emailed commentary.

    See: Will Powell use Jackson Hole speech to push back on hopes for September rate cut?

    Stocks have wobbled in the run-up to the speech, with a violent rotation out of high-flying megacap tech names sending the Nasdaq Composite COMP down 2.4% so far this week. The S&P 500 SPX has pulled back 1.2%, with both indexes remaining not far below record closes set last week. The less tech-centric Dow Jones Industrial Average DJIA is off just 0.4% this week.

    Fed-funds futures traders on Thursday were pricing in a 73.5% probability of a quarter-point interest-rate cut at the central bank’s Sept. 16-17 meeting, with at least another 25-basis-point reduction expected by year-end, according to the CME FedWatch Tool.

    Those expectations have helped fuel the stock-market rally over the past month, propelling the three major indexes to or near record territory after economic data showed consumer prices have only risen slightly due to tariffs and the labor market may be losing steam at a quicker pace than previously thought – factors that appear to support the case for a Fed rate cut.

    But the probability of a September cut priced into the market has faded from around 90% a week ago, reflecting that the economic picture is far from one-sided. The cost of wholesale goods and services – where rising inflation tends to show up first – posted the biggest increase in July in three years, possibly pointing to a sizable acceleration in price hikes tied to U.S. tariffs. The unemployment rate was still hovering at a historically low level – offering little justification for a Fed easing anytime soon.

    Policymakers last month “generally expected inflation to increase in the near term,” minutes of the Fed’s July meeting showed on Wednesday. While they disagreed on whether that would be a short-term increase in price pressure, they thought higher costs will eventually hit U.S. businesses and companies would have to pass through the costs to consumers.

    See: Fed officials see inflation just around the corner – and think consumers will bear the burden, minutes show

    That’s why Callie Cox, chief market strategist at Ritholtz Wealth Management, said Powell could throw cold water on investors’ near-certainty of a September rate cut.

    “I would expect him to weigh in on today’s market environment – I can’t imagine with inflation and jobs data at where they were [in July] that he will be able to confirm how sure markets are about getting a rate cut in September,” Cox told MarketWatch in a phone interview.

    But stock-market investors are not only expecting a September cut, they’re also yearning for reassurance that more Fed easing lies ahead, said Shannon Saccocia, chief investment officer of wealth at Neuberger Berman.

    “Last year at this time, this was the speech that Powell really set the stage for Fed action, so there’s a lot riding on his comments on Friday, particularly given what was deemed to be a disappointingly hawkish tone out of the last Fed meeting from him in the press conference,” Saccocia told MarketWatch via phone on Wednesday.

    That’s why Powell’s words could provide crucial clarity on whether these market expectations are well founded. But for a stock market that has enjoyed a seemingly relentless rally marked by unusually low volatility for most of the summer, choppy waters may finally lie ahead – and there’s little room for disappointment if Powell hints at policymakers requiring more data before resuming the easing cycle that has been put on hold ever since December, according to market analysts.

    See: Stocks often rise the week of the Fed’s big Jackson Hole gathering. Don’t count on it this year.

    To be sure, investors have reason to be cautious. Back in 2022, Powell’s keynote speech at Jackson Hole stopped a torrid bear-market rally when he insisted that the central bank remained committed to bringing down inflation by raising interest rates forcefully, even if this approach resulted in some pain for American consumers and businesses.

    “Jackson Hole has become increasingly important over the last couple of year – but this year, the potential for rate cuts coming in about a month, along with the political pressure that the Fed and the chair in particular are under, make Powell’s comments more market-moving than we expected,” Saccocia said.

    Powell’s speech comes amid intensifying pressure on the Fed from President Trump and his allies.

    Trump has repeatedly slammed and insulted the Fed chair for not quickly resuming rate cuts, and called for his resignation while stopping short of attempting to fire Powell. On Wednesday, the president called on Lisa Cook, a Fed governor, to resign after Bill Pulte, the head of the Federal Housing Finance Agency, alleged on social media that she had submitted what he described as fraudulent information on a pair of mortgage applications. Cook said she had no intention to resign and was gathering information to respond to questions.

    U.S. stocks DJIA SPX COMP finished lower on Thursday after economic data showed first-time jobless claims rose more than expected last week, adding to concerns the labor market is losing steam.

    -Isabel Wang

    This content was created by MarketWatch, which is operated by Dow Jones & Co. MarketWatch is published independently from Dow Jones Newswires and The Wall Street Journal.

    (END) Dow Jones Newswires

    08-21-25 1618ET

    Copyright (c) 2025 Dow Jones & Company, Inc.

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  • Novel alpha particle therapy holds promise in prostate, bladder cancer

    Novel alpha particle therapy holds promise in prostate, bladder cancer

    Alpha particles are highly effective at destroying tumor cells, but their therapeutic use has been limited by the short range in which these particles can travel in tissue. A novel mechanism called Alpha DaRT is exploring the possibility to diffuse atoms that emit alpha particles directly within solid tumors, thus overcoming the short travel distance limitation.1 This opens the door to new therapeutic approaches in radiation therapy beyond conventional modalities that rely on beta or gamma emissions.

    Alpha DaRT is currently being assessed across a broad range of malignancies, including lung cancer, pancreatic cancer, and skin cancer. In the genitourinary (GU) cancer space, the technology shows particular promise in prostate and bladder cancer, where highly targeted treatments are critical for sparing surrounding organs while maintaining oncologic control.

    Currently, Alpha DaRT is under investigation in a feasibility study (NCT04543903) as a neoadjuvant therapy in patients with prostate cancer. In total, the study plans to enroll 10 adult patients with pathologically confirmed prostate adenocarcinoma. The primary end points for the study are feasibility and safety, and primary completion is expected in December 2026.2

    In the following interview, Robert B. Den, MD, outlines the exploratory applications of the Alpha DaRT technology across the prostate and bladder cancer landscapes. Den is the Chief Medical Officer at Alpha Tau Medical as well as an associate professor of radiation oncology, cancer biology, and urology at Thomas Jefferson University in Philadelphia, Pennsylvania.

    Urology Times®: By way of background, could you explain what Alpha DaRT is for those who don’t know? What is the mechanism of action for this agent?

    Den: Alpha DaRT is a small stainless steel or titanium seed that we coat with a radiopharmaceutical, radium-224. Radium-224 is an unstable element, meaning it has too much energy, and it will release that energy naturally through radioactive decay. That process of radioactive decay releases the radiopharmaceutical radium-224 as it decays to become radon-220 from the physical seed. Therefore, what we’ve done is we’ve used a seed as a scaffold to introduce a radiopharmaceutical locally, intratumorally. Now, radon and the subsequent daughter atoms will continue the decay process, spreading Alpha dose approximately 5 mm from where we place the seeds. What we’ve figured out is a way to deliver the most potent form of radiation, which is alpha particles, and overcome the natural limitation of the alpha particle itself.

    Urology Times: How is this treatment approach being applied in the genitourinary oncology space? What have preclinical data shown?

    Den: We are currently utilizing this technology in the setting of prostate cancer, and we are moving toward utilizing it as well in bladder cancer. One of the main challenges in prostate cancer is that you want to maximize the amount of damage that you cause to the tumor and minimize it to the bladder, rectum, and urethra. The unique aspect of the Alpha DaRT and alpha technology is that the Alpha dose is very conformal, much more so than standard treatments that are available today. What that means is that we can put our sources touching the rectal wall or touching the bladder wall and not see damage to those structures because the dose falls off so quickly.

    We’ve shown in preclinical studies that we can have just as potent, if not a more potent, effect on stalling and reversing tumor growth. We also have the ability to activate an immune response in a much more brisk and robust manner than [with] standard therapy. We think that with the Alpha DaRT technology, we can not only augment the role of immunotherapy in bladder cancer, but we may also be able to trigger it even more in patients who are currently refractory to that type of therapy. There are multiple ways in which we see the Alpha DaRT being utilized for these patients.

    Urology Times: Alpha DaRT is currently being explored in a clinical trial in the prostate cancer space. How is that study designed? What are the key end points?

    Den: That study right now is a pilot study. It’s a feasibility and safety study. We are specifically studying it in the context of patients with recurrent prostate cancer who have had prior radiation to the prostate. We know that this can be a really challenging patient population. Surgical resection is more complicated in these patients, and reirradiation causes an increase in potential [adverse] effects.

    So, we’re doing 2 things in this study. First, we’re ensuring that we are able to safely deliver the Alpha DaRT technology to these patients. Second, we are also evaluating how to optimize the delivery in this patient population. We’ve built out a unique treatment planning software, as well as a new grid format in which we deliver the sources directly into the prostate itself. Of course, secondary end points are efficacy in terms of [prostate-specific antigen] control.

    Urology Times: If the data shows that this approach is feasible and effective, how do you see Alpha DaRT fitting into the current treatment paradigm?

    Den: In truth, Alpha DaRT can fit across the treatment paradigm. We anticipate that we will show the safety of this device in this population where there is a high propensity for adverse events to occur. [The agent could] then be utilized either in combination with current standard therapies or in lieu of certain standard therapies, and we can deliver it in such a way that we can make it a much more attractive option for patients who would otherwise not have as many options available to them. What I would also say is that with the ability to utilize it in combination with immunotherapy, it opens up a huge opportunity for a very diverse patient population, potentially even in the metastatic setting, setting us apart from what current technologies have available.

    Urology Times: We talked about the applications of Alpha DaRT across prostate cancer and bladder cancer. Looking at those 2 avenues, what are the next steps for this agent?

    Den: We plan on opening up US trials in both of these spaces, but prostate space will open up first. This will introduce the technology not only to the patients, but also to the different providers. Our technology is unique in that it can be delivered by urologists directly in conjunction with radiation oncology, and we can do this in multiple different settings. We currently have the product being utilized in the setting of non-GU cancers, as diverse as GBM

    [glioblastoma], pancreatic cancer, skin cancer, and these are being delivered by many different providers, whether it’s neurosurgeons, endoscopists, or dermatologists. We see this as a product that can be utilized across multiple specialties, and it is not only in the domain of one.

    Urology Times: Is there anything else that you wanted to add?

    Den: I think that this technology is unique in that it’s allowing us to access a very potent form of radiation, the alpha technology, which previously had been prohibitory, except in the setting of systemic therapy. We can utilize systemic therapy as precedent. In prostate cancer, we have product Xofigo, which is an alpha radium-223, and we have a similar product called samarium-153 that used to be on the market. One of the unique aspects and differences between samarium and radium is that although samarium showed a progression-free survival advantage, radium ultimately showed a survival advantage later on when there were more drugs available at the time. So, clearly, we see a unique difference between alpha vs beta in the context of prostate cancer and GU cancer. The thought is that we can replicate this as well in the intratumoral and in the localized setting.

    REFERENCES

    1. Alpha DaRT technology. Accessed August 21, 2025. https://www.alphatau.com/alpha-dart-radiotherapy

    2. Neoadjuvant interstitial brachytherapy using diffusing alpha emitters radiation therapy in men with prostate cancer. ClinicalTrials.gov. Last updated February 7, 2025. Accessed August 21, 2025. https://clinicaltrials.gov/study/NCT04543903

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  • Attack on Colombian police helicopter leaves at least 8 dead, president says

    Attack on Colombian police helicopter leaves at least 8 dead, president says

    An attack on a Colombian National Police helicopter Thursday killed at least eight people and injured several others, according to President Gustavo Petro.

    It’s still unclear who is behind the attack in the Antioquia department.

    In his most recent comments Thursday, Petro attributed it to the 36th Front of the Estado Mayor Central (EMC), dissidents of the former Revolutionary Armed Forces of Colombia (FARC), a leftist guerrilla group.

    However, earlier, he suggested the powerful criminal syndicate Gulf Clan might be involved, noting the attack came after the seizure of 1.5 tons of cocaine in the Urabá region of Antioquia.

    “We have the unfortunate news of eight police officers dead and eight injured in the helicopter whose mission was to transport personnel to eradicate coca leaf crops in Amalfi,” Petro wrote on his X account.

    National Police Director Carlos Fernando Triana Beltrán described the incident as a “terrorist act” and said police units are in the area treating the wounded.

    The helicopter was supporting the manual eradication of illicit crops when it was allegedly attacked by a drone, Antioquia Gov. Andrés Julián Rendón said, adding two uniformed officers were injured.

    The governor posted a video that appears to show the helicopter crashing into a hill.

    Rendón warned that both the Gulf Clan and dissidents of FARC operate in the area, and noted the national government has been unable to agree on who is responsible for the attack.

    “(We) have always known that these are FARC dissidents in charge of Calarcá: that’s their modus operandi, allied with the ELN,” he said, referring to the leftist guerrilla group National Liberation Army. “Coordination within the national government is urgent. This is a matter of life and death.”

    This is a developing story and will be updated.


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