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  • Rita Ora reveals major role Beyonce played in her ‘messy situation’

    Rita Ora reveals major role Beyonce played in her ‘messy situation’



    Rita Ora reveals how Beyonce took action her amid Jay-Z cheating rumours

    Rita Ora found Beyonce to be a “protector” in her corner when she became a target for Jay-Z cheating rumours.

    The 34-year-old songstress opened up about the time she was speculated to be “Becky with the good hair,” the woman involved in Jay-Z’s cheating rumours around the time when Beyonce released her album, Lemonade.

    The For You hitmaker shared that it was Queen Bey herself who emerged as her protector during the “messy situation,” during her appearance on the latest episode of Begin Again with Davina McCall podcast.

    After the host brought up the controversy, which was touched upon in Beyonce’s song, Sorry, Ora responded that she has been “affected worse” by other things.

    “Because it wasn’t real,” she said of the “Becky with the good hair” drama, “I wish I had good hair.”

    Ora continued, “None of that was real. That was the first time I experienced what it means to be in a messy situation, I guess.”

    She revealed that all throughout the scandal, “behind closed doors,” Beyonce was her “fairy godmother.”

    “She was my protector. That’s what’s insane because there was nothing but love. And, you know, again, being signed to JAY-Z, her husband, she being my biggest inspiration, she came to my first show in New York at The Box,” she said.

    The Big singer went on to add, “I was actually genuinely upset because that’s my big sister protector. She took it upon herself to really look after me. And I still see her to this day and she’s always been so, so nice and proud, checking in on my family and friends that I’ve had since childhood and remembering their names.” 

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  • New study uncovers links to neurodegeneration after viral infection

    New study uncovers links to neurodegeneration after viral infection

    CHENNAI: Dr. Danielle Beckman is a neuroscientist whose passion for studying the brain is helping to reveal how viral infections—like COVID-19—can affect brain health and possibly lead to long-term neurological conditions such as Alzheimer’s disease.

    Originally from Rio de Janeiro, Brazil, Dr. Beckman dreamed of being a writer. But after taking a college physiology course, she became fascinated with the brain. Her interest turned personal when her grandmother developed dementia, pushing her to understand what happens inside the brain during these conditions. Working at UC Davis under expert guidance, Dr. Beckman and her team created new monkey models that mimic how viruses interact with the human brain.

    A new study published in Genomic Press Brain Medicine reveals that these models have shown viruses like SARS-CoV-2 (the virus behind COVID-19) can reach brain cells quickly—within just seven days—and cause inflammation, a key contributor to memory problems and brain fog.

    This is different from other viruses like HIV, which affect the brain more slowly.

    Dr Beckman’s findings help explain why some people experience memory issues or “brain fog” after recovering from viral infections like COVID-19. Using advanced microscopy (a way to take detailed pictures of brain cells), Dr. Beckman has identified how viruses damage brain regions related to memory and thinking.

    Long COVID

    Dr. Beckman is also active in the Long COVID community, supporting people who are still sick months after infection. She hopes her work will lead to real treatments, especially since there are currently no approved therapies for Long COVID-related brain symptoms.

    Alzheimer’s & Beyond

    In addition to studying COVID-19, her team is working on better ways to study Alzheimer’s disease. They’ve created new monkey models that more closely reflect how the disease develops in humans—something rodents (like mice) can’t do as well. These models are helping scientists test new treatments more effectively.

    While the ultimate goal of this research is to find ways to prevent or reduce brain damage caused by viruses—both in conditions like Long COVID and in more traditional neurodegenerative diseases like Alzheimer’s, it is also laying the foundation for future treatments that could help millions around the world.

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  • GOP holdouts threaten Trump megabill with key vote underway

    GOP holdouts threaten Trump megabill with key vote underway



    CNN
     — 

    House Republicans remain in a dramatic overnight stalemate as President Donald Trump and Speaker Mike Johnson attempt to cajole nearly a dozen holdouts to support the effort to move forward on the president’s sweeping domestic policy agenda bill.

    Johnson has said he plans to keep a key vote to advance the bill open “as long as it takes.” Johnson and his leadership team are whipping members to back the procedural vote in a furious last-minute scramble.

    If GOP leadership succeeds, the House would move onto final passage as quickly as possible, following debate on the bill. If the vote fails, however, it would deal a major setback to Republicans, and GOP leaders would need to go back to the drawing board to find a way forward.

    A number of House Republicans are — for now — standing in the way of delivering Trump the first major legislative victory of his second term.

    For weeks, Trump and his team have promised Hill Republican leaders that he would deliver the headstrong GOP hardliners who are still vowing to defy the president on his agenda, according to three people familiar with the discussions.

    Now, it’s all coming down to the wire. Trump and his team have spent much of the day in talks with the GOP holdouts on the bill, including summoning groups of Republicans for meetings at the White House to air their grievances with the Senate-passed version of the package. And Johnson is again facing a test of his powers in the narrowly divided House, as he seeks to steer his fractious conference to swallow a vote that many of them dislike.

    In a meeting with centrist-leaning Republicans, Trump’s tone was “cordial,” one GOP member in the room said. The White House brought in Dr. Mehmet Oz – who leads the agency in charge of Medicaid – to help educate members on related provisions in the Senate GOP bill, such as provider taxes and a bolstered fund for rural hospitals, and the potential impacts to hospitals in their districts, according to another person familiar with the discussions. Trump and Vice President JD Vance were both in attendance, helping to convince members to back the bill, those two people said.

    “Those meetings are having a big impact, members are moving to yes,” Rep. Dusty Johnson of South Dakota told reporters after returning from the White House meeting with Oz, Trump and Vance.

    House Majority Whip Steve Scalise nodded to the importance of Trump’s involvement in the discussions earlier Wednesday, telling reporters at the US Capitol, “The president from day one has been our best closer, and he’s going to continue to be through today.”

    Rep. Steve Scalise speaks to reporters on Wednesday.

    Both Johnson and Trump have been adamant that the bill land on Trump’s desk in time for him to sign it on the Fourth of July, leaving almost no time for more talks. They also have almost no room for error: House Republicans can only afford to lose three votes if they have full attendance.

    It all amounts to a pivotal week that could define Trump’ second term: So far, the push to pass his agenda in Congress has been marred by weeks of tense GOP infighting that has even some Republicans worried about how the bill could play in the 2026 midterms.

    Yet if it passes next out of the House, Trump and his Hill allies believe it will help cement his legacy on issues like border security and tax policy – including fulfilling his campaign promises of no taxes on tips or overtime pay – while attempting to rein in federal spending by instituting work requirements for able-bodied adults for Medicaid and SNAP.

    Meetings were ongoing at the White House as of midday Wednesday, but key conservatives were still insisting they want to change the Senate bill — a promise that Trump and Johnson aren’t willing to make.

    “It’s not ‘take it or leave it.’ I don’t need take it or leave it legislating. How about we send it back to him. We say, ‘Take it or leave it,’ all right? So the Senate doesn’t get to be the final say on everything,” Texas Republican Rep. Chip Roy, one of the most vocal critics of Trump’s bill, said before he left for the White House on Wednesday. “We need more spending restraint.”

    Rep. Chip Roy at the US Capitol on Wednesday.

    Roy is a leading member of the ultra-conservative House Freedom Caucus, which outlined their opposition to the Senate’s version of Trump’s domestic policy bill in a new memo obtained by CNN.

    The right-wing group of Republicans pointed to more than a dozen problems they have with the current bill, including what they described as watered-down energy tax credit measures, an increase to the deficit and various Medicaid provisions that differ from the House-passed version of the bill.

    And in another troubling sign for the White House, the Freedom Caucus’ chairman, Rep. Andy Harris of Maryland, told reporters he declined to attend the meeting with Trump. “I’m still voting no on the rule. We have to get this thing right,” Harris said.

    Another possible “no” vote, Rep. Keith Self of Texas, said he was not invited to the White House.

    The Senate’s Tuesday passage of the bill had been a hard-fought victory for Trump, who spent days wrangling fellow Republicans behind the multi-trillion-dollar bill, which includes tax cuts and funding boosts for the Pentagon and border security. It also includes more contentious spending cuts to pay for the rest of the bill, including the biggest downsizing of the federal safety net in decades.

    Across the Capitol, House GOP leaders are confident the latest version can pass the House, according to multiple sources. But it will likely take significant political muscle, as Johnson grapples with his own high-stakes battle between centrists and right-wing hardliners.

    The legislative brawl inside the US Capitol has also included some dramatic moments – including over the weekend when a key Republican, Sen. Thom Tillis, stunned Washington by announcing he would not seek reelection after defying Trump and voting to block his bill on the floor. (Within a day of Trump threatening to primary him, Tillis exited the race altogether.)

    Those high-stakes moments will likely continue on Capitol Hill. Before the bill can come to a final passage vote in the House, the chamber must first take a key procedural vote known as a vote on the rule – and some conservative are threatening to rebel against it, creating a new headache for the speaker. (That vote was already delayed by several hours Wednesday.)

    The bill did clear one early hurdle in the House: The House Rules Committee voted to advance the rule on Trump’s agenda bill in the early hours of Wednesday morning after the panel met for almost 12 hours. GOP Reps. Ralph Norman and Chip Roy, two conservatives who have harshly criticized the Senate’s version of the package, joined Democrats on the panel to oppose advancing the rule.

    Rep. Thomas Massie wears a digital pin tracking the the US national debt on Wednesday.

    Some Republicans, including Rep. Thomas Massie of Kentucky, still insist July 4 was an “arbitrary” deadline.

    Massie, who has consistently voted against the bill over his deficit concerns and has faced the ire of Trump, said he intends to stand firm against the bill.

    Asked if there was anything at all leadership could do to win his vote, he said, “We could go back to the drawing board.” Asked about the self-imposed deadline, he added: “There’s no reason to bankrupt the country because you want to go shoot off some fireworks.”

    This headline and story has been updated with additional developments.

    CNN’s Sarah Owermohle, Lauren Fox, Arlette Saenz, David Wright, Aileen Graef, Kevin Liptak and Morgan Rimmer contributed to this report.

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  • Ignore climate change deniers, says TV naturalist Steve Backshall

    Ignore climate change deniers, says TV naturalist Steve Backshall

    Neve Gordon-Farleigh & Connor Bennett

    BBC News, Suffolk

    John Fairhall/BBC Steve Backshall is pictured smiling and wearing a light coloured T shirtJohn Fairhall/BBC

    Steve Backshall said it was important to recognise climate anxiety

    A television wildlife presenter said climate change “is happening” and people should ignore politicians and public figures who think otherwise.

    Steve Backshall was speaking as a guest at the Youth Climate Conference at Suffolk One Sixth Form College in Ipswich on Tuesday, which gave 250 young people from across the county the opportunity to engage in conversations about the climate.

    Previous speakers at the event includes Chris Packham, Megan McCubbin and activist Scarlett Westbrook.

    He said: “If you hear a politician or public figure trying to throw shade on the simple facts of climate change do not listen to another word they say in public ever again… it is happening.”

    The event featured talks from the charity, Kids Against Plastic, workshops and advice from location environmental groups.

    Known for children’s shows including Deadly 60, Backshall said it was a “great privilege” to share what he has experienced in his career, see how the planet is changing and feel a sense of hope.

    He said: “It’s critical that someone in position recognises that climate anxiety is a real thing… especially for young people there is nothing that takes away your impetus to act, than just a sense it’s all screwed and there’s nothing we can do about it.

    “People need to be empowered. They need to have a sense that they are important and the things they do can make a difference.”

    John Fairhall/BBC Amy Meek on the left sitting down next to Steve Backshall. She is wearing a black T-shirt and has short dark hair. Steve Backshall is also sitting down and he is wearing a grey T-shirt and is holding a microphone.John Fairhall/BBC

    Amy Meek says children play a “pivotal” role in climate change and plastic pollution

    Backshall said: “A young person who is energised, who has a purpose, who has a vision, who thinks they can make a massive change is the most exciting thing to be around on the planet.

    “We hear endlessly about Greta Thunberg. Well there are tens of thousands of Greta Thunbergs in this nation along and 250 possible Gretas right here, sat right here today – the things they could achieve are boundless.”

    The co-founder of Kids Against Plastic, Amy Meek, said young people play a “pivotal part” in tackling climate change and plastic pollution.

    She said: “Young people have this really infectious energy, especially kids who we often discount as being too young to really care about these issue… if we can mobilise that energy and that interest into actual positive action that can have a massive difference.”

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  • Tibetans in exile face a future without the charismatic Dalai Lama

    Tibetans in exile face a future without the charismatic Dalai Lama

    DHARAMSHALA, India (AP) — The Dalai Lama has announced that he intends to reincarnate, paving the way for a successor to take on a mantle stretching back 500 years after his death.

    But as he approaches his 90th birthday, that news hasn’t eased the worries of Tibetan Buddhists who wonder: What will happen when this Dalai Lama is gone?

    For decades, the 14th Dalai Lama has been more than a spiritual leader. He has sustained a nation in exile and managed to build a community that’s kept the Tibetan culture and identity alive. He is the China -reviled spokesperson for a Tibetan homeland that many, like him, can see only from afar. He has received a Nobel Peace Prize and been courted by royalty, politicians and Hollywood stars, helping him draw global attention and support for Tibet.

    An exiled Tibetan prostrates in prayer at the Tsuglakhang temple in Dharamshala, India, Tuesday, July 1, 2025. (AP Photo/Ashwini Bhatia)

    When his death comes, it will pitch the global Tibetan community into uncertainty, perhaps for years. His successor will have to be found through the traditional process of reincarnation. China, whose troops took control of Tibet in 1950, says it will reject anyone chosen without Beijing’s consent.

    Tibetans in India’s Himalayan town of Dharamshala, the Dalai Lama’s home in exile, and scattered around the world fear a new onslaught on their cultural and religious identity.

    “The absence of His Holiness would be a huge setback for the Tibetans,” said Penpa Tsering, the head of the democratically elected Tibetan government-in-exile. “The responsibility lies on us as to how we carry forward the legacy of His Holiness.”

    A long gap

    The Dalai Lama has become one of the world’s most recognizable figures while leading a Tibetan diaspora through their struggle for autonomy and opposition of China’s control of Tibet. He has not named a successor, but he says they will be born in the “free world” — outside China.

    Previous Dalai Lamas have been identified by senior monastic disciples, under strict religious rituals meant to identify their predecessor’s reincarnation. Monks interpret signs, consult oracles and send search committees to Tibetan households looking for a child who exhibits the qualities of the Dalai Lama.

    All of this takes years of effort, leaving a leadership vacuum. Years of religious education and training are needed before the identified successor grows up and takes up full responsibilities as spiritual leader.

    China has already sought to elevate other spiritual figures, particularly Tibetan Buddhism’s No. 2 figure, the Panchen Lama, whose legitimacy is highly contested by many Tibetans at home and in exile.

    Gyaltsen Norbu was installed by Beijing as the 11th Panchen Lama in 1995 after followers of the Dalai Lama recognized a different boy as the Panchen’s incarnation. That boy disappeared soon after.

    Joy and stubbornness

    And there’s no guarantee the successor will have the current Dalai Lama’s charisma, or his ability to balance a sense of joy with the stubbornness needed to counter China.

    “He is a fulcrum, he’s the epitome of the Tibetan movement,” said writer and activist Tenzin Tsundue, who was born in India.

    Tsundue for years has advocated for Tibet’s autonomy. To him, the current Dalai Lama’s absence will be hugely felt.

    Like many other Tibetans, however, his hopes are pinned on the government in exile. “How is home not anything but a genuine human demand?” he added.

    Such concerns are most prevalent in Dharamshala, where a Tibetan community of over 20,000 administers its own schools, hospitals and monasteries and elects its own lawmakers and president. The Dalai Lama handed over his political powers to a democratically elected government in 2011.

    Devotees wait to welcome Tibetan spiritual leader the Dalai Lama at an event celebrating his 90th birthday according to a Tibetan calendar in Dharamshala, India, Monday, June 30, 2025, ahead of his birthday according to the Gregorian calendar on July 6. (AP Photo/Ashwini Bhatia)

    Devotees wait to welcome Tibetan spiritual leader the Dalai Lama at an event celebrating his 90th birthday according to a Tibetan calendar in Dharamshala, India, Monday, June 30, 2025, ahead of his birthday according to the Gregorian calendar on July 6. (AP Photo/Ashwini Bhatia)

    Beijing is likely to appoint its own candidate

    China doesn’t recognize the Tibetan government-in-exile and brands the Dalai Lama a dangerous separatist. It has shunned direct contact with his representatives for more than a decade.

    It has insisted that the Dalai Lama’s successor will be from inside China and must be approved by its government.

    Tibetans in exile have long been wary of the officially atheist Chinese government’s attempts to meddle with the Tibetan Buddhism reincarnation system. They see it as part of Beijing’s plan to tighten its control over Tibet.

    “If they do it, they are actually making a mockery of themselves among the free countries,” said Geshe Lhakdor, a Tibetan Buddhist scholar, calling Beijing’s stance “hypocrisy.”

    Tibetans say they were effectively independent for centuries and accuse China of trying to wipe out Tibet’s Buddhist culture and language. Many of the more than 7 million Tibetans living under Chinese rule accuse Beijing of stifling religious freedoms, changing its ethnic makeup by moving millions of Han Chinese into the region and torturing political prisoners.

    The Chinese government denies these allegations.

    Waning global attention

    For years, governments across the world have feted the Dalai Lama for advocating for Tibetan rights and spreading a message of nonviolence. They have also helped him raise tens of millions of dollars to build Tibetan cultural and religious institutions.

    But Tsundue said that global powers have become more unreliable in their support of the Tibetan cause as China’s influence grows.

    “Everybody has benefited at our cost because they have been trading with China,” Tsundue said. “We are, in a way, a victim of geopolitics.”

    Some countries, including the United States, view Beijing’s attempts to control the reincarnation of the Dalai Lama as a violation of religious freedom and Tibetan cultural tradition. Others, like the European Union and India, have maintained a cautious stance to avoid friction with China.

    Penpa Tsering, President of the Tibetan government-in-exile, gestures as he speaks to the Associated Press at his office in Dharamshala, India, Tuesday, July 1, 2025. (AP Photo/Ashwini Bhatia)

    Penpa Tsering, President of the Tibetan government-in-exile, gestures as he speaks to the Associated Press at his office in Dharamshala, India, Tuesday, July 1, 2025. (AP Photo/Ashwini Bhatia)

    Tsering, the president of the government-in-exile, acknowledged this, calling Tibetans’ efforts to keep the issue of Tibet alive “a miracle.”

    He also cautioned that the future depends on the Tibetan people at large.

    Under the Dalai Lama’s “Middle Way” policy, the movement for Tibet’s autonomy has largely been nonviolent. It espouses autonomy under Chinese sovereignty.

    The newly announced succession plan, however, can prompt a reckoning of that policy, and it is unclear how the Dalai Lama’s successor might approach dialogue with Beijing.

    Tsering cautioned that much could change in the coming years. His biggest worry is that the Dalai Lama’s death in exile could trigger a violent response inside Tibet, where in recent years hundreds of monks and others reportedly set themselves on fire in protest against Chinese rule.

    “I hope the Tibetans won’t get radicalized,” he said.


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  • If You See These Messages On Your PC, You’re Being Hacked

    If You See These Messages On Your PC, You’re Being Hacked

    Republished on July 3 with reports into a new attack with a different twist.

    There’s a new attack “taking the threat landscape by storm,” and it should have all PC users worried. “While virtually nonexistent a year ago,” this attack has surged to such an extent in recent months that it’s now second only to phishing on the danger list.

    We’re talking so-called ClickFix attacks, in which you are tricked into hacking your own PC when you follow on-screen instructions to fix a technical issue, open a secure file or website, or prove your human through a popup CAPTCHA challenge.

    ForbesPorn Ban Warning For Millions Of iPhone And Android Users

    The latest warning comes from ESET, which says in its new Threat Report that these attacks have now “skyrocketed.” That should maybe be no surprise, given the multiple warnings that have been issued in recent months.

    But what should come as more of a surprise is that these attacks are still claiming countless victims, despite being so easy to detect and avoid — in theory at least.

    ESET warns “payloads at the end of ClickFix attacks vary widely – from infostealers to ransomware and even to nation-state malware – making this a versatile and formidable threat.” It targets different operating systems, but this is really a Windows PC threat.

    ClickFix always works by asking users to copy and paste text into a Run window, thus executing a script. That script can itself be dangerous, but more likely seems benign and actually downloads and runs the malicious script out of sight of the user.

    “By the end of 2024,” ESET says, “attacks using the same social engineering technique flooded the web. Threat actors have been creating fake websites mimicking popular services – such as Booking.com or Google Meet – compromising legitimate websites with fake browser update prompts, fake Cloudflare verifications or reCAPTCHA checks, and distributing links leading to ClickFix pages via email campaigns.”

    The ClickFix attack is just a shop window for multiple threats that will be installed on your device if you fall for that initial lure. “The list includes popular infostealers such as Lumma Stealer, VidarStealer, StealC, and Danabot; remote access trojans such as VenomRAT, AsyncRAT, and NetSupport RAT; remote monitoring and management tools such as MeshAgent; post-exploitation frameworks such as Havoc and Cobalt Strike; and cryptominers, loaders, clipboard hijackers, and much more.”

    If you’re not worried yet, then you should be. These attacks are varying rapidly. Hackers are seeking out new lures and testing what works best. The capability is also being farmed out to multiple groups with different malware to deploy. Recent attacks have even “attempted to deploy Interlock (formerly Rhysida) ransomware.”

    ForbesMicrosoft’s Password Change Is Just Days Away—Act Now

    If you ever see a message — however worded — asking you to press the Windows Key + “R” and then “Ctrl+V” to paste and then “Enter,” then your PC is being hacked. Period.

    Do none of those things. Escape or force exit the program. And then reboot your PC. If you think you have fallen into a ClickFix trap, run an antivirus scan on your PC and change all key account passwords. You should also check your financial accounts.

    While ClickFix is synonymous with Windows, there’s now a timely reminder that Mac users are also vulnerable to these tactics — being tricked into running a script on your device that seems to do one thing, when it’s actually hacking you in the background.

    SentinelOne warn that North Korean hackers have been caught targeting victims with various malware payloads, which are installed on machines after users run a script that purports to be a Zoom update ahead of joining a scheduled call.

    “The attack chain begins with a now-familiar social engineering vector: impersonation of a trusted contact over Telegram and inviting the target to schedule a meeting via Calendly. The target is subsequently sent an email containing a Zoom meeting link and instructions to run a so-called ‘Zoom SDK update script’.”

    While most ClickFix attacks are either wrapped in a tech support lure or a fake CAPTCHA challenge, we have seen multiple instances of users being asked to take actions to access a secure website or open a password protected document.

    That fake Zoom script “ends with three lines of malicious code that retrieve and execute a second-stage script from a command-and-control server hosted at support.us05web-zoom[.]forum. This domain name format has been chosen for similarity to the legitimate Zoom meeting domain us05web.zoom[.]us.”

    ForbesGoogle Play Store Warning—Find And Delete All Apps On This List

    Once installed on the user’s Mac, the malware is designed to root our and steal credentials from Arc, Brave, Firefox, Google Chrome and Microsoft Edge browsers, again highlighting the vulnerability in saving passwords in browsers.

    Beyond that, different malware payloads can be tasked with different outcomes. SentinelOne says this shows how threat actors will continually “introduce new levels of complexity for analysts.” As ever, the teams says, “in the cat-and-mouse game of threat and threat detection, when one side innovates, the other must respond.”

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  • Trump touts but Gaza truce still has stumbling blocks – Firstpost

    Trump touts but Gaza truce still has stumbling blocks – Firstpost

    The two sides have publicly rejected the other’s red lines, making compromise difficult even as humanitarian pressure mounts. Trump and international mediators push for a breakthrough, but mutual distrust and shifting priorities are complicating negotiations

    read more

    Hamas has not yet agreed or denied a 60-day ceasefire proposal by the US that President Donald Trump has said Israel has accepted, although Prime Minister Benjamin Netanyahu has not publicly addressed it.

    It is this lack of overall communication and negotiation that is stalling peace in Gaza. Despite US mediation,
    Israel and Hamas remain at odds over key conditions for a proposed 60-day cease-fire and hostage release deal.

    The two sides have publicly rejected the other’s red lines, making compromise difficult even as humanitarian pressure mounts. Trump and international mediators push for a breakthrough, but mutual distrust and shifting priorities, like Israel’s potential focus on rescuing hostages over military victory, are complicating negotiations.

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    ‘Eager to resume talks’

    Meanwhile, Israeli Foreign Minister Gideon Saar has said that the country is eager to resume negotiations with Hamas over a ceasefire agreement “as soon as possible”.

    “There are some positive signs. But our goal is to begin proximity talks as soon as possible,” Saar told reporters, referring to the details of the ceasefire that still need to be agreed upon through diplomacy.

    At the same time, Prime Minister Benjamin Netanyahu on Wednesday vowed to eradicate Hamas. “We will free all our hostages, and we will eliminate Hamas. It will be no more,” he said.

    Hamas said in a statement that it was studying the latest proposals and aiming “to reach an agreement that guarantees ending the aggression, achieving the withdrawal (of Israeli forces from Gaza) and urgently aiding our people in the Gaza Strip”.

    Possible terms of the deal

    A Palestinian source familiar with the ongoing mediated negotiations told AFP that the new proposal on the table shows “no fundamental changes” compared to earlier terms presented by the United States. This suggests that the underlying framework of the talks remains largely the same.

    The source explained that the revised proposal includes a 60-day truce. During this period, Hamas would release half of the Israeli captives still alive in Gaza, in exchange for Israel freeing a number of Palestinian prisoners and detainees.

    As of now, 49 hostages from the 251 captured by Palestinian militants in October 2023 remain in Gaza. According to the Israeli military, 27 of these hostages have already been confirmed dead.

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    With inputs from agencies

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  • A Case Report of Necrolytic Migratory Erythema Associated with Glucago

    A Case Report of Necrolytic Migratory Erythema Associated with Glucago

    Introduction

    NME is a rare disorder associated with multiple diseases, including glucagonoma, chronic pancreatitis, nutritional deficiency, liver diseases, and inflammatory bowel disease. About 70% of cases of glucagonoma may present with NME, therefore NME is an important visual clue for the diagnosis, enabling timely intervention.

    Glucagonoma is an unusual neuroendocrine tumor, derives from the pancreatic alpha cells with an estimated incidence of 1 in 20 million,1 most commonly affecting people in their 50s.2 The main manifestations are weight loss, NME, diabetes, diarrhea, anemia, and neuropsychiatric symptoms. NME is a crucial characteristic of glucagonoma. However, many primary dermatologists lack sufficient knowledge about the disorder, leading to potential misdiagnosis and missed diagnosis. Consequently, we report a case of typical NME combined with glucagonoma diagnosed in 2024 at Dermatology Hospital of Southern Medical University, designed to strengthen the diagnosis and differentiation ability of dermatologists.

    Case Presentation

    The patient was a 41-year-old male who presented with erythema with erosions on both lower limbs, accompanied by malnutrition and mild itching for the past three years. The patient was diagnosed with “eczema” in the local hospital. He had been treated with topical corticosteroids for years with improvement but frequently recurred. One month ago, the lesions gradually spread all over the body, with crusted papules and polycyclic plaques with a map-like margin mainly involving the face, groin, buttocks, and extremities. And his tongue appeared beefy red and fissuring (Figure 1). No nail abnormality was found.

    Figure 1 Clinical appearance. (a) Scattered erythematous seborrheic plaques on the face. (b) Bright red, swollen tongue; multiple fissures; beefy tongue appearance. (c) Well-defined erythema with raised borders and yellow crusting on both inguinal areas and scrotum. (d and e) Multiple erythema and erosion on the buttocks and knees. (f) Well-defined erythema with raised borders and yellow crusting on both ankles.

    Laboratory analysis found a serum glucagon level of more than 128 pmol/L (normal range, 2 to 18 pmol/L). Anti-bp180 and anti-bp230, cortisol levels were negative. A skin biopsy was performed and showed parakeratosis, inflammatory crust, spongiosis, localized necrosis in the upper epidermis, lymphocytes infiltrating peri-follicular and peri-vascular areas, and eosinophilic infiltration (Figure 2). A contrast-enhanced abdominal computed tomographic scan revealed an enhancing pancreatic body tail mass and liver metastases (Figure 3).

    Figure 2 Histological findings of plaque on the left thigh. Parakeratosis, spongiosis, localized necrosis in the upper epidermis. (HE, x 400).

    Figure 3 Enhanced abnormal computed tomography scan. Showing a pancreatic body tail mass (right arrow) and intrahepatic mass (left arrow), confirming glucagonoma.

    Diagnostic Evaluation

    The clinical presentation was characteristic of NME, confirmed by histopathological examination of skin biopsy. In accordance with the known correlation between NME and glucagonoma, serum glucagon levels were found to be significantly elevated. Subsequent abdominal CT demonstrated a pancreatic neuroendocrine tumor, establishing the definitive diagnosis of glucagonoma. Therefore, the diagnosis of NME combined with glucagonoma was made.

    Treatment with microelements such as zinc, Vitamin B, folic acid, antihistamines, and topical corticosteroids. The rash reduced slightly. However, the patient refused surgical treatment for financial reasons.

    Discussion

    Glucagonoma is a neuroendocrine tumor characterized by excessive proliferation of α-cells in the pancreas, with a higher prevalence in women than men. The tumor typically grows slowly and can metastasize. Due to the excessive secretion, glucagonoma syndrome occurs, which may present with NME, weight loss, diabetes, diarrhea, anemia, and neuropsychiatric symptoms.3 NME manifests as scaly, erosive, ring-shaped erythema with the formation of pustules and large blisters. Other manifestations may include nail dystrophy, cheilitis, and stomatitis.

    Given the rarity of NME, reports on the condition are few both nationally and internationally, and a standardized diagnostic criterion has not yet been made. In 2018, Xuechen Cao and Yan Lu reviewed and summarized previous cases and proposed diagnostic criteria for glucagonoma.4 The primary diagnostic criteria(Table-1) include (1) Imaging revealing a pancreatic mass, (2) Elevated plasma glucagon levels (>1000 ng/L), (3) Typical NME manifestations, (4) A history of multiple endocrine neoplasia. Secondary criteria include (1) New-onset diabetes (fasting plasma glucose, oral glucose tolerance test), (2) low serum zinc levels and hypoaminoacidemia, (3) Unexplained weight loss and diarrhea, (4) Cheilitis or glossitis. In this case, the patient met the primary criteria of (1), (2), and (3), as well as the secondary criterion of (4), confirming the diagnosis of NME associated with glucagonoma.

    Table 1 the Diagnostic Criteria and Differential Diagnosis

    Given its rarity and prolonged clinical course, NME is frequently misdiagnosed as eczema. In such cases, dermatologists should maintain a high clinical suspicion for associated systemic diseases. Several conditions can present with NME-like skin rashes, including Acrodermatitis Enteropathica (AE), pemphigus erythematosus(PE), drug eruption, essential fatty acid deficiency, vitamin deficiency-related dermatitis, and pseudoglucagonoma syndrome.

    AE: it is a rare, recessively inherited disorder associated with zinc metabolism abnormalities, typically presenting in infancy with symptoms such as eczema-like dermatitis, crusting, bullae, and pustules, commonly affecting the extremities and perioral areas.5 Additional symptoms include hair loss, diarrhea, stomatitis, photophobia, nail dystrophy, abnormal hair texture, growth retardation, and emotional disorders. Especially common in artificially fed infants, with few in adulthood.6 The serum zinc level is always low.7

    PE: the lesions appear as erythematous patches, often found on the face, neck, chest, and other areas, and may have an irregular shape with unclear borders. It may also present in a linear or ring-shaped pattern, with associated vesicles and bullae. Mucosal involvement, such as oral ulcers, throat pain, and ocular inflammation, may also occur. The disease progresses rapidly, with vesicles easily rupturing to form ulcers, and lesions may spread to adjacent skin, occasionally accompanied by secondary infections. Hematoxylin-eosin stain (HE) typically shows superficial epidermal acantholysis, usually located in the granular layer or upper epidermis. Spongiosis and dermal eosinophilic infiltration can be observed, and DIF typically reveals antibodies between epidermal keratinocytes as well as scattered granular deposits of antibodies along the basement membrane zone (BMZ).8

    Drug Eruption: it manifests in various clinical forms, with severe reactions presenting as generalized erythema, vesicles, and erosion. Drug eruption usually has a clear history of drug exposure before the onset of the rash, typically resulting from a non-anticipated inflammatory response affecting the skin and/or mucous membranes as a result of drugs entering the body through oral ingestion, inhalation, injection, suppositories, or topical absorption.2 It often shows a clear response to corticosteroid therapy.

    The pathogenesis of NME remains unclear. Hyperglucagonemia is believed to play a significant role, because excessive glucagon secretion induces amino acid metabolic dysregulation, culminating in hypoaminoacidemia and consequent impairment of epidermal protein synthesis. And surgical removal of glucagonomas or somatostatin analogs can control the skin rash.6,9 Additionally, hypoaminoacidemia, micronutrient depletion, and deficiencies in essential fatty acids and zinc should also be considered, as nutritional support and topical zinc therapy have been used to improve symptoms.10 Surgical resection is considered the only curative treatment.11 If left untreated, glucagonomas may metastasize to distant organs such as the liver and lungs, leading to progressive clinical deterioration and ultimately life-threatening complications. Surgical options include simple excision (for tumors <2 cm) with regional lymphadenectomy, pancreaticoduodenectomy with regional lymphadenectomy, distal pancreatectomy, and splenectomy. However, over half of glucagonomas are metastatic at diagnosis, with liver metastasis being the most common.12 Liver transplantation is considered a potential treatment for patients with liver metastasis. Transarterial chemoembolization (TACE), radiofrequency ablation, and surgery combined may offer advantages in resecting isolated metastatic tumors. Pharmacological treatments for glucagonoma include chemotherapy, somatostatin analogs, and targeted molecular therapies.13 Molecular targeted therapy: Agents such as sunitinib and everolimus inhibit specific molecular aberrations within tumors, thereby significantly prolonging progression-free survival (PFS).14

    Conclusion

    NME mainly presents a chronic course, but the recurrent rash seriously affects the patient’s quality of life. The lesions in our case are characterized by generalized erythema with erosions, which are easily misdiagnosed as pemphigus, eczema, and drug eruption, highlighting the importance of precise imaging to exclude pancreatic tumors, when facing similar conditions. Since NME might be the only clue for the early detection of this tumor, it is very important to correctly diagnose. This requires collaborative efforts from dermatologists, endocrinologists, gastroenterologists, and oncologists. This interdisciplinary approach is essential for the timely diagnosis and management of this rare condition. All in all, this case underscores the importance of recognizing NME as a dermatologic marker for systemic malignancies, necessitating collaborative care for timely diagnosis and treatment.

    Ethics Statement

    The publications of images were included with the patient’s consent.

    Consent Statement

    The patient had given written informed consent for the publication of his clinical details. Institutional approval is not required for this case study.

    Acknowledgments

    The authors would like to thank the patient for participation in this study.

    Author Contributions

    All authors made a significant contribution to the work reported, whether that is in the conception, study design, execution, acquisition of data, analysis and interpretation, or in all these areas; took part in drafting, revising or critically reviewing the article; gave final approval of the version to be published; have agreed on the journal to which the article has been submitted; and agree to be accountable for all aspects of the work.

    Funding

    This work was supported by The “Set Sail” Program for Young PhD Researchers in Basic and Applied Medical Research (SL2023A04J02432).

    Disclosure

    The authors report no conflicts of interest in this work.

    References

    1. He S, Zeng W, Geng S, Jia J. Glucagonoma syndrome with atypical necrolytic migratory erythema. Indian J Dermatol Venereol Leprol. 2021;87(1):49–53. doi:10.4103/ijdvl.IJDVL_588_18

    2. Yang WJ, Hu HH, Guo H, Li JH. Generalized migratory erythema in an elderly woman Necrolytic migratory erythema. J Dtsch Dermatol Ges. 2022;20(2):231–234. doi:10.1111/ddg.14664

    3. Liu JW, Qian YT, Ma DL. Necrolytic migratory erythema. JAMA Dermatol. 2019;155(10):1180. doi:10.1001/jamadermatol.2019.1658

    4. Cao X, Yan L. 坏死松解性游走性红斑临床研究进展. 中华医学杂志. 2018;98(33):2694–2696. doi:10.3760/cma.j.issn.0376-2491.2018.33.019

    5. Maverakis E, Fung MA, Lynch PJ, et al. Acrodermatitis enteropathica and an overview of zinc metabolism. J Am Acad Dermatol. 2007;56(1):116–124. doi:10.1016/j.jaad.2006.08.015

    6. van Beek AP, de Haas ER, van Vloten WA, Lips CJ, Roijers JF, Canninga-van Dijk MR. The glucagonoma syndrome and necrolytic migratory erythema: a clinical review. Eur J Endocrinol. 2004;151(5):531–537. doi:10.1530/eje.0.1510531

    7. Zou P, Du Y, Yang C, Cao Y. Trace element zinc and skin disorders. Front Med Lausanne. 2022;9:1093868. doi:10.3389/fmed.2022.1093868

    8. Hobbs LK, Noland MB, Raghavan SS, Gru AA. Pemphigus erythematosus: a case series from a tertiary academic center and literature review. J Cutan Pathol. 2021;48(8):1038–1050. doi:10.1111/cup.13992

    9. Zhang M, Wang S. 胰体尾切除术成功治愈坏死松解性游走性红斑1例. 中国皮肤性病学杂志. 1–5. doi:10.13735/j.cjdv.1001-7089.202402049

    10. Chen L, Guo X, Huihui W, Sun W, Ding H. 营养缺乏所致坏死松解性游走性红斑样皮损. 临床皮肤科杂志. 2022;51(05):282–285. doi:10.16761/j.cnki.1000-4963.2022.05.008

    11. John AM, Schwartz RA. Glucagonoma syndrome: a review and update on treatment. J Eur Acad Dermatol Venereol. 2016;30(12):2016–2022. doi:10.1111/jdv.13752

    12. Adams DR, Miller JJ, Seraphin KE. Glucagonoma syndrome. J Am Acad Dermatol. 2005;53(4):690–691. doi:10.1016/j.jaad.2005.04.071

    13. Remes-Troche JM, García-de-acevedo B, Zuñiga-Varga J, Avila-Funes A, Orozco-Topete R. Necrolytic migratory erythema: a cutaneous clue to glucagonoma syndrome. J Eur Acad Dermatol Venereol. 2004;18(5):591–595. doi:10.1111/j.1468-3083.2004.00981.x

    14. Öberg K. Management of functional neuroendocrine tumors of the pancreas. Gland Surg. 2018;7(1):20–27. doi:10.21037/gs.2017.10.08

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  • AI voice startup ElevenLabs plots global expansion, eventual IPO

    AI voice startup ElevenLabs plots global expansion, eventual IPO

    Founded in 2022, ElevenLabs is an AI voice generation startup based in London. It competes with the likes of Speechmatics and Hume AI.

    Sopa Images | Lightrocket | Getty Images

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    Undecided on location

    Founded in 2022 by Staniszewski and Piotr Dąbkowski, ElevenLabs is an AI voice generation startup that competes with the likes of Speechmatics and Hume AI.

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  • AI sewers in Sussex help prevent flooding, Southern Water says

    AI sewers in Sussex help prevent flooding, Southern Water says

    Artificial Intelligence (AI) deployed in the sewer system has helped prevent West Sussex homes from flooding, Southern Water says.

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