The death toll in Gaza has continued to rise, with at least 139 Palestinians killed and 487 wounded in Israeli airstrikes over the past 24 hours, according to the territory’s Health Ministry.
The ministry also reported that three more bodies were recovered from beneath rubble caused by earlier attacks.
The latest count includes 223 deaths newly confirmed by a judicial committee reviewing reports of missing persons.
Among those killed in the past day, 39 were aid seekers who arrived at hospitals, with over 210 others injured. The Health Ministry said the total number of aid seekers killed since the start of the conflict has now reached 640.
One of the deadliest strikes occurred in the al-Mawasi area, west of Khan Younis, where a tent was hit, killing 13 people — among them a couple and their four children.
Mourners react during the funeral of Palestinians, who, according to Gaza’s health ministry, were killed in an overnight Israeli strike on a tent, at Nasser Hospital in Khan Younis, southern Gaza Strip on July 3, 2025. —Reuters
Another attack struck the Mustafa Hafez School, which was sheltering displaced residents in western Gaza City, resulting in 11 fatalities.
A Palestinian girl looks at the damage at a school sheltering displaced people, following an overnight Israeli airstrike, in Gaza City, July 3, 2025. Photo: REUTERS
Read: At least 27 killed in Gaza City after fresh evacuation orders
An air strike near the Nabulsi Roundabout, also west of Gaza City, left at least six people dead and around 100 injured, many of whom were reportedly waiting for aid.
Palestinians inspect the damage at a school sheltering displaced people, following an overnight Israeli airstrike, in Gaza City, July 3, 2025. Photo: REUTERS
Palestinians inspect the damage at a school sheltering displaced people, following an overnight Israeli airstrike, in Gaza City, July 3, 2025. Photo: REUTERS
UNRWA calls for control of Gaza aid distribution
The United Nations Relief and Works Agency for Palestine Refugees (UNRWA) has urged an independent investigation into the deaths and injuries of Palestinians attempting to access food via the current US- and Israeli-supported aid delivery system in Gaza.
In a statement posted on X, the agency accused Israeli forces of opening fire on civilians and of people being fatally crushed by aid trucks.
“Lift the siege now,” UNRWA said. “Aid delivery must be safe, dignified and accessible to all. Let the UN, including UNRWA, do the work.”
UN rights expert calls for global sanctions on Israel
UN special rapporteur Francesca Albanese has urged states to impose a full arms embargo and sever trade and financial ties with Israel, which she accused of carrying out “one of the cruellest genocides in modern history” in Gaza.
Speaking before the UN Human Rights Council, Albanese presented a report naming more than 60 companies allegedly involved in supporting Israeli settlements and military operations in Gaza.
“This is not just a list; it’s a system,” she said. “We must reverse the tide.” She called on countries to suspend trade agreements and hold corporations accountable for violations of international law.
Read more: At least 27 killed in Gaza City after fresh evacuation orders
UN expert accuses Israel of weapon-testing in Gaza amid 85,000-tonne explosive devastation
In a report presented to the UN Human Rights Council, Francesca Albanese, the Special Rapporteur on human rights in the occupied Palestinian territories, said arms manufacturers had made near-record profits by supplying Israel with cutting-edge technology used to unleash 85,000 tonnes of explosives — six times the power of the Hiroshima bomb — on the Gaza Strip.
Albanese said the destruction in Gaza had coincided with gains on the Tel Aviv Stock Exchange since October 2023. “One people enriched, one people erased,” she told the council.
She alleged that the conflict had turned Palestine into a live-testing zone for “new weapons, customised surveillance, lethal drones and radar systems,” calling Gaza “an ideal laboratory for the Israeli military-industrial complex.”
The report named 48 companies — including arms manufacturers, banks, tech firms, energy conglomerates and academic institutions — allegedly tied to what Albanese described as an “economy of occupation.”
“From data systems that surveil Palestinians to fossil fuels that power illegal settlements, corporate complicity runs deep,” she said.
Citing international law, Albanese said even indirect ties to these systems carry legal responsibility. She urged states to impose a full arms embargo on Israel, suspend all trade and investment agreements, and ensure companies involved face legal consequences.
“Member states must act. The time for bold steps is now,” she said.
Israel’s government did not attend the session and has previously dismissed Albanese’s findings as “legally unfounded” and an abuse of her UN mandate.
Saudi Arabia condemns Israeli minister’s call for sovereignty over occupied West Bank
Saudi Arabia has strongly criticised recent statements by Israeli ministers advocating full sovereignty over the occupied West Bank, according to Asharq Al-Awsat.
In a statement issued by the Ministry of Foreign Affairs, the Kingdom said it “condemns and denounces” the remarks made by Israeli officials, reaffirming its stance against any moves to assert Israeli control over Palestinian territories.
Hamas reviews 60-day Gaza ceasefire proposal
Hamas said on Wednesday it was studying what US President Donald Trump called a “final” ceasefire proposal for Gaza but that Israel must pull out of the enclave, and Israeli leader Benjamin Netanyahu said Hamas would be eliminated.
Trump said on Tuesday that Israel had agreed to the conditions needed to finalise a 60-day ceasefire with Hamas after a meeting between his representatives and Israeli officials.
In a statement, the Palestinian group said it was studying new ceasefire offers received from mediators Egypt and Qatar but that it aimed to reach an agreement that would ensure an end to the war and an Israeli pullout from Gaza.
Meanwhile, Netanyahu called for the elimination of Hamas in his first public remarks since Trump’s announcement.
“There will not be a Hamas. There will not be a ‘Hamastan’. We’re not going back to that. It’s over,” Netanyahu told a meeting hosted by the Trans-Israel pipeline.
The two sides’ statements reiterated long-held positions, giving no clues as to whether or how a compromise agreement could be reached.
Israel’s war on Gaza
The Israeli army has launched a brutal offensive against Gaza since October 2023, killing at least 57,012 Palestinians, including 134,592 children. More than 111,588 people have been injured, and over 14,222 are missing and presumed dead.
Last November, the International Criminal Court issued arrest warrants for Israeli Prime Minister Benjamin Netanyahu and his former Defense Minister Yoav Gallant for war crimes and crimes against humanity in Gaza.
Israel also faces a genocide case at the International Court of Justice for its war on the enclave.
With the rapid evolution of the mobile threat landscape, this partnership expands access to the most comprehensive mobile application security
LEUVEN, Belgium – July 3, 2025 – Verdane, the European specialist growth investment firm, is entering a partnership with Guardsquare, a leader in mobile application security. The partnership follows previous investment from Battery Ventures and addresses the growing mobile app security threats by expanding access to GuardSquare’s critical mobile application security for global businesses of all sizes. It also combines Guardsquare’s deep technical expertise with Verdane’s growth strategy through M&A and continued organic growth.
Mobile applications are increasingly becoming the primary way users interact with businesses. Yet, mobile app security needs have historically remained underserved, especially as threat actors target mobile apps at an accelerated pace. Verdane’s investment enables Guardsquare to expand its reach in providing the most comprehensive approach to mobile application security on the market, delivering the highest level of protection with ease. Earlier this year, Cyber Defense Magazine recognized Guardsquare as the market leader in Mobile App Security and honored the company with its prestigious Mobile App Security Award.
“I’m excited to embark on this new partnership with Verdane. It marks an inspiring and well-aligned progression toward our long-term vision. We will benefit from their expertise as, together, we take Guardsquare to the next level, significantly expand our market share, and increase our global reach through organic growth, ongoing product enhancements, and M&A,” said Roel Caers, CEO at Guardsquare. “We’re grateful for the support provided by Battery Ventures over the past several years as we became the market leader in mobile application protection. Their guidance enabled us to scale our business globally and attract top talent, particularly in the U.S.”
“Guardsquare’s industry-leading mobile application protection is a critical cybersecurity service, and we’re excited to partner with Roel and the entire Guardsquare team to make this available for even more businesses globally. The company’s growth from a European to a global leader has been very impressive to behold, and we’re looking forward to supporting the company in its future journey,” said Morten Weicher, Partner at Verdane.
“It has been a privilege to partner with the Guardsquare team and support the company’s growth journey. As it scaled its business, Guardsquare has consistently demonstrated its commitment to innovation and leadership in mobile application security,” said Dharmesh Thakker, Partner at Battery Ventures. “We are confident that this new partnership with Verdane will open up many new growth opportunities and allow Guardsquare to continue to help set the standard for mobile application security worldwide.”
Completion of the transaction is subject to customary regulatory approvals.
About Verdane Verdane is an independent specialist growth investment firm that partners with tech-enabled and sustainable European businesses. Verdane can invest as a minority or majority investor, either in single companies or through portfolios of companies, and looks to invest inside two core growth themes; digitalisation and decarbonisation. Verdane has more than €8 billion in assets under management and its funds have made over 200 investments in fast-growing businesses since 2003. Verdane’s team of over 150 investment professionals and operating experts, based out of Berlin, Munich, Copenhagen, Helsinki, London, Oslo and Stockholm, is dedicated to being the preferred growth partner to tech-enabled and sustainable businesses in Europe. Verdane is a UN PRI signatory and also a certified B Corporation, the most ambitious sustainability accreditation globally. The firm only backs businesses that pass its 2040 test, which indicates whether the company can thrive in a more sustainable future economy. Additionally, the Verdane Foundation, which is managed by the group, focuses on supporting sustainability globally and inclusion locally.
About Guardsquare Guardsquare offers the most complete approach to mobile application security on the market, delivering the highest level of protection in the easiest possible way. Guardsquare’s software integrates seamlessly across the development cycle, from app security testing to code hardening to real-time visibility into the threat landscape. Guardsquare products provide enhanced mobile application security from early in the development process through publication. More than 900 organizations worldwide across all major industries rely on Guardsquare to help them identify security risks and protect their mobile applications and SDKs against reverse engineering and tampering in the ever-evolving threat landscape. Learn more at Guardsquare.com and on LinkedIn.
Nearly 1,000 British workers will adopt a permanently shorter working week, after the latest trial of a four-day week and similar changes to traditional working patterns.
All 17 British businesses in a six-month trial of the four-day week said they would continue with an arrangement consisting of either four days a week or nine days a fortnight. All the employees remained on their full salary.
The trial was organised by the 4 Day Week Foundation, a group campaigning for more businesses to take up shorter working weeks.
The latest test follows a larger six-month pilot in 2022, involving almost 3,000 employees, which ended in 56 of 61 companies cutting down their hours from a five-day working week.
The 4 Day Week Foundation is hoping to build on the shift around the end of the 19th century and the start of the 20th century, when campaigns led by trade unions gave birth to the two-day weekend. The previous norm for many people in Britain and other traditionally Christian countries had been a six-day working week, with time off only on Sundays.
Campaigners and some economists argue that the four-day week can offer benefits to workers such as less strain on their mental health, and to businesses, including more motivated staff and easier recruitment and retention.
Researchers at Boston College, a US university, said that the findings from the latest trial were “extremely positive” for workers. They found that 62% of workers reported that they experienced less burnout during the trial, according to a poll of 89 people. Forty-five percent of those polled said they felt “more satisfied with life”.
The 4 Day Week Foundation has run successive trials to gather data and demonstrate how companies can make the switch. In January, the foundation said more than 5,000 people from a previous wave had started the year permanently working a four-day week.
Companies involved in the latest trial, which started in November, included charities and professional services firms, with the number of employees at each employer ranging between five and 400. They included the British Society for Immunology and Crate Brewery in Hackney, east London,
Campaigners hope that they can build momentum for the change. The 4 Day Week Foundation said the government should create a working time council to coordinate policy between business and industry leaders as well as trade unions.
The concept of the four-day week faced strong opposition from the previous Conservative government. Labour ministers have previously expressed more support for the concept, although they have offered little in the way of formal recognition since coming to power in 2024.
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In 2023, Angela Rayner, who has since become deputy prime minister, said: “If you can deliver within a four-day working week, then why not. I think people will cotton on to the fact that it’s really good, if it works for their sector and boosts productivity.”
The small web software company BrandPipe said that the latest trial had been a success for the business, coinciding with increased sales. Geoff Slaughter, the BrandPipe chief executive, said: “The trial’s been an overwhelming success because it has been the launchpad for us to consider what constitutes efficiency, and financial performance is double what it was before.”
Slaughter added: “If we’re going to see it rolled out more substantially across different sectors, there should be incentives for early adopters, because we’re creating the blueprint for the future.”
Travel the universe with Dr. Ethan Siegel as he answers the biggest questions of all.
Here in the 21st century, we’ve learned so much more about our Universe than we could have imagined even just a single generation ago. Back in 1990, we hadn’t discovered any planets orbiting stars beyond our own Solar System; today, we’re closing in on 6000 confirmed exoplanets. Back then, the only prospects for life beyond Earth were potential microbes on planets or moons in our backyard; now, we know of scores of stars that may host living worlds around them. And a number of missions that didn’t just image the other planets and/or moons from afar, but orbited, probed, or even landed on them to explore them have occurred, teaching us about the complex chemistry and composition of worlds that are wildly different from our own.
Over all the time that’s passed since the Voyager missions, however, there are two major planets in our Solar System that remain unexplored from up close — unvisited — since the late 1980s, when Voyager 2 flew by them. Uranus and Neptune, the smallest gas giants in the Solar System and the closest analogues we have to the most common type of exoplanet found thus far: the mini-Neptune. In fact, in recent months, many have speculated that some of these mini-Neptunes may be potentially inhabited, advancing the science case for studying the worlds we do have that are like them, Uranus and Neptune, up close.
Here in the JWST era, we’ve seen these worlds better than ever since Voyager 2’s flyby, but haven’t designed or flown a mission to go visit them in all the time since. 2034 will be the perfect opportunity to change that, however. Here’s the science of why.
Pioneer 11, following in the footsteps of Pioneer 10, actually flew through Jupiter’s lunar system, then used Jupiter’s gravity as an assist maneuver to take it to Saturn. While exploring the Saturnian system, a planetary science first, it discovered and then nearly collided with Saturn’s moon Epimetheus, missing it by an estimated ~4000 km. Newtonian gravity, alone, was capable of calculating these maneuvers.
Credit: Phoenix7777/Wikimedia Commons
The Solar System is a complicated — but thankfully, regular — place. The best way to get to the outer Solar System, which is to say, any planet beyond Jupiter, is to use Jupiter itself to help you get there. In physics, whenever you have a small object (like a spacecraft) fly by a massive, stationary one (like a star or planet), the gravitational force can change its velocity tremendously, but its speed must remain the same.
But if there’s a third object that’s gravitationally important, that story changes slightly, and in a way that’s particularly relevant for reaching the outer Solar System. A spacecraft flying by, say, a planet that’s bound to the Sun, can gain-or-lose speed by stealing-or-giving-up momentum to the planet/Sun system. The massive planet doesn’t care, but the spacecraft can get a boost (or a deceleration) depending on its trajectory.
This type of maneuver is known as a gravity assist, and it was essential in getting both Voyager 1 and Voyager 2 on their way out of the Solar System, and more recently, in getting New Horizons to fly by Pluto. Even though Uranus and Neptune have spectacularly long orbital periods of 84 and 165 years, respectively, the mission windows for getting to them recur every 12 years or so: every time Jupiter completes an orbit and lines up with Earth, Uranus, and Neptune once again.
By either passing inside of a planet’s orbit while plunging toward the Sun (as shown), or outside of a planet’s orbit while moving away from the Sun, a spacecraft can get de-boosted via the gravity assist/gravitational slingshot mechanism. The two opposite maneuvers would increase the spacecraft’s speed, resulting in a velocity boost, rather than a de-boost. Both are used in navigating spacecraft across the Solar System.
Credit: Y. Guo et al., Acta Astronautica, 2021
A spacecraft launched from Earth typically flies by some of the inner planets a few times in preparation for a gravity assist from Jupiter. A spacecraft flying by a planet can get proverbially slingshotted — gravitational slingshot is a word for a gravity assist that boosts it — to greater speeds and energies. If we wanted to, the alignments are right that we could launch a mission to Neptune today. Uranus, being closer, is even easier to get to.
Bac in 2009, the Argo mission was proposed: it would fly-by Jupiter, Saturn, Neptune, and Kuiper belt objects, with a launch window lasting from 2015 to 2019. However, performing flyby missions are relatively easy, because you don’t have to slow the spacecraft down relative to the planet you’re targeting.
Inserting it into orbit around a world is harder, but it’s also far more rewarding. Instead of a single pass, an orbiter can get you whole-world coverage, multiple times, over long periods of time. You can see changes in the atmosphere of a world, and examine it continuously in a wide variety of wavelengths invisible to the human eye. You can find new moons, new rings, and new phenomena that you never expected. You can even send down a lander or probe to the planet or one of its moons. All of that and more already happened around Saturn with the Cassini mission, which came to a planned end in 2017.
A 2012 (top) and a 2016 (bottom) image of Saturn’s north pole, both taken with the Cassini wide-angle camera. The difference in color is due to changes in the chemical composition of Saturn’s atmosphere, as induced by direct photochemical changes.
Credit: NASA/JPL-Caltech/Space Science Institute/Hampton University
Cassini didn’t just learn about the physical and atmospheric properties of Saturn, although it did that spectacularly. It didn’t just image and learn about the rings, although it did that too. What’s most incredible is that we observed changes and transient events that we never would have predicted.
Saturn exhibited seasonal changes, which corresponded to chemical and color changes around its poles.
A colossal storm developed on Saturn, encircling the planet and lasting for many months.
Saturn’s rings were found to have intense vertical structures and to change over time; they’re dynamic and not static, and provide a laboratory to teach us about planet-and-moon formation.
And, with its data, we solved old problems and discovered new mysteries about its moons Iapetus, Titan, and Enceladus, among others.
In other words, we discovered all that we discovered about Saturn — along with its system of moons and rings — because we dared to go there with a high-tech, radiation-hard dedicated orbiter mission, and because we equipped it with a suite of instruments that could probe so much about this planet and the moons it encountered. It was loaded with discovery potential, and that enabled it to find out what was previously unknown about the Saturnian system: to the benefit of all of humanity.
Over a period of 8 months, the largest storm in the Solar System raged, encircling the entire gas giant world. The storm itself was large enough that it was capable of fitting as many as 10-to-12 Earths inside. Cassini, although it wasn’t expecting this to occur, was equipped with instrument technology that was more than sufficient to discover and study this unprecedented feature.
Credit: NASA/JPL-Caltech/Space Science Institute
Without a doubt, there’s no question that we absolutely want to do the analogous things for Uranus and Neptune. Many orbiting missions to Uranus and Neptune have been proposed and made it quite far in the mission submission process, but none have actually been slated to be built or fly. NASA, the ESA, JPL, and the UK have all proposed Uranus orbiters that are still in the running, but no one knows what the future holds.
One of the major, flagship-class missions proposed to NASA’s planetary science decadal survey in 2011 was a Uranus probe and orbiter; it was ranked #3, but in the most recent planetary science decadal, it was ranked as the highest-priority planetary flagship mission. Uranus, as well as its outer neighbor, Neptune, are both suspected (based on modeling and Voyager 2 data) to have enormous liquid oceans beneath their atmospheres, which an orbiter should be able to discover for certain. The mission could also include an atmospheric probe, with the potential to measure cloud-forming molecules, heat distribution, and how wind speed changes with depth.
In all the time since Voyager 2, which flew by Uranus in 1986 and Neptune in 1989, we’ve only studied these planets from afar. The most recent views that we have of these worlds, however, are indeed the most spectacular ones obtained in all the time since: visions of Uranus and Neptune from the James Webb Space Telescope.
Numerous features surrounding Neptune, as identified in the JWST images. All 7 of Neptune’s inner moons can be seen here, along with the two main rings and two dusty, more diffuse rings seen here. Triton, although captured by JWST, is too far away to be a part of this cropped JWST image.
Credit: NASA, ESA, CSA, and STScI, annotations by H. Hammel and E. Siegel
JWST’s views of Uranus and Neptune showed us features we only ever had hints of from Voyager 2 data, with Uranus in particular making a very interesting test case. You see, Neptune got its JWST close-up more than halfway through 2022, and so many features were revealed in a visually stunning way. They include:
Neptune’s disk,
its highly reflective clouds,
all seven of its known inner moons,
its four major rings (Adams, Lassell, Le Verrier, and Galle),
and its highly reflective largest moon, Triton,
in our best view of all of these features since 1989’s visit.
Uranus, on the other hand, has already been viewed twice by JWST, with its second, superior looking coming in late 2023. Uranus is a bit special: of all the planets in the Solar System, it’s the only one that rotates primarily on its side, with its rotational axis oriented at a nearly 90° tilt (at around 98°) to the “vertical” rotation of the other planets. With an 84 year orbit around the Sun, this means that every 21 years, it undergoes transitions from Uranian solstice, where one pole points directly at the Sun and the other point directly away, to Uranian equinox, where each part of that world receives equal night and daylight, and then back again in the next 21 years.
When Voyager 2 flew by Uranus in 1986, the planet was near solstice, with its southern hemisphere facing the Sun and its northern hemisphere facing away. In 2007, Uranus achieved equinox, and now heads toward its next 2028 solstice. It won’t reach equinox again until 2049, when JWST will likely be out of fuel and defunct, but when an orbiter mission could be present.
Credit: M. Showalter & M. Gordon, SETI Institute; modification by E. Siegel
When Voyager 2 flew by Uranus in 1986, it was at Uranian solstice. It appeared bland and featureless due to the Sun heating one of its poles, not the entire, rapidly rotating planet. Then, in 2007, Uranus was at equinox, displaying rapidly evolving atmospheric features and auroral activity visible remotely: from Hubble and from the world’s flagship ground-based telescopes. Now, however, it’s approaching Uranian solstice once again, which it will reach in 2028. This time, the opposite pole from 1986 is starting to face the Sun, and the planet, again, overall, will soon become largely featureless in appearance.
Therefore, when JWST takes its looks at Uranus, we’re seeing it as it’s finishing its transition from equinox-to-solstice, illuminating one pole, preferentially, but only obliquely: at an angle. What JWST saw was spectacular, and again, unprecedented since Voyager 2.
Uranus currently displays a polar cap, although those high-altitude ices and clouds are beginning to dissipate due to their continuous exposure to sunlight.
Surrounding that cap is a less dense region, where the cap is evaporating.
Dark lanes indicate further evidence of evaporation, punctuated by bright spots: Uranian storms.
Then the inner Zeta (ζ) ring, followed by the α and β rings, the η ring, the thin δ, and the thick ε ring.
After that, nine of Uranus’s prominent, inner moons appear: Bianca (#3) through Puck (#12), excluding only the too-small Cupid.
And finally, the five major moons Miranda, Ariel, Umbriel, Titania, and Oberon can be seen.
The five largest moons of Uranus, in order from the innermost to the outermost, are Miranda, Ariel, Umbriel, Titania, and Oberon, with the latter two being the largest and first-discovered among Uranus’s moons. All of these moons and the innermost one rotate within a single degree of Uranus’s orbital plane except for Miranda, which is inclined by 4.3 degrees.
Credit: NASA, ESA, CSA, STScI
While JWST can continue to image Uranus for approximately the next 20 years or so from afar, the ideal goal is to go there, in situ, during the opposite conditions from when we were last there. We went during solstice last time, with Voyager 2, and therefore the next time, ideally, we’ll go to coincide with equinox. And it just so happens that the travel-time to Uranus, to enter an easily-insertable orbit around it with the appropriate gravity assists on the way there, involves about a 13 year travel-time. Under ideal conditions, after leaving Earth, you’d get a gravity assist from Jupiter, and then you fly past Uranus, dropping off (and inserting) an orbiter and possibly an atmospheric probe as well, and then you’d continue on, assisted by Uranus’s gravity, to Neptune, where you’d then have a second orbiter and possibly atmospheric probe, too.
Most orbiters that have been proposed, with or without probes, typically are slated for about 5 year science lifetimes. What should give us all tremendous hope for a future mission is that there will be a launch window to reach both worlds with a single mission, Uranus and Neptune alike, that align at once: in 2034. That’s when the conceptual ODINUS mission would send twin orbiters to both Uranus and Neptune simultaneously: arriving at Uranus in 2047, just two years before the next (2049) Uranian equinox, and then allowing an orbiter to arrive at Neptune about three years later: in 2050. The ODINUS mission itself, as originally proposed, would be a spectacular, joint venture between NASA and the ESA.
Uranus and its five major moons are depicted here in this montage of images acquired by the Voyager 2 mission in 1986. The five moons, from largest to smallest, are Ariel, Miranda, Titania, Oberon, and Umbriel. Puck, the 6th largest moon, is interior to all of them, and appears in the first and second JWST images of Uranus alongside these five. An orbiter and atmospheric probe, combined, could revolutionize our knowledge of this world.
Credit: NASA/JPL
In order to get the maximum amount of science possible out of the mission, you’d have to design your instruments properly. The orbiter would require multiple separate instruments on it designed to image and measure various properties of Uranus, its rings, and its moons. Uranus and Neptune should have enormous liquid oceans beneath their atmospheres, and an orbiter should be able to discover it for certain. The atmospheric probe would measure cloud-forming molecules, heat distribution, and how wind speed changed with depth. Originally, missions were focused on just one world at a time: Uranus as the higher-priority one (because it’s closer and has been studied for longer), and Neptune as the secondary one.
As proposed by the ESA’s Cosmic Vision program, the Origins, Dynamics, and Interiors of the Neptunian and Uranian Systems (ODINUS) mission goes even farther: expanding this concept to two twin orbiters, where we would send one to Neptune and one to Uranus. A launch window in 2034, where Earth, Jupiter, Uranus, and Neptune all align properly, could send them both off simultaneously. The scientific advantages of orbiters over a flyby mission are tremendous: longer observing times over much longer temporal baselines, the ability to focus on multiple targets over time, and the ability to discover features you may not have even anticipated would be there. Its proposed suite of six-to-eight instruments would not just take images and spectra, but seismic, magnetic, and ion measurements. The only additional costs are in terms of fuel, and enabling your orbiting spacecraft to perform burns, slow down, and enter and maintain stable orbits. The deluge of science that you get from remaining around a planet, long term, more than makes up for those increased costs.
A Plutonium-238 oxide pellet glowing from its own heat. Also produced as a by-product of nuclear reactions, Pu-238 is the radionuclide used to power deep-space vehicles, from the Mars Curiosity Rover to the ultra-distant Voyager spacecraft. It is most useful very far from the Sun, and Pu-238 also powered the Cassini and Galileo missions.
Credit: Los Alamos National Laboratory/Department of Energy
The current limitations on a mission like this don’t come from technical accomplishments; the technology exists to do it today. The difficulties are a combination of:
political, arising from NASA’s finite, limited, and threatened budget,
physical, because even with low-cost, heavy payload launch vehicles, we can still only send a limited amount of overall mass to the outer Solar System,
and practical, because at these incredible distances from the Sun, solar panels will not power a sustained mission.
That practical limitation requires a power source of radioactive isotopes, with the radioisotope thermoelectric generator (RTG) Plutonium-238 serving as our preferred source for such missions.
However, most places in the world stopped producing Pu-238 back in the 20th century, and if we want enough to power a dual orbiter mission to Uranus and Neptune by the time the launch window arrives in 2034, we should really start producing it now. For the New Horizons mission to Pluto, an orbiter would have been a much more challenging mission strategy; New Horizons was too small and its speed was far too great, plus Pluto’s mass is quite low for attempting an orbital insertion. But for Neptune and Uranus, particularly if we choose the right gravity assists from Jupiter (and possibly Saturn), this could be feasible.
A unique, dual mission to both Uranus and Neptune could be launched in 2034, allowing us to fill in the biggest gaps in our knowledge of the Solar System: the gaps of what’s truly happening on and around our final two planets. The only way we’ll find out is if we dare and go look at what’s out there.
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Travel the universe with Dr. Ethan Siegel as he answers the biggest questions of all.
Microplastics are particles ranging from 1 micrometer to 5 millimeters in diameter, and nanoplastics, which are even smaller, are found in virtually every environment on Earth, from mountain peaks to ocean depths, and from the smallest animals in the food chain to human brain cells.
These particles can originate from the breakdown of larger plastic items or be intentionally manufactured for use in products, such as cosmetics, synthetic fabrics, and pharmaceuticals. Recent studies suggest that the human brain may contain up to a teaspoon of microplastics and nanoplastics, with the tiniest fragments primarily composed of polyethylene, the same material commonly used in plastic bags and food packaging.
These particles have been detected in areas such as the walls of blood vessels in the brain and within immune cells. However, it remains unclear whether microplastics contribute to the progression of neurological diseases or whether these conditions render the brain more susceptible to particle infiltration. In animal studies involving fish and rodents, prolonged exposure to nanoplastics has been linked to memory impairment, brain inflammation, and alterations in synaptic protein levels.
Beyond the brain, microplastics have been found in human feces, arterial plaques, and even the placenta. A study published in The New England Journal of Medicine linked the presence of microplastics in the arteries to a heightened risk for heart attack, stroke, and overall mortality.
Therapeutic Apheresis
According to a preliminary study published in Brain Medicine by researchers at Technische Universität Dresden in Dresden, Germany, therapeutic apheresis, a medical procedure that filters tiny particles from the blood, may help remove microplastics from the human body. The technique can capture particles as small as 200 nanometers, which is approximately 5000 times smaller than a millimeter.
In this study, the researchers evaluated the procedure in patients with myalgic encephalomyelitis, also known as chronic fatigue syndrome. They analyzed the waste fluid discarded during apheresis using a specialized infrared spectroscopy technique.
The analysis detected substances that matched the chemical signatures of polyamide and polyurethane, two common types of industrial plastics. This suggests that microplastics may have been successfully removed from the blood of patients during the procedure.
Notably, this study did not measure the total amount of microplastics removed or compare their levels in patients before and after apheresis. What has been demonstrated so far is the presence of microplastics in the waste material discarded by the device — an observation that suggests, but does not yet confirm, the effective removal of these substances from the human body.
Researchers have cautioned that the detected materials may reflect chemical structures common to proteins, meaning that further analysis is required to verify the exact nature of the removed particles. Nonetheless, the findings offer hope to researchers seeking to address the growing accumulation of microplastics in the human body.
The authors recommended conducting studies with larger groups and quantitative analyses comparing the levels of microplastics in the blood before and after the procedures. The authors concluded that “such analyses will help determine particle removal from blood and tissues and assess correlations with symptom improvement in conditions like myalgia encephalomyelitis/chronic fatigue syndrome.”
Alternative Approaches
Currently, evidence that microplastics are effectively removed from the human body after ingestion is limited.
A 2011 study examined bisphenol A (BPA) levels in blood, sweat, and urine samples from 20 individuals. In 16 cases, BPA appeared only in sweat, suggesting that induced perspiration may help eliminate certain compounds from the body. However, more studies are needed to assess its long-term safety and efficacy.
“That is why we focus on reducing exposure to microplastics in the first place,” said Nicholas Fabiano, MD, a psychiatry resident at the University of Ottawa, Ottawa, Ontario, Canada, and co-author of a related article in Brain Medicine.
The challenge of this research began with tracking the effects of microplastic particles. “From a clinical perspective, it is very difficult to establish a direct link between exposure to microplastics and adverse health outcomes,” said Fabiano.
To address this, he advocated the creation of new tools to measure dietary risks, such as a dietary microplastic index. “We propose the development of a Dietary Microplastic Index that could be integrated with existing dietary risk assessment tools to estimate microplastic exposure based on the types of food consumed,” he said.
This story was translated fromMedscape’s Portuguese edition.
As brain tumors grow, they must do one of two things: push against the brain or use finger-like extensions to invade and destroy surrounding tissue.
Previous research found tumors that push – or put mechanical force on the brain – cause more neurological dysfunction than tumors that destroy tissue. But what else can these different tactics of tumor growth tell us?
Now, the same team of researchers from the University of Notre Dame, Harvard Medical School/Massachusetts General Hospital, and Boston University has developed a technique for measuring a brain tumor’s mechanical force and a new model to estimate how much brain tissue a patient has lost. Published in Clinical Cancer Research, the study explains how these measurements may help inform patient care and be adopted into surgeons’ daily workflow.
During brain tumor removal surgery, neurosurgeons take a slice of the tumor, put it on a slide and send it to a pathologist in real-time to confirm what type of tumor it is. Tumors that originally arise in the brain, like glioblastoma, are prescribed different treatments than tumors that metastasize to the brain from other organs like lung or breast, so these differences inform post-surgical care. By adding a two-minute step to a surgeon’s procedure, we were able to distinguish between a glioblastoma tumor versus a metastatic tumor based on mechanical force alone.”
Meenal Datta, assistant professor of aerospace and mechanical engineering at Notre Dame and co-lead author of the study
Datta and collaborators collected data from 30 patients’ preoperative MRIs and their craniotomies, which include exposing the brain and using Brainlab neuronavigation technology. This technology provides surgeons with real-time, 3D visualization during brain surgeries and is considered commonly available for neurological procedures. Neurosurgeons can use this technique to measure the bulge caused by brain swelling from the tumor’s mechanical forces before the tumor is resected.
Then this patient data was used to determine whether brain tissue was displaced by a tumor’s mechanical force or replaced by a tumor. The researchers found that when there is more mechanical force on the brain (displacement), the swelling will be more substantial. But when a tumor invades and destroys surrounding tissue (replacement), the swelling will be less significant.
The researchers created computational models based on a point system of measurements and biomechanical modeling that can be employed by doctors to measure a patient’s brain bulge, to determine the mechanical force that was being exerted by the tumor, and to determine the amount of brain tissue lost in each patient.
Funded by the National Institutes of Health, National Science Foundation and various cancer research foundations, this study is among the first to show how mechanics can distinguish between tumor types.
“Knowing the mechanical force of a tumor can be useful to a clinician because it could inform patient strategies to alleviate symptoms. Sometimes patients receive steroids to reduce brain swelling, or antipsychotic agents to counter neurological effects of tumors,” said Datta, an affiliate of Notre Dame’s Harper Cancer Research Institute. Datta recently showed that even affordable and widely used blood pressure medications can counter these effects. “We’re hoping this measurement becomes even more relevant and that it can help predict outcomes of chemotherapy and immunotherapy.”
To get a better idea of what else mechanical force could indicate, the research team used animal modeling of three different brain tumors: breast cancer metastasis to the brain, glioblastoma and childhood ependymoma.
In the breast cancer metastasis tumor, researchers used a form of chemotherapy that is known to work in reducing metastasis brain tumor size. While waiting for the tumor to respond to the chemotherapy, the team found that a reduction in mechanical force changed before the tumor size was shown to change in imaging.
“In this model, we showed that mechanical force is a more sensitive readout of chemotherapy response than tumor size,” Datta said. “Mechanics are sort of disease-agnostic in that they can matter regardless of what tumor you are looking at.”
Datta hopes that doctors employ the patient models from the study to continue to grow the field’s understanding of how mechanical force can improve patient care management.
In addition to Datta, co-lead authors include Hadi T. Nia at Boston University, Ashwin S. Kumar at Massachusetts General Hospital and Harvard Medical School, and Saeed Siri at Notre Dame. Other collaborators include Gino B. Ferraro, Sampurna Chatterjee, Jeffrey M. McHugh, Patrick R. Ng, Timothy R. West, Otto Rapalino, Bryan D. Choi, Brian V. Nahed, Lance L. Munn and Rakesh K. Jain, all at Massachusetts General Hospital and Harvard Medical School.
Datta is also affiliated with Notre Dame’s Eck Institute for Global Health, the Berthiaume Institute for Precision Health, NDnano, the Warren Center for Drug Discovery, the Lucy Family Institute for Data & Society and the Boler-Parseghian Center for Rare Diseases. She is also a concurrent faculty member in the Department of Chemical and Biomolecular Engineering and a faculty adviser for Notre Dame’s graduate programs in bioengineering and materials science and engineering.
Source:
Journal reference:
Nia, H. T., et al. (2025). Solid Stress Estimations via Intraoperative 3D Navigation in Patients with Brain Tumors. Clinical Cancer Research. doi.org/10.1158/1078-0432.ccr-24-4159.
Vehari – A citizen staged a unique protest against the withdrawal of electricity subsidies for those consuming over 200 units by wearing a suit made of electricity bills and hanging a meter around his neck, an image that quickly went viral on social media and sparked widespread public outrage. People echoed former minister Khawaja Asif’s famous line, “There should be some shame, some decency,” as criticism mounted against the elite who receive thousands of free electricity units while the poor are burdened with heavy bills for minimal usage. Mukhtar Ahmad Bhatti, senior member of the Chamber of Small Traders, called the inflation “economic genocide,” while analyst Murshid Abdul Aziz Bhutta said the system is designed only for the rich. Advocate Rana Muhammad Sajid termed the policies unconstitutional and against fundamental human rights; Advocate Ms. Saima Noreen said punishing the poor and rewarding the rich is oppression, not justice; and Advocate Ms. Samer Fatima added that the public’s patience has run out and now rulers must answer.
Laborers, farmers, and vendors lamented that they can neither afford electricity nor feed their children, saying the system is out to destroy them. The public is now demanding fairness in the power system, equal subsidies for all, and an end to free units for the privileged.
The margins could not have been finer when Tilda Månsson (SWE) emerged victorious in a photo finish against Noelia Juan (ESP) at the 2023 Tiszaujvaros World Cup. Entering this year’s race, though, the former World Junior champion may have to summon something even more dramatic if she is to prevail once again as she faces up against the current WTCS Series leader, Lisa Tertsch (GER).
With a smaller women’s field present this year, there will only be two semi-finals on Saturday and energy conservation ahead of Sunday’s finale will be key. Such has been Tertsch’s form of late, she enters as the clear favourite. Nevertheless, every ounce of energy saved ahead of Sunday’s final – which will be live on TriathlonLive from 15:45 (CEST) – could prove the difference for Månsson or someone else upsetting the odds.
Tertsch meets Månsson in semi-final 1
With a win at WTCS Abu Dhabi and a medal at WTCS Yokohama, Tertsch has reiterated her status as one of the best triathletes in the world. It is therefore little surprise that she will wear number 1. In years gone by, the World Cup circuit has proven a happy hunting ground for the German athlete, with her win at the 2023 Tangier World Cup standing out. Equally, with WTCS Hamburg coming a week after Tiszy, there may be a chance that Tertsch will not be fully rested or dialled in for this weekend’s double header, potentially opening the door for others.
Already this year, Månsson has logged her best ever WTCS finishes yet. As a result, the triple World Cup winner will be confident of starring in Tiszy again. She wears number 3 in the first semi-final, handing her the option to shadow Tertsch. Separating the pair on the start list is Ilaria Zane (ITA); the experienced Italian medalled at the Saidia World Cup this past weekend. Zane’s teammate Costanza Arpinelli, another recent World Cup medallist (from Samarkand), then wears number 4.
World Cup medallists Lea Coninx (FRA) and Jessica Fullagar (GBR), who coincidentally both medalled in Samarkand (in 2024 and 2023, respectively), add to the firepower of the first heat. Likewise, talents like Maria López Faraudo (MEX), the 2nd place finisher at the Americas Championships, and Manami Hayashi (JPN), who has been dominant on the Asian circuit and tackles a first World Cup of year after placing 25th on her WTCS debut in Yokohama, could be names to watch when the final comes around. Finally, keep an eye on Carina Reicht (AUT). She is in great form following back-to-back Europe Cup wins and broke the Austrian 5km record earlier this year.
Vermeylen the proven quantity in semi-final 2
Jolien Vermeylen (BEL), a World Cup winner and the 3rd place finisher in Tiszaujvaros in 2023, enters as the number 1 seed in the second semi-final. Over the past few years, Vermeylen has developed to the point that her making the final (mishap aside) should be a formality. Her task will be to avoid burning any unnecessary energy in the semi-final before taking on the likes of Tertsch and Månsson.
Coming out on top in the second heat is not a given, though. One dark horse to watch will be Tilly Anema (GBR). The Brit looked set to win this year’s Samarkand World Cup before unfortunately crashing on the bike. She rallied to take 5th place in a demonstration of her mental fortitude, and her 2025 form definitely marks her out as dangerous. Another Brit, Sophie Alden, will start too in semi-final 2 as she looks to build back to her World Cup medal-winning form following injury.
Momentum is also on the side of both Sara Guerrero Manso (ESP), the bronze medallist at May’s Chengdu World Cup, and Italy’s Beatrice Mallozzi, the recent 4th place finisher at the Huatulco World Cup. With 2023 World U23 champion Selina Klamt (GER) and World U23 Winter Triathlon champion Zuzana Michalickova (SVK) starting the second semi-final, the race to qualify for Sunday could get spicy.
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MANILA, Philippines — Asian shares mostly gained on Thursday after U.S. stocks hit another all-time high.
U.S. futures edged up while oil prices fell.
Tokyo’s Nikkei 225 inched up 0.1% to 39,794.16. In South Korea, the Kospi added 1% to 3,106.46, while Australia’s S&P/ASX 200 was down 0.1% to 8,589.30.
The Hong Kong’s Hang Seng index lost 1% to 23,976.41. The Shanghai Composite index edged up 0.1% to 3,57.36.
Taiwan’s TAIEX surged 1.4% while India’s Sensex rose 0.3%
Mizuho Bank, Ltd., in a commentary, said there is lopsided optimism about Vietnam’s deal with the US, with Vietnamese imports subject to 20% tariffs in return for 0% tariffs on U.S. goods.
“A higher 40% tariff on goods deemed to be transshipped via Vietnam could accentuate risks to and from China,” it said, adding that “other Asian economies will be particularly vulnerable to a two-sided geoeconomic squeeze given that their reliance on both China and U.S. are significant.” President Donald Trump said on Wednesday that he reached a deal with Vietnam, where U.S. products sold in the country will face zero tariffs and Vietnamese-made goods will face a U.S. tariff of 20%. That helped companies that import lots of things from Vietnam, including Nike, whose stock rose 4.1%. Factories in Vietnam made half of all Nike brand footwear in its fiscal year of 2024. The S&P 500 rose 0.5% and set a record for the third time in four days. The Dow Jones Industrial Average edged down by 10 points, or less than 0.1%, and the Nasdaq composite gained 0.9%.
Tesla helped drive the market higher and rose 5% after saying it delivered nearly 374,000 of its Model 3 and Model Y automobiles last quarter. That was better than analysts expected, though the electric-vehicle maker’s overall sales fell 13% from a year earlier.
Worries have been high that CEO Elon Musk’s involvement in politics is turning off potential Tesla buyers.
Constellation Brands climbed 4.5% despite reporting a weaker profit for the latest quarter than analysts expected. It pointed to slowing growth for jobs in the construction industry and other “4000 calorie+” sectors, which tends to hurt demand for its beer.
But the company selling Modelo beer and Robert Mondavi wine nevertheless stuck with its financial forecasts for the full upcoming year.
They helped offset a 40.4% drop for Centene. The health care company withdrew its forecasts for profit this year after seeing data that suggests worse-than-expected sickness trends in many of the states where it does business. It was the worst day for the stock since its debut in 2001.
All told, the S&P 500 rose 29.41 points to 6,227.42. The Dow Jones Industrial Average slipped 10.52 to 44,484.42, and the Nasdaq composite climbed 190.24 to 20,393.13.
In the bond market, Treasury yields were mixed ahead of a highly anticipated report on Thursday, which will show how many jobs U.S. employers created and destroyed last month. The widespread expectation is that they hired more people than they fired but that the pace of hiring slowed from May.
A stunningly weak report released Wednesday morning raised worries that Thursday’s report may fall short. The data from ADP suggested that U.S. employers outside the government cut 33,000 jobs from their payrolls last month, when economists were expecting to see growth of 115,000 jobs.
The ADP report does not have a perfect track record predicting what the U.S. government’s more comprehensive jobs report will say each month. That preserves hope that Thursday’s data could be more encouraging. But a fear has been that uncertainty around President Donald Trump’s tariffs could cause employers to freeze their hiring.
Many of Trump’s stiff proposed taxes on imports are currently on pause, and they’re scheduled to kick into effect in about a week. Unless Trump reaches deals with other countries to lower the tariffs, they could hurt the economy and worsen inflation.
Other factors could also be dragging on the job market, such as the U.S. government’s termination of protected status for 350,000 Venezuelans, potentially exposing them to deportation. That alone could create a drag on payrolls of 25,000 jobs, according to Goldman Sachs economist David Mericle, whose forecast for Thursday’s report is weaker than many of his peers.
In other dealings on Thursday, the benchmark U.S. crude lost 45 cents to $67, while Brent crude, the international standard, shed 47 cents to $68.64. The dollar was trading at 143.77 Japanese yen, up from 143.65 yen. The euro was unchanged at $1.1790.