Author: admin

  • Brisk Walking May Help You Live Longer

    Brisk Walking May Help You Live Longer

    Share on Pinterest
    A new study has linked short bouts of daily brisk walking to a significantly lower risk of death from cardiovascular disease. Andreswd/Getty Images
    • A new study finds that short bouts of daily brisk walking are linked to a significantly lower risk of death.
    • The research underscores the importance of intensity, not just duration, during daily physical activity.
    • The study is the first to observe these health benefits in low-income, predominantly Black communities.

    Walking briskly for just 15 minutes a day is linked to a significantly lower risk of death than walking slowly, even for a much longer time.

    The findings may have important implications for underserved communities.

    It’s the first study to examine the health effects of walking pace in predominantly low-income and Black communities. The researchers said these communities often face economic barriers and are more likely to live in impoverished areas with little access to safe walking spaces.

    Wei Zheng, MD, PhD, MPH, the study’s senior author and director of the Vanderbilt Epidemiology Center, told Healthline that the link between brisk daily walking and lower mortality risk isn’t surprising. What’s notable, he said, is that the benefit remains strong in communities that are typically underrepresented in research.

    Most previous studies have focused on white, middle- and upper-income populations.

    Short bouts of brisk walking could offer an accessible way for people in underserved communities to improve their health — it’s low-cost, easy to do, and time-efficient.

    Zheng added that many people in these communities may not be able to afford a gym membership or may have a limited amount of leisure time for physical activity.

    “If they can do some intensive walking, it will have a beneficial effect. One of the reasons we looked at it is because, regardless of age and fitness level, it’s something most people can do,” Zheng said.

    Zheng and his team examined the relationship between walking pace and death rates in 85,000 people enrolled in the Southern Community Cohort Study. Most participants were low-income and Black, recruited from 12 southeastern U.S. states. About half of them reported earning less than $15,000 per year.

    Walking pace and duration were reported separately from other leisure-time physical activities. They were asked to estimate how many minutes per day they spent “walking slowly” (for example, moving around the house or walking the dog) or “walking fast” (such as climbing stairs or walking briskly).

    Over a 17-year follow-up period, 26,862 participants in the cohort died. When researchers compared reported walking patterns with mortality, they found that those who walked briskly for at least 15 minutes a day had nearly a 20% lower risk of death.

    Slow walking offered a modest benefit — a 4% reduction in mortality risk — but it required a significantly longer duration: more than three hours per day.

    The protective effect of walking was more strongly associated with a reduced number of deaths from cardiovascular disease compared to deaths from cancer. People with preexisting conditions — such as obesity or diabetes — saw even greater reductions in risk than healthier participants.

    “This study puts further emphasis on fast-paced walking as a viable strategy to address existing health disparities and lower the risk of cardiovascular disease, particularly in low-income and Black populations, which see disproportionate rates of heart disease,” said Lu Qi, MD, PhD, HCA Regents Distinguished Chair and professor of epidemiology in the Celia Scott Weatherhead School of Public Health and Tropical Medicine at Tulane University. Qi wasn’t involved in the research.

    Current guidelines recommend that adults get at least 150 minutes of moderate-intensity physical activity per week. Brisk walking, as long as the pace is vigorous enough, can help you meet that goal.

    Walking the dog or taking a leisurely stroll may not be enough to reach the moderate-intensity threshold.

    In recent years, both the medical and fitness communities have shown growing interest in the health benefits of higher-intensity exercise. In the gym, this might include HIIT workouts, while walking can be intensified with techniques like interval walking or “Japanese walking.”

    “While any activity is good, higher-quality activity can really pack a more powerful punch,” said Sarah F. Eby, MD, PhD, a sports medicine specialist at Mass General Brigham Sports Medicine and assistant professor of physical medicine and rehabilitation at Harvard Medical School.

    Workout intensity is subjective, but the goal of interval training is simple and widely applicable: alternate periods of higher intensity with periods of lower intensity. During a walk, this could mean switching between a slower pace and a brisk one, using your breathing as a guide to intensity.

    Zheng encourages everyone to “be mindful” of their pace when they are out walking to ensure they are getting a little extra intensity.

    “We walk all the time from one place to another. Increasing our pace and walking briskly during those periods not only saves time but it also offers these health benefits,” he said.

    However, even though walking is generally accessible, there may still be accessibility issues for some.

    “The barriers to entry aren’t zero. Unfortunately, folks with lower income levels tend to have less flexibility with work schedules and often live in more polluted areas that lack adequate, safe, walking infrastructure,” said Eby.

    She points out that there may still be opportunities for safe walking environments through participation in walking clubs or local community centers. Eby said she’s even had patients tell her about doing laps in their own homes by planning indoor walking paths.

    “The significant mortality benefit from regular walking demonstrated by this study highlights the need for investment in safe walkable infrastructure and considerations for workplace interventions to allow for brisk walking breaks, if even for just 15 minutes a day,” she said.

    Continue Reading

  • Five-try Ireland seal comeback win over Scotland in World Cup warm-up

    Five-try Ireland seal comeback win over Scotland in World Cup warm-up

    Five-try Ireland seal comeback win over Scotland in World Cup warm-up – BBC Sport

    Continue Reading

  • We Love Bluetti Portable Power Stations and You Can Save Hundreds on Them Right Now

    We Love Bluetti Portable Power Stations and You Can Save Hundreds on Them Right Now

    Between off-grid summer adventures and wanting to have a back-up in case the power goes out, a portable power station has almost become a household staple — that is, if you can afford the high price tag. Bluetti makes some of our top choice back up power stations, generators and solar panels, and right now Amazon has markdowns that range from a $100 to $1,400 off.

    We’ve highlighted some of the best bargains below, but be sure to browse the entire sale to find the right fit for you. Keep in mind, too, that some of the prices are a straightforward discount when added to cart and other offers need you to clip an on-page coupon to save the most.

    One of the biggest discounts is on the Bluetti Solar Generator Apex 300 and the B300K expansion battery combo. This setup typically sets you back $4,100. Amazon has the price down by 34%, which means you can get it for $2,698. That saves you $1,402.

    Hey, did you know? CNET Deals texts are free, easy and save you money.

    If you’re hoping to get your hands on another B300K expansion battery, you can save $600 with an on-page coupon, which drops the price down from $1,799 to $1,199.

    Grab the Bluetti Solar Generator Apex 300 and two, 200-watt solar panels for just $1,999, which is $1,300 less than the regular asking price for this off-grid combo.

    Top deals available today, according to CNET’s shopping experts

    Curated discounts worth shopping while they last.

    Why this deal matters

    A portable power station can be a great help whether you live in an area that suffers power cuts or you just want to take the power with you when camping. Bluetti offers some of our favorite power stations, and this is your chance to save hundreds of dollars off yours.


    Continue Reading

  • First chikungunya fever case in 6 years raises transmission risk in Hong Kong

    First chikungunya fever case in 6 years raises transmission risk in Hong Kong

    Health authorities in Hong Kong have not ruled out the possibility of local chikungunya fever transmissions after the city recorded its first imported case of the mosquito-borne disease since 2019, involving a boy who returned from outbreak-hit Foshan in mainland China.

    The Centre for Health Protection confirmed the case on Saturday, weeks after a surge in infections was recorded in neighbouring Guangdong province.

    Albert Au Ka-wing, head of the centre’s communicable disease branch, said the 12-year-old patient had travelled with his mother to Shunde district in Foshan between July 17 and 30, during which he was bitten by mosquitoes.

    The boy, who lives in On Tat Estate in Kwun Tong, was in good health previously.

    On Thursday, he developed a fever, rash and joint pain and visited a private doctor before being admitted to United Christian Hospital in Kwun Tong the following day. A blood sample tested positive for the disease on Saturday morning.

    The boy was in a stable condition, Au said, adding that his mother and another family member who was living with them had not shown any symptoms.

    Continue Reading

  • Hungarian GP qualifying: Leclerc takes surprise pole to upset McLarens

    Hungarian GP qualifying: Leclerc takes surprise pole to upset McLarens

    BUDAPEST, Hungary — Charles Leclerc took a shock pole position for Ferrari at the Hungarian Grand Prix ahead McLaren’s championship rivals Oscar Piastri and Lando Norris in second and third.

    Leclerc hooked up a 1:15.372 to beat championship leader Piastri to the fastest third and final qualifying session time by 0.026 seconds, with Norris a further 0.015 seconds adrift in third.

    Norris set the fastest time of all in Q2 — a 1:14.980 — but could not replicate it in Q3 when the sky clouded over, the wind picked up and the track temperature dropped.

    Leclerc’s pole position marks Ferrari’s first of the year for a grand prix — Lewis Hamilton secured sprint race pole in China — after the team introduced upgraded suspension to its car at the Belgian Grand Prix one week ago.

    “Today I don’t understand anything in Formula 1,” Leclerc said afterward. “Honestly, the whole qualifying has been extremely difficult. When I say extremely difficult, it’s not exaggerating. It was difficult for us to get to Q2, it was difficult for us to get to Q3.

    “I knew I just had to do a clean lap to target third, and at the end of the day it’s pole position. I definitely did not expect that.

    “Honestly, I have no words. It’s probably one of the best pole positions I’ve ever had. It’s the most unexpected, for sure,” he added.

    The McLaren teammates, who are increasingly in a battle of their own for the championship, looked comfortably fastest throughout practice and remain the favorites to take the fight to Leclerc and challenge for victory in Sunday’s race.

    The two drivers blamed the wind changes from Q2 to Q3, with Piastri saying: “I think the wind changed a lot. It always sounds so pathetic blaming things on the wind. It did a 180 from Q2 to Q3 and meant a lot of the corners felt completely different.

    “It was difficult to judge in those conditions and maybe not the best execution. I was surprised we couldn’t go quicker than that.

    “Second is still a decent spot to start, so we’ll see what we can do tomorrow.”

    While Norris said: “I think Charles did a good job on the last lap … he probably risked a little bit more in these conditions. The wind changed a lot and it really seemed to punish us in a bigger way it seems.”

    George Russell secured fourth place for Mercedes ahead of a strong result for Aston Martin’s Fernando Alonso, which matched his season-best qualifying performance at the Emilia-Romagna Grand Prix.

    Alonso’s teammate Lance Stroll will start sixth on the grid ahead of another impressive qualifying performance by Sauber’s Gabriel Bortoleto in seventh.

    Reigning champion Max Verstappen had to settle for eighth on the grid after struggling with the balance of his Red Bull throughout practice.

    Racing Bulls teammates Liam Lawson and Isack Hadjar rounded out the top ten in ninth and tenth.

    Haas driver Oliver Bearman will start 11th on the grid after missing out on a place in Q3 by 0.007 seconds. In an incredibly close battle for the final place in Q3, Hamilton also fell just short and will start the race 12th on the grid with a time just 0.008 seconds slower than Bearman.

    A despondent Hamilton told reporters afterwards that he was “absolutely useless” when asked about his qualifying.

    Andrea Kimi Antonelli also featured in the fight for the last place in Q3 but his fastest lap time, which looked set to secure him 11th on the grid, was deleted for exceeding track limits at Turn 14, leaving him 15th overall.

    Carlos Sainz will start 13th for Williams ahead of Franco Colapinto, who outqualified Alpine teammate Pierre Gasly for the second time since joining the French team at the Emilia-Romagna Grand Prix.

    Yuki Tsunoda missed out on a place in Q2 by 0.021 seconds, resulting in his fourth Q1 knockout since joining Red Bull. His margin to Verstappen in Q1 was only 0.163 seconds, one of the closer gaps between the two drivers as teammates, but it still left him 16th on the grid for Sunday’s race.

    Pierre Gasly will start 17th for Alpine ahead of the Haas of Esteban Ocon, the Sauber of Nico Hülkenberg and Alex Albon’s Williams in last place.

    Continue Reading

  • The next era of Wi-Fi is coming — Wi-Fi 8 prioritizes a rock-solid connection over raw speed

    The next era of Wi-Fi is coming — Wi-Fi 8 prioritizes a rock-solid connection over raw speed

    Wireless internet is a constantly changing area of technolgy. It feels like we were just celebrating the speed and performance offered by Wi-Fi 6 and then Wi-Fi 7 came along. Now, we’re already getting teasers for what Wi-Fi 8 could bring to the table. Surprisingly, it’s not speed that’s the main selling point.

    In a press release, Qualcomm detailed Wi-Fi 8 and its key features. “Wi-Fi 8 is being defined to prioritize reliable performance in challenging real-world conditions, enhancing connectivity even in congested, interference-prone and mobile environments,” said Qualcomm’s Rolf De Vegt.

    Continue Reading

  • The Colorful Sneaker We’ll Be Wearing on Repeat This Fall

    The Colorful Sneaker We’ll Be Wearing on Repeat This Fall

    A splash of color, whether it’s your handbag, jacket, or a piece of jewelry, has the power to transform even the most basic of outfits. Welcome: red sneakers.

    When it comes to making a statement with minimal effort in 2025, a colour-pop sneaker—specifically, in a shade of stop-sign red—seems to have particular allure.

    A satisfying mix of sporty and stylish, red sneakers as a trend sits halfway between casual staple and statement-making accessory, and has become a focal point for many an it-girl outfit this summer—that’s Emily Ratajkowski in a white linens and Iris Law’s urban, denim trompe l’oeil co-ord included.

    Emily Ratajkowski – Christopher Peterson / SplashNews.com / ipa-agency.net

    Red sneakers Iris Law

    Photo: Getty Images

    But the best thing about this look? While red is enjoying a moment in the spotlight right now, we know it’s a shade that will transcend any seasonal trend fluctuations. The red sneaker can look just as good on holiday with shorts and a tank top as it will during the first days of fall—simply style with baggy jeans, a cashmere crewneck, and sand-coloured trench coat—on lazy weekends and in your 9-5 if styled with suit pants for some welcome juxtaposition.

    sneakers rosse

    I prodotti sono selezionati con autonomia editoriale. Se acquisti uno di tali prodotti potremmo ricevere una commissione. Alcuni prodotti citati nell’articolo potrebbero essere soggetti a posizionamento privilegiato in cambio di compensoInstagram @tia_dewitt

    Continue Reading

  • Pakistan, China vow to further strengthening bilateral ties – RADIO PAKISTAN

    1. Pakistan, China vow to further strengthening bilateral ties  RADIO PAKISTAN
    2. Opinion | Pakistan Is Fast Becoming A Security Burden For China … But Are We Suprised?  NDTV
    3. Islamabad, Beijing pledge support for next stage of CPEC  The Express Tribune
    4. Gwadar, SEZs govt’s top priority, minister assures Chinese diplomat  Dawn
    5. CPSC Monitor (July 28, 2025)  Institute of Strategic Studies Islamabad (ISSI)

    Continue Reading

  • Valiltramiprosate Demonstrates Beneficial Imaging Impacts on Less Progressed Subgroup of APOE4 Homozygotes

    Valiltramiprosate Demonstrates Beneficial Imaging Impacts on Less Progressed Subgroup of APOE4 Homozygotes

    Susan Abushakra, MD, chief scientific officer at Alzheon

    In a pre-specified cohort of patients with mild cognitive impairment (MCI), results from the phase 3 APOLLOE4 trial (NCT04770220) showed that investigational valiltramiprosate (Alzheon) had significant impacts on imaging outcomes such as hippocampal volume (HV), cortical thickness, and whole brain volume. Investigators concluded that these strong correlations seen at the MCI stage support its efficacy and are consistent with its proposed mechanism of inhibiting amyloid oligomer formation.1

    In this double-blind, randomized trial, patients with early-stage Alzheimer disease (AD) who had 2 copies of the apolipoprotein e4 allele (APOE4/4 homozygotes) were randomly assigned to valiltramiprosate (n = 163) 265 mg BID or placebo (n = 162) for a 78-week period. The pre-specified MCI group included 125 patients (58 on placebo; 67 active), while the imaging population included 54 patients on placebo and 62 on active drug. Within this subgroup, there were significant slowing of HV by 26% (P = .004), cortical thickness by 35% (P <.0001), and whole brain volume atrophy by 22% (P = .027).

    Presented at the 2025 Alzheimer’s Association International Conference (AAIC), held July 27-31, in Toronto, Canada, the MCI subgroup demonstrated positive effects on ADAS-cog/Disability Assessment for Dementia (DAD; nominal P <.05) and a trend on Clinical Dementia Rating-Sum of Boxes (CDR-SB; P = .053), the study’s primary and key secondary outcome, respectively. In the study, lead investigator Susan Abushakra, MD, chief scientific officer at Alzheon, and others, used Spearman’s correlations to determine drug-effect correlations while pre-specifying each analysis based on disease stage.

    In the analysis, results showed those randomized to active treatment had changes in HV that correlated significantly with change in ADAS-cog13 (r = –0.40; P <.005), CDR-SB (r = –0.45; P <.005), and DAD (r = 0.33; P = .018). For cortical thickness, the correlations were also significant: ADAS-Cog13 (r = 0.34; P = .015), CDR-SB (r = 0.49; P <.005), and DAD (r = 0.40; P <.005). Notably, whole brain volume treatment effect also correlated with clinical outcomes (P ≤.01).

    READ MORE: Innovative Phase 1b/2a Trial to Test Anti-Tau Agent BIIB080 in Corticobasal Syndrome

    A second analysis presented at AAIC 2025 looked at valiltramiprosate’s effects on microstructural integrity of grey and white matter in both those with MCI (n = 84) and mild AD (n = 122). In the overall population, using mean water diffusivity (MD), treatment with the agent resulted in positive trends (P <0.1) on cingulate/occipital cortex and caudate/striatum relative to placebo, as well as significant effects on white matter (WM) structures such as corpus callosum genu (P <.001) and fornix (P = .007).2

    The mild AD group showed positive trends on occipital cortex and significant WM effects (GCC: P = .005; fornix: P = .019), while the MCI group showed significant effects in cingulate (P = .031) and WM (GCC/whole CC: P = .003/0.013) as well as fornix (P = .032). In the MCI active arm, dMRI effects showed significant correlations with both clinical and volumetric measures, including frontal cortex mean diffusivity with ADAS-Cog13/CDR-SB (P < 0.05) and with hippocampal volume and cortical thickness (both P = 0.002), as well as WM-GCC diffusivity with hippocampal volume (P = 0.03) and cortical thickness (P = 0.006).

    The first data release for APOLLOE4 was presented earlier this year at the 2025 AD/PD International Conference on Alzheimer’s and Parkinson’s Diseases, held April 1-5 in Vienna, Austria. In the study, valiltramiprosate, a valine prodrug of tramiprosate, did not meet its primary end point of change in ADAS-Cog13; however, did show more prominent benefits in the prespecified MCI population. In this group, investigators observed a nominally significant 52% benefit on ADAS-Cog13 and a 102% improvement in CDR-SB.3

    Additional data from the original release showed a 96% slowing (P = .016) on DAD and a 70% slowing (P = .268) in Instrumental Activities of Daily Living. For comparison, in the full analysis set, comprising both MCI and mild AD, treatment with the agent resulted in an 11% slowing in ADAS-Cog13 (P = .607), 23% slowing on CDR-SB (P = .309), 29% slowing on DAD (P = .279), and 17% slowing on Mini-Mental State Exam (P =.454).

    Click here for more AAIC 2025 coverage.

    REFERENCES
    1. Abushakra S, Doraiswamy M, Liang E, etl al. Correlations of Valiltramiprosate Effects on Hippocampal Volume and Cortical Thickness with Clinical Outcomes in the Pre-Specified MCI Group: Subgroup Analysis from the 78-Week APOLLOE4 Phase 3 Trial in APOE4/4 Homozygotes. Presented at: AAIC 2025; July 27-31; Toronto, Canada. ABSTRACT 108827
    2. Liang E, Abushakra S, Doraiswamy M, et al. Valiltramiprosate Effects on Microstructural Integrity of Grey and White Matter in APOE4/4 Homozygotes with Early AD and their Correlations to Clinical Outcomes: MRI Mean Diffusivity Results from the 78-Week APOLLOE4 Phase 3 Trial. Presented at: AAIC 2025; July 27-31; Toronto, Canada. ABSTRACT 108716
    3. Inhibition of beta amyloid oligomer neurotoxicity with oral valiltramiprosate/ALZ-801 in APOE e4/e4 homozygotes with early Alzheimer disease. Presented at: 2025 AD/PD Annual Meeting.

    Continue Reading

  • Infinix GT 30 5G+’s key specs and colors revealed by Flipkart

    Infinix GT 30 5G+’s key specs and colors revealed by Flipkart

    Infinix started teasing the GT 30 5G+ (aka GT 30) recently, and yesterday, we exclusively reported that the smartphone would be launched in India on August 8. That date has been corroborated by Indian online retailer Flipkart, which revealed that the Infinix GT 30 5G+ will debut in India on August 8 at noon local time.

    Flipkart also revealed that the Infinix GT 30 5G+ will be powered by the Dimensity 7400 SoC and have 8GB of LPDDR5X RAM and up to 256GB of storage onboard. The smartphone will pack a 144Hz 10-bit AMOLED display of 1.5K resolution, which will have 4,500 nits peak brightness and Gorilla Glass 7i protection.


    Infinix GT 30 5G+'s key specs
    Infinix GT 30 5G+'s key specs

    Infinix GT 30 5G+’s key specs

    The Infinix GT 30 5G+’s GT Shoulder Triggers can be customized for in-game controls, camera controls, quick app launches, and video playback, while the Mecha Lights on the back panel can be customized for 10+ scenarios.


    Infinix GT 30 5G+ will feature customizable GT Shoulder Triggers and lights
    Infinix GT 30 5G+ will feature customizable GT Shoulder Triggers and lights

    Infinix GT 30 5G+ will feature customizable GT Shoulder Triggers and lights

    The GT 30 5G+ will be available in Pulse Green, Cyber Blue, and Blade White colors, but it’s unclear how many memory options it will have. We could hear more about the smartphone either from Flipkart or Infinix before its August 8 launch.


    Infinix GT 30 5G+'s color options

    Infinix GT 30 5G+’s color options

    Source

    Continue Reading