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Fornaroli leads Invicta Racing 1-2 with superb drive in Budapest

Leonardo Fornaroli achieved his maiden FIA Formula 2 Feature Race victory, and in doing so led home an Invicta Racing one-two with his teammate Roman Stanek in second place.

The Championship leader managed the race expertly after being given a five-second time penalty for speeding in the pit lane to take his third win of the season, as Jak Crawford rounded out the podium for DAMS Lucas Oil.

AS IT HAPPENED

A rolling start kicked things off as pole-sitter Stanek led his teammate Fornaroli and Crawford away, as the top 12 drivers maintain position on the first lap with the track slightly wet off-line.

Crawford had lost ground to the top two and on Lap 4 was coming under pressure from Luke Browning. The Hitech TGR driver looked to have taken the place, but he ran wide at Turn 2 allowing his rival back through.

Lap 6 of 37 and Amaury Cordeel pulled his Rodin Motorsport car over to the side of the road, bringing out the Virtual Safety Car.

Racing resumed on Lap 8, and Arvid Lindblad, the lead driver on the Medium tyre, took two places at the opening two corners from Oliver Goethe and Joshua Duerksen to go to P5.

Lindblad’s Campos Racing teammate Josep María Martí lost two places to Gabriele Minì and Richard Verschoor at Turn 1 though, dropping the Spaniard to P11.

The Virtual Safety Car was signalled once again with Victor Martins stopping his ART Grand Prix on track at the exit of Turn 12.

Green flag conditions returned on Lap 11, and looking to get the jump on Lindblad, Goethe ran wide at Turn 12, dropping him to P8 behind Duerksen and Alexander Dunne.

Dunne and Duerksen then went wheel-to-wheel down the Main Straight, with the Irishman taking sixth from the AIX Racing driver, despite a lockup into Turn 2.

Stanek led the way at a rolling start with Fornaroli in second

Campos then informed Lindblad that the Prime tyre was quicker than the Options on Lap 13, and his teammate Martí showed that as he took back the two places he lost to Verschoor and Minì on the run to Turn 2. The Spaniard then overtook Goethe for P8 on the run to Turn 12.

The first set of Soft tyre runners at the front then pitted, with Browning coming in from fourth, with Duerksen, Goethe and Minì all joining him in swapping to the Mediums.

Race leader Stanek and Crawford came in on Lap 15, with Fornaroli and Dunne following on the next lap. The Italian made the overcut work as he came back out ahead of his teammate.

Out in front, and yet to pit on the Medium tyres, Lindblad led Martí, with Verschoor in third, ahead of Dino Beganovic, Kush Maini, Cian Shields and Ritomo Miyata.

Fornaroli was in eighth, but only one second separated him and Stanek, who closed the gap on Lap 19. The Championship leader’s race then got more difficult when he was given a five-second time penalty for speeding in the pitlane.

Back at the front, Verschoor was the first of the alternative strategy runners to be called in on Lap 22, and he came back out just behind Goethe in P12.

Lindblad was in from the lead on Lap 23, with Martí in on the next lap, but both struggling to get their tyres up to temperature. They lost out to Verschoor, who had gotten up to P7. The Briton was now 10th, while his teammate fell through the field to P15.

On to Lap 27 of 37, Crawford closed to within 0.4s off Stanek. The American made a move at Turn 1 on the next lap, but locked up into the corner, allowing his rival to keep the position. Their battling allowed Fornaroli to escape up the road and by Lap 29, he was 4.9s clear.

Crawford was struggling behind Stanek now, and behind them Browning set a personal best time on Lap 33 to close to within 1.6s.

The fight for seventh then heated up as Beganovic pilled the pressure on Lindblad. The two went side-by-side through Turns 1 and 2 on Lap 34 and 35, as Goethe and Dunne started to join the fight.

Miyata finally pitted on the penultimate lap, promoting Stanek to second and Crawford to third.

Onto the last lap, Fornaroli was 7.2s clear out in front across the line to achieve his third win in as many weekends and his first FIA Formula 2 victory.

Stanek made it an Invicta one-two, with Crawford third, Browning fourth, Verschoor fifth, while Lindblad held of Beganovic to take P6. Goethe also fought off Dunne for P8 as Martí fought through to take the final point in P10.

The top three celebrate on the podium after the race

KEY QUOTE – Leonardo Fornaroli, Invicta Racing

“What a race today. Finally, we managed to take a win in the Feature Race. It was a really stressful race especially at the end with the five second penalty, I had to stay in front by more than five seconds otherwise I was losing the win. But in the end, we didn’t have a Safety Car. Super happy about this race, now we go into the summer break, so some rest, but then we will be back for Monza.”

CHAMPIONSHIP STANDINGS

Leonardo Fornaroli, now on 154 points extends his lead at the top of the Drivers’ Championship, with Jak Crawford up to second on 137 points. Richard Verschoor is down to third on 135, as Luke Browning goes up to fourth on 125 points, while Alexander Dunne rounds out the top five on 124.

In the Teams’ Standings, Invicta Racing continue to lead the way with 231 points, as Campos Racing maintain second on 189, with Hitech TGR third on 183. DAMS Lucas Oil are fourth on 163 points, as MP Motorsport round out the top five on 158.

UP NEXT

The drivers set off for their summer breaks but will return to the track at Monza for Round 11 on September 05-07.

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August 3, 2025
First‑in‑Class mRNA‑2416 Shows Tolerability, Biologic Activity in Ovarian Cancer and Other Advanced Solid Tumors

Ovarian Cancer | Image
Credit: © magicmine
– stock.adobe.com

Intratumoral administration of the first‑in‑class mRNA therapeutic mRNA‑2416, given alone or in combination with durvalumab (Imfinzi), was well tolerated and demonstrated preliminary biologic activity in patients with ovarian cancer and other advanced solid tumors, according to results from a first‑in‑human, phase 1/2 study (NCT03323398).

Findings published in The Oncologist demonstrated that the overall response rate (ORR) was 0.0% (95%, 0.0%-11.9%) with mRNA‑2416 monotherapy in arm A (n = 29) and 5.3% (95% CI, 0.1%-26.0%) for mRNA‑2416 plus durvalumab in arm B (n = 19). In arm A, the stable disease (SD) rate was 31%; progressive disease (PD) occurred in 52% of patients, and 17% were not evaluable. In arm B, 1 patient (5%) with ovarian cancer experienced a partial response (PR) at the 4.0‑mg mRNA‑2416 dose; however, this response was unconfirmed due to a lack of a confirmatory scan. Additionally, 11% achieved SD, and 84% experienced PD.

Median progression‑free survival (PFS) was 60 days (95% CI, 50-108; range, 29-179) in arm A and 50 days (95% CI, 38-55; range, 11-117) in arm B. By immune‑related response criteria (irRC), SD was observed in 7 patients (24%) in arm A, with PD in 16 patients (55%) and 6 patients (21%) not evaluable. In arm B, 1 patient (5%) achieved PR, 2 patients (11%) achieved SD, 15 patients (79%) had PD, and 1 patient (5%) was not evaluable.

The maximum tolerated dose (MTD) was not reached. Treatment‑related adverse effects (TRAEs) were primarily grade 1/2 in severity; 8 grade 3 TRAEs occurred, and no grade 4/5 TRAEs were reported.

“Although predefined primary efficacy end points were not met, pharmacodynamic analyses provide evidence of the mechanism of action and support continued research into mRNA-based therapeutics to address the unmet challenge of difficult-to-treat malignancies,” lead study author Ryan J. Sullivan, MD, of Massachusetts General Hospital, and colleagues noted in the publication. “Additional research is needed to further elucidate biomarkers of response and identification of the subset of patients most likely to benefit.”

Phase 1/2 Study Design and Enrollment Criteria

The first‑in‑human, open‑label, multicenter study evaluated intratumoral administration of the mRNA therapeutic mRNA‑2416 alone or in combination with intravenous durvalumab in patients with advanced solid tumors or lymphoma. The trial included dose‑escalation, dose‑confirmation, and dose‑expansion phases.

Patients were required to have at least one measurable lesion per RECIST 1.1 criteria and a tumor of sufficient size to support intratumoral injection. Other eligibility criteria included an ECOG performance status of 0 or 1, adequate organ function, and a life expectancy of greater than 12 weeks. Patients in the ovarian cancer expansion cohort were required to have received more than 2 prior lines of therapy, and those with BRCA‑mutated disease must have progressed on prior PARP inhibitor therapy. There were no restrictions on prior immune checkpoint inhibitor exposure.

In the dose‑escalation phase, patients in arm A received mRNA‑2416 at 1.0 mg, 2.0 mg, 4.0 mg, or 8.0 mg. Following assessment of the MTD and recommended dose for expansion (RDE), arm B evaluated mRNA‑2416 starting at 4.0 mg in combination with durvalumab at 1500 mg every 4 weeks, with escalation to 8.0 mg. Dose expansion was not pursued in arm A due to modest single‑agent activity. In arm B, expansion was conducted in patients with recurrent ovarian cancer based on preclinical evidence supporting synergy between OX40L agonism and PD‑L1 inhibition.

In the combination arm, mRNA‑2416 was injected intratumorally first, followed by durvalumab infusion more than 30 minutes later. Durvalumab was administered at a fixed dose of 1500 mg intravenously every 4 weeks for patients weighing over 30 kg, or 20 mg/kg for patients below 30 kg.

The primary end points for phase 1 were safety, tolerability, and identification of the MTD/RDE. The primary end point for phase 2 was investigator‑assessed ORR. Secondary end points included disease control rate (DCR), PFS, duration of response (DOR), pharmacokinetics, and anti‑OX40L antibody development. Exploratory end points included assessment of systemic and intratumoral immune responses.

Safety Profile

Across both phases of the trial, no dose‑limiting toxicities (DLTs) were observed. In arm A the most common TRAEs occurring in at least 10% of patients included injection‑site pain (28%), flushing (26%), pyrexia (23%), fatigue (21%), injection‑site erythema (21%), nausea (18%), chills (15%), myalgia (13%), dyspnea (13%), back pain (10%), and influenza‑like illness (10%).

In arm B, the most common mRNA‑2416‑related TRAEs were pyrexia (46%), injection‑site pain (41%), nausea (32%), fatigue (27%), flushing (23%), chills (14%), influenza‑like illness (14%), tachycardia (14%), hypotension (14%), dyspnea (14%), and hyperhidrosis (14%). Durvalumab‑related AEs occurring in more than 10% of patients included fatigue (27%), pyrexia (23%), and nausea (23%).

Serious treatment-emergent AEs considered related to mRNA‑2416 occurred in 5 patients. In arm A, these effects included grade 3 skin ulceration, grade 3 dyspnea, grade 2 injection‑related reaction with hypoxia, and grade 2 systemic inflammatory response syndrome. In arm B, 1 patient experienced a grade 3 cerebrovascular accident with a positive lupus anticoagulant, assessed by the investigator as possibly related to both mRNA‑2416 and durvalumab.

Biomarker Assessments

Intratumoral administration of mRNA‑2416 induced pharmacodynamic changes consistent with immune activation. In monotherapy‑treated patients, OX40L protein expression increased within the tumor microenvironment after injection. In combination‑treated patients, OX40L expression increased in 4 of 4 biopsies obtained 24 to 48 hours post‑treatment.

Immunohistochemical and multiplex quantitative immunofluorescence analyses demonstrated increased T‑cell infiltration in tumor nests and surrounding stroma. Gene expression profiling revealed activation of proinflammatory immune pathways, including upregulation of T‑cell–inflamed signature genes in 6 of 9 monotherapy patients assessed. PD‑L1 expression, an interferon‑inducible marker, was also elevated following treatment, with effects most pronounced in injected lesions.

Reference

Sullivan RJ, Yeku OO, Teoh D, et al. First-in-human phase I/II, open-label study of mRNA-2416 alone or combined with durvalumab in patients with advanced solid tumors and ovarian cancer. Oncologist. 2025;30(6). doi:10.1093/oncolo/oyaf115

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August 3, 2025
AI is doing job interviews now—but candidates say they’d rather risk staying unemployed than talk to another robot

The next time you get buttoned-up and sit down for a long-awaited job interview, you might not find a human on the other end of the call. Instead, job-hunters are now joining Zoom meetings only to be greeted by AI interviewers. Candidates tell Fortune they’re either confused, intrigued, or straight-up dejected when the robotic, faceless bots join the calls.

“Looking for a job right now is so demoralizing and soul-sucking, that to submit yourself to that added indignity is just a step too far,” Debra Borchardt, a seasoned writer and editor who has been on the job-hunt for three months, tells Fortune. “Within minutes, I was like, ‘I don’t like this. This is awful.’ It started out normal…Then it went into the actual process of the interview, and that’s when it got a little weird.”

AI interviewers are only the newest change to the hiring process that has been upended by the advanced technology. With HR teams dwindling and hiring managers tasked to review thousands of applicants for a single role, they’re optimizing their jobs by using AI to filter top applicants, schedule candidate interviews, and automate correspondence about next steps in the process. AI interviewers may be a god-send for middle-managers, but job-seekers see them as only another hurdle in the intense hunt for work.

The experience for some job-hunters has been so poor that they’re swearing off interviews conducted by AI altogether. Candidates tell Fortune that AI interviewers make them feel unappreciated to the point where they’d rather skip out on potential job opportunities, reasoning the company’s culture can’t be great if human bosses won’t make the time to interview them. But HR experts argue the opposite; since AI interviewers can help hiring managers save time in first-round calls, the humans have more time to have more meaningful conversations with applicants down the line.

Job-seekers and HR are starkly divided on how they feel about the tech, but one thing is fact—AI interviewers aren’t going anywhere.

“The truth is, if you want a job, you’re gonna go through this thing,” Adam Jackson, CEO and founder of Braintrust, a company that distributes AI interviewers, tells Fortune. “If there were a large portion of the job-seeking community that were wholesale rejecting this, our clients wouldn’t find the tool useful… This thing would be chronically underperforming for our clients. And we’re just not seeing that—we’re seeing the opposite.”

Job-seekers are dodging AI interviewers

Social media has been exploding with job-seekers detailing their AI interviewer experiences: describing bots hallucinating and repeating questions on end, calling the robotic conversations awkward, or saying it’s less nerve-wracking than talking to a human. Despite how much hiring managers love AI interviewers, job-seekers aren’t sold on the idea just yet.

Allen Rausch, a 56-year-old technical writer who has worked at Amazon and Electronic Arts, has been on the job hunt for two months since getting laid off from his previous role at InvestCloud. In looking for new opportunities, he was “startled” to run into AI interviewers for the first time—let alone on three occasions for separate jobs. All of the meetings would last up to 25 minutes, and featured woman-like cartoons with female voices. It asked basic career questions, running through his resume and details about the job opening, but couldn’t answer any of his questions on the company or culture.

Rausch says he’s only open to doing more AI interviews if they don’t test his writing skills, and if human connection is guaranteed at some point later in the process.

“Given the percentage of responses that I’m getting to just basic applications, I think a lot of AI interviews are wasting my time,” he tells Fortune. “I would probably want some sort of a guarantee that, ‘Hey, we’re doing this just to gather initial information, and we are going to interview you with a human being [later].’”

While Rausch withstood multiple AI interviews, Borchardt couldn’t even sit through a single one. The 64-year-old editorial professional says things went downhill when the robotic interviewer simply ran through her resume, asking her to repeat all of her work experiences at each company listed. The call was impersonal, irritating, and to Borchardt, quite lazy. She ended the interview in less than 10 minutes.

“After about the third question, I was like, ‘I’m done.’ I just clicked exit,” she says. “I’m not going to sit here for 30 minutes and talk to a machine… I don’t want to work for a company if the HR person can’t even spend the time to talk to me.”

Alex Cobb, a professional now working at U.K. energy company Murphy Group, also encountered an AI interviewer several months ago searching for a new role. While he’s sympathetic towards how many applications HR has to sift through, he finds AI interviewers to be “weird” and ultimately ineffective in fully assessing human applicants. The experience put a bad taste in his mouth, to the point where Cobb won’t pursue any AI-proctored interviews in the foreseeable future.

“If I know from looking at company reviews or the hiring process that I will be using AI interviewing, I will just not waste my time, because I feel like it’s a cost-saving exercise more than anything,” Cobb tells Fortune. “It makes me feel like they don’t value my learning and development. It makes me question the culture of the company—are they going to cut jobs in the future because they’ve learned robots can already recruit people? What else will they outsource that to do?”

AI interviewers are a god-send for squeezed hiring managers

While many job-seekers are backing away from taking AI interviews, hiring managers are accepting the technology with open arms. A large part of it comes from necessity.

“They’re becoming more common in early-stage screening because they can streamline high-volume hiring,” Priya Rathod, workplace trends editor at Indeed, tells Fortune. “You’re seeing them all over. But for high-volume hiring like customer service or retail or entry-level tech roles, we’re just seeing this more and more… It’s doing that first-stage work that a lot of employers need in order to be more efficient and save time.”

It should be noted that not all AI interviewers are created equal—there’s a wide range of AI interviewers entering the market. Job-seekers who spoke with Fortune described monotonous, robotic-voiced bots with pictures of strange feminized avatars. But some AI interviewers, like the one created by Braintrust, distribute a faceless bot with a more natural sounding voice. Its CEO says applicants using the tech are overall happy with their experience—and its hiring manager clientele are enthusiastic, too.

However, Jackson admits AI interviewers still have their limitations, despite how revolutionary they are for HR teams.

“It does 100 interviews, and it’s going to hand back the best 10 to the hiring manager, and then the human takes over,” he says. “AI is good at objective skill assessment—I would say even better than humans. But [when it comes to] cultural fit, I wouldn’t even try to have AI do that.”

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August 3, 2025
Brazil opens world’s largest mosquito factory to fight arbovirus infections

In the Brazilian state of Parana launched the world’s largest mosquito biofactory specialising in the fight against insect vectors of arbovirus infections, including dengue fever, Zika virus and Chikungunya virus. This is reported by
Band News, a partner of TV BRICS.

The peculiarity of the project lies in the use of innovative technology, in which insects are infected with Wolbachia bacterium harmless to humans. It does not allow viruses to develop inside the insect, and the mosquito ceases to be a vector of disease. It is noted that the method does not involve the use of chemicals and is not associated with gene modification.

As the publication specifies, the larvae are grown in sterile conditions under constant supervision of specialists. Once they reach the right size, experts manually separate males from females to ensure accurate selection. As a result, the harmless mosquitoes are released into the environment.

The factory is expected to produce 100 million eggs a week and more than 5 billion a year. The first batches of mosquitoes will be sent to six Brazilian cities as early as August.

The report says that the effectiveness of the method has already been proven in other countries as well as in Brazil itself. In Niteroi (Rio de Janeiro state), where the technology was launched about 10 years ago, the number of dengue fever cases has dropped by 70 per cent.

Photo: frank600 / iStock

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August 3, 2025
‘The BBC feels very samey and boring’: the over-50s who prefer YouTube | YouTube

UK viewers over the age of 55 watched almost twice as much YouTube last year as they did in 2023, with 42% of them watching on a TV, according to a survey by the communications regulator Ofcom.

Here, six people over 50 describe why they prefer YouTube and how it compares with the broadcast TV they grew up with.

‘YouTube is very personal and you feel involved’

YouTube is full of hidden gems and many videos are made by ordinary people. There’s so much more on offer in one place than other streaming services or broadcast channels. Also, some streaming channels can be difficult to navigate to find what you want. At the moment, I’m really enjoying reaction videos. One of my favourites is Regeneration Nation TV where an American duo react to music, comedians and TV shows like Fawlty Towers. They’re fun to watch and you feel involved. I also think it’s helpful for those who feel lonely – it’s almost like the people in these videos are with you. I used to work as a volunteer for the Samaritans so I can understand loneliness. I feel YouTube fills a need that other services don’t. It’s very personal and is a place where you can find anything, and often find what you’re looking for.
Lloyd , 62, disabled and unemployed, Kent

‘Terrestrial TV just feels old-fashioned’

YouTube offers so much content that aligns with my interests and hobbies including music, photography, science and movie reviews. Not to mention it’s all on demand and much of it is available in bite-size form (15 to 20 minutes). For dramas and films, I use streaming services. Now in my late 50s, I also really value YouTube’s treasure trove of live music performances – there’s always something new or nostalgic to discover. There is just nothing on traditional TV that comes anywhere close to the choice and niche subjects that I can find on YouTube, like Adobe Lightroom or Photoshop tutorials. While I occasionally miss watching live events (women’s football, or Ozzy Osbourne’s funeral), I don’t feel I’m missing out.
Steve, 50s, customer services manager, Gloucestershire

‘I like how short content is on YouTube’

I like how short content is on YouTube, making it easy to watch something while you’re eating in the kitchen. I prefer it to other streaming services for the wide choice of things to watch. My favourite shows are when people are making something out of nothing, whether it’s the Great Pottery Throwdown or Rust Valley where they do up old cars. I had a TV licence because I didn’t want to have a problem with the authorities thinking I watch the television, even though I didn’t. I rescinded it recently, though, as I don’t think the BBC makes very good programmes any more. I’m not interested in their output and it feels very samey and boring. I’m also on a state pension and it was difficult to justify the fee.
Andrea, 67, retired care worker, Bedfordshire

‘You can watch anything from deep space to quantum theory’

Watching broadcast TV is madness – having to see something at a specific time makes no sense. I stopped about 20 years ago when Tivo came out, and over time not watching TV got easier once broadband improved and there were more streaming services. YouTube is so much better than others as you can watch anything from deep space to quantum theory. I like watching really detailed scientific videos that are overwhelmingly technical. One channel is PBS Eons, which is about the history of life on Earth. I find that TV is too long-winded and the episode recaps make me feel like I have a memory of a goldfish – it drives me up the wall. Out of politeness, I still have a TV licence. I’ve heard stories of people not being able to prove they’re not watching TV and being taken to court. It’s more for my peace of mind.
Stu Smith, 54, IT consultant, Ipswich

‘I just got fed up with terrestrial TV’

I watch YouTube because I can never find anything entertaining on terrestrial television. I really like to watch travel shows where I can sit at home and feel I can do things like climb in the Himalayas, trek in New Zealand or go to amazing restaurants in different countries. Even though I occasionally watched sport, I gave up my TV licence two years ago. I couldn’t abide so-called celebrities or look-at-me types who interrupted the programme so you get to look at their faces all the time. I don’t mean to be presenter-bashing, but when you get old you need to be a bit more calm in your life, and presenters tend to jump out the TV at you. I just got fed up with it.
Gillian, 73, retired secretary, Stratford-upon-Avon

‘Whether you’re learning or relaxing, YouTube is much more precise than TV’

I’ve played in a few bands and do a lot of recording at home and in 2018 I started watching help videos for recording with Logic Pro X on YouTube. Then I found a lot of guitar tutors as I was studying for my grade 5 classical, then moved on to using the platform for science and history documentaries. Suddenly I could access a lot of information. I also like watching it on the TV as it’s more comfortable than sitting at a desk or using a laptop. I find the ability to scroll through a multitude of topics to find something that fits my mood much better than the offerings on TV. YouTube seems to offer the ability to immerse and satisfy, whether learning or relaxing, in a much more precise way than TV or other streaming services.
Gerry McCart, 60, works in financial services, Edinburgh

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August 3, 2025
At least one killed in Israeli strike on Gaza Red Crescent HQ, says aid group

Published On: Sun, 03 Aug 2025

14:54:28 PKT

(AFP) – The Palestine Red Crescent Society (PRCS) said on Sunday that an Israeli strike on its headquarters in Khan Younis, Gaza, killed at least one staff member and wounded three others.

“One Palestine Red Crescent Society (PRCS) staff member was killed and three others injured after Israeli forces targeted the Society’s headquarters in Khan Younis, igniting a fire on the building’s first floor,” the aid organisation said in a post on X.

A video, which the PRCS said “captures the initial moments” of the attack, shows fires burning in a building, with the floors covered in rubble.

It comes two days after US envoy Steve Witkoff visited a US-backed aid station in Gaza to inspect efforts to get food into the devastated Palestinian territory.

Nearly two years after the war began, UN agencies have warned that time was running out and that Gaza was “on the brink of a full-scale famine”.

Eight staff members from the Red Crescent, six from the Gaza civil defence agency and one employee of the UN agency for Palestinian refugees were killed in an attack by Israeli forces in southern Gaza in March, according to the UN humanitarian office OCHA.

Hamas’s October 2023 attack on Israel, which triggered the war, resulted in the deaths of 1,219 people, mostly civilians, according to a tally based on official Israeli figures.

Israel’s campaign in Gaza has killed at least 60,332 people, mostly civilians, according to figures from the Hamas-run territory’s health ministry, deemed reliable by the UN.

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August 3, 2025
Cure for Type 1 diabetes? Cancer research accidentally stumbles upon 90 per cent effective ‘sugar-coating’ method – MSN
1. Cure for Type 1 diabetes? Cancer research accidentally stumbles upon 90 per cent effective ‘sugar-coating’ method MSN
2. Sugar Molecule on Beta Cells Linked to Immune System Evasion in Type 1 Diabetes Research geneonline.com
3. This sugar molecule could stop type 1 diabetes, by fooling the immune system ScienceDaily
4. Sugar layer on beta cells prevents immune system from causing type 1 diabetes Medical Xpress
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August 3, 2025
Here’s How to Show the Volume Bar on Your iPhone’s Lock Screen Again

If you’re listening to music or a podcast and want to change the volume without unlocking your iPhone, then you probably press the buttons on the side of your phone. Those buttons can increase or decrease your volume a set amount, but they could leave you choosing between a volume that is slightly too loud or a bit too quiet. If you keep your iPhone up to date with the latest iOS releases, you can bring the volume bar back to your device’s Lock Screen, giving you more precise control over your iPhone’s volume without unlocking your device.

Apple removed the volume bar from your Lock Screen when the company released iOS 16 in 2022. But when the company released iOS 18.2 in December, that update allowed you to bring the volume bar back to your iPhone’s Lock Screen. If you like using the volume bar, you can return it to your Lock Screen.

Here’s how you can reintroduce the volume bar to your Lock Screen in a few easy steps.

How to get the volume bar on your iPhone

1. Open Settings.
2. Tap Accessibility.
3. Tap Audio & Visual under Hearing.
4. Tap the toggle next to Always Show Volume Control.

Apple/CNET

Now, the next time you’re listening to music or a podcast at the gym or on the bus, you can change the volume by using the slider on your Lock Screen.

For more on iOS 18, here’s what you need to know about iOS 18.6 and iOS 18.5, as well as our iOS 18 cheat sheet. You can also check out what you should know about iOS 26 and my first impressions of the iOS update.

Watch this: 26 More Things Hidden in iOS 26

05:29

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August 3, 2025
‘The Colonel and the King’ review: Elvis biographer tackles Tom Parker

Book Review

The Colonel and the King: Tom Parker, Elvis Presley, and the Partnership That Rocked the World

By Peter Guralnick
Little, Brown & Co.: 624 pages, $38
If you buy books linked on our site, The Times may earn a commission from Bookshop.org, whose fees support independent bookstores.

The popular perception of Colonel Tom Parker is that he chiseled Elvis Presley out of a lot of money, forced his participation in some really bad 1960s movies and ensured Presley’s late-career servitude to Las Vegas with a gambling addiction to match the King’s own drug habit. But this is not the story Peter Guralnick looks to tell in his mammoth new book, “The Colonel and the King: Tom Parker, Elvis Presley, and the Partnership that Rocked the World.”

The book is long on the “Colonel,” a moniker Parker claimed as his first name after the governor of Louisiana gave him the honorary title in 1948, and short on the King, who, after all, has been the subject of countless previous volumes. Some of the best were actually written by Guralnick, including “Last Train to Memphis” and “Careless Whispers.” Few writers know more about early rock ‘n’ roll and roots music, or have such passion for the subject. If you haven’t read Guralnick, you should make a point to.

Does that mean you should read “The Colonel and the King?” Only if you deeply seek a comprehensive study of Elvis’ longtime manager, who, it must be said, led a fascinating life defined by self-mythology and willful deception. Guralnick knew Parker from 1988 until his death in 1997, and you get the feeling the author saw his subject also as a friend. The book isn’t hagiography, because Guralnick does so much research and reporting for every book that he’s incapable of writing a one-sided account of any subject. That said, “The Colonel and the King” often reads like a Parker apologia, or at least a concentrated effort to set some records straight.

For instance, there’s Parker’s oft-reported reluctance to let Elvis tour internationally near the end of his career, for the reason that Parker wasn’t a U.S. citizen and therefore didn’t have a passport. “The subject of much uninformed speculation,” Guralnick writes, suggesting other reasons. “How could Elvis go to Japan, with its strict drug laws, how could he pass through all the customs stations he would have to clear in Europe if it were not to be a single small-country tour, without his prescribed medications? And who was going to carry those medications for him?”

Author Peter Guralnick is a passionate expert on early rock ‘n’ roll and roots music.

(Mike Leahy)

Parker’s background as a carnival worker is often used to deride him. How could a mere carny know about the music business, or qualify him to steward the king of rock ‘n’ roll? But the liveliest and most revealing parts of “The Colonel and the King” actually come before the Colonel meets the King, as Guralnick paints a picture of a tireless hustler desperate to reinvent himself.

Parker long claimed that he was born Thomas Andrew Parker in West Virginia. In fact, he was born Andreas Cornelis van Kuijk in Breda, Holland. As a boy, he went by “Dries.” His father was a liveryman and retired soldier. When young Dries fell in with a family circus and taught his father’s horses to do tricks, his dad roared that the kid “was no son of his, that he would never amount to anything, and, after beating him to within an inch of his life, announced that he would be banned from having anything to do with the stables.” As a teen, Parker smuggled himself to the U.S., got sent back, then made the trek again, this time successfully.

He developed a habit of being unofficially adopted by surrogate families and then disappearing without a trace, a pattern that continued when he joined the U.S. Army, went AWOL and eventually received an honorable discharge in 1933, with a certificate of disability that cited reasons of “Psychic Psychogenic Depression” (Parker claimed he was discharged for having a bad leg). He eventually ended up in Florida, where he became a jack-of-all-trades carny and developed a sharp instinct for advance publicity and promotion.

Elvis wasn’t Parker’s first music client; he developed his chops first with early pop superstar Gene Austin, then country star Hank Snow. But when Parker first witnessed Elvis and Elvis mania at the Louisiana Hayride in 1955, he was determined to manage him. Then it was on to selling him, cunningly and ferociously, to RCA, 20th Century Fox and whoever else would help build the mighty Elvis industry.

“The Colonel and the King” is a hunk of a book, weighing in at 624 pages. That includes about 250 pages of annotated letters to and from the Colonel, which might have been better used, in truncated form, spread throughout the narrative proper. You also get the sense that perhaps the author was rather quick to take Parker for his word, considering Parker himself once joked that he was writing an autobiography called “The Benevolent Con Man.”

One can admire Guralnick’s thoroughness and sense of mission while also wishing for tighter results. I found the arc of Parker’s story quite intriguing, even as I got a little tired of it.

Vognar is a freelance culture writer.

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August 3, 2025
16 Best Primer for Mature Skin for a Smooth Makeup Application
“Primer for mature skin is like an insurance policy for your foundation,” says Emmy-nominated makeup artist Ngozi Olandu-Young. “It helps everything you put on wear better.” While primer may be best-known for its ability to lock a makeup look into place—providing a smooth, even base that stays put for hours—the best primers for mature skin also have anti-aging effects.

Vogue’s Favorite Primers for Mature Skin

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Best Blurring

StriVectin Line BlurFector Instant Wrinkle Blurring Primer

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Best Anti-Aging

Victoria Beckham Beauty Cell Rejuvenating Priming Moisturizer

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According to celebrity makeup artist Jillian Dempsey, the best primers stop foundation and concealer from settling into fine lines, wrinkles, or pores, which gives any makeup look a fresher, more youthful appearance. Of course, a good primer will also control shine and pamper the complexion with skin-loving ingredients.

Indeed, there’s more than one reason pro makeup artists always have at least one primer in their kit, particularly when they’re working with clients over 50. The question is, which ones are the, ahem, primest examples? Ahead, makeup artists and Vogue editors reveal the best primers for that smooth, blurred makeup look that seems to make time rewind.

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Best for Sallowness: RMS Beauty ReEvolve Radiance Locking Primer

RMS Beauty

ReEvolve Radiance Locking Primer
- Why We Love It: Vogue’s beauty team once reverse-engineered Michelle Pfeiffer’s perfect 60-plus makeup look with melting formulas from RMS Beauty. The brand’s ReEvolve Radiance Locking Primer provides the perfect underpinning for the softly glam look, priming the skin with a sheer, glowy formula that counteracts sallowness with its pinky-peach hue. Made with the patented firming ingredient Tightenyl, the formulation also keeps the complexion hydrated with vegetable squalane and hyaluronic acid. As a pro tip, RMS founder Rose-Marie Swift says that primer can increase the efficacy of skincare, which will help aging skin look all the fresher. “People think primers are just for holding your makeup on, but that’s not the case,” she says. “Primers also help hold on to your skincare and lock it in underneath your makeup.”
- Key Ingredients: Hyaluronic acid, Tightenyl (a patented natural alternative to retinol), vegetable squalane
- Finish: Sheer, natural, and glowy
- Size: 1.01 fl oz
Best for Fine Lines: L’Oréal Paris Age Perfect Face Blurring Primer

L’Oréal

Age Perfect Face Blurring Primer
- Why We Love It: Want that soft-focus smolder? L’Oréal’s creamy, serum-infused primer instantly blurs fine lines for a smoother, more youthful-looking complexion. Luckily, it can be found at most drugstores, with pricing to match. “This is a winner because it’s very affordable and it actually works,” says Emmy-award-winning makeup artist Nyssa Green, founder of The Green Room Beauty Agency. “It also has a good dose of skincare-grade ingredients that work better and better over time.” The formula is infused with vitamin E for antioxidant protection; it also has bisabolol to soothe irritation and glycerin for moisture.
- Key ingredients: Dimethicone, water, glycerin
- Finish: Natural-looking, soft-focus
- Size: 1.0 fl oz
Best Oil-Free: Lancôme La Base Pro Makeup Primer

Lancôme

La Base Pro Makeup Primer
- Why We Love It: “Lancôme La Base Pro Makeup Primer is excellent for mature skin because of its lightweight, oil-free formula that helps blur imperfections without feeling heavy,” celebrity makeup artist Sheika Daley says. “Its silicone-based texture smooths fine lines and wrinkles, giving the skin a soft-focus effect. It also provides a strong base for makeup, ensuring that foundation stays put longer without settling into creases.” The formulation harnesses the brand’s proprietary Elasto-Smooth Technology, which diffuses light to hide imperfections and give the skin a smooth, satiny look. Daley adds that “the primer is designed to enhance radiance while keeping the skin looking fresh, which is crucial for a youthful appearance.”
- Key Ingredients: Elasto-Smooth Technology, cyclopentasiloxane, dimethicone crosspolymer
- Finish: Radiant with a silky-soft, airbrushed look
- Size: 0.8 oz
Best Plumping: Estée Lauder Futurist Peptide-Power Serum Primer

Estée Lauder

Futurist Peptide-Power Serum Primer
- Why We Love It: With a weightless serum-gel texture, this moisturizing primer plumps up the skin, infusing it with hydrating ingredients, also serving as a protectant from antioxidants and blue light. “I like this one for skin that needs both support and smoothness,” Perisco says. “It applies like skincare but grips like a primer, and its peptide blend makes it ideal for mature skin that could benefit from some added elasticity and barrier care.” She adds that the product layers well and doesn’t interfere with a foundation’s performance.
- Key Ingredients: Hyaluronic acid, peptides
- Finish: Luminous
- Size: 1.0 fl oz
Best Anti-Aging: Victoria Beckham by Augustinus Bader Cell Rejuvenating Priming Moisturizer

Victoria Beckham Beauty

Cell Rejuvenating Priming Moisturizer
- Why We Love It: Powered by Augustinus Bader’s much-lauded TFC8 technology, which works to diminish signs of aging, Victoria Beckham’s primer of choice blurs wrinkles and fine lines while moisturizing, tightening, and lifting the skin. Perisco is a fan, saying that calling the product a primer merely begins to describe its benefits. “This is more than a primer—it’s a hybrid treatment that truly preps the skin,” she says. “It feels active without being aggressive and helps visibly plump and firm before makeup. It’s great to reach for when you want skin to look energized and supple—especially on skin with more texture or dryness.”
- Key Ingredients: Microalgae extract, natural black tea ferment, natural papaya enzymes, avocado oil, peptides
- Finish: Radiant, with a blurred effect
- Size: 1.7 fl oz
Best Moisturizing: Bobbi Brown Vitamin Enriched Face Base

Bobbi Brown

Vitamin Enriched Face Base
- Why We Love It: This melt-into-your-skin cream creates a smooth makeup base that makes it easy to apply an even, dewy layer of foundation. Drawing on skin-conditioning vitamins B, C, and E, this yields the skin a healthy, pepped-up glow. Launched in 2001 and still in high-demand, this is a “longtime staple,” Periso says. “It nourishes, hydrates, and preps all in one step. I especially like it on skin that needs a little extra bounce; it holds makeup beautifully without making the skin feel too slick or too matte.”
- Key Ingredients: Vitamin E, shea butter, squalane
- Finish: Natural, healthy-looking luminosity
- Size: 1.7 fl oz
Best Long-Wearing: Milk Hydro Grip Primer
- Why We Love It: Beloved by Gen Z and mature skin types alike, Milk’s long-wearing primer offers multi-generational appeal, hydrating all skin types with with hyaluronic acid, plus niacinamide to improve skin texture and brighten tone. Blue agave extract, another key ingredient, floods the skin with antioxidants such as vitamins A and C, while cannabis seed extract has moisturizing and antioxidant benefits that are a boon to mature skin. Known to help makeup stay in place for up to 12 hours, this makes it a favorite of red-carpet regulars like Emma Chamberlain, who need their glam locked and loaded the whole night through. (No one wants to be caught with faded makeup at the Met Gala!)
- Key Ingredients: Blue agave extract, hyaluronic acid, aloe water, hemp-derived cannabis seed extract
- Finish: Dewy
- Size: 1.52 fl oz
Best Radiant Finish: Saie Glowy Super Gel
- Why We Love It: This lightweight gel imparts a radiant finish that infuses any makeup look with a subtle, sunlit gleam. “I personally love this formula,” pro makeup artist Alexis Perisco attests. “It acts almost like a sheer moisturizer and glow serum in one. I’ve used this many times before applying makeup when I want the skin to feel fresh, hydrated, and radiant.” The result? “It gives that healthy, real-skin glow that looks incredible under minimal makeup or a lightweight foundation,” she says. With two hues to choose between—Starglow, a champagne tone, and Sunglow, a golden-bronze tint—you can customize your radiance.
- Key Ingredients: Plant-derived glycerin, olive-derived squalane, rosehip seed oil, mica
- Finish: Subtly glowy, without glitter
- Size: 1.0 fl oz
Best Protective: Tatcha The Liquid Silk Canvas
- Why We Love It: Formulated with silk extracts, Tatcha’s featherlight primer protects skin from pollutants while boosting makeup’s color payoff. “This gives a silky, poreless look while nourishing the skin,” says Olanu-Young. “It’s a red-carpet staple for my kit because it’s perfect for my mature clients that may have textured skin, revealing that luxurious, smooth finish.” Green is also a fan. “I love this primer because it’s lightweight, but really effective and safe for all types of skin,” she says. “It also feels amazing going onto the skin, so I use it on almost all of my luxury brides.”
- Key Ingredients: Silk extracts, anti-pollution natural actives, Hadasei-3 (Tatcha’s signature complex of green tea, rice, and algae)
- Finish: Smooth and natural
- Size: 1.0 fl oz
Best Blurring: StriVectin Line BlurFector Instant Wrinkle Blurring Primer

StriVectin

Line BlurFector Instant Wrinkle Blurring Primer
- Why We Love It: Formulated with optical microspheres to scatter light, StriVectin’s blurring primer gives mature skin a poreless, velvety appearance. The formula also pampers mature skin with the patented NIA-114, which has been clinically shown to strengthen the skin barrier. Though it has a pale, peachy hue when dispensed, the product was designed to sink seamlessly into any skin tone without settling into creases, apt to plump and smooth deep wrinkles. What’s more, Strivectin products are dermatologist-approved for aging skin, whether it’s the tightening serum for pesky neck wrinkles or its body cream for taking care of crepiness.
- Key Ingredients: Optical microspheres, Cyclopentasiloxane, polymethyl methacrylate
- Finish: Matte
- Size: 1 fl oz
Best for Oily Skin: Hourglass Vanish Airbrush Primer
- Why We Love It: The blurring microspherical powders enriched in the Hourglass Vanish Airbrush Primer smooths out the appearance of pores while sopping up excess oil. The translucent formula has a gel formulation that comfortably sits on skin all day, extending the wear of makeup. It’s so good, it comes highly recommended by the pros. “I cannot say enough wonderful things about this primer, and it’s a beloved staple in my kit,” makeup artist El DeBratto previously told Vogue. “This silicone-based gel formula has a stunning blurring effect on the skin and is perfect for filling in fine lines and pores.” They add that they love using the formula for more oil-prone clients or men’s grooming “because it instantly absorbs any excess oil and leaves the skin looking velvety and healthy.”
- Key Ingredients: Microspherical powders
- Finish: Translucent, with an airbrushed effect
- Size: 1 fl oz
Best for Irritated Skin: Danessa Myricks Beauty Yummy Skin Moisture Repair Balm Serum

Danessa Myricks

Beauty Yummy Skin Moisture Repair Balm Serum
- Why We Love It: Danessa Myricks’s balm-to-serum sinks into the skin, moisturizing the face with glow-enhancing ingredients. The 98% natural primer also helps to soothe tightness, flaky patches, and irritation thanks to soothing Asiatic pennywort. “This is one of my favorite primers,” says Olandu-Young. “It plumps, hydrates, and gives the skin a healthy bounce before I even apply foundation.” In all, she describes it as the ideal skincare-primer-combo for mature skin.
- Key Ingredients: Hyaluronic acid, blue tansy flower extract, centella asiatica
- Finish: Smooth and natural
- Size: 1.41 oz
Best for Dry Skin: Smashbox Photo Finish Primerizer+ Hydrating Primer

Smashbox

Photo Finish Primerizer+ Hydrating Primer
- Why We Love It: “Primer is a game-changer for mature skin,” says celebrity brow and makeup artist Stevi Christine. “It helps smooth out texture, soften the look of fine lines, and helps with your foundation, naturally, so your makeup doesn’t settle or slide off halfway through the day.” This formula is one of her favorites for that staying power, and she notes that it’s “especially incredible for photoshoots or red carpets.” With a silkscreen complex that smooths the skin and locks in moisture, Smashbox’s beloved primer is also packed with hydrating ingredients that instantly plump dry or sagging skin.
- Key Ingredients: Triple hyaluronic acid, niacinamide
- Finish: Dewy and fresh
- Size: 1 fl oz
Best for a Subtle Glow: No. 1 De Chanel Skin Enhancer

Chanel

No. 1 De Chanel Skin Enhancer
- Why We Love It: Chanel’s illuminating primer gives skin an instant boost of radiance, and patience also pays off. After one month, the featherlight primer creates a more even skin tone. Infused with hyaluronic acid, the hydrating formula can be worn on its own as a tinted gel-cream or under foundation. “This formula adds radiance in a very refined way,” says Perisco. “It’s lightweight, blends seamlessly into the skin, and gives that soft luminosity without feeling greasy.” She particularly loves the French formula under sheer foundations or even mixed with complexion products. “It gives a subtle glow that really flatters mature skin,” she says.
- Key Ingredients: Red camellia extract, red camellia oil, hyaluronic acid
- Finish: Sheer with a pearlescent sheen
- Size: 1 fl oz
Best Pore Minimizing: Benefit Cosmetics Benefit the POREfessional Face Primer

Benefit Cosmetics

The POREfessional Face Primer
- Why We Love It: This translucent formula flatters all skin tones and instantly makes pores and fine lines disappear. “This is an oldie but a goodie that’s been in my kit for years,” says Green. “It’s so effective, I use it underneath makeup and for on-set touch-ups throughout the day.” One of Vogue’s top primers for an airbrushed finish, this pore-minimizing product has been a staple for beauty commerce writer Conçetta Ciarlo for more than a decade. “Back in the early 2010s, this pick was my holy grail—and it remains a bestseller for the brand,” she says. “Revisiting this formula 15 years later, it still boasts that velvety-to-the-touch, creamy texture which dries down translucent to instantly smooth over the appearance of pores and fine lines.”
- Key Ingredients: Cyclopentasiloxane, dimethicone, dimethicone/vinyl dimethicone crosspolymer
- Finish: Matte
- Size: 1.5 fl oz
Best Softening: Giorgio Armani Luminous Silk Hydrating Primer

Giorgio Armani

Luminous Silk Hydrating Primer
- Why We Love It: Infused with moisturizing ingredients, the smoothing primer gives the skin a softer, more supple feel. Whether used with makeup or on clean skin, it instantly boosts luminosity—and it has a thumbs-up from the pros. “This pairs beautifully with both sheer and medium coverage foundations,” Perisco says. “It smooths the skin with a weightless feel and helps grip makeup without a heavy silicone texture.” For mature skin, she says, the formula leaves the skin looking elegantly hydrated. “Never tacky, never oily,” Perisco says of the always luminous finish.
- Key Ingredients: Shea butter, rice bran, glycerin
- Finish: Luminous
- Size: 1 fl oz
Everything You Need to Know
What’s the difference between regular primers and those for mature skin?

As opposed to primers for mature skin, “I find that regular primers tend to be very sticky and don’t blend as nicely into the skin, because they are holding extreme amounts of makeup that younger people tend to wear,” says makeup artist and RMS Beauty founder Rose-Marie Swift. “A woman who has mature skin requires something made for her skin type.” In other words: A formula that’s both lightweight and packed with hydrating ingredients—but more on that below.

Should people with mature skin wear a primer?

According to Daley, “People with mature skin can benefit from using a primer, especially when dealing with fine lines, wrinkles, or texture issues. Primers can help create a smooth surface for makeup application, improving the overall look and longevity of foundation. However, the decision to wear primer also depends on individual skin concerns. For mature skin, hydrating and blurring primers are often ideal as they can add moisture while minimizing the appearance of lines and pores.”

What to Look for in a Primer for Mature Skin

According to Dr. Jeannette Graf, board-certified dermatologist and assistant clinical professor of dermatology at Mt. Sinai School of Medicine, “Primers for mature skin will typically be more hydrating and have a thicker consistency to address concerns like wrinkles and fine lines as well as make the skin smoother for better makeup application.” Ingredients-wise, Graf recommends seeking out moisture-boosting ingredients such as hyaluronic acid, glycerin, and peptides.

Swift’s go-to primer is the RMS ReEolve Radiance Locking Primer, which contains a blend of natural peptides that soften dry skin. The formulation also contains a slightly peachy hue, which “corrects sallowness that is often found in mature skin,” Swift says. For Graf, the hyaluronic-acid-infused One Size Secure the Blur Makeup Magnet Primer stands out. “It will minimize the appearance of your pores and any fine lines,” she says.

Is matte or dewy primer better for mature skin?

Dewy primers are almost always a better fit for mature skin, according to Perisco. “As we age, skin naturally loses moisture and radiance, so I gravitate toward primers that bring hydration and a soft glow,” she says. “Matte formulas can sometimes exaggerate fine lines or dryness, while dewy primers help plump, smooth, and create that youthful, lit-from-within base that I love.”

To get the maximum results from a primer, apply it “after your skin care and before your makeup,” says Swift. “Simple as that. One thing I find that works too is to use my primer to lock in my skin care as a final step—especially when I’m not planning to wear makeup.”

To apply the product, Graf recommends using the fingers to apply a dime-sized amount to the face, focusing on areas with wrinkles or other signs of aging. “I also recommend applying it after sunscreen,” she notes. “Since the purpose of a primer is to create a smooth canvas for makeup to lay on, it should be applied right before any makeup goes on.”

Does primer really help smooth the appearance of wrinkles?

Indeed, “Certain primers can help smooth the appearance of wrinkles by filling in fine lines and creating a more even skin texture,” Daley says. “Silicone-based primers are particularly effective at blurring imperfections and creating a smooth canvas. To get the best results, it’s important to apply the primer after your skin-care routine, focusing on areas with deeper wrinkles or uneven texture.” She suggests gently pressing the primer into the skin with your hands rather than rubbing it in, as it “helps it settle more effectively into fine lines for a more youthful finish.”

Alexa Perisco is a celebrity makeup artist and the founder of Alexa Perisco Cosmetics.

Ngozi Olandu-Young is an Emmy-nominated and two-time NAACP Image Award-winning makeup artist and entrepreneur.

Jillian Dempsey is a celebrity makeup artist and the founder of Jillian Dempsey.

Nyssa Green is an Emmy-award-winning makeup artist and founder of The Green Room Beauty Agency.

Stevi Christine is a celebrity brow and makeup artist.

Rose-Marie Swift is the founder of RMS Beauty.

Sheika Daley is a celebrity makeup artist for the likes of Serena Williams, Anok Yai, and Da’Vine Joy Randolph.

Dr. Jeannette Graf is a board-certified dermatologist and assistant clinical professor of dermatology at Mt. Sinai School of Medicine.
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August 3, 2025