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  • Biggest part of U.S. economy barely grew in July, ISM finds, due to tariff knock-on effects

    Biggest part of U.S. economy barely grew in July, ISM finds, due to tariff knock-on effects

    By Jeffry Bartash

    ISM services index shows higher inflation and lower employment

    The large services side of the U.S. economy barely grew in July as ongoing trade wars raised costs, spurred reductions in employment and forced businesses to delay future plans until the scope of tariffs become clear.

    A survey of businesses such as retailers, restaurants and package deliverers slipped to 50.1% last month from 50.8% in June, the Institute for Supply Management said Tuesday.

    Any number above 50% signals expansion, but the latest survey suggests the services sector is straddling a fine line.

    “The employment index’s continued contraction and faster expansion of the prices index are worrisome developments,” said Steve Miller, chair of the survey.

    The services sector employs most Americans and is more immune to tariffs than the manufacturing sector, but virtually every company has felt the knock-on effects of the Trump administration’s new levies.

    “Tariffs are causing additional costs as we continue to purchase equipment and supplies,” an executive at a healthcare company told ISM.

    A construction executive also said the trade wars have made it harder to plan for next year. “Trade uncertainty [is] causing client re-evaluation of feasibility for projects in certain sectors, resulting in some delays or cancellations,” the executive said.

    Key details:

    — The new-orders index dipped 1.0 point to 50.3% but stayed positive.

    — The employment barometer fell slightly to 46.4%, the lowest level in four months.

    — The prices-paid index, a measure of inflation, rose 2.4 points to 69.9 and hit a nearly three-year high.

    “Tariffs are now starting to show up in pricing, and we are seeing increases across the board,” a transportation executive told ISM.

    Big picture: The economy is still growing, but it has taken a turn for the worse during the summer as the trade wars have dragged on. Economists predict slow growth and higher inflation in the second half of 2025 as well.

    The White House has negotiated a number of trade deals, and it’s possible the economy could pick up steam if the disputes are settled, and especially if the Federal Reserve cuts interest rates soon.

    For now, “economic uncertainty remains the dominant theme,” a real-estate executive said.

    Market reaction: The Dow Jones Industrial Average DJIA and S&P 500 SPX fell in Tuesday trading but stayed near record highs.

    -Jeffry Bartash

    This content was created by MarketWatch, which is operated by Dow Jones & Co. MarketWatch is published independently from Dow Jones Newswires and The Wall Street Journal.

    (END) Dow Jones Newswires

    08-05-25 1038ET

    Copyright (c) 2025 Dow Jones & Company, Inc.

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  • Guy’ and St Thomas’ Trust chooses Scitech for advanced therapy facility expansion

    Guy’ and St Thomas’ Trust chooses Scitech for advanced therapy facility expansion


    Guy’s and St Thomas’ NHS Foundation Trust (GSTT) is expanding its Advanced Therapy Manufacturing Platform to meet rising demand for clinical trial production of cell and gene therapies. 


    The project is being delivered in collaboration with the NIHR Maudsley Biomedical Research Centre at King’s College London.


    The facility – formally known as the Clinical Research Facility GMP Unit (CRF GMP Unit) – is a dedicated cleanroom environment designed for the manufacture of Investigational Medicinal Products (IMPs) and unlicensed Specials for use in clinical trials.


    Already recognised for its work in regulatory T-cell immunotherapy, the unit is now being scaled up to accommodate a wider portfolio of advanced therapies, including stem cell-derived photoreceptors and adherent cell products.


    The expansion will see the addition of two new ISO Class 7 cleanrooms


    The expansion will see the addition of two new ISO Class 7 cleanrooms, Grade A processing areas equipped with Class II Biosafety Cabinets or isolators, and improved material flow systems.


    Controlled storage, waste handling, and an overall increase of up to 60% in production capacity are also part of the upgrade.


    Cleanroom design and engineering specialist Scitech has played a central role in the project, supporting it from concept through to full detailed design and now into the final stages of construction.


    Headquartered in Woking, Surrey, Scitech specialises in the design, engineering, and construction of facilities for the life sciences, healthcare, and technology sectors.


    Already recognised for its work in regulatory T-cell immunotherapy, the unit is now being scaled up to accommodate a wider portfolio of advanced therapies


    Scitech’s scope of work included designing cleanrooms capable of full-room biodecontamination, integrating CO₂ and compressed air infrastructure, and implementing controlled access with electronic pressure monitoring.


    The facility layout ensures segregated flows for personnel and materials, maximising GMP efficiency and regulatory compliance while enabling cost-effective delivery of Advanced Therapy Medicinal Products (ATMPs).


    The project is being delivered within the operational 15th floor of a live hospital building, requiring close coordination with NHS staff and departments.


    Controlled storage, waste handling, and an overall increase of up to 60% in production capacity are also part of the upgrade


    Scitech worked in collaboration with GSTT to minimise disruption to patient care and ensure safety during construction.


    “The onsite coordination has been to the millimetre, one of the most complex threading of utilities we have done, to fit into the space available,” said a Scitech spokesperson. “The work has been carried out safely on the 15th floor of an operational building with patients, families, doctors, and NHS staff working in rooms around, above, and below the site.”


    The upgraded facility is expected to significantly enhance the Trust’s capacity to support clinical research and manufacture GMP-compliant therapies for a growing pipeline of advanced treatments, further reinforcing the UK’s capabilities in this rapidly evolving field.


     


    Top image: Processing area in the CRF GMP Unit at Guy’s and St Thomas’ NHS Foundation Trust 

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  • Dengue surge in Samoa prompts swift New Zealand response – Insurance Business America

    Dengue surge in Samoa prompts swift New Zealand response – Insurance Business America

    1. Dengue surge in Samoa prompts swift New Zealand response  Insurance Business America
    2. As the Pacific grapples with dengue fever, here’s what you need to know – ABC Pacific  Australian Broadcasting Corporation
    3. Dengue Cases Rise in New Zealand After Overseas Travel  Indianweekender
    4. Samoan family lose second son to dengue fever in days  Stuff
    5. Dengue on the rise and causing more long-term complications than COVID-19  NZ Doctor

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  • LEGO Launches Nintendo Game Boy Model Building Set – License Global

    1. LEGO Launches Nintendo Game Boy Model Building Set  License Global
    2. Where To Pre-Order LEGO Game Boy  Nintendo Life
    3. Lego Game Boy 72046 Sets Resell  Resell Calendar
    4. The Lego Game Boy is a thing of beauty, available for pre-order  Polygon
    5. Classic Consoles That Deserve The Lego Nintendo Gameboy Treatment Next  TheGamer

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  • NDMA issues flood alert amid rising water levels in Sutlej River – RADIO PAKISTAN

    1. NDMA issues flood alert amid rising water levels in Sutlej River  RADIO PAKISTAN
    2. NEOC issues flood alert amid intensifying monsoon activity in upper and central Pakistan  ptv.com.pk
    3. Weather pundits warn of heaviest rain spell in Punjab  Dawn
    4. Monsoon misery  The Express Tribune
    5. Weather to remain hot and humid in most parts of country: PMD  Dunya News

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  • Trans women athletes banned from ‘extraordinary ability’ visas

    Trans women athletes banned from ‘extraordinary ability’ visas

    The US Citizenship and Immigration Services (USCIS) is set to update visa policies to prevent the “entry of male athletes seeking to compete in women’s sports”, as the Trump administration continues its campaign to roll back trans rights.

    The Department for Homeland Security issued guidance on Monday (4 August) to “support and align” with Executive Order 14201, “Keeping Men Out of Women’s Sports”, and vowing not to issue “extraordinary ability” visas to trans women athletes.

    The executive order, signed by Donald Trump in February, described trans women’s involvement in female sports as “demeaning, unfair and dangerous” to women and girls.

    The directive laid out that the policy of the US government was to “rescind all funds from educational programmes that deprive women and girls of fair athletic opportunities, which results in the endangerment, humiliation and silencing of women and girls and deprives them of privacy” as well as “oppose male competitive participation in women’s sports more broadly, as a matter of safety, fairness, dignity and truth”.

    Other Trump anti-trans policies include declaring official US policy was that there are “only two sexes”, banning transgender men and women from the armed forces and restricting gender-affirming healthcare for trans people under the age 19.

    Trump signs executive order, “Keeping Men Out of Women’s Sports”.
    President Trump signed the executive order soon after taking office. (ANDREW CABALLERO-REYNOLDS/AFP via Getty Images)

    The latest guidance does not use the words “trans” or “transgender”, instead referring to “male athletes” to describe who was being targeting, following a trend set the executive order that aimed to ban trans people from the military.

    The USCIS said it did not consider a male athlete who has “gained the necessary acclaim in men’s sports and seeks to compete in women’s sports in the United States to be seeking to continue work in his area of extraordinary ability for both the relevant non-immigrant and immigrant classifications”, while a trans woman competing against women would be seen as a “negative factor in determining whether the alien is among the small percentage at the very top of the field”.

    In a statement published on the immigration services’ website, Matthew Tragesser said: “Men do not belong in women’s sports. USCIS is closing the loophole for foreign male athletes whose only chance at winning elite sports is to change their gender identity and leverage their biological advantages against women.

    “It’s a matter of safety, fairness, respect and truth that only female athletes receive a visa to come to the US to participate in women’s sports. The Trump administration is standing up for the silent majority who’ve long been victims of leftist policies that defy common sense.”

    The new policy is also seen as an effort to ban any trans athlete who qualifies for the summer Olympics in Los Angeles in three years’ time.

    Since the International Olympic Committee (IOC) first allowed trans athletes to compete in 2004, only a few have taken part in the Games, including New Zealand weightlifter Laurel Hubbard, Canadian footballer Quinn and American skateboarder Alana Smith.

    Imane Khelif was caught in a media storm. (Richard Pelham/Getty Images)

    Algerian boxer Imane Khelif was thrust into the centre of a media storm at last year’s Games in Paris when she was accused of being a trans woman.

    The controversy flared after she failed an eligibility criteria test set by the Russian boxing governing body. While no details were given about what standards Khelif had failed to meet, the president of the International Boxing Association, Umar Kremlev, claimed the results “proved [Khelif] had XY chromosomes”.

    The IOC backed Khelif – who went on to win the gold medal in the women’s 66kg category – and questioned the validity of the Russian tests. Spokesperson Mark Adams said not only did she meet Olympic eligibility criteria but also that it was “not a transgender issue“.

    In March, Khelif said she planned to defend her Olympic title in LA. “The US president issued a decision related to transgender policies in America, I am not transgender. This does not concern me and it does not intimidate me,” she told ITV.

    Share your thoughts! Let us know in the comments below, and remember to keep the conversation respectful.
     

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  • Shop Funko Pop, Voluspa, Lego

    Shop Funko Pop, Voluspa, Lego


    We’ll keep you updated on all the latest ‘Wicked’ drops, from Lego sets to candles.

    If Cynthia Erivo’s version of ‘Defying Gravity’ plays on a constant loop in your head like it does mine, then you’ll be delighted to know that we’re finally just a few months away from the release of the highly anticipated “Wicked” sequel, “Wicked: For Good.” The bewitching follow-up to last year’s film adaptation of the hit Broadway musical hits theaters on Friday, November 21 and following in the footsteps of “Barbie” and most recently, “F1 The Movie,” the collabs are showing up in a big way for fans.

    In the lead up to the film’s November 2025 release, tons of brands are already releasing special product collaborations that pay homage to the enchanting world of “Wicked,” with limited-edition launches from Funko Pop, Voluspa, Lego, Roots and plenty more set to go live in the coming months.

    To help you gear up for the new film, we’ll be keeping a running list of the best “Wicked” product launches that are worth shopping—no matter if you’re a good witch or a bad witch:

    Shop all the best ‘Wicked’ product collabs: Funko Pop, Voluspa and more

    When does “Wicked: For Good” come out?

    The highly anticipated “Wicked: For Good” film is set to release on Friday, November 21, 2025. The film will serve as a follow-up or ‘part 2’ of the first “Wicked” film, which was released on November 22, 2024.

    The musical film will feature the same primary cast members, including Cynthia Erivo, Ariana Grande, Jonathan Bailey and more.

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  • Justin Timberlake describes the physical and mental toll of Lyme disease

    Timberlake’s symptoms

    The 44-year-old singer shared the news in an Instagram post, explaining that the disease had taken a toll on him behind the scenes.

    “If you’ve experienced this disease or know someone who has — then you’re aware: living with this can be relentlessly debilitating, both mentally and physically,” Timberlake wrote. “When I first got the diagnosis, I was shocked for sure. But, at least I could understand why I would be onstage and in a massive amount of nerve pain or just feeling crazy fatigue or sickness.”

    According to People, Timberlake initially believed his symptoms were related to aging and the physical demands of performing. “He’s not 20 anymore,” a family source said. “But when his symptoms worsened, he realized something deeper was going on.” The source added that Timberlake had “pushed through for months before finally getting answers,” and that the diagnosis “brought clarity to a series of unexplained issues that he’s been quietly dealing with.”

    Jessica Biel, Timberlake’s wife, “felt like something was off” and encouraged him to seek medical help, the source told People. “She could tell that he wasn’t himself. She’s incredibly supportive.”

    Following the end of his tour, Timberlake is now focusing on rest and recovery. “He’s taking it seriously,” the source added. “The plan is to rest, spend time with Jess and the kids and do everything he can to heal … Now he can focus on his health.”

    Timberlake also acknowledged his reluctance to share his diagnosis publicly. “I was always raised to keep something like this to yourself,” he wrote. “But I am trying to be more transparent about my struggles so that they aren’t misinterpreted.” 

    What is Lyme disease?

    Lyme disease is a bacterial infection primarily transmitted by the bite of an infected black-legged tick. According to CDC, it is the most common vector-borne illness in the United States, with an estimated 476,000 people treated for it in annually. In 2023, more than 89,000 cases were officially reported.

    “In the U.S., Lyme disease is most commonly found in the Northeast and upper Midwest — in a belt stretching from New England to Wisconsin — with peak transmission from late spring to early fall,” MedPage Today reports.

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  • PTCL Outlines Acquisition Strategy for Telenor Pakistan Before CCP Panel

    PTCL Outlines Acquisition Strategy for Telenor Pakistan Before CCP Panel

    Pakistan Telecommunication Company Limited (PTCL) has presented its case before the Competition Commission of Pakistan (CCP) as part of a regulatory review under Section 11(6) of the Competition Act, 2010, regarding its proposed acquisition of 100% shareholding in Telenor Pakistan (Private) Limited and Orion Towers (Private) Limited.

    The senior leadership of PTCL appeared before the CCP bench, chaired by Dr. Kabir Ahmed Sidhu, with Member Salman Amin and Member Abdul Rashid Sheikh, to explain the scope of the deal and its expected efficiencies and to provide regulatory documentation, including the company’s business plan.

    PTCL executives were questioned thoroughly about the merger’s competitive implications, especially in terms of market share, infrastructure ownership, and the consumer impact. The Commission has sought additional clarifications before it reaches a final decision.

    PTCL’s Move Toward Market Consolidation

    PTCL’s interest in acquiring Telenor Pakistan is part of a broader strategy to consolidate its position in the mobile and telecom space. If the deal is approved, PTCL will gain complete control of Telenor Pakistan, the country’s second-largest telecom operator by subscriber base, a move that could significantly shift the market’s power balance.

    This acquisition is being pursued through PTCL’s parent company, e& (Emirates Telecommunications Group, formerly known as Etisalat), which has also been in advanced talks with Telenor Group, the Norway-based telecom giant that owns Telenor Pakistan.

    Telenor has been gradually pulling back from several Asian markets in recent years to focus on core European operations. As part of this global realignment, Telenor Group has been exploring exit options from Pakistan, and PTCL emerged as the most viable buyer due to its local footprint and strategic alignment.

    While PTCL owns Ufone, it has historically struggled to gain a substantial mobile market share. Ufone has faced stiff competition from dominant players like Jazz and Zong, primarily due to limited 4G spectrum and underinvestment in infrastructure. The company has also recorded frequent losses in recent years, making profitability a challenge.

    By acquiring Telenor Pakistan, PTCL seeks to instantly boost its mobile business capabilities, network strength, and subscriber base. Telenor’s nationwide 4G coverage, active user count, and established tower infrastructure (through Orion Towers) offer significant synergies for PTCL’s struggling mobile segment.

    Industry insiders view this as a potential game-changer, one that could revive PTCL’s competitive edge and possibly reshape Pakistan’s mobile telecom landscape.

    Regulatory Oversight and Future Outlook

    The CCP now holds a critical role in determining whether the proposed merger would harm market competition or consumer interest. Mergers of this scale require careful assessment of market dominance, anti-competitive risks, and the potential for price control or service quality issues. The Commission has not yet given a final verdict and has requested further documentation and analysis from PTCL before proceeding.

    If the acquisition is approved, it would not only create one of the largest integrated telecom entities in Pakistan but could also signal the beginning of a new consolidation wave in the industry. As the telecom sector faces growing pressure from rising operational costs and declining ARPU (Average Revenue Per User), strategic mergers like this could become more common.

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  • Unlocking spatial metabolomics with isotopically labelled internal standards

    Unlocking spatial metabolomics with isotopically labelled internal standards

    Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

    This is a summary of: Wang, G. et al. Spatial quantitative metabolomics enables identification of remote and sustained ipsilateral cortical metabolic reprogramming after stroke. Nat. Metab. https://doi.org/10.1038/s42255-025-01340-8 (2025).

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