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  • Homo Sapiens procreated with Neanderthals 100,000 years earlier than previously thought

    Homo Sapiens procreated with Neanderthals 100,000 years earlier than previously thought

    A groundbreaking study of a child’s skull found in a northern Israeli cave has found that the world’s first incidence of sex between Homo sapiens and Neanderthals took place at least 100,000 years before scientists previously thought.

    Research teams from Tel Aviv University and the French National Center for Scientific Research applied new research techniques to the 140,000-year-old skull of a five-year-old child discovered 90 years ago in the Skhul Cave on Mount Carmel, in northern Israel.

    They discovered that the skull — initially thought to belong to a Homo sapiens child — bore physical characteristics of both Homo sapiens and Neanderthals.

    Until that point, the earliest evidence of such morphological mingling anywhere in the world was found in a skull dated to some 40,000 years in a Romanian cave.

    Genetic analysis had also suggested interaction for a short period between 40,000 and 50,000 years ago.

    The new study was led by Prof. Israel Hershkovitz of the Gray Faculty of Medical and Health Sciences at Tel Aviv University and Anne Dambricourt-Malassé of the French National Centre for Scientific Research.

    The skull of the so-called Skhul I child shows cranial curvature typical of Homo sapiens. (Tel Aviv University)

    It involved scanning the skull and jaw using micro-CT technology at the Shmunis Family Anthropology Institute at Tel Aviv University.

    This created an accurate three-dimensional model from the scans and enabled the researchers to perform a complex morphological analysis of the anatomical structures (including non-visible structures such as the inner ear) and compare them to various hominid populations.

    To study the structure of the blood vessels surrounding the brain, they also created an accurate 3D reconstruction of the inside of the skull.

    The lower jaw of Skhul I child showing features characteristics of Neanderthals. (Tel Aviv University)

    “The fossil we studied [provides] the earliest known physical evidence of mating between Neanderthals and Homo sapiens,” said Hershkovitz, explaining that “the child’s skull, which in its overall shape resembles that of Homo sapiens — especially in the curvature of the skull vault — has an intracranial blood supply system, a lower jaw, and an inner ear structure typical of Neanderthals.”

    He added, “Traditionally, anthropologists have attributed the fossils discovered in the Skhul Cave, along with fossils from the Qafzeh Cave near Nazareth, to an early group of Homo sapiens. The current study reveals that at least some of the fossils from the Skhul Cave are the result of continuous genetic infiltration from the local, and older, Neanderthal population into the Homo sapiens population.”

    Prof. Israel Hershkovitz. (Tel Aviv University

    Hershkovitz believes that contrary to previous assumptions, it was the earliest waves of Homo sapiens who interbred with Neanderthals already living in the area after leaving Africa and entering the land bridge Israel provided to Europe.

    In a phone conversation with The Times of Israel, he elaborated that according to his previous research on fossils from various Israeli caves, Neanderthals arrived in the Land of Israel some 400,000 years ago and were still in the area 50,000 years ago.

    It was some 200,000 years ago that Homo sapiens arrived in the Land of Israel from Africa, he went on. From that point, the two “sister populations” (who belong to the same species) would likely have mixed, exchanging technology and hunting techniques. The new findings confirmed they were interbreeding from as early as 140,000 years ago.

    Given the lack of evidence of violent encounters, Hershkovitz said he believed that the Neanderthals, who went globally extinct 40,000 years ago, were not overpowered by Homo sapiens, but were absorbed into them, gradually diminishing as a distinct population. Today’s human genes still carry traces of Neanderthal origins, he noted.

    The findings of the latest discovery were published in the journal L’Anthropologie.


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  • Mbappe converts penalty kick as Real Madrid beats Osasuna 1-0 in Spanish league opener | Football News

    Mbappe converts penalty kick as Real Madrid beats Osasuna 1-0 in Spanish league opener | Football News

    Kylian Mbappe got off to a scoring start in his second season with Real Madrid, leading the team to a 1-0 victory over Osasuna in their Spanish league opener Tuesday.

    Real Madrid’s Kylian Mbappe celebrates scoring their first goal(REUTERS)

    Mbappé, the leading scorer in his debut with Madrid last season, converted a 51st-minute penalty kick to give the hosts the victory. A nice run by Mbappé through the right side of the area, followed by a neat cutback move, prompted the foul.

    The goal gave new coach Xabi Alonso a winning debut in his first full season with the club. The former Madrid player arrived before the Club World Cup to replace Carlo Ancelotti, who left to take the Brazil job.

    “It was special to be back here as a coach, unforgettable,” Alonso said. “Hopefully it was the first of many victories celebrated here.”

    Alonso started the match with three of the club’s new signings for the season — left back Álvaro Carreras, right back Trent Alexander-Arnold and central defender Dean Huijsen. Teenage forward Franco Mastantuono came off the bench to replace Brahim Díaz in the 68th, being loudly cheered by the crowd at the Santiago Bernabeu Stadium.

    Some fans had not been happy after the former River Plate player praised Lionel Messi — the fellow Argentine who was a star at rival Barcelona — during his introductory news conference.

    The 18-year-old Mastantuono had a chance to score in the 89th, but his shot from inside the area was saved by the Osasuna goalkeeper.

    “They all did well,” Alonso said of the newcomers. “They are players who will be helping us for years. None of them felt the pressure of the Madrid jersey or of the Bernabeu.”

    Osasuna defender Abel Bretones was sent off in stoppage time with a straight red card for a high arm to block Madrid forward Gonzalo García.

    “They dominated, we knew it was going to be like that,” Osasuna midfielder Rubén García said. “We played a good game but couldn’t get too close to their goal. In the end, they deserved the victory.”

    Madrid forward Rodrygo stayed on the bench the whole match, intensifying speculation of a possible transfer. Alonso downplayed Rodrygo’s lack of minutes, saying he still counts on the Brazil international for now.

    “It was only a match,” he said. “If in three months he still isn’t getting these minutes, then it’s different.”

    The game was played Tuesday instead of last weekend along with the rest of opening matches because Madrid’s players needed more rest following the team’s participation at the Club World Cup. Madrid’s attempt to delay its debut even further was denied by the league.

    Madrid controlled possession — more than 70% — but struggled to break through the tight Osasuna defense early, threatening with a few long-range shots.

    “There were positives, beginning with the result,” Alonso said. “We still need a few things that will give us stability to keep progressing.”

    Mbappé, with the No. 10 jersey this season, had one of Madrid’s best first-half chances with a curling shot from inside the area that just missed the top corner, but finally broke through with the winner early in the second half as Madrid continued to press forward. He sent a low shot from the spot into the right side of the net as the goalkeeper dived the other way.

    “You can tell that Mbappé wants more,” Alonso said.

    Barcelona began its title defense with a comfortable 3-0 win at nine-man Mallorca on Saturday, while Atletico Madrid squandered a late lead in a 2-1 loss at Espanyol on Sunday.

    Madrid was runner-up to Barcelona in the Spanish league last season. Osasuna finished ninth.

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  • He quit drinking and lost 20kg after alcohol abuse led to terrifying health scare

    He quit drinking and lost 20kg after alcohol abuse led to terrifying health scare

    People experience wake-up calls at various stages in their lives. For Derry Ainsworth, his big one came in 2024 while lying alone in pain in a Hong Kong hospital bed surrounded by the screams of sick and dying patients.

    The Hong Kong-based British photographer’s health nightmare started on July 24, 2024, when he woke up with what he thought was a mild hangover. Then severe abdominal pain took over.

    He called an ambulance and, in hospital, spent the first few hours crying in pain on a toilet floor until a nurse rushed him for a CAT scan and gave him morphine.

    The diagnosis was severe acute pancreatitis (SAP), a serious condition in which the pancreas – a gland behind the stomach that plays a vital role in both digestion and blood sugar regulation – becomes severely inflamed. This can lead to organ failure and even death.
    Derry Ainsworth in hospital in July 2024 after being diagnosed with severe acute pancreatitis. Photo: Derry Ainsworth
    While gallstones and alcohol abuse are common causes of acute pancreatitis, many factors can lead to SAP. Sometimes the cause is unknown.

    Ainsworth, who was 34 at the time, was told that the situation would have been much worse if the infection had entered his bloodstream or shut down his surrounding organs.

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  • PTA Issues Public Advisory on Password Security

    PTA Issues Public Advisory on Password Security

    The Pakistan Telecommunication Authority (PTA) has issued a detailed advisory urging citizens to adopt stronger password practices to safeguard their personal data and online accounts.

    The advisory emphasizes the importance of password security, particularly for financial services and email accounts, which are prime targets of cyberattacks.

    According to the guidelines, users should create complex passwords that include upper and lower-case letters, numbers, and special characters. PTA stressed the need for enabling two-factor authentication (2FA) on all critical accounts to add an extra layer of protection against cyber threats.

    The authority advised users to avoid reusing the same password across multiple applications and to change their passwords regularly. Citizens were further cautioned against using easily guessable passwords, such as dictionary words or personal information like birth dates, which make accounts more vulnerable to hacking attempts.

    PTA also recommended prioritizing biometric or facial recognition features for financial services and applications, highlighting that traditional passwords can often be compromised. The advisory noted that biometrics provide a stronger level of authentication compared to text-based passwords.

    The authority reiterated that a password is the first line of defense against cyber threats, and strengthening it is crucial for digital safety. By following these guidelines, users can better protect their personal data, financial transactions, and online communications from unauthorized access.


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  • UN slams Israel’s curbs on Gaza aid

    UN slams Israel’s curbs on Gaza aid


    GENEVA:

    The United Nations took aim Tuesday at Israel’s months-long block on bringing tents into the Gaza Strip, despite continual displacement orders being issued to civilians in the devastated territory.

    Jens Laerke, spokesman for the UN humanitarian agency OCHA, said shelter items had been banned from entering Gaza for about five months — a period in which more than 700,000 people had been displaced or re-displaced.

    “They may have been provided with a tent, and then they are displaced again and they have no possibility of taking the tent with them,” he told a press briefing in Geneva.

    He said Israel had classified tents as “dual use” because they considered tent poles could potentially be used for a military purpose.

    He decried “layers of bureaucracy which seem designed not to facilitate fast entry of anything but rather the opposite”.

    Israel announced earlier this month that it intended to take over Gaza City and issued another displacement order to residents on Saturday.

    Laerke said tents were still not being allowed into the territory.

    The UN human rights office meanwhile said the Gaza City takeover plans bore “huge risks for civilians”.

    “There are risks of mass displacement and more and more killings and more misery,” said spokesman Thameen Al-Kheetan.

    He accused Israel of displacing Palestinians to areas where strikes were continuing.

    Kheetan said “hundreds of thousands” were being told to go south to Al-Mawasi, which he said was still under bombardment.

    He said Palestinians in Al-Mawasi had “little or no access to essential services and supplies, including food, water, electricity and tents”.

    Across the Gaza Strip, Kheetan said the risk of starvation was “everywhere”.

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  • Martyrdom anniversary of Pilot Officer Rashid Minhas (Nishan-e-Haider) today – RADIO PAKISTAN

    1. Martyrdom anniversary of Pilot Officer Rashid Minhas (Nishan-e-Haider) today  RADIO PAKISTAN
    2. The legacy of pilot officer Rashid Minhas  The Express Tribune
    3. Rashid Minhas Shaheed to be remembered on Aug 20  Associated Press of Pakistan
    4. 54th martyrdom anniversary of Rashid Minhas today  Dunya News
    5. A Flight into Immortality: Pakistan Remembers Rashid Minhas  Daily Lead Pakistan

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  • Review finds coffee linked to longer life and lower disease risk

    Review finds coffee linked to longer life and lower disease risk

    A sweeping review of global research shows coffee drinkers may live longer and face lower disease risks, though experts urge caution for pregnancy and unhealthy additives.

    Review: Coffee’s Impact on Health and Well-Being. Image Credit: flowtrume / Shutterstock

    In a recent review published in the journal Nutrients, researchers in the United States conducted a comprehensive review comprising more than 100 peer-reviewed large-scale epidemiological studies and meta-analyses to elucidate the physiological benefits of coffee consumption.

    Review findings revealed that moderate coffee consumption is associated with more benefits than harms, with epidemiological evidence consistently demonstrating that three to five cups of coffee per day is linked to a lower risk of all-cause mortality and a reduced incidence of cardiovascular disease (CVD), type 2 diabetes (T2D), and several types of cancer. The review also noted benefits across conditions such as respiratory disease, kidney disease, and reduced risk of frailty and accidents.

    Background

    Since its discovery and first use (ancient Ethiopia), coffee has been a fixture of human culture for centuries. Reports estimate that more than two billion cups of the beverage are consumed daily worldwide, making coffee one of the world’s most popular drinks (after water and tea).

    Despite this immense popularity, coffee consumption has long been subject to assumed health concerns, with historical anxieties linking the beverage to everything from cancer to heart problems. However, decades of coffee-centric research have produced a wealth of high-quality scientific evidence that suggests a much more positive physiological impact.

    Unfortunately, since most of this research is veiled behind medical jargon, consumers and policymakers are left having to sift through layers of misinformation, keeping global coffee anxiety high. As public interest in the health effects of diet grows, there is a need for a clear, accessible, and updated summary of current scientific knowledge of coffee’s health associations. The review also references a recent U.S. Food and Drug Administration (FDA) ruling that coffee containing fewer than five calories per serving can qualify for a “healthy” claim, underscoring its recognized safety profile.

    About the review

    The present comprehensive review aims to fulfil this knowledge requirement by consolidating more than 100 publications comprising high-quality epidemiological research and meta-analyses, to establish coffee’s health impacts. The review aims to provide a comprehensive overview for clinicians, dietitians, and consumers, drawing on decades of research up to 2025.

    The review focuses on several key aspects of coffee’s efficacy: 1. Overall and cause-specific mortality, 2. Significant chronic disease associations (specifically, cardiovascular diseases [CVDs], cancers, type 2 diabetes [T2D], and neurodegenerative disorders), 3. Mechanisms of action – biological pathways explaining coffee’s observed health benefits, and 4. Areas of concern: Side effects and dosage considerations, including the effects of additives like sugar, and consumption during pregnancy.

    Additionally, the review aimed to elucidate coffee’s effects on holistic well-being by examining participants’ variables like hydration, physical performance, and mental acuity following its consumption. The review also summarized findings on bowel recovery after surgery and sleep disruption, which remain areas of caution. By integrating evidence from massive, multi-decade cohort studies like the National Institutes of Health American Association of Retired Persons (NIH-AARP) Diet and Health Study and the UK Biobank, the review provides a robust, evidence-based summary of coffee’s role in health and disease.

    Review findings

    The reviews concluded that most current scientific evidence promotes coffee as a safe and health-improving beverage. The data on mortality and chronic disease emphasize that moderate coffee intake lowers the overall risk of death. A pivotal meta-analysis of 40 studies (~3.8 million participants) found that the lowest risk for all-cause mortality occurred at an intake of 3.5 cups per day, corresponding to a 15% risk reduction (Relative Risk [RR] 0.85; 95% CI 0.82–0.89).

    When specifically investigating coffee’s association with CVDs (the world’s leading cause of mortality), a meta-analysis of 36 studies found that consuming 3-5 cups daily reduced mortality risk by 15%. T2D outcomes were observed to be even better, with a meta-analysis revealing a 29% risk reduction among regular coffee drinkers. Additionally, studies have established coffee-driven benefits across liver cancer, uterine cancer, Parkinson’s disease, and cognitive disorders. Protective associations were also noted for respiratory conditions and kidney disease.

    The review elucidates that while the evidence for coffee’s physiological benefits is vast, mechanistic investigations of its impacts remain comparatively scarce. Science currently believes that the beverage’s health benefits (reduced inflammation, improved glucose metabolism, and increased fat oxidation) are driven by a combination of its bioactive compounds (e.g., caffeine) and a rich array of polyphenols.

    Finally, the review confirms that while coffee is an ideal beverage for most humans, a few notable concerns remain. For pregnant women, major health organizations like the American College of Obstetricians and Gynecologists (ACOG) recommend limiting caffeine intake to less than 200 mg per day (about two cups of coffee). However, the review also noted that some meta-analyses have reported increased risk of low birthweight with higher intake, though confounding factors and recall bias complicate these findings. Additionally, while adding sugar and cream doesn’t completely negate coffee’s benefits, the evidence is mixed; some studies show sugar can nullify benefits, while others suggest benefits persist even with additives. Excessive consumption can also lead to sleep disruption and anxiety in sensitive individuals.

    Conclusions

    The present review collated and synthesized up-to-date evidence on coffee’s health impacts and found that when consumed in moderation (typically 3-5 cups per day), it is a safe and beneficial beverage for most adults. It highlights that the evidence linking moderate coffee intake to a longer life and a lower risk of numerous chronic diseases is consistent and compelling.

    Nonetheless, the authors emphasize that most current findings are based on observational studies, and future randomized controlled trials and Mendelian randomization studies are needed to clarify causality. While further research is required to establish the mechanisms underpinning coffee’s observed benefits, the sheer volume of high-quality observational data from diverse populations makes a strong case for coffee as a key component of a healthy lifestyle.

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  • Advancing Care in Alzheimer’s Disease: Current Treatments and Their Impact on Quality of Life

    Advancing Care in Alzheimer’s Disease: Current Treatments and Their Impact on Quality of Life


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  • PathoPlex technology maps protein patterns across human organs

    PathoPlex technology maps protein patterns across human organs

    Each organ in the human body contains different types of cells arranged in specific ways.

    These arrangements aid protein interactions, which drive important functions such as nutrient and waste processing in the liver and kidneys or neuron function in the brain.

    Abnormal changes in protein levels and patterns can result in diseases.

    Understanding protein organization can improve treatments and minimize disease symptoms.

    In a study published in Nature, a global team of researchers developed a new technology called pathology-oriented multiplexing, or PathoPlex, to map more than 140 different proteins across 40 tissue samples.

    They used PathoPlex to analyze tissue samples from people with diabetic kidney disease and identified disease-specific protein patterns.

    The location of proteins in tissues can be visualized using antibodies with fluorescent tags that bind to specific proteins and glow under a microscope.

    However, the lack of high quality antibody panels has hindered research efforts on organ-level protein expression.

    The team developed PathoPlex by combining images from multiple protein-bound antibodies and using a software program that could interpret patterns across several tissues.

    The system was optimized to map more than 140 different proteins from at least 40 biopsy specimens.

    “PathoPlex paves the way towards understanding and imaging complex tissues in human diseases like diabetes,” said Matthias Kretzler, professor of internal medicine and member of Caswell Diabetes Institute, who was a part of the team.

    “We can finally develop atlases that describe changes in protein functions and how to improve them with new treatments.”

    As proof of concept, PathoPlex was used to analyze biopsy samples from people with diabetic kidney disease.

    The researchers were able to link protein expression to organ dysfunction and identify healthy protein patterns in groups of cells that work well and those that are associated with disease in damaged cells.

    PathoPlex also revealed kidney stress-related cell changes in people with type 2 diabetes before their kidneys showed any signs of disease.

    The readouts assessed how these tissues would respond to specific drug treatments, suggesting that the technology could eventually accelerate both diagnosis and treatment timelines for patients.

    Source:

    Michigan Medicine – University of Michigan

    Journal reference:

    Pathology-oriented multiplexing enables integrative disease mapping, Nature. DOI: 10.1038/s41586-025-09225-2

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  • Stormy weather disrupts internet nationwide – Pakistan

    Stormy weather disrupts internet nationwide – Pakistan

    • Country’s internet connectivity drops to 20pc after major PTCL, Ufone outage
    • Other telcos also experience data service disruptions

    ISLAMABAD: Heavy rainfall in Karachi caused widespread disruptions to PTCL internet and Ufone services, affecting subscribers across the country.

    Since other telecom operators purchase wholesale internet from PTCL, users of Jazz, Zong and Telenor also experienced data service disruptions.

    Netblocks, a global internet watchdog, confirmed a major disruption to internet connectivity across Pakistan, with PTCL being significantly impacted. National connectivity dropped to 20 per cent of ordinary levels.

    Responding to a query, a PTCL spokesperson acknowledged the issue. “Our teams are diligently working to restore the services as quickly as possible. We regret any inconvenience caused,” the spokesperson said but did not mention the cause for the nationwide outage.

    Sources in the Ministry of IT and Telecom suggested that the disruption might be due to a technical fault at the landing station of submarine cables in Karachi’s Clifton area.

    “No submarine cable issue has been reported, so the problem is likely at the landing station and some technical fault in the main hub,” and official said. “As a result, it’s a nationwide outage now with upstream traffic facing issues too.”

    The Pakistan Telecommunication Authority (PTA) said in a statement that technical teams were working to resolve the issue.

    IT Minister Shaza Fatima attributed the disruptions to power outages and network congestion, with many towers down in Karachi.

    “The other localised issue is temporary choking of the network as too many people were stranded at the same spot and almost everyone was either making calls or receiving them. And now with PTCL going dead, all connectivity has shifted at telephony creating more choking,” Ms Fatima added.

    Karachi’s 12 million mobile phone subscribers were affected, with the load shifting to the remaining three telcos after Ufone’s service disruption.

    A PTA official noted that running generators for 12 hours was not feasible, and supplying diesel to towers was challenging in the current situation.

    He added that more than 200 telecom sites (towers) were damaged in the flood in KP and most of the towers were restored in flood-affected areas of Swat, Buner, Shangla, etc, and the teams were ensuring restoration of remaining sites.

    As heavy urban flooding hit Karachi, residents faced telephony disruptions in many areas, losing connections with each other.

    Saher, a Gulistan-i-Jauhar resident, expressed concern: “I received one call from my husband, Jamal, saying he was stuck on the street, but his phone isn’t connecting since sunset. I’m really worried.”

    Published in Dawn, August 20th, 2025

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