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  • Vegetarianism associated with decreased cancer risk

    Vegetarianism associated with decreased cancer risk

    Cancer is the second leading cause of death globally, accounting for 1 in 6 deaths worldwide in 2018, according to the World Health Organization. Cancer is caused by both genetic and environmental factors, which vary depending on cancer type. Diet is known to be a major risk factor for multiple cancers, with processed and red meat being a risk factor for bowel cancer.

    Previous studies have explored the association between vegetarianism and multiple common cancers, but associations with less common cancers have yet to be explored, and in research published in The American Journal of Clinical Nutrition, Gary Fraser and colleagues used cohort study data from The Adventist Health Study-2 (AHS-2) to assess the relationship between vegetarianism and risk of different uncommon and common cancer types. The study found that vegetarians had a 12% lower risk of developing cancer overall compared to non-vegetarians.

    To observe the effects of diet and the odds of developing cancer, the study collected baseline data of participants from the AHS-2. This cohort study recruited more than 95,000 US and Canadian participants between 2002 and 2007, all of whom were volunteer members of the Seventh-day Adventist church. Dietary habits were obtained from a validated food frequency questionnaire. Vegetarians included those categorised as vegans (who avoided all animal products, consuming fewer than one such product per month), lacto-ovo-vegetarians (who avoided meat and fish but consumed eggs/dairy once or more per month), and pesco-vegetarians (who avoided meat but consumed eggs/dairy/fish once or more per month).

    Cancer diagnosis (identified using the International Classification of Diseases version 10 and International Classification of Diseases, Oncology codes) was obtained by matching the AHS-2 data to cancer registries, with follow-up lasting from 2010 to 2013, depending on the US state and Canadian province/territory. In total, 79,468 participants were included in the study. Compared to non-vegetarians, vegetarians had a 12% lower risk of developing cancer overall. Vegetarians were also shown to have decreased risk of bowel cancer development, with a 45% lower risk of developing stomach cancer, a 20% lower risk of developing colon cancer, and a 21% lower risk of developing colorectal cancer. Other than bowel cancers, vegetarians had a lower risk of lymphoma and lymphoproliferative cancers compared to non-vegetarians, both with a 25% decreased risk.

    The study by Fraser and colleagues provides further evidence of vegetarianism being a protective factor against bowel cancers, and also provides new evidence for vegetarianism being a protective factor against lymphoproliferative cancers. The study therefore provides an incentive to explore what aspects of vegetarianism protect against these cancers specifically. However, it is important to note that information on dietary habits was taken at the beginning of the study, which was subject to change during follow-up. GlobalData epidemiologists forecast that in the 16 major markets (16MM: Australia, Brazil, Canada, China, France, Germany, Italy, Japan, India, Mexico, Russia, South Africa, South Korea, Spain, the UK and the US), five-year diagnosed prevalent cases of colorectal cancer in men and women aged 18 years and over will increase from 4.6 million in 2025 to 5.4 million in 2031.



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  • How Galaxy Watch’s Innovative Sensor Breaks New Ground in Preventative Care – Samsung Newsroom Malaysia

    How Galaxy Watch’s Innovative Sensor Breaks New Ground in Preventative Care – Samsung Newsroom Malaysia

    Navigating today’s scattered health data and a healthcare system geared towards treating illness, not preventing it, hinders our ability to build healthy habits and prioritize long-term wellbeing. So how do we take back control?

     

    Powered by Samsung’s cutting-edge sensor technology that provides a holistic, real-time overview of our health, the new Galaxy Watch8 series[1] shifts the focus to preventative care. It provides clear, actionable insights based on your lifestyle patterns to help you understand your body and mind more deeply, build healthy habits and help identify silent threats such as ectopic beats early on.

     

    ▲The Galaxy Watch8 series’ Antioxidant Index allows you to monitor your antioxidant intake by measuring carotenoid levels in the skin.

     

     

    Preventative Care Through Early Detection

    With new heart metrics, Galaxy Watch8 series spots the potential for health issues sooner, so you can prevent them before they start:

     

    • Ectopic Beat Detection: Galaxy Watch8’s enhanced Electrocardiogram (ECG)[2] can better capture ectopic beats – premature heartbeats that often go undetected in routine checkups as they frequently occur without noticeable symptoms. It is well known that frequent ectopic beats can be considered clinically significant and may lead to arrhythmias that drive up stroke and heart-failure risk. Galaxy Watch8 series provides enhanced ECG measurement with the ability to differentiate instances of frequent ectopic beats providing earlier insights to support preventive care.

     

    • Vascular Load: While you sleep, Galaxy Watch8 reads Photoplethysmogram (PPG) waveforms – optical signals associated with blood flow during sleep. It measures blood volume and vascular stiffness and precisely analyzes changes in stress on blood vessels. Because diet, stress, and rest all affect this metric, regular monitoring shows which habits to fine-tune and helps you cut cardiovascular risk before it takes hold.

     

     

     

    Lifestyle Changes Motivated by Sensor-Driven Insights

    The Galaxy Watch8 series’ advanced sensor now gives you more immediate insights for your nutrition and sleep patterns to steer you towards lasting, sustainable habits:

     

    • Antioxidant Index: Because lifestyle often outweighs genetics, the Galaxy Watch8 series shines a light on your daily choices. The BioActive Sensor measures skin carotenoids in five seconds using multi-wavelength absorption spectroscopy. After analyzing these carotenoids, an antioxidant which reflects fruit and vegetable intake, you are given a score of 0–100, which is categorized into one of three levels. This score shows how diet, UV light, alcohol and stress are impacting your antioxidant levels. With insufficient fruit and vegetable intake linked to major health risks, this non-invasive metric offers meaningful insight, promotes healthier choices and adds another layer of prevention to your daily routine.

     

     

    • Bedtime Guidance: Leveraging the science behind the two-process model of sleep regulation, the Galaxy Watch8 series tracks your circadian rhythm (internal body clock) and sleep pressure (how much your body needs sleep), over three days. It then interprets this data as a differential equation to calculate the optimal bedtime for waking up refreshed. The algorithm uses changes in sleep threshold and individual sleep needs throughout the day to deliver personalized guidance. Developed by KAIST and clinically tested at Samsung Medical Center, this feature helps build healthier sleep routines that lead to deeper, less interrupted sleep and more energized mornings.

     

     

     

    Pioneering the Next Era of Preventative Care

    Samsung’s sensor innovation is setting a new standard for preventative care. The Galaxy Watch8 series helps unify your patterns, expose hidden risks, and deliver real-time actionable insights so you can safeguard your health in advance. Samsung is not only redefining what a smartwatch can do today, but also accelerating the next wave of preventative-care breakthroughs for tomorrow.

     

    Grab the all new Galaxy Watch Series with these rebates as well to expand your Galaxy ecosystem:

    Model Connectivity Colour RRP Rebates
    Galaxy Watch8 (44mm) Bluetooth Graphite RM1,399 ·  Fabric Band M/L worth RM159

     

    OR

     

    ·  Fabric Band S/M worth RM159

    ·  Enhanced trade-in Rebate up to RM200

    Silver RM1,399
    Bluetooth + LTE Graphite RM1,699
    Silver RM1,699
    Galaxy Watch8 (40mm) Bluetooth Graphite RM1,299
    Silver RM1,299
    Bluetooth + LTE Graphite RM1,599
    Silver RM1,599
    Galaxy Watch8 Classic (46mm) Bluetooth Black RM1,799 ·  Sport Band M/L worth RM159

    ·  Enhanced trade-in Rebate up to RM200

    White RM1,799
    Bluetooth + LTE Black RM2,099
    White RM2,099
    Galaxy Watch Ultra (2025) Bluetooth + LTE Titanium Blue RM3,399 ·  Trail Band worth RM399

    ·  Galaxy SmartTag2 worth RM149

    ·  15W Power Adapter without Cable worth RM59

    ·  10,000mAh Battery Pack worth Rm159

    ·  Enhanced Trade-in Rebate up to RM200

    Titanium Gray RM3,399
    Titanium Silver RM3,399
    Titanium White RM3,399

     

    To purchase Samsung’s latest devices, please visit the following sites:

     

     

     

     

    [1] Availability and features may vary depending on market, model and the smartphone paired; visit https://www.samsungmobilepress.com/feature-stories/great-health-can-happen-overnight-with-galaxy-watch for details. Not intended for use in detection, diagnosis, treatment of any medical condition. The result is for your personal reference only. Please consult a medical professional for advice.
    [2] The ECG feature is only available in select markets. It is not intended to replace traditional methods of diagnosis or treatment. The feature is not intended for users with known arrhythmias other than AFib. Users should not interpret or take clinical action based on the device output without consultation with a qualified healthcare professional.

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  • Uniting people via live music – and helping rising stars 


    Uniting people via live music – and helping rising stars 


    The infectious, unifying exuberance of live music is what drives Si Blatchly, the driving force behind the Chai Wallahs touring festival stage. Now, Blatchly has teamed up with others to respond to the unprecedented challenges facing the sector with a brand new, crowdfunded model

    Si Blatchly live music organiser

    Fifty people are crammed together as their bright outfits sparkle under the stage lights. Horns blast, strings pluck, guitars ring out and drums pound, as the UK’s biggest folk band explodes with energy. “It was epic,” recalls Si Blatchly, who’s also known as Si Chai. “The crowd went absolutely ballistic. There was so much joy in the room and every single person on the stage was utterly beaming.”

    Blatchly is recalling the moment The Conservatoire Folk Ensemble, made up of an ever-rotating number of students from the Royal Birmingham Conservatoire, took to the Chai Wallahs stage for the first time. “Some of those kids had never even been to a festival before, let alone played in front of 2,000 people,” he says. “So, to see them absolutely smash it was such a massive rush. It gives me such a kick to see that. It’s such a beautiful thing to witness that I can get quite weepy sometimes.”

    Blatchly has been involved with Chai Wallahs since 2004, when he came up with the idea of combining his two passions. “I wanted to introduce people to health products and things like natural incense, goji berries, wheatgrass and juices,” he recalls. “And I was also passionately into music, so I merged the two.”

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    Initially it was a stall that served up brews, juices and herbal shots, along with DJs spinning tunes, but by 2007 it had evolved into a touring live stage. Since then, Chai Wallahs has been a staple at festivals across the UK, such as Green Man, Kendal Calling, Secret Garden Party and Shambala, putting on the likes of Ezra Collective, Portico Quartet, Kae Tempest, Rag & Bone Man and literally thousands of other acts.

    Chai Wallahs has always been a place of solace and discovery away from the hustle and bustle of busy main stages, he explains, in line with his aim to give a platform to up-and-coming artists – potential stars of tomorrow.

    We’ve always been about supporting unsupported artists,” says Blatchly. “But providing them with a really professional platform, amazing sound, great hospitality and a nice venue. So that new audiences can engage and hear that music the way it was meant to be heard and open people’s minds up to the fact that you don’t need to go and watch the headliner. There’s so much talent at this level.”

    ‘Music is a universal language. You can express so much through it and it’s an amazing form of communication and education. But it can also provide so much joy that it can evolve your soul – which is really what it’s all about’ says Blatchly

    However, times are tough in the world of music festivals. The Association of Independent Festivals reports that the UK lost 78 of them in 2024 alone. Unprecedented strains on the live music sector, particularly on those operating at a smaller level, has made things especially challenging of late.

    The grassroots scene has been under a lot of pressure,” admits Blatchly. “A massive rise in infrastructure costs, the cost-of-living crisis and a whole string of other issues has basically rinsed any available money out of the industry. Some drastic steps were needed, so we thought: ‘Why don’t a bunch of us get together and pool all of our skills, experience and knowledge?

    The result is Grassroots Rising, a new Community Benefit Society (CBS) venture that’s billed as a ‘festival of festivals’ and is intended to put power back in the hands of the independents. A crowdfunding campaign will launch this August and, if successful, in June 2026 a group of independent festivals, venues and promoters will join forces to create a collaborative event over one weekend in Cambridgeshire.

    This model will make it more affordable, and allow us to create a showcase for grassroots music. This is a true return to festival culture – a blueprint for the future

    If we all join together, our collective power and reach is huge,” says Blatchly. “The model will help reduce running and ticket costs, making it more affordable, and allow us to create a showcase for grassroots music. This is a true return to festival culture and that’s what we need to go back to, because the existing model doesn’t work for the vast majority. This can be a blueprint for the future.” 

    Luke Potter, a singer songwriter who performs as Potter, has seen up close just how crucial these spaces can be for aspiring musicians. “What Chai Wallahs has achieved in the last 20 years is remarkable,” he says. “It’s saved my life on more than one occasion. Si supported my band for 10 years playing there and I still sing on that stage every year. It isn’t just a venue or a support platform for bands, it can literally be a lifesaver for people.”

    Despite the ongoing difficulties that the industry faces, the infectious spirit, exuberance and magic that live music can produce is the thing that keeps Blatchly pushing forward. He remains passionately in search of moments that will create a buzz similar to seeing 50 smiling young musicians packed on to a stage.

    “Music is a universal language,” he says. “You can express so much through it and it’s an amazing form of communication and education. But it can also provide so much joy that it can evolve your soul – which is really what it’s all about.”

    Photography: Sam Bush 

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  • US Open 2025: Why Emma Raducanu has turned to Rafael Nadal’s old coach Francisco Roig

    US Open 2025: Why Emma Raducanu has turned to Rafael Nadal’s old coach Francisco Roig

    With Petchey making it clear he was unwilling to sacrifice his role as a television commentator to coach on a full-time basis, Raducanu continued to assess her options.

    Roig’s availability came to attention over the summer and the pair worked together in a covert trial following Wimbledon.

    Raducanu likes to learn and once put her high turnover of coaches down to asking “provoking” questions. She found Roig’s sessions to be stimulating, challenging and instantly encouraging.

    “Francis is very passionate for tennis,” said Vilaro.

    “What’s amazing is he can watch a match on TV and he doesn’t care about the result – he’s checking how they are moving, the positioning and how they are hitting the ball. He’s watching many specific things.

    “When we created the academy he said, ‘I want to do it but I don’t want any paperwork. I just want to be on the court’. The court is his passion.”

    Raducanu has already impressed Roig with her work ethic.

    In his first tournament at the helm, the pair had multiple daily practices at the Cincinnati Open, where she confidently breezed past Serbia’s Olga Danilovic before – more notably – pushing world number one Aryna Sabalenka to her limit.

    While Raducanu fell short of a shock, it was a promising performance which provides optimism for the US Open.

    “I spoke to Francis after Raducanu beat Danilovic and before she played Sabalenka,” said Vilaro.

    “He said, ‘It’s amazing, I like working with this player a lot because she loves to be on court. We spent two hours training the return, the return plus second shot and what to do when the opponent attacks’.

    “He enjoyed it a lot. The most important thing for him is having a player who loves being on court – and it looks like this is the case.”

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  • FX Daily: Dovish cut from RBNZ shows importance of spare capacity | articles

    FX Daily: Dovish cut from RBNZ shows importance of spare capacity | articles

    The dollar has quietly gone a little bid this week. We’re not sure what’s driving it, but we wouldn’t read too much into it at this stage. Perhaps it’s just that sitting short dollars is expensive with one-week dollar rates still well above 4.00%. There hasn’t really been that much progress on Ukraine this week, despite European leaders hailing a ‘breakthrough’. Let’s see whether any more details emerge about the level of support the US is prepared to offer Europe in defending Ukraine, and also whether President Putin is prepared to accept European boots on the ground in Ukraine – the threat of which (under NATO) prompted Russia to invade Ukraine in the first place. EUR/CHF is trading lower in a slightly disappointed fashion over progress on a ceasefire/peace, but CEE FX seems happy to hold onto gains.

    In terms of the calendar today, we have prospective Fed Chair front-runner Christopher Waller speaking at 17CET, though the subject here is payments. More interesting will be the FOMC minutes released at 20CET, which will air more of the views of the two dissenters (Waller and Bowman) who voted for a rate cut in July. Market moves, however, may be limited given that the July jobs report was released a few days later. A much better read on the Fed situation should emerge on Friday afternoon during Chair Powell’s speech at Jackson Hole. In all, we don’t see the need for big DXY moves today and struggle to see it breaking above 98.50/60 resistance.

    Where there have been big moves, however, is in New Zealand. While delivering the much-anticipated 25bp cut to 3.00%, the RBNZ seriously debated a 50bp cut – for which two of the six committee members voted. NZD/USD fell 1.1% and the terminal rate for the easing cycle was marked some 20bp lower, close to 2.50%. Despite acknowledging that CPI would increase to and possibly breach the top of its 1-3% target range in the next quarter, the RBNZ felt that the spare capacity, both in labour and business, meant that inflation wouldn’t stick and would be lower next year. The backdrop is that the New Zealand unemployment rate has risen to 5.2% from 3.2% over the last three years. The RBNZ also felt that US tariff uncertainty might be reducing the effectiveness of rate cuts, where uncertainty continues to depress business investment.

    We mention all this because of the battles being faced by both the Fed and the Bank of England in terms of how to react to higher short-term inflation. Certainly, neither has the same spare capacity in labour markets as New Zealand does. But the reaction in NZD FX and rates markets today serves as a reminder that if the labour market shows serious signs of softening, doors open for central banks to cut rates back to neutral or even below neutral. That’s why we’re bearish on the dollar and, to a lesser degree, sterling in 2026.

    Chris Turner

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  • Pine nuts can make the list, say experts

    Pine nuts can make the list, say experts

    Michelle Roberts

    Digital health editor, BBC News

    Getty Images A plate of pesto pasta accompanied by a bowl of pine nuts and a sprig of basilGetty Images

    Pesto often contains pine nuts

    Allergic reactions to foods such as pine nuts and goats milk happen frequently enough they may need warning labels, say experts.

    Food packaging in the UK and EU already lists the most common allergens for people to be aware of, such as egg, peanuts and sesame.

    But at least four more could be added to the mandatory risk list, according to an article in the journal Clinical & Experimental Allergy.

    Lead investigator Dr Dominique Sabouraud-Leclerc from the Allergy Vigilance Network said evidence of increased reactions to a wider range of foods suggested it was time to review the list of foods with mandatory labels and consider adding “at least the most severe of these emerging food allergens”.

    Why are food allergies on the rise?

    The foods the researchers say should be added to the list now are:

    • goat or sheep milk
    • buckwheat
    • peas and lentils
    • pine nuts

    And other emerging ones to keep a watch on are:

    • alpha-gal, found in red meat such as beef or lamb
    • kiwi
    • beehive products, such as wax and pollen, as well as honey
    • apple

    The recommendation comes from experts who looked at food-induced anaphylaxis cases reported in Europe between 2002–2023.

    Anaphylaxis is a potentially life-threatening allergic reaction that is a medical emergency.

    Symptoms, such as swollen lips and throat and difficulty breathing, can happen very quickly.

    People who know they are allergic to certain foods can carry an adrenalin auto-injector pen in case they need urgent treatment.

    Getty Images A child holds a kiwi, which has been cut into two halves, in their handsGetty Images

    Some people are allergic to kiwi fruit and may get symptoms such as a tingling mouth if they eat it

    The researchers analysed nearly 3,000 cases and 413, including two deaths, were caused by one of the eight emerging food allergies.

    Based on their frequency, severity, recurrence, and potential for hidden exposure, the top four new ones are goat’s and sheep’s milk, buckwheat, peas and lentil, and pine nuts.

    That would put them in the same list as the current 14:

    • cereals containing gluten – wheat, rye, barley, oats.
    • crustaceans – crabs, prawns, lobsters
    • eggs
    • fish
    • peanuts
    • soybeans
    • milk
    • nuts – almonds, hazelnuts, walnuts, cashews, pecan nuts, brazil nuts, pistachio, macadamia
    • celery
    • mustard
    • sesame seeds
    • Sulphur dioxide and sulphites used as a preservative (at concentrations of more than 10mg/kg or 10mg/L in terms of total sulphur dioxide)
    • lupin (an ingredient in some pastas and baked goods)
    • molluscs – mussels, oysters, squid, snails

    The Food Standards Agency says it recognises that there are a significant number of foods that can cause allergies or intolerances.

    “This is why pre-packed foods must list all ingredients, why food businesses must provide clear information about allergens and why we encourage consumers to speak up about their allergies,” said spokesman Dr James Cooper.

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  • FES-PET shows promise staging women with invasive lobular cancer

    FES-PET shows promise staging women with invasive lobular cancer

    F-18 fluoroestradiol (FES) PET/CT has excellent specificity and moderate sensitivity for diagnosing axillary lymph node metastasis in women with invasive lobular cancer, a group in South Korea has reported. 

    The finding is from a prospective phase II feasibility study involving 20 women and suggests the technique holds promise for improving surgical plans in newly diagnosed patients, noted lead author Jeongryul Ryu, PhD, of the University of Ulsan in Seoul, and colleagues. 

    “This study serves as the first feasibility analysis investigating the potential utility of F-18 FES PET/CT as a staging modality in early-stage [invasive lobular cancer],” the group wrote. The work was published August 14 in the Journal of Nuclear Medicine

    Invasive lobular breast cancer (ILC) is the second most prevalent type of breast cancer, representing approximately 15% of all invasive breast cancers. ILC grows in a linear pattern through the breast without distorting the surrounding structures or forming a lump and thus is difficult to detect on mammography, ultrasound, MRI, and F-18 FDG-PET, the authors explained. 

    Conversely, F-18 FES radiotracer (Cerianna, GE HealthCare) binds to estrogen receptors on ILC cells and was approved in the U.S. in 2020 for diagnosing distant metastasis or recurrence in patients with estrogen receptor-positive breast cancers, such as ILC, they added. Yet to date, there is a lack of evidence from prospective clinical trials for initial staging, the researchers noted. 

    To that end, the group conducted a phase II single-center prospective feasibility trial. They enrolled 20 women (median age, 52) with newly diagnosed estrogen receptor-positive ILC. Subjects had a confirmed or suspected axillary lymph node (ALN) metastasis on physical examination or imaging and were scheduled to undergo axillary surgery. 

    All patients underwent F-18 FES PET/CT (Biograph Vision, Siemens Healthineers) within 90 days of their initial diagnosis via biopsy, with the scans interpreted visually and semiquantitatively within a few days of acquisition compared with surgical specimens. 

    According to the results, out of the 20 subjects, 12 had proven ALN metastasis. On visual analysis, F-18 FES PET/CT showed a sensitivity of 67% (8/12) and a specificity of 100% (8/8). There were four false-negative cases, all of whom had a single metastasis on the sentinel lymph node, and the researchers detected an unexpected F-18 FES-positive ipsilateral internal mammary lymph node in one patient.

    A 58-year-old woman was diagnosed with ER-positive (Allred score 8) ILC in her right breast. Ultrasound and MRI found prominent lymph nodes in right axillary level I area, diagnosed as metastasis on ultrasound-guided fine-needle aspiration. F-18 FES-PET/CT showed a positive mass in right breast (white arrow; SUVmax, 5.6) and multiple F-18 FES–positive lymph nodes in right axillary level I, II, and II/III junction areas (red arrows; SUVmax, up to 12.2). In addition, a small F-18 FES-positive lymph node was observed in the right second internal mammary area (red circles; SUVmax, 1.8). However, biopsy could not be performed because it was too small and not visible on ultrasound; the clinician decided to include internal mammary lymph node in treatment field for adjuvant radiotherapy. The patient underwent lumpectomy with ALN dissection, with five metastases being identified in 13 lymph nodes dissected, and is scheduled to receive adjuvant chemotherapy, radiotherapy, and endocrine therapy.Journal of Nuclear MedicineSemiquantitative analysis revealed a median maximum standardized uptake value (SUVmax) of 3.4 for metastatic ALNs and 1.0 for benign ALNs. With an optimal cutoff of at least 1.2, SUVmax showed a sensitivity of 75% (9/12) and a specificity of 100% (8/8), the researchers reported. 

    “In this prospective feasibility study, F-18 FES PET/CT exhibited favorable diagnostic performance for ALN metastasis in patients with ILC, with moderate sensitivity and excellent specificity and [positive predictive value],” the group wrote. 

    Currently, ultrasound-guided fine-needle aspiration or core-needle biopsy serves as the initial step for axillary staging in patients with ILC breast presenting with clinically suspicious lymph nodes, yet preoperative identification is achieved in only about 50% of women with axillary involvement, the group noted. 

    Thus, F-18 FES PET/CT presents a promising alternative to meet an unmet clinical need for accurate detection, they suggested. 

    “F-18 FES PET/CT had excellent specificity and moderate sensitivity for the detection of ALN metastasis in ILC, suggesting its potential as a valuable preoperative staging modality in patients with ILC with clinically suspicious ALNs,” the researchers concluded. 

    The full study can be found here

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  • Cena H, Calder PC. Defining a healthy diet: evidence for the role of contemporary dietary patterns in health and disease. Nutrients. 2020;12:334.

    PubMed 
    PubMed Central 

    Google Scholar 

  • WHO. Global action plan for the prevention and control of noncommunicable diseases 2013–2020. Geneva, Switzerland: World Health Organization; 2013.

    Google Scholar 

  • Mitrache C, Libura J, Petrikkos L, Seiler W, Gratwohl A, Stähelin H, et al. Anemia: an indicator for malnutrition in the elderly. Ann Hematol. 2001;80:295–8.

    CAS 
    PubMed 

    Google Scholar 

  • Frangos E, Trombetti A, Graf CE, Lachat V, Samaras N, Vischer UM, et al. Malnutrition in very old hospitalized patients: a new etiologic factor of anemia? J Nutr Health Aging. 2016;20:705–13.

    CAS 
    PubMed 

    Google Scholar 

  • Styszyński A, Chudek J, Mossakowska M, Lewandowski K, Puzianowska-Kuźnicka M, Klich-Rączka A, et al. Causes of anemia in Polish older population—results from the polsenior study. Cells. 2021;10:2167.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Bianchi VE. Role of nutrition on anemia in elderly. Clin Nutr ESPEN. 2016;11:e1–11.

    PubMed 

    Google Scholar 

  • Andrès E, Serraj K, Federici L, Vogel T, Kaltenbach G. Anemia in elderly patients: new insight into an old disorder. Geriatr Gerontol Int. 2013;13:519–27.

    PubMed 

    Google Scholar 

  • Bouillanne O, Morineau G, Dupont C, Coulombel I, Vincent J-P, Nicolis I, et al. Geriatric nutritional risk index: a new index for evaluating at-risk elderly medical patients. Am J Clin Nutr. 2005;82:777–83.

    CAS 
    PubMed 

    Google Scholar 

  • Knight ZA, Schmidt SF, Birsoy K, Tan K, Friedman JM. A critical role for mTORC1 in erythropoiesis and anemia. eLife. 2014;3:e01913.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Lehtisalo J, Ngandu T, Valve P, Antikainen R, Laatikainen T, Strandberg T, et al. Nutrient intake and dietary changes during a 2-year multi-domain lifestyle intervention among older adults: secondary analysis of the Finnish geriatric intervention study to prevent cognitive impairment and disability (FINGER) randomised controlled trial. Br J Nutr. 2017;118:291–302.

    CAS 
    PubMed 

    Google Scholar 

  • Andrès E, Federici L, Serraj K, Kaltenbach G. Update of nutrient-deficiency anemia in elderly patients. Eur J Intern Med. 2008;19:488–93.

    PubMed 

    Google Scholar 

  • Wang P-C, Gussekloo J, Arai Y, Abe Y, Blom JW, Duncan R, et al. The effects of single and a combination of determinants of anaemia in the very old: results from the TULIPS consortium. BMC Geriatr. 2021;21:457.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Borelli P, Blatt S, Pereira J, de Maurino B, Tsujita M, de Souza A, et al. Reduction of erythroid progenitors in protein–energy malnutrition. Br J Nutr. 2007;97:307–14.

    CAS 
    PubMed 

    Google Scholar 

  • Rattanasompattikul M, Molnar MZ, Zaritsky JJ, Hatamizadeh P, Jing J, Norris KC, et al. Association of malnutrition–inflammation complex and responsiveness to erythropoiesis-stimulating agents in long-term hemodialysis patients. Nephrol Dial Transplant. 2013;28:1936–45.

    CAS 
    PubMed 

    Google Scholar 

  • Pasini E, Corsetti G, Aquilani R, Romano C, Picca A, Calvani R, et al. Protein-amino acid metabolism disarrangements: the hidden enemy of chronic age-related conditions. Nutrients. 2018;10:391.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Bruserud Ø, Vo AK, Rekvam H, Hematopoiesis. Inflammation and Aging—The biological background and clinical impact of Anemia and increased C-Reactive protein levels on elderly individuals. J Clin Med. 2022;11:706.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Norman K, Haß U, Pirlich M. Malnutrition in older adults—recent advances and remaining challenges. Nutrients. 2021;13:2764.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Boaz M, Kaufman-Shriqui V. Systematic review and meta-analysis: malnutrition and in-hospital death in adults hospitalized with COVID-19. Nutrients. 2023;15:1298.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Röhrig G. Anemia in the frail, elderly patient. CIA. 2016;11:319-26. https://doi.org/10.2147/CIA.S90727.

  • Sousa IM, Burgel CF, Silva FM, Fayh APT. Prognostic value of isolated sarcopenia or malnutrition–sarcopenia syndrome for clinical outcomes in hospitalized patients. Nutrients. 2022;14:2207.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Pourhassan M, Cederholm T, Donini LM, Poggiogalle E, Schwab U, Nielsen RL, et al. Severity of inflammation is associated with food intake in hospitalized geriatric patients—a merged data analysis. Nutrients. 2023;15:3079.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Ramel A, Jonsson PV, Bjornsson S, Thorsdottir I. Anemia, nutritional status, and inflammation in hospitalized elderly. Nutrition. 2008;24:1116–22.

    CAS 
    PubMed 

    Google Scholar 

  • Clark AB, Reijnierse EM, Lim WK, Maier AB. Prevalence of malnutrition comparing the GLIM criteria, ESPEN definition and MST malnutrition risk in geriatric rehabilitation patients: RESORT. Clin Nutr. 2020;39:3504–11.

    PubMed 

    Google Scholar 

  • Cederholm T, Jensen G, l. Mc, Fukushima R, Higashiguchi T, et al. 2019 GLIM criteria for the diagnosis of malnutrition– A consensus report from the global clinical nutrition community. Journal of Cachexia, Sarcopenia and Muscle. 10:207–17.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Cabrerizo S, Cuadras D, Gomez-Busto F, Artaza-Artabe I, Marín-Ciancas F, Malafarina V. Serum albumin and health in older people: review and meta analysis. Maturitas. 2015;81:17–27.

    CAS 
    PubMed 

    Google Scholar 

  • Moramarco S, Morciano L, Morucci L, Messinese M, Gualtieri P, Carestia M, et al. Epidemiology of hypoalbuminemia in hospitalized patients: A clinical matter or an. Emerg Public Health Problem? Nutrients. 2020;12:3656.

    CAS 

    Google Scholar 

  • Abbasi AA, Rudman D. Observations on the prevalence of protein-calorie undernutrition in VA nursing homes. J Am Geriatr Soc. 1993;41:117–21.

    CAS 
    PubMed 

    Google Scholar 

  • Romagnoni F, Zuliani G, Bollini C, Leoci V, Soattin L, Dotto S, et al. Disability is associated with malnutrition in institutionalized elderly people. The I.R.A.* study. Aging Clin Exp Res. 1999;11:194–9.

    CAS 

    Google Scholar 

  • Pourhassan M, Cederholm T, Trampisch U, Volkert D, Wirth R. Inflammation as a diagnostic criterion in the GLIM definition of malnutrition—what CRP-threshold relates to reduced food intake in older patients with acute disease? Eur J Clin Nutr. 2022;76:397–400.

    CAS 
    PubMed 

    Google Scholar 

  • Rondoni F, Simonelli G, Lunghi PM, Rossetti F, Bondi L. Institutionalized elderly people and malnutrition: research on the patients of a nursing home. Ital J Med. 2013;7:183–92.

    Google Scholar 

  • Nutritional anaemias. Report of a WHO scientific group. World Health Organ Tech Rep Ser. 1968;405:5–37.

    Google Scholar 

  • Witten D, Hastie T, Tibshirani R, James G. An introduction to statistical learning. New York, NY: Springer; 2013.

    Google Scholar 

  • O’Brien RM. A caution regarding rules of thumb for variance inflation factors. Qual Quant. 2007;41:673–90.

    Google Scholar 

  • Koury MJ, Ponka P. New insights into erythropoiesis: the roles of folate, vitamin B12, and iron. Annu Rev Nutr. 2004;24:105–31.

    CAS 
    PubMed 

    Google Scholar 

  • Mohn ES, Kern HJ, Saltzman E, Mitmesser SH, McKay DL. Evidence of drug–nutrient interactions with chronic use of commonly prescribed medications: an update. Pharmaceutics. 2018;10: 36.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Zeilinger EL, Zrnic-Novakovic I, Oppenauer C, Fellinger M, Knefel M, Unseld M, et al. Prevalence and biopsychosocial indicators of fatigue in cancer patients. Cancer Med. 2024;13:e7293.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Fraenkel PG. Anemia of inflammation. Med Clin North Am. 2017;101:285–96.

    PubMed 

    Google Scholar 

  • Muckenthaler MU, Rivella S, Hentze MW, Galy B. A red carpet for Iron metabolism. Cell. 2017;168:344–61.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Kum L, Zeilinger EL, Vohla D, Kitta A, Brunevskaya N, Adamidis F et al. Routine laboratory parameters to support decision on parenteral nutrition in palliative care. Front Nutr.2023;10:1173106. https://doi.org/10.3389/fnut.2023.1173106.

  • Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med. 2005;352:1011–23.

    CAS 
    PubMed 

    Google Scholar 

  • Guralnik JM, Eisenstaedt RS, Ferrucci L, Klein HG, Woodman RC. Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia. Blood. 2004;104:2263–8.

    CAS 
    PubMed 

    Google Scholar 

  • Kalantar-Zadeh K, Ikizler TA, Block G, Avram MM, Kopple JD. Malnutrition-inflammation complex syndrome in dialysis patients: causes and consequences. Am J Kidney Dis. 2003;42:864–81.

    PubMed 

    Google Scholar 

  • Röhrig-Herzog G, Steinmetz T, Stein J, Geisel T, Virgin G, Schaefer R, et al. Wirksamkeit und verträglichkeit einer intravenösen eisentherapie Bei geriatrischen patienten Mit anämie: Gepoolte Daten Aus Drei nicht-interventionellen studien. MMW. 2014;156:48–53.

    Google Scholar 

  • Rothschild MA, Oratz M, Schreiber SS. Albumin synthesis: (First of two parts). N Engl J Med. 1972;286:748–57.

    CAS 
    PubMed 

    Google Scholar 

  • Rothschild MA, Oratz M, Schreiber SS. Albumin synthesis: (Second of two Parts). N Engl J Med. 1972;286:816–21.

    CAS 
    PubMed 

    Google Scholar 

  • Cunha MCR, Lima FDS, Vinolo MAR, Hastreiter A, Curi R, Borelli P, et al. Protein malnutrition induces bone marrow mesenchymal stem cells commitment to adipogenic differentiation leading to hematopoietic failure. PLoS One. 2013;8: e58872.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Kalantar-Zadeh K, Block G, McAllister CJ, Humphreys MH, Kopple JD. Appetite and inflammation, nutrition, anemia, and clinical outcome in hemodialysis patients. Am J Clin Nutr. 2004;80:299–307.

    CAS 
    PubMed 

    Google Scholar 

  • Moeller M, Pink C, Endlich N, Endlich K, Grabe H-J, Völzke H, et al. Mortality is associated with inflammation, anemia, specific diseases and treatments, and molecular markers. PLoS One. 2017;12:e0175909.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Nakajima K, Crisma AR, Silva GB, Rogero MM, Fock RA, Borelli P. Malnutrition suppresses cell cycle progression of hematopoietic progenitor cells in mice via cyclin D1 down-regulation. Nutrition. 2014;30:82–9.

    CAS 
    PubMed 

    Google Scholar 

  • Röhrig G, Becker I, Polidori MC, Schulz R-J, Noreik M. Association of anemia and hypoalbuminemia in German geriatric inpatients: relationship to nutritional status and comprehensive geriatric assessment. Z Gerontol Geriat. 2015;48:619–24.

    Google Scholar 

  • Calder PC, Albers R, Antoine J-M, Blum S, Bourdet-Sicard R, Ferns GA, et al. Inflammatory disease processes and interactions with nutrition. Br J Nutr. 2009;101:1–45.

    CAS 

    Google Scholar 

  • Dibble CC, Manning BD. Signal integration by mTORC1 coordinates nutrient input with biosynthetic output. Nat Cell Biol. 2013;15:555–64.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Laplante M, Sabatini DM. mTOR signaling in growth control and disease. Cell. 2012;149:274–93.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Saxton RA, Sabatini DM. mTOR signaling in growth, metabolism, and disease. Cell. 2017;169:361–71.

    CAS 
    PubMed 

    Google Scholar 

  • Liu GY, Sabatini DM. mTOR at the nexus of nutrition, growth, ageing and disease. Nat Rev Mol Cell Biol. 2020;21:183–203.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Zhang X, Campreciós G, Rimmelé P, Liang R, Yalcin S, Mungamuri SK, et al. FOXO3-mTOR metabolic cooperation in the regulation of erythroid cell maturation and homeostasis. Am J Hematol. 2014;89:954–63.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Zoncu R, Efeyan A, Sabatini DM. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol. 2011;12:21–35.

    CAS 
    PubMed 

    Google Scholar 

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  • The New and Bold Kurono Tokyo Vermilion Chronograph

    The New and Bold Kurono Tokyo Vermilion Chronograph

    Let’s get something out of the way immediately: yes, it is brightly coloured, and yes, it isn’t the easiest watch to acquire. Right, let’s now be more serious about Kurono Tokyo and its latest watch, the Vermilion Chronograph. What is Kurono? Well, that’s the accessible brand of independent watchmaker Hajime Asaoka, a bit like so-called “second vins,” a term commonly associated with Bordeaux wine to talk about the more accessible labels of the greatest estates. Still very good, still has some of its great character, not the same price tag though. And while we’re on the topic of red colours, let’s get cracking with this new Vermilion Chronograph. 

    As we’ve explained on multiple occasions, Kurono is the brainchild of Hajime Asaoka, one of the most recognised independent watchmakers of Japan, who’s capable of creating rather fascinating, yet expensive watches such as tourbillons or an inverted chronograph. Kurono isn’t playing in the same league, as it’s about creating elegant, slightly retro watches with the man’s design language, and encasing outsourced Japan-made movements inside (Seiko and Miyota, mostly). Still, Asaoka here delivers handsome watches with a focus on traditional crafts, such as Urushi lacquer.

    With its latest creation, the Vermilion Chronograph, Kurono adds a bold model to its stopwatch lineup, which has already been made in multiple variants. Design-wise, the recipe is that of a vintage-inspired chronograph with compact proportions, made of polished steel with a box-shaped sapphire crystal on top. The watch is only 38mm in diameter with a relatively reasonable 13.5mm thickness. It sits short on the wrist too, just under 47mm in length. The caseback is closed, the pushers are traditional pump-style and water-resistance is limited to 30m. Not a chronograph for aquatic activities, but you’ve guessed that from the design.

    What sets this new edition apart is, without a doubt, the dial. That unmistakable orange-red dial, with a colour named Vermilion (SHU:朱 in Japanese). This tone, in Japan’s culture, is often associated with nobility and is used for torii gates and samurai armours, but it’s also a sign of good fortune. There’s a bit of a story with this dial. As Hajime Asaoka explains, “we take a prototype dial and stick it to the south-facing window of my atelier. Half of the dial is covered with black tape. It then stays exposed to sunlight – about 40 days in summer and 60 days in winter. This is equivalent to more than 10 years of exposure under normal use. At the end of the test, the black tape is removed, and we check whether there is any difference in colour. I had long wanted to create a chronograph with a vivid orange dial, but most paints (pigments) failed this test. Only two pigments passed: ‘selenium red’ and ‘vermilion.’ These were the vivid orange colours I had finally found that would not fade.”

    The rest of the dial is classic for Kurono, with sunken black sub-counters, applied polished pearls as hour markers and domed, polished hands. There’s a date window at 6 o’clock, which we could certainly see removed. The contrast between the orange-red colour and the black sub-dial is strong, and the Kurono Tokyo Vermilion Chronograph surely has a strong personality. Inside, no surprises. The watch is powered by Seiko NE86 (also known as 8R46 when used by Seiko). It is a more advanced movement than what you’d expect, as it relies on a column wheel and vertical clutch architecture, and is an integrated automatic movement. It beats at 4Hz and stores about 45h of power reserve. The watch is worn on a discreet black leather strap.

    Availability & price

    No Kurono watch is easy to acquire, but the Vermilion Chronograph is even harder to get, being a small batch release available only at Kurono salons in Aoyama (a district of Tokyo) and in Shanghai, China. No online ordering will be possible, and only one watch can be purchased at a time, from August 22nd, 2025. It is also said to be a limited production run (no numbers mentioned) that will not be repeated.

    The Kurono Tokyo Vermilion Chronograph is priced at JPY 598,950 (incl. taxes) or RMB 29,300 (incl. taxes), about EUR 3,470 at the time of publication. For more details, please visit kuronotokyo.com.

    https://monochrome-watches.com/kurono-tokyo-vermilion-chronograph-salon-exclusive-model-introducing-specs-price/

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  • Fibre optics detect the invisible waves that melt Greenland’s ice sheet 

    Fibre optics detect the invisible waves that melt Greenland’s ice sheet 


    View of the fjord and front of the Eqalorutsit Kangilliit Sermiat glacier in southern Greenland.


    Andreas Vieli, University of Zurich

    The breaking off of large chunks of ice from glaciers accelerates the melting of the Arctic ice sheet in Greenland. This has been measured for the first time by an international research team using fibre-optic technology, which is also used to study Swiss glaciers. 

    Greenland’s ice sheet is melting at an increasingly rapid pace. Since 2002, it has lost an average of around 270 billion tonnes of ice per yearExternal link, causing a sea-level rise of nearly two centimetres. 

    The calving of large ice blocks is one of the most visible effects of ice-sheet mass loss caused by climate change. But it’s also a phenomenon that itself further intensifies melting: when an iceberg collapses into the sea, it brings warmer water to the surface, which in turn accelerates the melting process. 

    This is the discovery made by an international research team led by the universities of Zurich and Washington, which for the first time measured how ice break-up speeds up the retreat of Greenland’s Arctic ice sheet. The study, part of the Swiss Polar Institute’s GreenFjordExternal link project, was published on August 13 in NatureExternal link

    “We now better understand what happens when ice falls into the sea: it not only breaks off, but also increases melting below the water’s surface,” Andreas Vieli, professor of glaciology at the University of Zurich and co-author of the study, told Swissinfo. 

    These observations help improve our understanding of Greenland’s ice sheet, which covers an area about 40 times the size of Switzerland. It’s a fragile system whose complete melting would have serious consequences for ocean currents, global climate, and coastal regions around the world. 

    >> Glacier melting has global consequences: 

    Alpine scene

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    Climate solutions

    Why melting glaciers affect us all



    Alpine glaciers could disappear by the end of the century. The consequences will be felt not only in the Swiss Alps but all over the planet.


    Read more: Why melting glaciers affect us all

    Giant waves bring warm water to the surface 

    The Zurich and Washington researchers studied the effects of iceberg calving at the Eqalorutsit Kangilliit Sermiat glacier, located in a fjord in southern Greenland. Around 3.6 cubic kilometres of ice break off from the glacier each year – nearly three times the volume of the Rhône Glacier in the Swiss Alps. 

    The impact of ice falling into the sea initially generates surface waves, similar to tsunamis, that stir the upper part of the water column. Later, it also causes deep waves, invisible to the human eye. These can be as tall as skyscrapers and carry warm water from the ocean floor to the surface, intensifying melting and erosion at the glacier front. 

    >> Watch the spectacular footage of ice breaking off a glacier in Greenland: 


    External Content

    Dominik Gräff, a researcher at the University of Washington and lead author of the study, compares the process to ice cubes melting in a hot drink. If you don’t stir the drink, a layer of cold water forms around the cube, insulating it from the warmer liquid. But if you stir it, that layer is disrupted and the cube melts much faster. 

    In the case of Greenland’s ice sheet, about half of the current mass loss is due to underwater melting and iceberg calving, says Vieli. 

    Fibre optics on the seafloor 

    To measure what happens at depth, the researchers laid a ten-kilometre-long fibre-optic cable on the seafloor. Using a technology called Distributed Acoustic Sensing (DAS), they were able to record changes in the fibre – stretching or compression – caused by underwater waves. 

    “The fibre-optic cable allowed us to measure this incredible calving multiplier effect, which wasn’t possible before,” Gräff is quoted as saying in a University of Zurich press release. 

    Two researchers lower the fibre-optic cable to the seabed to take measurements.

    Two researchers lower the fibre-optic cable to the seabed to take measurements.


    Dominik Gräff, University of Washington

    The significance of seawater and iceberg calving dynamics has long been known. However, measuring these processes directly on site presents considerable challenges, as the large number of icebergs in the fjords poses a constant risk from falling ice blocks. 

    Moreover, conventional satellite-based remote-sensing methods cannot penetrate below the water’s surface, where glacier-seawater interactions occur, Vieli points out. “Thanks to the fibre-optic cable, it’s as if we had a thousand sensors beneath the glacier front.” 

    Technology used on Swiss glaciers 

    Using fibre optics to study glaciers is a relatively recent technique. Researchers in Switzerland and other mountainous regions like Alaska have begun using it to detect micro-vibrations in glaciers and potential early signs of instability. 

    “Fiber optics allow us to detect extremely small seismic events, which other technologies could not measure,” said Thomas Hudson, a seismologist at the Swiss federal technology institute ETH Zurich, in an interview with Swissinfo. 

    In 2023, Hudson installed 1.2 kilometres of fibre-optic cable on the Gorner Glacier in Switzerland, detecting thousands of seismic waves. These vibrations can provide insights into changes within the ice. 

    >> Fibre optic research projects in Switzerland are opening up new possibilities for monitoring glaciers and natural hazards: 

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    Researchers in Switzerland have tested the use of fibre optics on several Alpine glaciers (picture shows the Rhone Glacier).

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    Glaciers & permafrost

    Fibre optics on glaciers open new frontiers for natural disaster predictions




    This content was published on




    The fibre-optic cables we use to surf the Internet and make phone calls could help us predict a landslide or the collapse of a glacier.


    Read more: Fibre optics on glaciers open new frontiers for natural disaster predictions

    Fibre optics also offer information about the structure and composition of the ice. Compared to traditional seismic sensors, which are placed at specific points, fibre optics make it possible to monitor much larger areas thanks to their relatively easy installation. This technology could enable the monitoring of entire glaciers, even in hard-to-reach regions. 

    Edited by Reto Gysi von Wartburg/dos 

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