Author: admin

  • Mitchum apologises after deodorant left users with itchy, burning armpits

    Mitchum apologises after deodorant left users with itchy, burning armpits

    Faarea Masud & Connie BowkerBBC News

    Mitchum A hand holding a green and pink bottle of Mitchum powder-fresh roll-on deodorant.Mitchum

    Mitchum has apologised after customers were left with “burning armpits”

    A well-known deodorant brand has apologised after some of its roll-on products reportedly left customers with itchy, burning armpits.

    Consumers of Mitchum’s 48-hour roll-on anti-perspirant and deodorant complained on social media of having “agonising weeping spots”, redness and irritation after using the product.

    Posting on TikTok, one customer claimed she wanted to “rip my armpits out”, while another said her underarms felt like they were “on fire”.

    The company said it was “truly sorry” and explained how a change in the manufacturing process had affected 100ml batches sold in the UK, Ireland and South Africa. It said it was removing the affected products from shelves.

    ‘I started smelling really bad’

    @steph_chulo, TikTok Screenshot of a TikTok video. A woman is holding a can of Mitchum aerosol powder fresh deodorant. @steph_chulo, TikTok

    Steph Buttery shared her Mitchum nightmare experience on TikTok

    Steph Buttery, 34, from Manchester, has been a loyal Mitchum customer for the last 15 years.

    But after she started using a new bottle of the firm’s aerosol Powder Fresh deodorant in July, she developed an itchy red rash around her armpits and says she “started smelling really bad”.

    Steph, who runs a soft drinks company, says she had to keep her arms down throughout an important business meeting, because she was so conscious of the smell.

    She has since switched deodorant brands and says the problems have stopped.

    “I’ve been totally turned off [Mitchum] for life. I’m going to go for natural deodorant from now on.”

    Mitchum has not included any aerosol deodorants in the list of affected products.

    Steph is one of hundreds of people who have taken to sharing videos of their experience on TikTok.

    One woman said she was unable to sleep after using the roll-on because it left her with “second degree chemical burns on my armpits”.

    Another described her underarm skin as developing a pink rash which had “scabbed over”.

    A third said she was left in agony because of “weeping spots” under her arm.

    “I won’t be using any Mitchum products again because I’m not risking this happening again,” she said.

    A Mitchum spokesperson said the brand was “truly sorry some of our customers have experienced temporary irritation”.

    In a statement, the company said: “We want to reassure there has been no change to the formula of our products, but we have identified a change in the manufacturing process affecting one of our raw materials.

    “This has impacted how the roll-on interacts with the skin of some users.”

    It did not give details of what the change to its manufacturing process was but said the issue had since been resolved and it was working to “remove the small amount of product” left in shops.

    “In addition, we have reverted to the original manufacturing process to ensure no other batches are affected,” the spokesperson said.

    Mitchum advised all those affected to contact its customer services team so it could “make this right”.

    The firm has issued a list of all the affected 100ml roll-on products. These are:

    • Powder Fresh
    • Shower Fresh
    • Unscented
    • Pure Fresh
    • Flower Fresh
    • Ice Fresh
    • Clean Control
    • Sport


    Continue Reading

  • NCCN Adds Dordaviprone to Clinical Practice Guidelines in H3K27M-Mutant Diffuse High-Grade Glioma

    NCCN Adds Dordaviprone to Clinical Practice Guidelines in H3K27M-Mutant Diffuse High-Grade Glioma

    H3K27M-Mutant Diffuse High-Grade Glioma

    | Image Credit: © iDoPixBox – stock.adobe.com

    The National Comprehensive Cancer Network (NCCN) has updated its Clinical Practice Guidelines in Oncology to include dordaviprone (Modeyso) as a category 2A single agent for the treatment of pediatric and adult patients with recurrent or progressive diffuse high-grade glioma harboring an H3K27M mutation.1

    In August 2025, the FDA granted accelerated approval to dordaviprone for the treatment of adult and pediatric patients at least 1 year of age with diffuse glioma who harbored an H3K27M mutation and experienced disease progression after prior therapy.2 Dordaviprone is a protease activator and is the first systemic therapy for H3K27M-mutant diffuse midline glioma that has been FDA approved.

    Continued approval for the respective indication could be contingent upon verification and description of clinical benefit in the phase 3 ACTION confirmatory trial (NCT05580562).1

    “The rapid addition of [dordaviprone] to the NCCN Guidelines—in both the Pediatric Central Nervous System Cancers and Central Nervous System Cancers guidelines—reflects the urgency of the unmet need that patients are faced with when diagnosed with this devastating and aggressive brain tumor,” Kelvin Tan, MBBCh, MRCPCH, chief medical affairs officer of Jazz Pharmaceuticals, the developer of dordaviprone, stated in a news release. “We are proud to bring [dordaviprone] to patients in the United States as the first treatment option for recurrent H3K27M-mutant diffuse midline glioma, representing a meaningful shift in the treatment landscape for patients and their families.”

    The accelerated approval of dordaviprone was supported by an integrated efficacy analysis that included 50 patients with recurrent H3K27M-mutant diffuse midline glioma, who were selected from 5 open-label studies based on prespecified eligibility criteria. These included the phase 2 ONC006 (NCT02525692), phase 2 ONC013 (NCT03295396), phase 1 ONC014 (NCT03416530), phase 2 ONC018 (NCT03134131), and expanded-access ONC016 (NCT05392374) studies.1,2

    In this analysis, the overall response rate (ORR) assessed by blinded independent central review (BICR) per Response Assessment in Neuro-Oncology 2.0 criteria was 22% (95% CI, 12%-36%). Additionally, the median duration of response was 10.3 months (95% CI, 7.3-15.2) in those who showed a response, with 73% of patients maintaining a response for at least 6 months and 27% for at least 12 months.

    Additional efficacy data from the pooled analysis revealed that the corticosteroid response rate was 46.7% (n = 7 of 15; 95% CI, 21.3%-73.4%), and the median time to corticosteroid response was 3.7 months (range, 1.9-5.6).3

    Regarding safety, 376 patients were evaluated from 4 open-label studies.1 Serious adverse effects (SAEs) were observed in 33% of patients. SAEs reported in at least 2% of patients included hydrocephalus (5%), vomiting (4.3%), headache (3.2%), seizure (2.4%), and muscular weakness (2.1%). Furthermore, the most common AEs occurring in at least 20% of patients treated with dordaviprone included fatigue, headache, vomiting, nausea, and musculoskeletal pain.

    Of note, in the pooled analysis, patients were at least 90 days post-radiation therapy, had an adequate washout period before receiving anticancer therapies, a Karnofsky performance status/Lansky performance status of 60 or greater, and stable or decreasing corticosteroid use.2 Patients were not permitted to have diffuse intrinsic pontine glioma, primary spinal tumors, atypical histology, or cerebrospinal fluid dissemination.

    Among the 50 patients included in the pooled analysis, 28.6% of patients were 40 years of age and older, 20.5% were White, and 22.2% were male.3 Of note, 24.2% of patients had a primary tumor in the thalamus, and 24.4% had less than 2 target lesions.

    References

    1. Modeyso (dordaviprone) included in National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines in Oncology for H3 K27M-mutant diffuse glioma. News release. Jazz Pharmaceuticals. September 9, 2025. Accessed September 9, 2025. https://investor.jazzpharma.com/news-releases/news-release-details/modeysotm-dordaviprone-included-national-comprehensive-cancer
    2. FDA grants accelerated approval to dordaviprone for diffuse midline glioma. FDA. August 6, 2025. Accessed September 9, 2025. https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-accelerated-approval-dordaviprone-diffuse-midline-glioma
    3. Arrillaga- Romany I, Gardner SL, Odia Y, et al. ONC201 (Dordaviprone) in Recurrent H3 K27M-Mutant Diffuse Midline Glioma. J Clin Oncol. 2024;42(13):1542-1552. doi:10.1200/JCO.23.01134

    Continue Reading

  • Six recent sporadic borealpox cases in Alaska tied to rodents

    Six recent sporadic borealpox cases in Alaska tied to rodents

    Hanna Knutsson / Flickr cc

    A Centers for Disease Control and Prevention–led study links spillover from small mammals such as voles and squirrels to cases of borealpox in five adults and one child in Alaska from 2020 to 2023.

    Borealpox virus (BRPV; formerly Alaskapox virus) is an orthopoxvirus (OPXV) first found in 2015 in a woman living near Fairbanks, in Alaska’s interior. The infection was identified as a novel OPXV, but the source was unidentified.

    Published yesterday in Clinical Infectious Diseases, the study involved patient or parent interviews, trapping 176 wild small mammals at six sites for OPXV testing, and phylogenetic analyses of viral DNA sequences to reconstruct their evolution.

    Nearly all OPXVs are zoonotic viruses that infect mammals, with rodents often the primary animal reservoir. “Human population immunity to OPXVs is waning globally after the eradication of smallpox, which is likely a reason why OPXVs are being identified with increasing frequency globally,” the investigators wrote.

    Immune-compromised patient died

    Five of the infected patients had one or more lesions and lymph node swelling and later recovered, most after receiving antibiotics. The other patient, an older man with a weakened immune system, was hospitalized and died despite receiving experimental OPXV medications. 

    Better understanding BRPV ecology might help develop more focused prevention measures in addition to standard recommendations to prevent zoonotic infections, such as practicing hand hygiene and avoiding contact with wild animals.

    One patient reported vaccination against smallpox, and all had contact with domestic animals, many of which hunted small mammals. One patient’s dog tested positive for borealpox. 

    No patients had traveled outside of Alaska, and no evidence of person-to-person spread was found. All BRPV genomes were nearly 100% identical to that of the virus isolated from the 2015 patient.

    Several small-mammal species had BRPV DNA and evidence of past OPXV infection in their blood. Genetic distance and phylogenetic analyses pointed to multiple animal-to-human spillover events.

    “Better understanding BRPV ecology might help develop more focused prevention measures in addition to standard recommendations to prevent zoonotic infections, such as practicing hand hygiene and avoiding contact with wild animals, including taking measures to keep small mammals out of buildings,” the authors wrote.

    They called for research into BRPV’s geographic range in small mammals in northern regions.

    Continue Reading

  • New weather system over Sindh, Balochistan may bring torrential rains: PMD

    New weather system over Sindh, Balochistan may bring torrential rains: PMD

    The Pakistan Meteorological Department on Tuesday cautioned that the active weather system, developed over Sindh and Balochistan, is likely to persist through the evening. According to the Met office, the active weather system over the two provinces will bring thunderstorms, lightning and intermittent rain to dozens of districts.

    The new weather system may lash Lasbela, Khuzdar, Qalat, Awaran, Khāran, Panjgur, Kech, Zhob, Musa Khel, Barkhan, Dera Bugti, Naseerabad, Kohlu, Quetta, Ziarat, Pishin, Washuk, Loralai, Qila Saifullah, Qila Abdullah, Jhal Magsi, Makran, Qambar, Larkana, Shaheed Benazirabad, Jamshoro, Karachi, Badin, Thatta, Sujawal, Tando Allahyar, Tando Muhammad Khan, Hyderabad, Mirpurkhas, Khairpur, Shikarpur, Jacobabad, Kashmore, Ghotki and Sukkur.

    Read More: At least 13 dead, over 4m affected as Punjab reels from severe floods

    Officials fear that in some areas the rainfall may turn torrential, flooding low-lying areas of Shaheed Benazirabad, Matiari, Dadu, Jamshoro, Tando Allahyar, Thatta, Badin, Sujawal and Karachi. In Balochistan’s southern and eastern belt — Lasbela, Khuzdar, Awaran, Ormara, Wadh and Hingol Valley — hill torrents may experience flash floods.

    Authorities have also cautioned that strong winds and lightning may cause damage to katcha houses, walls, power poles, billboards, vehicles and solar panels. People have been advised to avoid unnecessary travel, stay clear of weak structures and park vehicles in safe places.

    Meanwhile, the NDMA has issued a flood alert for Sindh and Balochistan, warning of heavy showers in Karachi, Thatta, Jamshoro, Dadu, Hyderabad, Badin, Sujawal, Tharparkar, Umerkot, Sanghar, Jacobabad and adjoining districts.

    Also Read: Five injured as garment factory collapses in Karachi blaze

    Sukkur, Rohri, Larkana, Shikarpur, Ghotki and Kashmore are also likely to receive downpours, while flash floods may hit the Kirthar Range, according to NDMA. 

    In Balochistan, heavy rainfall is forecast for Lasbela, Hub, Khuzdar, Awaran, Barkhan, Sui, Sibi, Dera Bugti, Nasirabad, Kohlu, Kalat and Zhob, as well as coastal districts including Kech, Gwadar, Pasni, Ormara, Surab and Washuk.

    The NDMA has warned that torrential rains may swell nullahs and seasonal streams in Wadh, Khuzdar, Bela, Ormara and Hingol Valley, potentially damaging farmland, mud houses and rural roads. Residents in flood-prone areas have been strongly advised not to cross the submerged roads or underpasses, avoid unnecessary travel and stay on high alert.

    Continue Reading

  • Tessa Thompson In Nia DaCosta’s Ibsen Reimagining

    Tessa Thompson In Nia DaCosta’s Ibsen Reimagining

    “What are you up to?” someone asks our leading lady in a plot so thick with cattiness, intrigue and betrayal that it’s often hard to work out anyone’s true motivations. You might ask the same question of director Nia DaCosta, following three very modern genre movies with an adaptation of Henrik Ibsen’s late 19th century stage classic, a period drama at that. But despite a certain staginess, and a tendency for the plot to suddenly stop to make way for the acting, Hedda is actually a genuine attempt to mine something new from the old text, a compelling fusion of Emerald Fennell’s Saltburn and Stephen Fry’s Bright Young Things.

    When we first meet Hedda (Tessa Thompson), she is being questioned by the police about a shooting, of which she has only a dim memory (“It was a party, after all”). Hedda’s smirk speaks volumes as the film flashes back to that fateful night. We’re in a stately home in England, sometime in the 1950s, and Hedda Tesman, née Gabler, is throwing a ball. As we are about to learn, Hedda, a general’s daughter with a wild past, has recently tied the knot with George (Tom Bateman), an academic. George is fishing for a major teaching post but is disconcerted to find that, as well as the board of professors he is trying to impress, Hedda has also invited his main rival for the job.

    So far, so much the play, but DaCosta has a trick up her sleeve: George’s nemesis is now female, a woman named Eileen (Nina Hoss), Hedda’s ex-lover. Eileen’s imminent arrival is made even more dramatic when a younger woman named Thea (Imogen Poots) turns up at Hedda’s door in a state of distress. Thea recently broke up with Eileen, but the two have written a book together, making it hard for Thea to make a clean break. But when Eileen makes her entrance, she no longer seems to be the same woman we’ve heard about: sober and, like Hedda, she has married well (“You’ve never cured of your vices, you resist them,” she explains). Eileen, hoping to use the party for her own advantage, has brought with her the manuscript of her book — which Hedda knows is the only copy, and she wants it.

    Perhaps understanding that a woman stealing a book from a bag isn’t exactly Mission: Impossible stuff, DaCosta reframes the story as a kind of Wildean black comedy, with lashings of ribald innuendo (notably the eyebrows that raised when George innocently declares that his wife “loves eating out”). In that respect, Thompson is perfect, playing Hedda as a stealth socialite ninja who’s always one step ahead of the competition. “Before you were domesticated, you were like fire,” a guest tells her, and, despite Hedda’s surface layer of gowns and finery, Thompson’s layered work means it does seem possible.

    Generously, Thompson’s performance leaves room for two more, the first being Poots’ low-key but impressive Thea, a mousy woman who arrives wet and bedraggled, causing Hedda to dress her in her own clothes (a gesture that has more than one meaning for Hedda, who’s still in love with Eileen). It’s Hoss, however, that sets fire to the screen. As the supposedly “reformed” Eileen, Hoss really gets to tear the roof off, spectacularly falling off the wagon and humiliating herself more and more throughout the evening.

    Despite the film’s ominous introduction, the ending doesn’t quite live up to all the foreshadowing — to outdo Chekhov, there are at least four instances of guns being waved — but DaCosta perhaps isn’t so committed to the plot as she is to the people. Unusually for a party movie, the revelry seems quite real, and makes a very intriguing backdrop to the story, becoming more and more debauched as Hedda gets deeper and deeper in the weeds with her plot against Eileen and, it even seems, the world. Salient use of Roxy Music’s “Love Is the Drug” rounds things off nicely, a wryly ironic comment on everything we’ve just seen.

    Title: Hedda
    Festival: Toronto (Special Presentations)
    Director: Nia DaCosta
    Screenwriter: Nia DaCosta, from the play by Henrik Ibsen
    Cast: Tessa Thompson, Nina Hoss, Imogen Poots, Nicholas Pinnock, Tom Bateman
    Sales agent: Amazon MGM Studios
    Running time: 1 hr 47 mins

    Continue Reading

  • Finalists from 37 Countries Vie for 2025 Platts Global Energy Awards

    Number of Countries Represented by Finalists up 12% from Year Ago  

    - Winners to be announced live on December 11, 2025, in New York City at Black-Tie Gala -   

    NEW YORK, Sept. 9, 2025 /PRNewswire/ — Companies and individuals from 37 countries have been selected as finalists for the Platts Global Energy Awards program, now in its 27th year as the industry’s premier recognition event. The 2025 finalists, over 50% of which hail from outside of the United States, were just announced by program host and organizer S&P Global Commodity Insights, the leading independent provider of information, data, analysis and benchmark prices for the energy, petrochemicals, metals, shipping, commodities, and energy transition markets.     

    S&P Global Inc. logo

    A must-participate event, the Platts Global Energy Awards, often described by participants and attendees as the “Oscars” of energy, recognizes corporate and individual innovation, leadership, and exemplary performance in 21 categories spanning the entire energy and chemicals value chain.   

    This year’s Platts Global Energy Awards program saw increased nomination submissions from Latin America, which garnered finalists from Colombia, Brazil, Argentina, and Mexico. In addition to the Americas’ finalists, many other nations were represented, including Italy, Morocco, the Netherlands, Finland, Turkey, and Australia. 

    The award categories attracting the most nominations in 2025 were:  

    Chief Executive of the Year – honoring renowned leaders who are driving transformation, while demonstrating courage, perseverance, and integrity to the global energy community. 

    Commercial and Emerging Technologies of the Year – recognizing innovative solutions being developed and deployed across commodities and continents. 

    Corporate Impact Award – Targeted Program – paying tribute to companies positively impacting the communities they serve through humanitarian efforts. This category attracted so many strong entries this year that the Platts Global Energy Awards committee split the category into two, breaking it into global regions: Global West (Western Hemisphere) and Global East (Eastern Hemisphere). 

    “The shifting landscape within the energy industry has brought forward numerous business-impacting challenges. Platts Global Energy Awards is pleased to spotlight companies and individuals who not only navigate the environment well, but continue to lead the way in pioneering vision, progress, exemplary performance, and innovation for a more sustainable energy future,” said Allison Sacco, Executive Producer, S&P Global Commodity Insights. 

    See the full list of finalists here: 2025 Platts Global Energy Awards Finalists

    Winners of the 27th annual Platts Global Energy Awards will be announced the evening of December 11 at a black-tie gala in downtown Manhattan. The winners of the Platts Global Energy Awards are determined by an independent judging panel of international energy experts whose backgrounds and experiences include regulation, policymaking, corporate leadership, trading, and strategic consulting. S&P Global Commodity Insights nor its event sponsors submit votes or select winners.  

    Event sponsorships are available by contacting Ashley Matthews Greenleaf at ashley.greenleaf@spglobal.com or by calling +1 346-651-8174.  

    Media Contacts   
    Americas/EMEA: Kathleen Tanzy + 1 917-331-4607, kathleen.tanzy@spglobal.com 
    Asia/EMEA: Melissa Tan + 65-6597-6241, melissa.tan@spglobal.com    

    About S&P Global Commodity Insights 
    At S&P Global Commodity Insights, our complete view of global energy and commodity markets enables our customers to make decisions with conviction and create long-term, sustainable value.   

    We’re a trusted connector that brings together thought leaders, market participants, governments, and regulators and we create solutions that lead to progress. Vital to navigating commodity markets, our coverage includes oil and gas, power, chemicals, metals, agriculture, shipping and energy transition. Platts® products and services, including leading benchmark price assessments in the physical commodity markets, are offered through S&P Global Commodity Insights. S&P Global Commodity Insights maintains clear structural and operational separation between its price assessment activities and the other activities carried out by S&P Global Commodity Insights and the other business divisions of S&P Global.    

    S&P Global Commodity Insights is a division of S&P Global (NYSE: SPGI). S&P Global is the world’s foremost provider of credit ratings, benchmarks, analytics and workflow solutions in the global capital, commodity and automotive markets. With every one of our offerings, we help many of the world’s leading organizations navigate the economic landscape so they can plan for tomorrow, today. For more information visit https://www.spglobal.com/commodityinsights.  

     

    SOURCE S&P Global Commodity Insights

    Continue Reading

  • Refinery-state senators look to block Trump from shifting renewable fuel obligation – Reuters

    1. Refinery-state senators look to block Trump from shifting renewable fuel obligation  Reuters
    2. White House Review of Biofuel Waiver Plan Pits Farmers Against Refiners  Successful Farming
    3. EPA scheduled to issue final RFS ‘Set 2’ rule in October  Ethanol Producer Magazine
    4. Opinion | The Wrong Way to Help Farmers  The Wall Street Journal
    5. NWRA among groups pushing back on RFS proposal  Waste Dive

    Continue Reading

  • Eric Trump Removed From Board Role After Firm Consults Nasdaq

    Eric Trump Removed From Board Role After Firm Consults Nasdaq

    Topline

    A Trump Organization-backed crypto deal was quietly revised weeks after it was announced, with Eric Trump no longer joining the board of fintech firm Alt5 Sigma as initially planned, following the firm’s consultation with Nasdaq—though the company did not explain why.

    Key Facts

    Alt5 Sigma announced in August it would raise $1.5 billion through direct and private sales of its shares and use the proceeds to buy digital tokens from World Liberty Financial, a crypto startup whose cofounders include Donald Trump and his three sons.

    As part of the deal, Alt5 Sigma said “Eric Trump will become a director on its board of directors” and World Liberty Financial COO and fellow co-founder Zak Folkman would join as a board observer.

    Two weeks later, Alt5 Sigma disclosed in an SEC filing that, after discussions with Nasdaq, to comply with its listing rules, Trump would instead be a board observer and, subject to stockholder approval, Folkman would be appointed as a director.

    The filing did not specify which Nasdaq rule prompted the change, and the company offered no explanation.

    A Trump-affiliated LLC owns around 38% of World Liberty Financial, as well as 22.5 billion of its $WLFI tokens and is entitled to about 75% of the proceeds from token sales.

    Alt5, World Liberty Financial and Eric Trump did not respond to Forbes’ inquiries, and a Nasdaq spokesperson declined to comment.

    Why Was Eric Trump Relegated To A Board Observer?

    It’s not clear. The SEC filing said the change was made “after discussion with The Nasdaq Stock Market LLC (‘Nasdaq’), and in order to comply with Nasdaq’s listing rules.” But it did not specify which rule or explain why Eric Trump was replaced by another World Liberty Financial executive, Zak Folkman. Three securities law professors reviewed the filings at Forbes’ request, but none could identify a clear reason why Nasdaq would accept one appointee from the company while rejecting another. Nasdaq rules require a majority of board members at listed companies to be independent, but if Trump didn’t qualify as independent, it’s not clear why Folkman would. The change also does not appear to be related to Trump’s legal standing in New York, where he is barred from serving as an officer of a New York corporation, as Alt5 Sigma is incorporated in Nevada.

    Key Background

    World Liberty Financial launched in September 2024, presenting itself as a decentralized finance platform “inspired by the vision of Donald J. Trump.” It began selling non-transferable $WLFI tokens the following month to accredited and foreign investors, initially pricing them at $0.015, with a second round at $0.05. The tokens do not represent ownership in the company and are not backed by any underlying assets, but they allow holders to vote on rule changes to the protocol. In July, investors voted to allow early holders to sell a portion of their tokens, though founders—including the Trumps—remain restricted. As of Sept. 8, the tokens were trading at $0.2092, more than four times what many early investors paid, but down about 30% from their high on the public market.

    Big Number

    $1.5 billion—the market value of Alt5 Sigma’s $WLFI holdings as of Sept. 8, based on the token’s trading price of $0.2092. The company acquired 7.3 billion tokens at $0.18 each, meaning the stake has appreciated by about $210 million in less than a month.

    Crucial Quote

    “After discussion with The Nasdaq Stock Market LLC (‘Nasdaq’), and in order to comply with Nasdaq’s listing rules, Zachary Witkoff, has accepted his appointment as Chairman of the Board and is the initial nominee to the Board selected by WLF,” the SEC filing said. “Both Eric Trump and Zachary Folkman have been designated as observers. Subject to and following the approval of the Company’s stockholders in accordance with Nasdaq’s listing rules, the Board has also approved the appointment of Zachary Folkman, the other nominee to the Board selected by WLF, as a director.”

    Surprising Fact

    Alt5 Sigma’s website still lists Eric Trump as a director on both its leadership and investor relations pages, despite the SEC filing stating he is a board observer.

    News Peg

    Donald Trump is richer than ever. Forbes now estimates his net worth at $7.3 billion, up from $4.3 billion in 2024—driven largely by cryptocurrency holdings and the financial benefits of returning to the presidency. The $3 billion gain pushed him to No. 201 on this year’s Forbes 400, his highest rank ever. Other family members—Eric among them—also saw their fortunes surge.

    Tangent 1

    In the same SEC filing that disclosed Eric Trump’s role change, Alt5 Sigma revealed a Rwandan court had recently found its Canadian subsidiary and former principal, Andre Beauchesne, criminally liable for illicit enrichment and money laundering. The court dissolved the subsidiary, sentenced Beauchesne to prison and ordered the seizure of $3.5 million. The company and Beauchesne appealed in June, claiming they were the victims of fraud. Alt5 said its board only became aware of the ruling in late August.

    Tangent 2

    The same SEC filing also disclosed Alt5 Sigma received a summons and complaint in August tied to a bankruptcy case involving its former CFO, Virland Johnson. The complaint alleges Johnson failed to disclose restricted stock units entitling him to 330,000 shares in his January 2024 bankruptcy petition. U.S. trustees are seeking to recover the shares or their value from the company, which disputes any allegations against it.

    Further Viewing

    Further Reading

    “How Trump’s Sons Cashed In On Their Father’s Comeback” (Forbes)

    “Trump’s Crypto Firm Raised $52 Million—Likely Sending Millions To His Family, New Disclosure Reveals” (Forbes)

    “How Barron Trump May Have Earned $40 Million From His Dad’s Crypto Venture” (Forbes)

    “Crypto Now Accounts For Most Of Donald Trump’s Net Worth” (Forbes)

    “Trump’s New Partner For Crypto Venture Is KuCoin — An Exchange Banned In U.S., Fined $300 Million For Money Laundering” (Forbes)

    “Don Jr. And Eric Trump Joined By Three Trump Org Executives On Revived Advisory Board At Little-Known Firm” (Forbes)

    Continue Reading

  • Exposure to Air Pollution Worsens Alzheimer’s Disease

    Exposure to Air Pollution Worsens Alzheimer’s Disease

    Exposure to high concentrations of air pollution may worsen Alzheimer’s disease (AD) by accelerating the buildup of toxic proteins in the brain and speeding up cognitive decline. For the first time, post-mortem tissue from people with AD revealed that those who lived in areas with higher concentrations of fine particulate matter in the air even just one year had more severe accumulation of amyloid plaques and tau tangles—hallmarks of Alzheimer’s pathology—compared to those with less exposure. These individuals also experienced faster cognitive and functional decline, including memory loss, impaired judgment, and difficulty with personal care, according to research published today in JAMA Neurology from the Perelman School of Medicine at the University of Pennsylvania.

    “This study shows that air pollution doesn’t just increase the risk of dementia—it actually makes Alzheimer’s disease worse,” said Edward Lee, MD, PhD, co-director of Penn’s Institute on Aging. “As researchers continue to search for new treatments, it’s important to uncover all of the factors that contribute to the disease, including the influence of the environment in which they live.”

    Health risks from tiny air particles

    Air pollution is made up of fine particulate matter, or the tiny, inhalable particles, ranging from 10 micrometers to less than 2.5 micrometers wide, about half the width of a single strand of spider web. It can come from wildfire smoke, car exhaust, construction site debris, or combustion from factories. Particulate matter 2.5 micrometers and smaller (PM2.5) is so small that when inhaled, the particles can be absorbed into the blood stream and cause health concerns. Previous research has linked air pollution containing PM2.5 with dementia, loss of cognitive function, and accelerated cognitive decline.

    The researchers examined brain samples from over 600 autopsies from the Penn Medicine Brain Bank. Using data from satellites and local air quality monitors, the researchers modeled the amount of PM2.5 in the air based on where each person lived. They found that for every increase of 1 microgram per cubic meter of PM2.5, the risk for worse Alzheimer’s disease amyloid and tau buildup increased by 19 percent.

    Further, when they examined the clinical records of these individuals, researchers found that those who lived in areas with high concentrations of PM2.5 with advanced pathology also had greater cognitive impairment and more rapid onset of symptoms, including memory loss, difficulty with speech, and diminished judgement, compared to people who lived in areas with lower concentrations of air pollution.

    While this study focused on exposures to PM2.5 based on geographic location, researchers acknowledge that they could not account for individual-specific exposures to air pollution, such as exposure to second-hand smoke in the home, or working with potentially dangerous chemicals.

    “In the United States, air pollution is at the lowest levels in decades, but even just a year living in an area with high levels of pollution can have a big impact on a person’s risk for developing Alzheimer’s disease,” said Lee. “It underscores the value of environmental justice efforts that focus on reducing air pollution to improve public health.”

    Reference: Kim B, Blam K, Elser H, et al. Ambient air pollution and the severity of alzheimer disease neuropathology. JAMA Neurol. 2025. doi: 10.1001/jamaneurol.2025.3316

    This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source. Our press release publishing policy can be accessed here.

    Continue Reading

  • Sengun becomes youngest player to post EuroBasket triple-double

    Sengun becomes youngest player to post EuroBasket triple-double

    The official EuroBasket app

    RIGA (Latvia) – Türkiye superstar Alperen Sengun made another statement in his magical FIBA EuroBasket 2025 campaign by becoming the youngest player to register a triple-double in the competition’s history.

    The 23-year-old center scored 19 points, grabbed 12 rebounds and dished out 10 assists in helping Türkiye defeat Poland 91-77 in the Quarter-Finals – become the fifth player with a EuroBasket triple-double.

    Earlier in the tournament, Luka Doncic became only the fourth player since 1995 to post a triple-double in a EuroBasket game with 26 points, 11 assists and 10 rebounds in Slovenia’s 86-69 win over Belgium.

    Player

    Edition

    Age

    Triple-Double

    Alperen Sengun (TUR)

    2025

    23

    19 PTS, 12 REB, 10 AST

    Luka Doncic (SLO)

    2025

    26

    26 PTS, 10 REB, 11 AST

    Mateusz Ponitka (POL)

    2022

    29

    26 PTS, 16 REB, 10 AST

    Andrei Mandache (ROU)

    2017

    29

    14 PTS, 10 REB, 11 AST

    Toni Kukoc (CRO)

    1995

    26

    15 PTS, 12 REB, 11 AST

    *Stojan Vrankovic of Croatia posted a triple-double in FIBA EuroBasket 1993 which however is not taken into consideration as records of blocks before 1995 are not ratified.

    Sengun, who claimed TCL Player of the Game honors for his showing, is younger than any of Doncic, Mateusz Ponitka, Andrei Mandache and Toni Kukoc were when they achieved the feat.

    Sengun just missed a triple-double against Czechia in the second game of the tournament with 23 points, 12 rebounds and 9 assists.

    The big man also was close in the big showdown to close the group stage against Serbia and superstar Nikola Jokic with 28 points, 13 rebounds and 8 assists.

    FIBA

    Continue Reading