Author: admin

  • Brown, J. M. Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation. Br. J. Radiol. 52, 650–656 (1979).

    Google Scholar 

  • Hanahan, D. & Weinberg, R. A. Hallmarks of cancer: the next generation. Cell 144, 646–674 (2011).

    Google Scholar 

  • Hockel, M. & Vaupel, P. Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J. Natl Cancer Inst. 93, 266–276 (2001).

    Google Scholar 

  • Michiels, C., Tellier, C. & Feron, O. Cycling hypoxia: A key feature of the tumor microenvironment. Biochim. Biophys. Acta. 1866, 76–86 (2016).

    Google Scholar 

  • Span, P. N. & Bussink, J. Biology of hypoxia. Semin Nucl. Med. 45, 101–109 (2015).

    Google Scholar 

  • Tatum, J. L. et al. Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy. Int. J. Radiat. Biol. 82, 699–757 (2006).

    Google Scholar 

  • Thomlinson, R. H. & Gray, L. H. The histological structure of some human lung cancers and the possible implications for radiotherapy. Br. J. Cancer. 9, 539–549 (1955).

    Google Scholar 

  • Vaupel, P. & Mayer, A. Hypoxia in tumors: pathogenesis-related classification, characterization of hypoxia subtypes, and associated biological and clinical implications. Adv. Exp. Med. Biol. 812, 19–24 (2014).

    Google Scholar 

  • Muz, B., de la Puente, P., Azab, F. & Azab, A. K. The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy. Hypoxia (Auckl). 3, 83–92 (2015).

    Google Scholar 

  • Rankin, E. B. & Giaccia, A. J. Hypoxic control of metastasis. Science 352, 175–180 (2016).

    Google Scholar 

  • Rockwell, S., Dobrucki, I. T., Kim, E. Y., Marrison, S. T. & Vu, V. T. Hypoxia and radiation therapy: past history, ongoing research, and future promise. Curr. Mol. Med. 9, 442–458 (2009).

    Google Scholar 

  • Shannon, A. M., Bouchier-Hayes, D. J., Condron, C. M. & Toomey, D. Tumour hypoxia, chemotherapeutic resistance and hypoxia-related therapies. Cancer Treat. Rev. 29, 297–307 (2003).

    Google Scholar 

  • Walsh, J. C. et al. The clinical importance of assessing tumor hypoxia: relationship of tumor hypoxia to prognosis and therapeutic opportunities. Antioxid. Redox Signal. 21, 1516–1554 (2014).

    Google Scholar 

  • Brizel, D. M., Sibley, G. S., Prosnitz, L. R., Scher, R. L. & Dewhirst, M. W. Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck. Int. J. Radiat. Oncol. Biol. Phys. 38, 285–289 (1997).

    Google Scholar 

  • Brown, J. M. The hypoxic cell: a target for selective cancer therapy–eighteenth Bruce F. Cain memorial award lecture. Cancer Res. 59, 5863–5870 (1999).

    Google Scholar 

  • Denny, W. A. Hypoxia-activated prodrugs in cancer therapy: progress to the clinic. Future Oncol. 6, 419–428 (2010).

    Google Scholar 

  • Duan, J. X. et al. Potent and highly selective hypoxia-activated achiral phosphoramidate mustards as anticancer drugs. J. Med. Chem. 51, 2412–2420 (2008).

    Google Scholar 

  • Hunter, F. W., Wouters, B. G. & Wilson, W. R. Hypoxia-activated prodrugs: paths forward in the era of personalised medicine. Br. J. Cancer. 114, 1071–1077 (2016).

    Google Scholar 

  • Melillo, G. Targeting hypoxia cell signaling for cancer therapy. Cancer Metastasis Rev. 26, 341–352 (2007).

    Google Scholar 

  • Patel, A. & Sant, S. Hypoxic tumor microenvironment: opportunities to develop targeted therapies. Biotechnol. Adv. 34, 803–812 (2016).

    Google Scholar 

  • Phillips, R. M. Targeting the hypoxic fraction of tumours using hypoxia-activated prodrugs. Cancer Chemother. Pharmacol. 77, 441–457 (2016).

    Google Scholar 

  • Wigerup, C., Pahlman, S. & Bexell, D. Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer. Pharmacol. Ther. 164, 152–169 (2016).

    Google Scholar 

  • Wilson, W. R. & Hay, M. P. Targeting hypoxia in cancer therapy. Nat. Rev. Cancer. 11, 393–410 (2011).

    Google Scholar 

  • Zeman, E. M., Brown, J. M., Lemmon, M. J., Hirst, V. K. & Lee, W. W. SR-4233: a new bioreductive agent with high selective toxicity for hypoxic mammalian cells. Int. J. Radiat. Oncol. Biol. Phys. 12, 1239–1242 (1986).

    Google Scholar 

  • Oostveen, E. A. & Speckamp, W. N. Mitomycin Analogs.1. Indoloquinones as (Potential) bisalkylating agents. Tetrahedron 43, 255–262 (1987).

    Google Scholar 

  • Patterson, A. V. et al. Mechanism of action and preclinical antitumor activity of the novel hypoxia-activated DNA cross-linking agent PR-104. Clin. Cancer Research: Official J. Am. Association Cancer Res. 13, 3922–3932 (2007).

    Google Scholar 

  • Nishida, C. R. & de Ortiz, P. R. Reductive heme-dependent activation of the n-oxide prodrug AQ4N by nitric oxide synthase. J. Med. Chem. 51, 5118–5120 (2008).

    Google Scholar 

  • Liu, Q. et al. TH-302, a hypoxia-activated prodrug with broad in vivo preclinical combination therapy efficacy: optimization of dosing regimens and schedules. Cancer Chemother. Pharmacol. 69, 1487–1498 (2012).

    Google Scholar 

  • Patterson, A. V. et al. The hypoxia-activated EGFR-TKI TH-4000 overcomes erlotinib-resistance in preclinical NSCLC models at plasma levels achieved in a phase 1 clinical trial. Cancer Res. 75 (15_Supplement), 5358 (2015).

    Google Scholar 

  • Patterson, A. V. et al. TH-4000, a hypoxia-activated EGFR/Her2 inhibitor to treat EGFR-TKI resistant T790M-negative NSCLC. J. Clin. Oncol. 33, e13548–e13548 (2015).

    Google Scholar 

  • Abbattista, M. R. et al. Pre-clinical activity of PR-104 as monotherapy and in combination with Sorafenib in hepatocellular carcinoma. Cancer Biol. Ther. 16, 610–622 (2015).

    Google Scholar 

  • Benito, J. et al. Hypoxia-Activated prodrug TH-302 targets hypoxic bone marrow niches in preclinical leukemia models. Clin. Cancer Research: Official J. Am. Association Cancer Res. 22, 1687–1698 (2016).

    Google Scholar 

  • Del Rowe, J. et al. Single-arm, open-label phase II study of intravenously administered Tirapazamine and radiation therapy for glioblastoma multiforme. J. Clin. Oncol. 18, 1254–1259 (2000).

    Google Scholar 

  • Konopleva, M. et al. Phase I/II study of the hypoxia-activated prodrug PR104 in refractory/relapsed acute myeloid leukemia and acute lymphoblastic leukemia. Haematologica 100, 927–934 (2015).

    Google Scholar 

  • Masunaga, S. et al. Usefulness of combined treatment with continuous administration of Tirapazamine and mild temperature hyperthermia in gamma-ray irradiation in terms of local tumour response and lung metastatic potential. Int. J. Hyperth. 28, 636–644 (2012).

    Google Scholar 

  • Sun, J. D. et al. Selective tumor hypoxia targeting by hypoxia-activated prodrug TH-302 inhibits tumor growth in preclinical models of cancer. Clin. Cancer Research: Official J. Am. Association Cancer Res. 18, 758–770 (2012).

    Google Scholar 

  • Groshar, D. et al. Imaging tumor hypoxia and tumor perfusion. J. Nucl. Med. 34, 885–888 (1993).

    Google Scholar 

  • Lee, C. T., Boss, M. K. & Dewhirst, M. W. Imaging tumor hypoxia to advance radiation oncology. Antioxid. Redox Signal. 21, 313–337 (2014).

    Google Scholar 

  • Minn, H. et al. Imaging of tumor hypoxia to predict treatment sensitivity. Curr. Pharm. Design. 14, 2932–2942 (2008).

    Google Scholar 

  • Pacheco-Torres, J., Lopez-Larrubia, P., Ballesteros, P. & Cerdan, S. Imaging tumor hypoxia by magnetic resonance methods. NMR Biomed. 24, 1–16 (2011).

    Google Scholar 

  • Reischl, G. et al. Imaging of tumor hypoxia with [124I]IAZA in comparison with [18F]FMISO and [18F]FAZA–first small animal PET results. J. Pharm. Pharm. Sciences: Publication Can. Soc. Pharm. Sci. Societe Canadienne des. Sci. Pharmaceutiques. 10, 203–211 (2007).

    Google Scholar 

  • Vaupel, P. & Mayer, A. The clinical importance of assessing tumor hypoxia: relationship of tumor hypoxia to prognosis and therapeutic opportunities. Antioxid. Redox Signal. 22, 878–880 (2015).

    Google Scholar 

  • Baudelet, C. & Gallez, B. How does blood oxygen level-dependent (BOLD) contrast correlate with oxygen partial pressure (pO2) inside tumors? Magn. Reson. Med. 48, 980–986 (2002).

    Google Scholar 

  • Ding, Y. et al. Simultaneous measurement of tissue oxygen level-dependent (TOLD) and blood oxygenation level-dependent (BOLD) effects in abdominal tissue oxygenation level studies. J. Magn. Reson. Imaging. 38, 1230–1236 (2013).

    Google Scholar 

  • O’Connor, J. P. et al. Oxygen-Enhanced MRI accurately Identifies, Quantifies, and maps tumor hypoxia in preclinical cancer models. Cancer Res. 76, 787–795 (2016).

    Google Scholar 

  • Gulaka, P. K. et al. GdDO3NI, a nitroimidazole-based T1 MRI contrast agent for imaging tumor hypoxia in vivo. J. Biol. Inorg. Chem. 19, 271–279 (2014).

    Google Scholar 

  • Rojas-Quijano, F. A. et al. Synthesis and characterization of a hypoxia-sensitive MRI probe. Chemistry 18, 9669–9676 (2012).

    Google Scholar 

  • Mason, R. P., Rodbumrung, W. & Antich, P. P. Hexafluorobenzene: a sensitive 19F NMR indicator of tumor oxygenation. NMR Biomed. 9, 125–134 (1996).

    Google Scholar 

  • Kodibagkar, V. D., Cui, W., Merritt, M. E. & Mason, R. P. Novel 1H NMR approach to quantitative tissue oximetry using hexamethyldisiloxane. Magn. Reson. Med. 55, 743–748 (2006).

    Google Scholar 

  • Kodibagkar, V. D., Wang, X., Pacheco-Torres, J., Gulaka, P. & Mason, R. P. Proton imaging of siloxanes to map tissue oxygenation levels (PISTOL): a tool for quantitative tissue oximetry. NMR Biomed. 21, 899–907 (2008).

    Google Scholar 

  • Agarwal, S., Gulaka, P. K., Rastogi, U. & Kodibagkar, V. D. More bullets for PISTOL: linear and Cyclic siloxane reporter probes for quantitative (1)H MR oximetry. Sci. Rep. 10, 1399 (2020).

    Google Scholar 

  • Hoehn-Berlage, M., Tolxdorff, T., Bockhorst, K., Okada, Y. & Ernestus, R. I. In vivo NMR T2 relaxation of experimental brain tumors in the cat: a multiparameter tissue characterization. Magn. Reson. Imaging. 10, 935–947 (1992).

    Google Scholar 

  • Zhao, D., Jiang, L. & Mason, R. P. Measuring changes in tumor oxygenation. Methods Enzymol. 386, 378–418 (2004).

    Google Scholar 

  • Dula, A. N., Gochberg, D. F., Valentine, H. L., Valentine, W. M. & Does, M. D. Multiexponential T2, magnetization transfer, and quantitative histology in white matter tracts of rat spinal cord. Magn. Reson. Med. 63, 902–909 (2010).

    Google Scholar 

  • Harkins, K. D., Valentine, W. M., Gochberg, D. F. & Does, M. D. In-vivo multi-exponential T2, magnetization transfer and quantitative histology in a rat model of intramyelinic edema. Neuroimage Clin. 2, 810–817 (2013).

    Google Scholar 

  • Stokes, A. M., Hart, C. P. & Quarles, C. C. Hypoxia imaging with PET correlates with antitumor activity of the Hypoxia-Activated prodrug Evofosfamide (TH-302) in rodent glioma models. Tomography 2, 229–237 (2016).

    Google Scholar 

  • Takakusagi, Y. et al. Pyruvate induces transient tumor hypoxia by enhancing mitochondrial oxygen consumption and potentiates the anti-tumor effect of a hypoxia-activated prodrug TH-302. PLoS One. 9, e107995 (2014).

    Google Scholar 

  • Cherk, M. H. et al. Lack of correlation of hypoxic cell fraction and angiogenesis with glucose metabolic rate in non-small cell lung cancer assessed by 18F-Fluoromisonidazole and 18F-FDG PET. J. Nucl. Med. 47, 1921–1926 (2006).

    Google Scholar 

  • Piert, M. et al. Hypoxia-specific tumor imaging with 18F-fluoroazomycin arabinoside. J. Nucl. Med. 46, 106–113 (2005).

    Google Scholar 

  • Solomon, B. et al. Modulation of intratumoral hypoxia by the epidermal growth factor receptor inhibitor gefitinib detected using small animal PET imaging. Mol. Cancer Ther. 4, 1417–1422 (2005).

    Google Scholar 

  • Lin, Y., Wang, X. & Jin, H. EGFR-TKI resistance in NSCLC patients: mechanisms and strategies. Am. J. Cancer Res. 4, 411–435 (2014).

    Google Scholar 

  • Choi, K., Creighton, C. J., Stivers, D., Fujimoto, N. & Kurie, J. M. Transcriptional profiling of non-small cell lung cancer cells with activating EGFR somatic mutations. PLoS One. 2, e1226 (2007).

    Google Scholar 

  • Anderson, N. G., Ahmad, T., Chan, K., Dobson, R. & Bundred, N. J. ZD1839 (Iressa), a novel epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, potently inhibits the growth of EGFR-positive cancer cell lines with or without erbB2 overexpression. Int. J. Cancer. 94, 774–782 (2001).

    Google Scholar 

  • Brown, J. M. & Wilson, W. R. Exploiting tumour hypoxia in cancer treatment. Nat. Rev. Cancer. 4, 437–447 (2004).

    Google Scholar 

  • Wilson, W. R. et al. Bystander effects of bioreductive drugs: potential for exploiting pathological tumor hypoxia with Dinitrobenzamide mustards. Radiat. Res. 167, 625–636 (2007).

    Google Scholar 

  • Arvold, N. D., Heidari, P., Kunawudhi, A., Sequist, L. V. & Mahmood, U. Tumor hypoxia response after targeted therapy in EGFR-Mutant Non-Small cell lung cancer: proof of concept for FMISO-PET. Technol. Cancer Res. Treat. 15, 234–242 (2016).

    Google Scholar 

  • Bains, L. J., Baker, J. H., Kyle, A. H., Minchinton, A. I. & Reinsberg, S. A. Detecting vascular-targeting effects of the hypoxic cytotoxin Tirapazamine in tumor xenografts using magnetic resonance imaging. Int. J. Radiat. Oncol. Biol. Phys. 74, 957–965 (2009).

    Google Scholar 

  • Baker, J. H. et al. Targeting the tumour vasculature: exploitation of low oxygenation and sensitivity to NOS Inhibition by treatment with a hypoxic cytotoxin. PLoS One. 8, e76832 (2013).

    Google Scholar 

  • Huxham, L. A., Kyle, A. H., Baker, J. H., McNicol, K. L. & Minchinton, A. I. Tirapazamine causes vascular dysfunction in HCT-116 tumour xenografts. Radiother Oncol. 78, 138–145 (2006).

    Google Scholar 

  • Huxham, L. A., Kyle, A. H., Baker, J. H., McNicol, K. L. & Minchinton, A. I. Exploring vascular dysfunction caused by Tirapazamine. Microvasc Res. 75, 247–255 (2008).

    Google Scholar 

Continue Reading

  • Trading at PSX turns choppy as investors lock in gains

    Trading at PSX turns choppy as investors lock in gains

    Trading at the Pakistan Stock Exchange remained choppy on Wednesday as early optimism faded in the face of mounting profit-taking. This volatile performance came after a sustained rally over recent sessions, prompting investors to adopt a cautious stance.

    The benchmark KSE-100 index kicked off the session on a bullish footing, racing to an intra-day peak of 175,232.90 and briefly breaching the landmark 175,000-point level for the first time. However, the momentum could not be sustained. As the session progressed, investors chose to lock in gains, prompting a gradual retreat from the day’s highs. As a result, the index slipped to an intra-day low of 173,564.33 amid broad-based selling.

    Pressure was most evident in heavyweight sectors such as automobile assemblers, commercial banks, power generation, and refineries, which collectively dragged the market lower. By the close, the KSE-100 index ended in negative territory, shedding 418.47 points, or 0.24%, to settle at 174,054.32.

    Meanwhile, the broader market outlook remains constructive despite near-term volatility. The KSE-100 index emerged as the second-best performing frontier market in CY25, delivering a robust 51% return and closing the year at a fresh record high, Arif Habib Limited (AHL) reported.  

    This performance extends its three-year streak of double-digit gains, following returns of 55% in CY23 and an exceptional 84% in CY24, with only Romania outperforming Pakistan among frontier markets.
    Over the past three years, the index has generated an average annual return of 64%, placing it among the top-performing equity markets globally. In dollar terms, cumulative returns reached 249%, a level unmatched by any other market over the same three-year period, AHL wrote.

    Overall trading volume increased to 957.2million shares compared with Tuesday’s tally of 851milion. Value of traded shares stood at Rs44.2 million. Shares of 481 companies were traded. Of these, 221 closed higher, 223 fell and 37 remained unchanged. K-Electric was the volume topper with trading in 95.9 million shares, gaining Rs0.21 to close at Rs5.93.

    Continue Reading

  • Engineering Innovation: Cedarville Prof Reinvents Bridge Safety

    Engineering Innovation: Cedarville Prof Reinvents Bridge Safety

    Engineering the Future of Infrastructure

    Strengthening America’s infrastructure starts with innovation — and one Cedarville University researcher is helping lead that charge. Dr. Hema Jayaseelan, assistant professor of civil engineering at Cedarville University, has received national recognition for pioneering research that could reshape how engineers design, monitor and maintain bridges across the United States and beyond. 

    Smarter Models, Safer Bridges

    With more than 20 years of structural engineering experience, Jayaseelan has developed advanced analytical models that more accurately predict “pre-stress losses” in concrete bridges — the gradual reduction of internal tension that weakens structural performance over time. When these losses are miscalculated, bridges can experience deflections, vibrations and cracking that shorten their expected 50- to 75-year lifespan, creating costly and potentially hazardous outcomes. 

    Jayaseelan discovered that many traditional Department of Transportation (DOT) formulas overestimate or underestimate pre-stress losses. Her groundbreaking study introduced a data-driven method that uses real-time information from instrumented bridges, producing predictions that closely align with actual field performance. 

    National Recognition and Industry Impact

    Her peer-reviewed paper, “Assessment and Validation of Prestresses Loss Prediction Models Using Real-Time Prestress Loss Measurements,” applied the new method of monitoring bridge data. Coauthored with structural engineering experts Alla Eddine Acheli, Ph.D.; Bruce W. Russell, Ph.D., P.E., S.E., F.A.C.I.; Walter Peters, P.E.; and Chris Filip, the piece was published in the 2024 September to October issue of the PCI journal. The research earned the 2025 Charles C. Zollman Award from the Precast/Prestressed Concrete Institute (PCI), honoring the year’s best technical paper discussing the use of precast concrete in transportation infrastructure. 

    “We were humbled and grateful to receive the PCI award,” Jayaseelan said. “It’s a blessing and a reminder that God’s timing is perfect. The recognition shows that DOTs nationwide are beginning to see the importance of this research.” 

    Her work has also been nominated for the prestigious T.Y. Lin Award from the American Society of Civil Engineers (ASCE), one of the highest honors in global structural engineering. The award celebrates research that advances the science and practice of prestressed concrete design and construction — a vital component of resilient infrastructure worldwide.

    From South India to Smart Bridges

    Jayaseelan’s passion for building began in Coimbatore, South India, where she grew up exploring how structures worked. “I’ve always loved working with my hands — playing in the mud, getting dirty. That’s still what I do today in the lab,” she said. 

    After earning her bachelor’s degree in civil engineering from the Government College of Technology in India and a master’s degree from Oklahoma State University, Jayaseelan pursued doctoral research at Oklahoma State integrating real-time data from sensors embedded in bridges — technology she describes as “listening to a structure’s heartbeat.” 

    These sensors use smart technology, solar power and wireless connectivity to transmit data remotely, allowing engineers to continuously monitor bridge performance. By combining traditional engineering principles with advanced data analysis, Jayaseelan’s approach creates an early warning system that can detect potential structural issues before they become critical. 

    Advancing Global Infrastructure Standards

    Her current collaboration with U.S. Department of Transportation officials aims to simplify the new predictive equations for integration into national and international bridge design codes, supporting safer, longer-lasting infrastructure. 

    “We can’t change everything overnight,” Jayaseelan said. “But through smaller, smarter improvements guided by real-time data and sound engineering, we can make bridges stronger, safer and built to last.” 

    Jayaseelan’s research underscores a global movement toward smarter, sensor-integrated infrastructure — aligning with worldwide efforts to improve sustainability, safety and resilience in public works. 

    About Cedarville University

    Cedarville University, an evangelical Christian institution in southwest Ohio, offers undergraduate and graduate residential and online programs across arts, sciences and professional fields. With 7,265 students, it is among Ohio’s largest private universities and is ranked among the nation’s top five evangelical universities in the Wall Street Journal’s 2026 Best Colleges in the U.S. Cedarville is also known for its vibrant Christian community, challenging academics and high graduation and retention rates. Learn more at cedarville.edu.  

    Continue Reading

  • Dozens of pubs hit by power cuts ahead of Edinburgh’s Hogmanay

    Dozens of pubs hit by power cuts ahead of Edinburgh’s Hogmanay

    Owners of the bars have written a letter to the chief executive of SP Energy Networks about the problems with power cuts, which they say they have suffered during the festive periods since 2021.

    The letter, which has been copied to City of Edinburgh Council’s chief executive Paul Lawrence and local MSP Angus Robertson, says there is “deep concern” about the problem.

    It reads: “While we appreciate SP Energy Networks’ apologies and the assurance that network condition reviews are underway, the recurring nature of these outages indicates systemic vulnerabilities that require urgent and permanent solutions.

    “The current approach of reactive repairs is insufficient to safeguard businesses and customers in this critical hospitality district.”

    The businesses said they were counting the cost of multiple power failures that have driven party-goers from the area.

    It said “the longstanding issue remained unresolved”.

    Some venues have reported experiencing power cuts multiple times a day during the festive season, “putting Christmas trade in the dark”.

    In one December weekend alone, Grassmarket businesses lost the whole of Friday night’s service and the entire Saturday lunch service, meaning thousands of pounds in lost revenue across a number of venues.

    “Meanwhile, business costs remain. Staff must still be paid in case power returns, food is wasted, and bookings are lost,” the letter’s authors said.

    Continue Reading

  • PSX Says Goodbye to 2025 By Achieving 2nd Best Frontier Market Status

    PSX Says Goodbye to 2025 By Achieving 2nd Best Frontier Market Status

    KSE-100 achieved an impressive 51 percent return in CY25, closing at a new high and extending its three-year streak of double-digit growth, following gains of 55 percent in CY23 and 84 percent in CY24.

    According to Arif Habib Limited (PSX), the index also ranked as the second-best performing frontier market during the year, after Romania.

    Over the last three years, the average annual return stands at 64 percent, positioning the KSE-100 among the top-performing global markets over this period.

    In USD terms, the market generated cumulative returns of 249 percent over the last three years, a level unmatched by any other market on a three-year cumulative basis.

    The KSE-100 outperformed other asset classes such as real estate (17 percent), PIBs (12 percent), T-bills (12 percent), Defence Savings Certificates (11 percent), and bank deposits (9 percent), while gold delivered higher returns of 65 percent over the same timeframe.

    Despite periods of short-term volatility, the market has demonstrated sustained long-term growth, with 30-year returns of 23 percent, 25-year returns of 27 percent, 20-year returns of 21 percent, 15-year returns of 23 percent, 10-year returns of 22 percent, and 5-year returns of 37 percent, underscoring its resilience.


    Continue Reading

  • Chinese premier chairs State Council executive meeting on water network construction

    Chinese premier chairs State Council executive meeting on water network construction

    BEIJING, Dec. 31 — Chinese Premier Li Qiang Wednesday chaired a State Council executive meeting at which…

    Continue Reading

  • Heated Rivalry author reveals TV series has helped her Parkinson’s treatment

    Heated Rivalry author reveals TV series has helped her Parkinson’s treatment

    Thanks to the success of the hit TV adaptation of Heated Rivalry, its author has been able to afford specialist Parkinson’s treatment, she has revealed.

    Canadian show Heated Rivalry, which tells the story of a same-sex relationship between two ice…

    Continue Reading

  • Xiaomi refreshes Photo Editor with new features for HyperOS 3 devices – Huawei Central

    1. Xiaomi refreshes Photo Editor with new features for HyperOS 3 devices  Huawei Central
    2. Xiaomi HyperOS 3.0 Rollout: Full List of Eligible Devices Getting the Update Before 2026  Nokiamob
    3. Xiaomi reveals the list of Redmi and POCO cell phones that will…

    Continue Reading

  • Any breach of territorial integrity to face decisive response: CDF – RADIO PAKISTAN

    1. Any breach of territorial integrity to face decisive response: CDF  RADIO PAKISTAN
    2. CDF Munir warns of ‘firm and decisive’ response if Pakistan’s territorial integrity is violated  Dawn
    3. CDF lauds Balochistan’s patriotism, vows to thwart…

    Continue Reading

  • Pakistan Expresses Concern Over Resurgence of Violence in Yemen

    Pakistan expresses deep concern over resurgence of violence in Yemen. Pakistan reiterates its support for the unity and territorial integrity of Yemen, as well as all efforts aimed at establishing lasting peace and…

    Continue Reading