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A network analysis of the depression and anxiety comorbidity: a nationwide survey among Chinese adolescents during the normalization phase of COVID-19 pandemic prevention and control | BMC Psychiatry
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Post your questions for Rosanna Arquette | Film

Rosanna Arquette – the older sister of actors Patricia and David – found fame as the bored housewife to Madonna’s bohemian drifter in 1985’s Desperately Seeking Susan. Elsewhere in your cinematic memory, she helped save Uma Thurman from accidentally overdosing in Pulp Fiction, and had her fishnet stockings ripped off by James Spader in David Cronenberg’s Crash.

But Arquette has been in all sorts of films, opposite all sorts of actors: she co-starred with Joe Pesci and Danny Glover in trip gone wrong comedy Gone Fishin’, Tim Roth and Renée Zellweger in mystery film Liar, and Christina Ricci, Vincent Gallo and Mickey Rourke in Buffalo 66. In the 2000s, she starred in the thriller Diary of a Sex Addict, as the wife of an otherwise happily married chef who has a penchant for – well, the clue is in the title.

A move into directing saw her direct and produce Searching for Debra Winger, a documentary about the American actor who left the industry at the height of her career, which was selected for the Cannes film festival. And in 2011, Arquette teamed up with Jane Fonda for comedy drama Peace, Love, and Misunderstanding. On TV, she has popped up everywhere from Will & Grace to Malcolm in the Middle and Ray Donovan.

Now Arquette has a role in “mind-bending new romantic sci-fi” Futra Days, in which she plays a doctor with a time machine for rent, which sounds oddly familiar … Please get your questions in by 6pm BST Wednesday 2 July, and we’ll print her answers in Film&Music later that month.

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DS PENSKE to field Kvyat and Bedrin in Berlin

Bedrin is multiple winner in international karting competition, having made headlines by dominating the 2020 WSK Super Master Series (OK), where he won heats, qualifying sessions, prefinals, and finals over the final two rounds.

More recently, he captured his first FIA Formula 3 Sprint Race victory in 2024, confirming his potential at the highest levels of junior single-seater racing.

As part of the Penske Driver Development Program, Bedrin will work closely with the DS PENSKE engineering team, contributing to simulator development and gaining valuable insight into the technical and strategic demands of electric racing at the elite level.

“We’re thrilled to welcome Nikita into our development structure,” said Deputy Team Principal Phil Charles. “His talent is undeniable, and we believe he has the mindset and dedication to thrive within the DS PENSKE environment.”

Kvyat tests Formula E machinery once more

The former Formula 1 driver has taken part in rookie sessions before, at the Rookie Test in Berlin with then-NIO 333. The Russian also took the wheel of the DS E-TENSE FE25 during the FP0 session at the Jeddah Corniche Circuit earlier this season.

READ MORE: Everything you need to know about the Rookie Free Practice session in Jeddah

Kvyat, 30, is an accomplished driver with extensive experience in top-tier motorsport. Having competed in multiple Formula 1 seasons with teams such as Red Bull Racing and Scuderia Toro Rosso, Kvyat has demonstrated skill and adaptability at the top level.

“With podium finishes and years of experience in high-pressure race environments, he brings a wealth of knowledge and expertise to the DS PENSKE squad,” say the team.

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RWE to produce solar power for KRONOS TITAN at Nordenham site

RWE and KRONOS TITAN (KRONOS) are breaking new ground in the sustainable energy supply of industrial sites. RWE plans to build and operate a ground-mounted photovoltaic plant with an output of 24.7 megawatts peak on a 20-hectare site at the KRONOS location in Nordenham, Lower Saxony. RWE has leased the land for this project from KRONOS, and KRONOS will purchase the green electricity generated there by means of a long-term PPA. Construction of the solar plant is scheduled to begin in summer, with commissioning planned for spring 2026.

Carsten Büsing, Plant Manager of KRONOS TITAN GmbH at the Nordenham site: “We are delighted to be working with RWE to lead our site into a more sustainable future. With the new solar farm, we can cover a significant part of our energy needs with green electricity. This plant plays a crucial role in achieving our transformation goals and underlines our commitment to environmentally friendly solutions at the site.”

Katja Wünschel, CEO RWE Renewables Europe & Australia GmbH: “The joint project with KRONOS TITAN shows how industrial customers can play an active role in the energy transition. They provide land and we take over the planning, construction, investment and operation of the solar farm. The customer receives long-term green electricity at predictable conditions. In this way, we combine our expertise in the expansion of renewable energies with our experience in energy trading.”

A total of around 38,200 solar modules will generate approximately 22,000 megawatt hours of electricity per year, enough to cover a significant part of KRONOS’ electricity requirements at the Nordenham site. The immediate neighbours have also been notified about the joint project of RWE and KRONOS.

An image for media purposes is available in the RWE media library (Image rights: KRONOS TITAN).

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Citizen scientists spot rare exploding star in real-time

Previously described as playing astronomical ‘spot the difference,’ Kilonova Seekers asks the public to compare the latest images of a section of night sky to an image of the same section of space taken on previous nights. Their goal – to spot new stars or significant changes in light intensity that may indicate that something remarkable has happened in space.

Published today (July 1) in Astronomy & Astrophysics, the project has announced its first published major discovery – a bright exploding star.

The object underwent an extreme brightening (increasing by 2500 times) that was not seen when compared to the image taken 2 days earlier. The quick response and diligent work of the public allowed the object to be studied and classified early in its evolution, identifying it as a cataclysmic variable star, and given the name GOTO0650.

Co-lead of Kilonova Seekers, Dr. Tom Killestein, Warwick Prize Fellow in the Astronomy and Astrophysics group, University of Warwick said: “Kilonova Seekers is a unique opportunity for members of the public to take part in true real-time astrophysics. Remarkably, public volunteers identified this star as an object of interest within 3 1/2 hours of the image being taken by the GOTO telescopes – this discovery could have been missed among many other objects without their efforts.

“The involvement of the volunteers didn’t stop there, as there was a huge follow-up response from the public. It was flagged for further observations from the Swift and Einstein Probe space observatories, and GOTO0650 was bright enough for amateur astronomers to take impressively high-quality observations of with their own equipment, which formed a key part of the paper and really helping us understand the object.”

Cataclysmic variable stars sporadically increase in brightness by large amounts before dropping back to normal levels. They are compact binary star systems, consisting of a white dwarf star stealing matter from its companion donor star. Periodically, material from the donor star hits a critical density and temperature within the disc of gas that surrounds the white dwarf, which causes an explosive outburst and bright flashes of light.

The fast response of the public enabled the team to get an unusually highly complete dataset on the star, including spectroscopy, X-ray, and UV measurements, supplemented by the impressively high-quality observations of the amateur astronomers. These observations suggest it is a period bouncer, the final state of a cataclysmic variable star, and a rare object to find even in the age of widespread wide-field imaging surveys.

Co-lead of Kilonova Seekers, Dr Lisa Kelsey, Leverhulme Early Career Fellow, Institute of Astronomy and Kavli Institute for Cosmology, Cambridge said: “Citizen science is a powerful way to make novel serendipitous discoveries in vast datasets that would normally need to be analysed in depth by scientists.

“With over 2.8 million classifications so far, the discovery of GOTO0650 is really the pinnacle of 2 years of consistent hard work from our volunteers. Without the Kilonova Seekers volunteers flagging this object, rapid follow-up would not have been possible, and this object may have been missed entirely.”

The Kilonova Seekers Project is approaching its two-year anniversary of inviting members of the public to analyse near real-time data collected from the Warwick-led Gravitational-wave Optical Transient Observer (GOTO) project. This project takes all-sky survey images of space from two arrays of telescopes located on opposite sides of the planet — in Spain and Australia.

The vast numbers of observations taken in these imaging surveys will soon be beyond the capacity of individual and small teams of scientists to label and validate. Citizen Science is a viable, mutually beneficial solution to avoid objects like GOTO0650 being missed.

As a shining example of such efforts, Kilonova Seekers has provided over 3,500 members of the public with the opportunity to discover supernovae and variable stars using real data. With volunteers from around the world, there is almost always someone online looking at the data in real-time.

Svetoslav Alexandrov, Kilonova Seekers Volunteer based in Bulgaria said: “Traffic in Sofia, Bulgaria, is always awful during the mornings so I have to pass time on the bus somehow, and contributing to citizen science is an excellent way to do that! Kilonova Seekers is on the top of my list, because it’s mobile-friendly and most importantly, it offers us fresh imagery almost every single day.

“I literally screamed with joy when I saw that I was going to be a co-author of the research paper. I’m certain that people on the street raised their eyebrows when they saw me screaming and dancing, but I didn’t care. I knew I am a co-discoverer of something significant, and this was all that mattered”

Cledison Marcos da Silva, Kilonova Seekers Volunteer based in Brazil said: “This discovery was very important to me, as I was going through a serious health problem and the citizen science we do at Kilonova Seekers was distracting me from my situation. I never imagined that we would discover such a bright transient, so it was a huge surprise, and we were very happy when we found out. This discovery shows the importance of citizen science, both scientifically and personally. Even from your bed, or on the street with your cell phone, there is the possibility of making a very important discovery.”

Mayahuel Torres-Guerrero, Kilonova Seekers Volunteer based in Mexico said: “The journey from the discovery of GOTO0650 to the publication of the paper in Astronomy & Astrophysics has been personally rewarding. I had the opportunity to learn how to download data from LCO telescopes and to produce light curves that allowed us to monitor echo outbursts. It was very exciting when GOTO0650 produced an echo outburst on Christmas Day and New Year’s Day! It was a great journey for someone who has studied social sciences like me!”

GOTO is a network of telescopes that is principally funded by the Science and Technology Facilities Council (STFC) and operated by the University of Warwick at the Roque de los Muchachos Observatory on La Palma, Spain, and Siding Spring Observatory in NSW, Australia, on behalf of a consortium including the University of Warwick, Monash University, Armagh Observatory & Planetarium, the University of Leicester, the University of Sheffield, the National Astronomical Research Institute of Thailand (NARIT), the University of Turku, the University of Portsmouth, the University of Manchester and the Instituto de Astrofisica de Canarias (IAC).

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WIN: An Exclusive WhatsApp Call With George!

Ever wanted to sit down and have a chat with George Russell? Well, this is your chance.

With his home Grand Prix on the horizon, we’re giving one lucky fan the chance to win a WhatsApp call with George.

A track that has provided George so many brilliant memories in his racing career, Silverstone is the perfect place to launch our latest fan competition.

Sign-up below to be in with a chance winning. It could be you who answers the phone and gets to say: ‘Blimey, hi George!’

Full T&Cs can be found at the bottom of this page.

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Metabolite Succinate Linked to IBD Progression

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Northwestern Medicine investigators have identified a surprising culprit in the progression of inflammatory bowel disease: a naturally occurring metabolic compound in the gut, according to a study published in Nature Immunology.

Inflammatory bowel disease (IBD), a chronic condition that includes Crohn’s disease and ulcerative colitis, is characterized by persistent inflammation of the gastrointestinal tract. It affects millions worldwide and can lead to debilitating symptoms such as abdominal pain, diarrhea, fatigue and weight loss. While the exact causes of IBD remain unclear, it is widely believed to be influenced by a mix of genetic, environmental and immune factors.

The new study revealed that elevated levels of the metabolite succinate may actively contribute to the disease by disrupting the function of regulatory T-cells (Tregs), which are essential for maintaining immune balance and preventing runaway inflammation.

The findings shed light on a previously unknown mechanism that could open new avenues for treatment, said Deyu Fang, PhD, the Hosmer Allen Johnson Professor of Pathology, who was senior author of the study.

“Succinate is a normal metabolite we all have, but levels are increased in the blood, gut and stool of colitis patients and those with other inflammatory diseases,” Fang said. “We’ve known this for years. But how succinate causes inflammation, we don’t know much about.”

In the study, Fang and his collaborators observed mice that consumed succinate in their drinking water. They found that higher succinate levels were associated with more severe symptoms of colitis, according to the findings.

Next, investigators administered succinate to cultured Treg cells from mice. They found that succinate impairs the expression of FOXP3, a key protein essential for the suppressive function of Tregs. This disruption makes FOXP3 more vulnerable to degradation. As a result, Tregs lose their ability to control inflammation, leading to more severe colitis in mouse models.

Further experiments demonstrated that deleting the gene Dlst mimicked the effects of high succinate levels, resulting in reduced FOXP3 expression, impaired Treg function and increased gut inflammation. However, restoring FOXP3 levels in these cells reversed the damage, highlighting the central role of this protein in immune regulation.

The study also examined samples from people with IBD and found that their Treg cells had lower levels of FOXP3, which correlated with higher succinate levels and more severe inflammation.

“This gives us a better understanding of why people have colitis,” Fang said. “One of the reasons is that increased succinate impairs the Treg immunosuppressive function through a direct mechanism. That’s the clinical implication that will help us to understand the pathogenesis of the disease.”

The discovery could pave the way for new therapeutic strategies aimed at restoring Treg function or targeting succinate metabolism to treat IBD more effectively, Fang said.

Next, Fang and his colleagues will examine other immune cells in patients with IBD to understand how and why succinate levels are heightened in the disease, he said.

“The bacteria that make succinate are actually ‘good’ bacteria and probiotic in the gut microbiome, not the bad ones, so it’s really puzzling the field,” Fang said. “We don’t know exactly why succinate levels increase in active disease and return to normal in recovery, but this study may provide a clue for us to understand.”

Reference: Wang H, Hu D, Cheng Y, et al. Succinate drives gut inflammation by promoting FOXP3 degradation through a molecular switch. Nat Immunol. 2025;26(6):866-880. doi: 10.1038/s41590-025-02166-y

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Taiwan’s currency jumps as life insurers rush to hedge against weak US dollar – Financial Times

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Death toll rises to 36 after India pharmaceutical factory blast, fire | Workers’ Rights News

Another 36 workers remain in hospital with burns and other injuries after the blast and fire at the Sigachi factory.

At least 36 people have been confirmed dead after a powerful explosion triggered a fire at a pharmaceutical factory in the southern Indian state of Telangana.

“The condition of the bodies is such that we’ve had to deploy a specialised medical team to carry out DNA tests,” said Health and Medical Cabinet Minister of Telangana Damodar Raja Narasimha on Tuesday.

A government panel has been formed to investigate the cause of the disaster.

The blast, which erupted on Monday afternoon at a facility run by Sigachi Industries, took place in the plant’s spray dryer unit – a section used to convert raw materials into powder for drug manufacturing. The factory is located roughly 50km (31 miles) from Hyderabad, the state capital.

Authorities recovered 34 bodies from the debris, while two more workers succumbed to injuries in hospital, according to Telangana’s fire services director, GV Narayana Rao.

“The entire structure has collapsed. The fire is under control and we’re continuing to clear the rubble in case more people are trapped,” he told the Associated Press news agency.

Twenty-five of the deceased are yet to be identified, a district administrative official, P Pravinya, said.

About 36 workers remain in hospital with burns and other injuries. Police officials said that more than 140 people were working in the plant when the incident occurred.

Local residents reported hearing the blast from several kilometres away.

The incident has raised new concerns about industrial safety in India’s booming pharmaceutical sector. Despite the country’s reputation as a global supplier of low-cost medicines and vaccines, fatal accidents at drug manufacturing units are not rare, particularly in facilities handling chemicals or solvents.

Sigachi Industries, which has its headquarters in India, produces active pharmaceutical ingredients and nutrient blends, and operates manufacturing plants across the country. It also runs subsidiaries in the United Arab Emirates and the United States, according to its website.

Officials say rescue and recovery efforts will continue until the entire site has been cleared. The factory’s operations have been suspended pending the outcome of the investigation.

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5,000 light-year-old Nebula photographed in UAE: A first for Emirati astronomers | World News

Crescent Nebula captured in stunning detail from UAE skies. (Tameem Al Tamimi / Emirates Astronomy Society)

In a remarkable astronomical achievement, astrophotographers from the Emirates Astronomy Society (EAS) have captured breathtaking images of a distant nebula from the skies of the UAE. The phenomenon was spotted in the country’s eastern mountainous regions, offering a rare and awe-inspiring view of the Crescent Nebula, an object located thousands of light-years away from Earth.What Was Seen: the Crescent NebulaThe celestial object observed is the Crescent Nebula, scientifically designated as NGC 6888 and also known as Caldwell 27-Sharpless 105. This stunning emission nebula lies in the Cygnus constellation, roughly 5,000 light-years away from Earth.According to Tamim Al Tamimi, a member of the Emirates Astronomy Society and an astronomical photographer, the nebula was not only observed but also photographed in high resolution, providing a vivid glimpse into deep space from the UAE.

How the Nebula Was Formed

The nebula’s origin is tied to a dramatic cosmic event involving a dying star. Ibrahim Al Jarwan, Chairman of the Emirates Astronomy Society, explained the formation process in a statement to WAM (Emirates News Agency).He said the Crescent Nebula was created by strong stellar winds from a Wolf-Rayet star, known as WR 136, which clashed with material previously ejected by the same star during its red giant phase. The result is a massive glowing bubble of gas composed largely of ionized hydrogen and oxygen.“This large gas bubble of ionized hydrogen and oxygen is formed and appears in fine detail when imaged using narrow-field techniques,” Al Jarwan noted.

How the Image Was Captured

The stunning images were the result of over 10 hours of observation, using specialized filters, H-alpha and O3, that help isolate specific wavelengths of light emitted by the nebula’s chemical elements. The data was then processed using the HOO (H-alpha, OIII, OIII) scientific color mode to clearly reveal the chemical structures within the nebula.Capturing these detailed images required a combination of advanced equipment and careful planning. The setup included:

Camera: Cooled ZWO ASI183MM Pro
Telescope: Explore Scientific 152mm David H. Levy Comet Hunter Maksutov-Newtonian
Mount: iOptron HAE43
Guidance System: ASIAir Plus
Post-Processing Tools: PixInsight and Photoshop

A Milestone for Emirati Astronomy

The observation and photography of such a distant and intricate deep-sky object underscore the dedication and technical expertise of UAE’s growing astronomy community.Al Jarwan emphasized that this achievement reflects the resilience of Emirati astrophotographers, who continue their work despite harsh environmental conditions. “Night-time temperatures during the photographing period sometimes reach between 36 and 40 degrees Celsius in the mountainous or desert regions,” he said.This sighting not only showcases the beauty of space but also positions the UAE as an emerging center for serious astronomical observation and documentation, especially in regions not traditionally associated with deep-sky astrophotography.