Ayaneo started teasing the Pocket Play, its first smartphone, back in November, and then in December it showed us what it would look like, Sony Ericsson Xperia Play vibes and all.
Today, Ayaneo has finally revealed the chipset sitting at…

Ayaneo started teasing the Pocket Play, its first smartphone, back in November, and then in December it showed us what it would look like, Sony Ericsson Xperia Play vibes and all.
Today, Ayaneo has finally revealed the chipset sitting at…

Imagine you’re about to go on a first date. You’ve had a shower (hopefully), done your hair, put on a nice scent, picked out some lovely clothes and you’re getting ready to set off.
But there’s one simple aspect missing: a confirmation text. While…
Zeckey, C. et al. Risk of symptomatic heterotopic ossification following plate osteosynthesis in multiple trauma patients: an analysis in a level-1 trauma centre. Scand. J. Trauma Resusc. Emerg. Med 17, 55 (2009).
Mital, M. A., Garber, J. E. & Stinson, J. T. Ectopic bone formation in children and adolescents with head injuries: its management. J. Pediatr. orthopedics 7, 83–90 (1987).
Levi, B. et al. Risk factors for the development of heterotopic ossification in seriously burned adults: a National Institute on Disability, Independent Living and Rehabilitation Research burn model system database analysis. J. Trauma Acute Care Surg 79, 870–876 (2015).
Nauth, A. et al. Heterotopic ossification in orthopaedic trauma. J. Orthop. Trauma 26, 684–688 (2012).
Dey, D. et al. The traumatic bone: trauma-induced heterotopic ossification. Transl. Res 186, 95–111 (2017).
Kluger, G., Kochs, A. & Holthausen, H. Heterotopic ossification in childhood and adolescence. J. Child Neurol. 15, 406–413 (2016).
Merkely, G., Chisari, E., Lola Rosso, C. & Lattermann, C. Do nonsteroidal anti-inflammatory drugs have a deleterious effect on cartilage repair? a systematic review. Cartilage 13, 326S–341S (2021).
Oh, J. H. et al. Do selective COX-2 inhibitors affect pain control and healing after arthroscopic rotator cuff repair? A preliminary study. Am. J. Sports Med 46, 679–686 (2018).
Suda, R. K. et al. Circulating osteogenic precursor cells in heterotopic bone formation. Stem Cells 27, 2209–2219 (2009).
Alm, J. J. et al. Circulating plastic adherent mesenchymal stem cells in aged hip fracture patients. J. Orthop. Res 28, 1634–1642 (2010).
Eghbali-Fatourechi, G. Z. et al. Circulating osteoblast-lineage cells in humans. N. Engl. J. Med 352, 1959–1966 (2005).
Sorkin, M. et al. Regulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healing. Nat. Commun. 11, 722 (2020).
Loder, S. J. et al. Characterizing the Circulating Cell Populations in Traumatic Heterotopic Ossification. Am. J. Pathol. 188, 2464–2473 (2018).
Sullivan, J. P. et al. Brain tumor cells in circulation are enriched for mesenchymal gene expression. Cancer Discov. 4, 1299–1309 (2014).
Ting, D. T. et al. Single-cell RNA sequencing identifies extracellular matrix gene expression by pancreatic circulating tumor cells. Cell Rep. 8, 1905–1918 (2014).
Miyamoto, D. T. et al. RNA-Seq of single prostate CTCs implicates noncanonical Wnt signaling in antiandrogen resistance. Science 349, 1351–1356 (2015).
Fachin, F. et al. Monolithic Chip for High-throughput Blood Cell Depletion to Sort Rare Circulating Tumor Cells. Sci. Rep. 7, 10936 (2017).
Kalinich, M. et al. An RNA-based signature enables high specificity detection of circulating tumor cells in hepatocellular carcinoma. Proc. Natl. Acad. Sci. USA 114, 1123–1128 (2017).
Hong, X. et al. Molecular signatures of circulating melanoma cells for monitoring early response to immune checkpoint therapy. Proc. Natl. Acad. Sci. USA 115, 2467–2472 (2018).
Kwan, T. T. et al. A Digital RNA Signature of Circulating Tumor Cells Predicting Early Therapeutic Response in Localized and Metastatic Breast Cancer. Cancer Discov. 8, 1286–1299 (2018).
Miyamoto, D. T. et al. An RNA-Based Digital Circulating Tumor Cell Signature Is Predictive of Drug Response and Early Dissemination in Prostate Cancer. Cancer Discov. 8, 288–303 (2018).
Ozkumur, E. et al. Inertial focusing for tumor antigen-dependent and -independent sorting of rare circulating tumor cells. Sci. Transl. Med 5, 179ra47 (2013).
Wong, K. H. K. et al. Whole blood stabilization for the microfluidic isolation and molecular characterization of circulating tumor cells. Nat. Commun. 8, 1733 (2017).
Agarwal, S. et al. Surgical excision of heterotopic ossification leads to re-emergence of mesenchymal stem cell populations responsible for recurrence. STEM CELLS Transl. Med. 6, 799–806 (2017).
Jeffery, E. C., Mann, T. L. A., Pool, J. A., Zhao, Z. & Morrison, S. J. Bone marrow and periosteal skeletal stem/progenitor cells make distinct contributions to bone maintenance and repair. Cell Stem Cell 29, 1547–1561.e6 (2022).
Zhong, L. et al. Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment. eLife 9, e54695 (2020).
Baccin, C. et al. Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization. Nat. Cell Biol. 22, 38–48 (2020).
Kan, C. et al. Gli1-labeled adult mesenchymal stem/progenitor cells and hedgehog signaling contribute to endochondral heterotopic ossification. Bone 109, 71–79 (2018).
Huber, A. K. et al. Immobilization after injury alters extracellular matrix and stem cell fate. J. Clin. Invest. 130, 5444–5460 (2020).
Lee, S. et al. NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma. Nat. Commun. 12, 4939 (2021).
Vishlaghi, N. et al. Vegfc-expressing cells form heterotopic bone after musculoskeletal injury. Cell Rep. 43, 114049 (2024).
Kang, H. et al. The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism, leading to aberrant musculoskeletal repair. Bone Res. 12, 17 (2024).
Feuermann, M. et al. A compendium of human gene functions derived from evolutionary modelling. Nature 640, 146–154 (2025).
Khuman, J. et al. Tumor necrosis factor alpha and Fas receptor contribute to cognitive deficits independent of cell death after concussive traumatic brain injury in mice. J. Cereb. Blood Flow. Metab. 31, 778–789 (2011).
Guardiola, O. et al. Induction of acute skeletal muscle regeneration by cardiotoxin injection. J. Vis. Exp. 54515 https://doi.org/10.3791/54515 (2017).
Zondervan, R. L., Vorce, M., Servadio, N. & Hankenson, K. D. Fracture apparatus design and protocol optimization for closed-stabilized fractures in rodents. J. Vis. Exp. 58186 https://doi.org/10.3791/58186 (2018).
Peterson, J. R. et al. Early detection of burn-induced heterotopic ossification using transcutaneous Raman spectroscopy. Bone 54, 28–34 (2013).
Perosky, J. E. et al. Early detection of heterotopic ossification using near-infrared optical imaging reveals dynamic turnover and progression of mineralization following Achilles tenotomy and burn injury. J. Orthop. Res 32, 1416–1423 (2014).
Ranganathan, K. et al. High-frequency spectral ultrasound imaging (SUSI) visualizes early post-traumatic heterotopic ossification (HO) in a mouse model. Bone 109, 49–55 (2018).
Brownley, R. C. et al. Characterization of heterotopic ossification using radiographic imaging: evidence for a paradigm shift. PloS one 10, e0141432 (2015).
Citak, M. et al. The roles of serum alkaline and bone alkaline phosphatase levels in predicting heterotopic ossification following spinal cord injury. Spinal Cord. 54, 368–370 (2016).
Lin, Y., Lin, W. Y., Kao, C. H. & Tsai, S. C. Easy interpretation of heterotopic ossification demonstrated on bone SPECT/CT. Clin. Nucl. Med 39, 62–63 (2014).
Eekhoff, E. M. W. et al. 18F]NaF PET/CT scan as an early marker of heterotopic ossification in fibrodysplasia ossificans progressiva. Bone 109, 143–146 (2018).
Ghanem, M. A., Dannoon, S. & Elgazzar, A. H. The added value of SPECT-CT in the detection of heterotopic ossification on bone scintigraphy. Skelet. Radio. 49, 291–298 (2020).
Dai, X. et al. Phosphorylation of angiomotin by Lats1/2 kinases inhibits F-actin binding, cell migration, and angiogenesis. J. Biol. Chem. 288, 34041–34051 (2013).
Kwon, E. K. et al. The role of ellis-van creveld 2(EVC2) in mice during cranial bone development. Anat. Rec. (Hoboken) 301, 46–55 (2018).
Herdenberg, C. et al. LRIG proteins regulate lipid metabolism via BMP signaling and affect the risk of type 2 diabetes. Commun. Biol. 4, 90 (2021).
Cao, H. et al. The Pitx2:miR-200c/141:noggin pathway regulates Bmp signaling and ameloblast differentiation. Development 140, 3348–3359 (2013).
Cui, Y. et al. Hemicentin-1 is an essential extracellular matrix component during tooth root formation by promoting mesenchymal cell differentiation. Front Cell Dev. Biol. 12, 1435241 (2024).
Wischmann, J. et al. Matrix mineralization controls gene expression in osteoblastic cells. Exp. Cell Res. 372, 25–34 (2018).
Li, P. et al. Mice lacking the matrilin family of extracellular matrix proteins develop mild skeletal abnormalities and are susceptible to age-associated osteoarthritis. Int. J. Mol. Sci. 21, 666 (2020).
Vallet, S. D. & Ricard-Blum, S. Lysyl oxidases: from enzyme activity to extracellular matrix cross-links. Essays Biochem 63, 349–364 (2019).
Vadon-Le Goff, S. et al. Identification of PCPE-2 as the endogenous specific inhibitor of human BMP-1/tolloid-like proteinases. Nat. Commun. 14, 8020 (2023).
Mukherjee, A. & Rotwein, P. Insulin-like growth factor binding protein-5 in osteogenesis: facilitator or inhibitor? Growth Horm. IGF Res 17, 179–185 (2007).
Tian, B. et al. CRYAB suppresses ferroptosis and promotes osteogenic differentiation of human bone marrow stem cells via binding and stabilizing FTH1. Aging (Albany NY) 16, 8965–8979 (2024).
Granéli, C. et al. Novel markers of osteogenic and adipogenic differentiation of human bone marrow stromal cells identified using a quantitative proteomics approach. Stem Cell Res 12, 153–165 (2014).
Bonnet, N., Conway, S. J. & Ferrari, S. L. Regulation of beta-catenin signaling and parathyroid hormone anabolic effects in bone by the matricellular protein periostin. Proc. Natl. Acad. Sci. 109, 15048–15053 (2012).
Duchamp de Lageneste, O. et al. Periosteum contains skeletal stem cells with high bone regenerative potential controlled by Periostin. Nat. Commun. 9, 773 (2018).
Chen, P. et al. Scara3 regulates bone marrow mesenchymal stem cell fate switch between osteoblasts and adipocytes by promoting Foxo1. Cell Prolif. 54, e13095 (2021).
Sono, T. et al. Perivascular Fibro-Adipogenic Progenitor Tracing during Post-Traumatic Osteoarthritis. Am. J. Pathol. 190, 1909–1920 (2020).
Harvey, T., Flamenco, S. & Fan, C.-M. A Tppp3+Pdgfra+ tendon stem cell population contributes to regeneration and reveals a shared role for PDGF signalling in regeneration and fibrosis. Nat. Cell Biol. 21, 1490–1503 (2019).
Mishra, A. et al. Ultrahigh-throughput magnetic sorting of large blood volumes for epitope-agnostic isolation of circulating tumor cells. Proc. Natl. Acad. Sci. USA 117, 16839–16847 (2020).
Karabacak, N. M. et al. Microfluidic, marker-free isolation of circulating tumor cells from blood samples. Nat. Protoc. 9, 694–710 (2014).
Hahaut, V. et al. Fast and highly sensitive full-length single-cell RNA sequencing using FLASH-seq. Nat. Biotechnol. 40, 1447–1451 (2022).
Robinson, M. D., McCarthy, D. J. & Smyth, G. K. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics 26, 139–140 (2010).
Love, M. I., Huber, W. & Anders, S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 15, 550 (2014).
Uhlen, M. et al. A genome-wide transcriptomic analysis of protein-coding genes in human blood cells. Science. 366, eaax9198 (2019).
Zheng, G. X. Y. et al. Massively parallel digital transcriptional profiling of single cells. Nat. Commun. 8, 14049 (2017).
Hao, Y. et al. Dictionary learning for integrative, multimodal and scalable single-cell analysis. Nat. Biotechnol. 42, 293–304 (2024).
Korsunsky, I. et al. Fast, sensitive and accurate integration of single-cell data with Harmony. Nat. Methods 16, 1289–1296 (2019).
Severe, N. et al. Stress-induced changes in bone marrow stromal cell populations revealed through single-cell protein expression mapping. Cell Stem Cell 25, 570–583.e7 (2019).
Baryawno, N. et al. A cellular taxonomy of the bone marrow stroma in homeostasis and leukemia. Cell 177, 1915–1932.e16 (2019).
Giannoudis, V. P., Rodham, P., Giannoudis, P. V. & Kanakaris, N. K. Severely injured patients: modern management strategies. EFORT Open. Rev. 8, 382–396. https://doi.org/10.1530/eor-23-0053 (2023).


Tyla, Usher, Kesha, Zara Larsson, and more music stars kick off the 2026 Grammys weekend with a big event!
Epic Records and Hennessy hosted a special evening to celebrate their Grammy nominees on Friday night (January 30) at the Sunset Tower…

DARA will be singing for Bulgaria at Vienna 2026
On Saturday 31 January, we had eight artists performing for success in Sofia, as viewers of the Bulgarian national final were tasked with selecting their…

Islamabad [Pakistan], February 1 (ANI): A National Dialogue Committee (NDC) in Pakistan expressed concern about the health of jailed Pakistan Tehreek-e-Insaf (PTI) founder and former prime minister Imran Khan, calling for immediate access to his…