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  • Arsenal women complete signing of Taylor Hinds from Liverpool

    Arsenal women complete signing of Taylor Hinds from Liverpool

    Arsenal women have completed the signing of Jamaica international Taylor Hinds on a free transfer after the expiry of her contract at Liverpool, the club have announced.

    The 26-year old leaves Liverpool after five years and having held the vice-captaincy at the club, she makes the move back to north London after starting her career in Arsenal’s academy.

    “I’m so proud to have signed for Arsenal,” Hinds said in a statement. “I want to push, compete and be winning trophies — and this club encompasses all of that. You can see what direction Arsenal is going in and everyone at the club wants to win.

    “This is a full-circle moment for me and I’m grateful to come back to a place I called home when I was younger. I can’t wait to get started and to step out on the pitch at Emirates Stadium in front of all our incredible supporters.”

    Hinds played a key role in Liverpool’s promotion to the Women’s Super League in 2022 and made 131 appearances for the Reds scoring eight goals in her time at the club.

    She is the European champions’ second signing of the summer after they made loanee Chloe Kelly’s move permanent.

    “We’re delighted to welcome Taylor back to Arsenal. She’s a versatile player who has great experience from multiple seasons in the WSL with Liverpool, where she took on a leadership role,” head coach Renée Slegers said.

    Hinds represented England at under-17 and under-20 World Cups before switching allegiance to Jamaica — making her debut in October last year.

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  • 9 Healthcare Startups Next in Line to Go Public, According to Bankers

    9 Healthcare Startups Next in Line to Go Public, According to Bankers

    Transcarent contracts with employers to provide health navigation and virtual care to employees. The startup looks a lot closer to an exit after a big acquisition earlier this year.

    The startup bought the public health benefits company Accolade in a $621 million deal that closed in April. The acquisition looks to have significantly increased Transcarent’s customer base and thus made a big contribution to its top line — before the Transcarent deal, Accolade said it contracted with over 1,400 employers and health plans, and the company reported $414 million in revenue in the fiscal year 2024. Now, with Accolade on board, Transcarent says it works with over 1,700 employers and health plans. Transcarent hasn’t publicly shared its revenue.

    The Accolade acquisition was financed by Transcarent investors including General Catalyst and CEO Glen Tullman’s 62 Ventures, cash on Transcarent’s balance sheet, and debt provided by JP Morgan. Transcarent has raised about $450 million since its 2020 founding, including $126 million in a Series D funding round in May 2024 at a $2.2 billion valuation.

    Tullman has by far the most experience with taking companies public of the CEOs on this list. Before Transcarent, he led three companies through public listings — Livongo, Allscripts, and Enterprise Systems. His success with Livongo, the diabetes care company he founded, stands out as a rare example of blockbuster digital health returns; Livongo went public in 2019 at a $2.5 billion valuation, before being acquired by Teladoc the next year for $18.5 billion, at the time the biggest deal ever in the digital health market.

    That experience could set Transcarent up to pursue an IPO when market conditions look favorable. Tullman told MedCity News in May 2024 that he had “no interest” in selling the company, but would consider an IPO in the future.

    Transcarent will have to separate itself from previous care navigation IPOs, however, including Health Catalyst, whose stock has declined more than 85% since its 2019 IPO. It’ll also need to contend with Accolade’s cash burn, since the health benefits company reported a net loss of $100 million in the fiscal year 2024.

    In a statement to BI, Tullman said Transcarent is focused on integrating its solutions to bring its AI-powered platform, called WayFinding, to more members and employers to make healthcare more accessible and affordable.

    “At Transcarent, our priority is meeting the needs of our Members and delivering measurable results for our clients. If we do those things well, the rest will follow,” Tullman said.


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  • Weekly Markets Monitor: Big data, little reaction | Post by Weekly Markets Monitor | Gold Focus blog

    Weekly Markets Monitor: Big data, little reaction | Post by Weekly Markets Monitor | Gold Focus blog

    Important information and disclaimers

    © 2025 World Gold Council. All rights reserved. World Gold Council and the Circle device are trademarks of the World Gold Council or its affiliates.
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    Reproduction or redistribution of any of this information is expressly prohibited without the prior written consent of World Gold Council or the appropriate copyright owners, except as specifically provided below. Information and statistics are copyright © and/or other intellectual property of the World Gold Council or its affiliates or third-party providers identified herein. All rights of the respective owners are reserved.
    The use of the statistics in this information is permitted for the purposes of review and commentary (including media commentary) in line with fair industry practice, subject to the following two pre-conditions: (i) only limited extracts of data or analysis be used; and (ii) any and all use of these statistics is accompanied by a citation to World Gold Council and, where appropriate, to Metals Focus or other identified copyright owners as their source. World Gold Council is affiliated with Metals Focus.
    The World Gold Council and its affiliates do not guarantee the accuracy or completeness of any information nor accept responsibility for any losses or damages arising directly or indirectly from the use of this information.
    This information is for educational purposes only and by receiving this information, you agree with its intended purpose. Nothing contained herein is intended to constitute a recommendation, investment advice, or offer for the purchase or sale of gold, any gold-related products or services or any other products, services, securities or financial instruments (collectively, “Services”). This information does not take into account any investment objectives, financial situation or particular needs of any particular person.

    Diversification does not guarantee any investment returns and does not eliminate the risk of loss. Past performance is not necessarily indicative of future results. The resulting performance of any investment outcomes that can be generated through allocation to gold are hypothetical in nature, may not reflect actual investment results and are not guarantees of future results. The World Gold Council and its affiliates do not guarantee or warranty any calculations and models used in any hypothetical portfolios or any outcomes resulting from any such use. Investors should discuss their individual circumstances with their appropriate investment professionals before making any decision regarding any Services or investments.
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    Information regarding QaurumSM and the Gold Valuation Framework

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  • Newsroom » Carlsberg Group supports Global Standards Coalition for Responsible Drinking « Carlsberg Group

    Newsroom » Carlsberg Group supports Global Standards Coalition for Responsible Drinking « Carlsberg Group

    Carlsberg Group is proud to be part of the Global Standards Coalition launched by the International Alliance for Responsible Drinking (IARD). New report highlights responsible drinking efforts across industry. 

    Bringing together over 100 members from across the world, the Coalition includes the leading global beer, wine and spirits producers as well as the leading retailers, e-commerce platforms, marketing and advertising agencies, sports organizations, travel retail and hospitality sectors, self-regulatory bodies, and digital platforms. Together, we are working to accelerate efforts in reducing harmful alcohol use.

    Since its launch in 2023, the Global Standards Coalition, led by IARD, has continued to grow, united by a shared commitment to raising industry standards and driving global action. Key focus areas include:

    • Further prevent sales to those underage or intoxicated
    • Prevent marketing and advertising to those underage
    • Provide training and guidance that empowers staff to deny sale, service, and delivery of alcohol where necessary
    • Respect the choices of those who choose not to drink alcohol
    • Elevate industry standards to reduce the harmful use of alcohol

    New report highlights how industry leaders are driving innovative solutions to tackle harmful drinking globally

    The newly published report Standards in Action showcases the extensive global efforts of leaders across the beer, wine, and spirits sectors. Carlsberg Group is featured with a case story from Sweden. 

    In 2024, Carlsberg Sweden launched a targeted campaign titled “Don’t Drink and Fish”, aimed at discouraging alcohol consumption while fishing – Sweden’s most popular leisure activity. Alcohol and fishing can be a dangerous mix, leading to fatal accidents.

    Together with the Swedish expert angler, Claes Claesso, the team developed a unique fishing lure shaped like a drunk fisherman with a realistic staggering motion in the water, named “DrunkenBait”. It was created in collaboration with Sportfiskarna, Sveriges Sportfiske- och Fiskevårdsförbund (Sweden’s Sport Fishing and Fisheries Conservation Association), a non-profit organization that organises more than 73,000 sport fishers.

    Contact

    Please address enquiries to:

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  • ‘Free of human logic’: the modern artists inspired by surrealism’s 100-year-old parlour game | Art and design

    ‘Free of human logic’: the modern artists inspired by surrealism’s 100-year-old parlour game | Art and design

    Some time in the winter of 1925-1926, the French author André Breton and his comrades Yves Tanguy, Jacques Prévert and Marcel Duchamp invented an old-fashioned parlour game. You write a word on a piece of paper, then fold it over so the next person can’t see what you’ve written, and you end up with a strange sentence. The game is now known as Exquisite Corpse, after the result of their first go: Le cadavre exquis boira le vin nouveau (The exquisite corpse will drink the new wine).

    Exquisite Corpse gave Breton so much joy because it summed up the essence of the surrealist school of art he was trying to articulate at the time. In his first 1924 manifesto, he told budding surrealists to put themselves in “as passive, or receptive, a state of mind” as they can and write quickly. Forget about talent, about subject, about perception or punctuation. Simply trust, he writes, “in the inexhaustible nature of the murmur”.

    Receptive state of mind … an invitation to Exquisite Corpse from 1927. Photograph: API/Gamma-Rapho/Getty Images

    In the year of its centenary, the spirit of Breton’s Exquisite Corpse is not just un-dead but frantically rattling the lid of its coffin from the inside. Several modern artists are continuing the surrealist tradition by composing with found materials (words, images, objects), drawn from the accidental debris of the everyday, to make the unexpected.

    For a recent show at Frith Street Gallery, the British artist Fiona Banner showed works made with discarded mannequin parts she’d found in an abandoned Topshop in north-west England. In a film, titled DISARM (Portrait), she has emblazoned words like “disarm” on arms, “obsolete” on soles, and “delegation” on legs. At first she thought of it as a concrete poem or a Breton-esque poème objet. Then she realised, she says, that “actually, it’s more liquid than concrete”.

    For Banner, the power of Exquisite Corpse, “its radical space”, lies not in the finished sentence but on that fold. “I think to not understand is a very important space,” she says. “To be free of human logic.”

    Discarded mannequin parts from an abandoned Topshop … Fiona Banner’s DISARM. Photograph: Fiona Banner

    Dimitri Rataud, a French actor turned artist, whose work is now on show at HIS Paris gallery, makes what he calls “haikus marinières”: surrealist-inspired concrete poems he finds by blacking out most of the words on a ripped-out page of a random book. The name itself is a word play: the pieces look like Breton tops AKA marinières because of the stripes. And the poems (et soudain … le bonheur – “and suddenly … happiness”) are as light as a feather on the breeze.

    The printed word, which he handles like a builder might a brick, is useful raw material. And each poem is but a moment. Rataud starts by tearing the cover off the book then opening it on the last page. He can never do the same thing twice. To his gallery’s dismay, he refuses to make copies.

    Rataud is popular on Instagram, and you can of course see why: Breton tops, French romance, Japanese minimalism. And yet, these found poems are luminous, in the way they balance on that paper-thin edge between accident and intention. “I’ve found extremely beautiful haikus in sordid books.”

    Popular on Instagram … Poème 10 of Haiku Marinière. Photograph: ©Haiku Marinière-2025

    For the Paris surrealists of the 1920s – crawling out of the wreckage of the first world war – nonsense was a deadly serious matter. When the Centre Pompidou’s exhibition, Surréalisme (a touring mega-show currently at the Hamburger Kunsthalle), opened in September 2024, co-curator Marie Sarré described the centennial movement as one of the most politically engaged of the avant gardes. “Throughout its history, the political and the poetic ran in parallel,” she said. “It wasn’t an artistic movement or a formalism, but a collective adventure and a philosophy.” Contrary to other avant garde movements which embraced the notion of progress, it questioned everything. The surrealists were among the first anticolonialists, the staunchest anti-fascists, proponents of social revolution and proto-eco warriors.

    “They asked the questions artists today are asking,” said Sarré.

    To wit, Malaysian-born artist Heman Chong, whose work is currently on show at the Singapore Art Museum. This survey exhibition is organised into nine categories: words, whispers, ghosts, journeys, futures, findings, infrastructures, surfaces and endings. One piece, “This pavilion is strictly for community bonding activities only”, reproduces a sign Chong found in a communal space within one of Singapore’s Housing and Development Board block of flats. “The sentence itself is nuts, right?” he says. “That you would insist on community bonding activities, which means, literally, you cannot be there alone, right? Because you can’t bond with anyone alone.”

    By contrast, he often makes installations with things people could secrete away – stacks of postcards; mountains of sentences from spy novels shredded on to the floor; a library of unread books. “I would love it if people just take things out of their own accord,” says Chong. “Coming from Singapore, which is an extremely paternalistic, authoritarian state, a lot of my work is not about telling people what they cannot do.”

    Shredded sentences … Secrets and Lies (The Impossibility of Reconstitutions) by Heman Chong. Photograph: Heman Chong; Image courtesy of MGSR Collection

    In November 2024, South Africa-based Nhlanhla Mahlangu, who is a long-term collaborator of William Kentridge, gave a performance lecture titled Chant for Disinheriting Apartheid. It collates several spoken word compositions and improvised works, which delve into the brutal flattening of colonial oppression: language stolen, names mangled, bodies which have learned to recognise different guns by the sounds they make.

    In one section, he performs, one by one, various unrelated sentences in the languages of isiZulu, Sesotho, Xitsonga, Venda, Xhosa. And then, “the language of apartheid”. He stands stock still, in total silence, for two whole minutes.

    He recounts doing a workshop with children from Hillbrow, a part of inner Johannesburg beset by high crime and intense poverty. They were working on a performance of Aimé Césaire’s 1939 masterwork, Return to My Native Land – a gut punch of a poem against colonialism, which Breton called “the greatest lyrical monument of this time”. Mahlangu’s students, who were witnessing crime and death and abandonment on the way to class, said: “We experience surrealisms every day. We don’t understand why people go to universities and study it. Our lives are surreal.”

    “Surrealism offers ways to look awry at things,” says Patricia Allmer, an art historian at the Edinburgh College of Art. She recently co-curated The Traumatic Surreal at the Henry Moore Institute in Leeds. “Because you can’t encounter trauma head on, you have to find ways of seeing it, either as a distortion, through a distorting lens or from the side.” For Mahlangu, it is about “bringing fluidity to what seems stable, and understanding that stability can be a weakness. It’s constantly not answering the question, but questioning the answers, asking more questions.”

    In the 21st century, we may have grown wary of “isms” in art. In a climate of constant technological and economic interruption, the promise of a transformative cultural revolution can feel suspicious; the most powerful movement in modern art, contended a recent article in the Art Newspaper, may be the art market itself. But it’s worth remembering that when Breton first wrote about his ideas in 1924, he didn’t think of it as a manifesto, just a preface to a book of poems he wanted to publish. And that’s why Exquisite Corpse sums up surrealism’s most lasting legacy to modern art today: a tool that taps you into something unexplored, a game for “pure young people who refuse to knuckle down”.

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  • Best Kindle deal: Save $140 on Kindle Scribe

    Best Kindle deal: Save $140 on Kindle Scribe

    SAVE $140: As of July 7, the Kindle Scribe is on sale for $259.99 at Amazon. That’s a saving of 35% on list price.


    The Kindle Scribe is one of Amazon’s most popular products, and not just for book lovers. Combine an e-reader and a notebook together, and you get the Scribe. The latest redesign added the ability to write on books — big news for margin people.

    And there’s big pre-Prime Day news, because the Kindle Scribe is at its lowest-ever price ahead of Prime Day. Down to just $259.99, this price is for the 16GB and color tungsten option. This deal includes the Premium Pen, so you can jot down notes and convert them to text as easily as writing in a notebook.

    SEE ALSO:

    This essential Kindle Scribe bundle just got a huge new discount before Prime Day — save over $200

    This is a big upgrade on the basic pen, as this model comes with an eraser at the top so you can quickly remove mistakes just by flipping the pen. It is also battery-free and works through a special power source embedded in the Kindle Scribe, so you don’t need to charge it.

    The Scribe has a 10.2-inch, 300 ppi Paperwhite display, glare and ink-free. Like the OG Kindle model, it’s perfect for sitting outside in the sun or in hard-to-read lighting. And if you’re a hectic note taker, don’t worry, you can summarize your notes, as well as change their length and tone with clever built-in AI notebook tools.

    Mashable Deals

    Head to Amazon now and start working on that TBR list.

    The best early Prime Day deals, hand-picked by Mashable’s team of experts

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  • Watch Vaibhav Suryavanshi In Action — Time, Venue & Live Streaming Details

    Watch Vaibhav Suryavanshi In Action — Time, Venue & Live Streaming Details

    Vaibhav Suryavanshi match Live Streaming: While India’s senior team battles it out in the Test series against England, the spotlight also shines on the India Under-19 team, currently touring England for a 5-match ODI series.

    Led by captain Ayush Mhatre, the young Indian side is gearing up for the fifth and final match of the series, scheduled for Monday.

    Fans are once again eager to watch Vaibhav Suryavanshi, who will take the field after a record-breaking performance in the last match.

    India U-19 vs England U-19 5th ODI Live Streaming Details

    How to watch IND U19 vs ENG U19 4th ODI match Live?

    The fifth ODI between India U-19 and England U-19 will take place at Worcester, with the toss scheduled at 3:00 PM IST and the match starting at 3:30 PM IST.

    This game will not be broadcast on television, but Indian fans can watch the full match live on the official YouTube channel of the England and Wales Cricket Board (ECB) — where the entire series has been streamed.

    All Eyes on Vaibhav Suryavanshi

    The star of the last match, Vaibhav Suryavanshi, stunned everyone with a sensational knock — smashing 143 runs off just 78 balls, including 13 fours and 10 sixes.

    He reached his century in only 52 deliveries, and after the match, confidently expressed his ambition of scoring a double century soon. With that kind of form, all eyes will be on him once again as India seeks to wrap up the series on a high.

    Squads for the 5th U-19 ODI

    India U-19 Team: Ayush Mhatre (C), Abhigyan Kundu (VC/WK), Harvansh Singh (WK), Vaibhav Suryavanshi, Vihaan Malhotra, Moulyaraj Singh Chavda, Rahul Kumar, R.S. Ambareesh, Kanishk Chauhan, Khilan Patel, Henil Patel, Yudhajit Guha, Pranav Raghavendra, Mohammad Enan, Aditya Rana, Anmoljit Singh.

    England U-19 Team: Thomas Reeve (C), Ralphie Albert, Ben Dawkins, Jayden Denly, Rocky Flintoff, Alex French, Alex Green, Jack Home, James Isbell, Ben Mayes, James Minto, Isaac Mohammed, Joseph Moores, Seb Morgan, Alex Wade.

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  • Review finds there’s no ‘safe’ level of processed food consumption – NewsNation

    1. Review finds there’s no ‘safe’ level of processed food consumption  NewsNation
    2. Warning issued to anyone eating hot dogs or burgers  Daily Express
    3. Fourth of July: New study warns there’s ‘no safe amount’ of hot dogs to eat  Hindustan Times
    4. EarthTalk® -Installment 160  Splash Magazines
    5. Studies have shown that just eating processed meat equivalent to a hot dog can increase the risk of  매일경제

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  • ESTI team issues guidance on lung nodule management

    ESTI team issues guidance on lung nodule management

    The new European Society of Thoracic Imaging (ESTI) nodule management recommendations for low-dose CT lung cancer screening emphasize lesion aggressiveness, size, and morphology, while building on previous guidance.

    A team led by Prof. Mathias Prokop, chair of radiology at Radboud University Center, Nijmegen, the Netherlands, and Dr. Annemiek Snoeckx, chair of radiology at Antwerp University Hospital in Belgium, published the new guidance on 1 July in European Radiology. They noted that ESTI sought a balance between mitigating the number of follow-up visits, the possibility of overtreatment, and reducing the risk of a major stage shift in developing its recommendations.

    Flowchart for management of new nodules. New nodules that had been missed or not reported on previous scans are managed according to the same rules as nodules found at baseline.Courtesy Prokop, Snoeckx, ESTI; European Radiology.

    The guidelines emphasize categorizing by the size of the solid nodule or the solid part of a subsolid or cystic nodule. Volume is the recommended method for measurement; the authors stated that measurements taken with calipers are substantially less accurate and reproducible than volumetric measurements. However, manual diameter measurements are recommended as backup if segmentation at volumetry is found to be inaccurate and cannot be corrected. The authors gave specific guidelines for both methods of measuring, as well as for calculating the repeatability coefficient.

    Additionally, volume-doubling time (VDT) is recommended here as the preferred measure for the growth rate of the tumor; the aggressiveness of the nodule is estimated from this VDT or from yearly diameter change. However, the authors cautioned that the calculation of the growth rate is affected by measurement variability, with larger error margins in cases of shorter follow-up periods and slower growth.

    Furthermore, the VDT has been shown to vary among types, with solid nodules growing faster than either partially solid or nonsolid nodules. Therefore, the guidelines set the growth thresholds for stages in order that rapidly growing nodules could be identified while still small, and unnecessary follow-up could be avoided for those that are slow-growing, for which a conservative approach is generally recommended.

    Likewise, as the authors stated that rapid growth is associated with aggressiveness in tumors, stage shift is also more likely in rapidly growing tumors and after longer intervals between follow-up visits, and with nodules closer in size to the next stage. Larger nodule size increases the risk for lymphatic and distant metastases, and if those metastases develop, or if a tumor stage T1a (<1 cm) at baseline develops into a tumor stage T1c (2 cm) during follow-up, a major stage shift has occurred, according to these guidelines.

    The guidelines are structured to provide management for nodules according to type, size, and morphology. They underscore again that subsolid and cystic nodules are generally less aggressive and a more conservative approach with long-term surveillance is appropriate; furthermore, new nonsolid nodules are usually infectious, and even when premalignant, are slow-growing. However, the authors also added that the development of a solid component in these nodules indicates invasiveness.

    Growth with solid nodules may be variable; while rapid growth is a measure of aggressiveness, the guidelines also caution that malignant nodules may be slow-growing. For this reason, the authors added an absolute growth threshold of 5 mm: Should a slow-growing lesion increase in diameter by at least 5 mm, the decision should be made to weigh possible overtreatment against the risk from the cancer. Through this standard, the ESTI aims at “avoiding stage-shift in patients with a good life expectancy while reducing aggressive management in patients who might not profit from it.”

    Overtreatment is most likely to occur with slow-growing tumors, which are unlikely to metastasize, or in patients with comorbidities that are much more likely to affect their survival than the lung tumor, according to the authors.

    For follow-up intervals, the ESTI team states that “[t]he nodule with the shortest follow-up interval determines participants’ management”; benign nodules should have no effect on management. Furthermore, while nodule management is based on malignancy risk, it should always take into account the lesion’s projected aggressiveness to avoid overdiagnosis and overtreatment, as well as to minimize the amount of follow-up a patient must undergo. Regular lung cancer screening should be performed at one-year intervals, the authors wrote.

    Read the new ESTI recommendations here.

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  • Improved Liver Organoids Enhance Hemophilia Research

    Improved Liver Organoids Enhance Hemophilia Research

    Scientists from Cincinnati Children’s and colleagues based in Japan report achieving a major step forward in organoid technology–producing liver tissue that grows its own internal blood vessels.

    This significant advance could lead to new ways to help people living with hemophilia and other coagulation disorders while also taking another step closer to producing transplantable repair tissues for people with damaged livers.

    The study, led by Takanori Takebe, MD, PhD, director for commercial innovation at the Cincinnati Children’s Center for Stem Cell and Organoid Research and Medicine  (CuSTOM), was published online June 25, 2025,  in Nature Biomedical Engineering. Co-authors included experts from the Institute of Science Tokyo, the Ichan School of Medicine at Mount Sinai, and Takeda Pharmaceutical Co., which also provided funding for the study.

    “Our research represents a significant step forward in understanding and replicating the complex cellular interactions that occur in liver development. The ability to generate functional sinusoidal vessels opens up new possibilities for modeling a wide range of human biology and disease, and treating coagulation disorders and beyond,” Takebe says.

    What are organoids?

    For more than 15 years, researchers at Cincinnati Children’s and many other institutions have been working to grow human organ tissue in the laboratory. Such tissues already have become important tools for medical research and may soon become sophisticated enough to be used directly to help repair damaged organs.

    The complex process involves placing induced pluripotent stem cells (iPSCs) in special gels designed to prompt the stem cells to grow into specific tissue types. The stem cells can be generic or come from specific individuals with health conditions and can be gene-edited before beginning the process.

    Cincinnati Children’s has been a leader in organoid research since 2010 when experts here developed the first functional intestinal organoid grown from iPSCs. Since then, CuSTOM has grown and evolved to include 37 labs across 16 research divisions, where teams are improving organoid technology and using organoids to shed new light on a wide range of diseases and conditions.

    Overcoming a challenge

    Until recently, the size of lab-grown organoids has been fundamentally limited because they have not included important tissues that connect organs to the rest of the body; such as nerves and blood vessels.

    This study recounts how the research team overcame the blood vessel obstacle. The experiments involved required nearly a decade to complete.

    Ultimately, the project succeeded at differentiating human pluripotent stem cells into CD32b+ liver sinusoidal endothelial progenitors (iLSEP). Then the team used an inverted multilayered air-liquid interface (IMALI) culture system to support the iLSEP cells as they self-organized into hepatic endoderm, septum mesenchyme, arterial, and sinusoidal quadruple progenitors.

    The advantage of using the iLSEP progenitor cells as building blocks is that they are specific to the liver. Some other studies seeking to add vascularization to organoids have depended upon “fully committed” arterial endothelial cells. These vessels may not function inside an organ as well as progenitor cells from that organ.

    Location and timing also were crucial to achieving the initial vessel formation.

    “The success occurred in part because the different cell types were grown as neighbors that naturally communicated with each other to take their next development steps,” says the study’s first author Norikazu Saiki, PhD, of the Institute of Science Tokyo.

    Key findings from the research include:

    • Development of Fully Functional Human Vessels: The new method produced “perfused blood vessels with functional sinusoid-like features,” which means the vessels were fully open and included the pulsing cell types needed to help blood move through.
    • Correction of Coagulation Disorders: The advanced organoids also generated the correct cell types needed to produce four types of blood coagulation factors, including Factor VIII, which is missing among people with hemophilia A. In mice that mimic hemophilia, the study showed that organoid-derived Factor VIII rescued them from severe bleeding.
    • Potential Application Beyond Liver Organoids: By developing IMALI culture methods for allowing multiple cell types to self-organize naturally, the new technology may open a possibility to grow organ-specific vesselsin other types of organoids.

    Big Step Closer to Improved Treatments for Hemophilia, Liver Failure

    In the U.S. an estimated 33,000 males live with hemophilia. Most have hemophilia A (factor VIII deficiency), while a smaller group has hemophilia B (factor IX deficiency).

    The condition can cause repeated bleeding within joints that can lead to chronic pain and mobility limitations. Hemophilia makes surgery risky and other wounds harder to heal. It also can lead to seizures and paralysis when bleeding affects the brain.

    Hemophilia is treated by injecting commercially prepared concentrates to replace the missing coagulation factors. However, human blood contains a dozen different clotting factors and there are no available human protein sources for missing coagulation factors V or XI. Also, about 20% of people with hemophilia A develop inhibitors to standard treatment products.

    “These advanced liver organoids can secrete these coagulation factors. If they can be produced at scale, they could become a viable treatment source that would benefit people who have developed inhibitors or are not indicated for gene therapy,” Takebe says.

    Meanwhile, people experiencing acute or chronic liver failure also do not produce adequate supplies of coagulation factors, placing them at higher risk of bleeding complications during surgery. A factor-secreting organoid ‘factory’ also could help these patients.

    Longer-term, increasingly sophisticated liver organoids may eventually supply repair tissues that can help diseased livers heal themselves.

    Reference: Saiki N, Nio Y, Yoneyama Y, et al. Self-organization of sinusoidal vessels in pluripotent stem cell-derived human liver bud organoids. Nat Biomed Eng. 2025. doi: 10.1038/s41551-025-01416-6

    This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source. Our press release publishing policy can be accessed here.

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