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  • Legal wrangling over estate of Jimmy Buffett turns his widow’s huge inheritance into a cautionary tale

    Legal wrangling over estate of Jimmy Buffett turns his widow’s huge inheritance into a cautionary tale

    Lawyers often tell their clients that everyone should have a will that clearly states who should inherit their assets after they die. But even having a will is not necessarily enough to avoid a costly and contentious legal dispute.

    Consider what happened after Jimmy Buffett died of skin cancer at the age of 76 in 2023. The singer and entrepreneurial founder of the Margaritaville brand ordered in his will that his fortune be placed in a trust after his death. To manage the trust, Buffett named two co-trustees: his widow, Jane Slagsvol, and Richard Mozenter, an accountant who had served as the singer’s financial adviser for more than three decades.

    In dueling petitions filed in Los Angeles and Palm Beach, Florida, in June 2025, however, Slagsvol – identified as Jane Buffett in her legal filing – and Mozenter are both seeking to remove each other as a trustee.

    The outcome of this litigation will determine who gets to administer Buffett’s US$275 million estate.

    As law professors who specialize in trusts and estates, we teach graduate courses about the transfer of property during life and at death. We believe that the Buffett dispute offers a valuable lesson for anyone with an estate, large or small. And choosing the right person to manage the assets you leave behind can be just as important as selecting who will inherit your property.

    Buffett’s business empire

    Buffett’s estate includes valuable intellectual property from his hit songs, including “It’s 5 O’Clock Somewhere,” “Oldest Surfer on the Beach” and “Cheeseburger in Paradise.” Buffett’s albums have sold more than 20 million copies worldwide and continue to generate some $20 million annually in royalties. Buffett also owned a yacht, real estate, airplanes, fancy watches and valuable securities.

    In addition, he owned a 20% stake in Margaritaville Holdings LLC, a brand management company he and Slagsvol founded in the 1990s. Margaritaville owns 30 restaurants and 20 hotels, along with vacation clubs, casinos and cruise ships. It also sells branded merchandise.

    According to Slagsvol’s petition, Buffett’s trust was set up to benefit his widow. Slagsvol, who married Buffett in 1977, is one of two trustees of that trust, which is required to have at least one “independent trustee” in addition to her “at all times.” That requirement is stated expressly in Buffett’s trust declaration.

    Slagsvol receives all income earned by the trust – an estate-planning technique for giving away property managed by a trustee on behalf of the trust beneficiaries – for the rest of her life. She can also receive additional trust funds for her health care, living expenses and “any other purpose” that the independent trustee – Mozenter, as of July 2025 – deems to be in Slagsvol’s best interests.

    The estate plan also created separate trusts for their three children: Savannah, Sarah “Delaney” and Cameron Buffett, who are in their 30s and 40s. Each child reportedly received $2 million upon Jimmy’s death. When Slagsvol dies, she can decide who will receive any remaining assets from among Buffett’s descendants and charities.

    The structure of Buffett’s plan is popular among wealthy married couples. It provides lifelong support for the surviving spouse while ensuring that their kids and grandchildren can inherit the remainder of their estate – even if that spouse remarries. This type of trust typically cannot be changed by the surviving spouse without court approval.

    If you’re fortunate enough to reach your golden years with a sizable nest egg, it helps your loved ones if you can draft a detailed will. You might also want to consider establishing a trust.
    Maskot/Getty Images

    Dueling trustee removal petitions

    Slagsvol is trying to remove Mozenter as the trust’s independent trustee.

    She claims he refused to comply with her requests for financial information, failed to cooperate with her as her co-trustee, and hired a trust attorney who pressured her to resign as trustee. Slagsvol also raised numerous questions about the trust’s income projections and compensation paid to Mozenter for his services.

    Mozenter’s petition, filed in Florida, is not available to the public. According to media coverage of this dispute, he seeks to remove Slagsvol as trustee. He claims that, during his decades-long role as Buffett’s financial adviser, the musician “expressed concerns about his wife’s ability to manage and control his assets after his death.”

    That led Buffett to establish a trust, Mozenter asserted, “in a manner that precluded Jane from having actual control” over it.

    Estate planning lessons

    We believe that the public can learn two important estate planning lessons from this dispute.

    First, anyone planning to leave an estate, whether modest or vast, needs to choose the right people to manage the transfer of their property after their death.

    That might mean picking a professional executor or trustee who is not related to you. A professional may be more likely to remain neutral should any disputes arise within the family, but hiring one can saddle the estate with costly fees.

    An alternative is to choose a relative or trusted friend who is willing to do this for free. About 56% of wills name an adult child or grandchild as executor, according to a recent study. Some estates, like Buffett’s trust, name both a professional and a family member. An important consideration is whether the people asked to manage the estate will get along with each other – and with anyone else who is slated to inherit from the estate.

    The second lesson is, whether you choose a professional, a loved one or a friend to manage your estate, make clear what circumstances would warrant their removal. Courts are reluctant to remove a handpicked trustee without proof of negligence, fraud or disloyalty. But trustees can be removed when a breakdown in cooperation interferes with their ability to administer the estate or trust.

    Some trusts anticipate such conflicts by allowing beneficiaries to replace a professional trustee with another professional trustee. That can resolve some disputes while avoiding the cost of seeking court approval.

    Preventing disputes from erupting in the first place can help people avert the costly and embarrassing kind of litigation now ensnaring Jimmy Buffett’s estate.

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  • Western Digital sees HAMR capacity advantage over Seagate – Blocks and Files

    Western Digital sees HAMR capacity advantage over Seagate – Blocks and Files

    Interview: We had the opportunity to speak with Ahmed Shihab, Western Digital chief product and engineering officer, and he told us that WD’s HAMR tech is progressing well, that OptiNAND can provide a capacity advantage, and that the company has a way to increase the bandwidth per terabyte of disk drives.

    Shihab joined Western Digital in March, following more than a year as a corporate VP for Microsoft Azure storage and eight years as AWS VP for Infrastructure hardware. Azure and AWS will be two of the largest hyperscaler buyers for nearline disk drive storage, which is WD’s biggest market. Shihab will have detailed knowledge of how these hyperscalers evaluate disk drive product transitions and what they look out for, invaluable to Western Digital as it follows Seagate with its own HAMR technology transition. It will not want to endure Seagate’s multi-year HAMR drive qualification saga.

    Blocks & Files: Could you start by talking about the state of Western Digital and HAMR, how that’s going?

    Ahmed Shihab: Actually, I was a little afraid when I first came in. It’s like, what will I find? But I was really happy with what I found because actually HAMR technology works. That’s the good news. Obviously there’s a lot of work to do to get it to the reliability levels and density levels and things like that. So there’s a lot of engineering work. So the physics, we got that done. The basics in terms of the media and the heads and all the recording technology, we got that done. There is a bunch of manufacturing stuff we have to get done to dial everything in. You know how that works. A new technology; you’ve got to do some cleanup from the initial concept. 

    Ahmed Shihab

    We have a couple of customers helping us out. So that was always very gratifying. They’re looking at the drives, they’re giving us a bunch of feedback. 

    One of the lessons we learned is engage your customers early and being a former customer, I really appreciate that because I always wanted to know how. I don’t want to be surprised by the end of the day when somebody comes to me and says, well, here’s our technology now could you start using it? It takes a long time to qualify. So in one of my prior roles, we always engaged early. I encourage my team to engage early with technology so that we can get on the leading edge of its release and that’s what we’re doing.

    Blocks & Files: Do you anticipate that the qualification period with hyperscaler customers for HAMR will be as long as the one Seagate has been enduring?

    Ahmed Shihab: I hope not. The thing is there’s an advantage to being a fast follow-up because, if you think about it, AWS was always a fast follow-up for a long time and it did us well. We didn’t start leading until the 2017, 2018 sort of time frame and that is a very good philosophy in the sense a lot of the lessons were already learned. Customers will tell us what to expect and what works and what doesn’t. And we’ve certainly benefited from that experience. So that’s one of the things that’s really helping us accelerate that. And we have been working on HAMR for a long time. The ecosystems were mature. We had developed the technology. It wasn’t as much of a focus because we had the density of roadmap in ePMR, which is also unique to us. That takes us into the high thirties, early forties (TB). So we needed to accelerate it. That’s what we’re doing now.

    Blocks & Files: Do you think that with an 11-platter technology you have more headroom for HAMR development? It’s less rigorous than for Seagate with its 10-platter technology to match any particular capacity point.

    Ahmed Shihab: It certainly gives us more headroom to play with. We can use the extra platter to give us the overall capacity at lower density. So it gives us more headroom. It means we can go to market faster than they can. It’s not a trivial thing to do, obviously, to operate on 11 versus 10. It sounds easy, but all the tolerances, I’m sure you can appreciate, get tight. So we think that is an advantage and we’re certainly taking advantage of it.

    Blocks & Files: Will you use what I understand to be the same tactic as Seagate, which is provide lower capacity drives by just stripping out platters and heads and basically using the same HAMR technology, manufacturing for everything?

    Ahmed Shihab: I think in time, maybe. Right now we don’t need to. Our ePMR technology is mature, it works, it’s high yield, it’s good margins with the OptiNAND and everything else we’re doing. We can actually continue to deliver that technology for some years.

    Blocks & Files: Will OptiNAND give you particular opportunities with HAMR drives that don’t accrue to Seagate or Toshiba? 

    Ahmed Shihab: Let’s look at what OptiNAND does. UltraSMR (shingling) is what really is enabled by OptiNAND and UltraSMR is an algorithmic gain of capacity. Because of OptiNAND, we can actually get more capacity per platter than our competition can. So it’s an algorithmic thing that translates across the technologies. We expect it to apply equally to HAMR. We’re probably going to be a little less aggressive in the beginning, but it has the headroom, and it’s already implemented in the drives because we take technology from PMR to HAMR. It’s just the recording technology that’s different.

    Blocks & Files: Does OptiNAND mean that, again, you’ve got a little bit more headroom with HAMR density than you would without it?

    Ahmed Shihab: Yes. So one of the things we want to do is to be able to return that capacity to customers and in the beginning you’ll probably see us being a little conservative. We generally are more conservative. Our roots, we came from IBM and HGST and places like that where we are very, how shall I put this? We’re not flamboyant. We always deliver what we say we’ll deliver. As a customer, I’ll give you an example. We had HGST and IBM and WD drives that lasted way, way longer and with less failure rates than the competition. So we’ve always been appreciative of that and that is part of our culture. 

    We’re not flamboyant. We’re going to go on with it. We’re going to match and exceed Seagate’s capacity because we can win with things like OptiNAND that all our customers have qualified. They have qualified UltraSMR on ePMR. That’s already qualified in their software and we don’t have to do anything different when they come to the new drives with HAMR in them. They’ll qualify them for physical vibrations, all the usual things we help them with. But beyond that, there’s no new software they have to create.

    Blocks & Files: How do you see the disk drive market developing?

    Ahmed Shihab: One of the things I would say from being a customer is this: disk drives are really the bedrock of all the data economy that’s been developed. Data is constant. If you think about the cloud players’ object store, S3 and Blob stores, and all this data is constantly moving around, moving up and down the tiers, it’s moving to different regions, and moving for maintenance purposes. It’s all transparent to the user. Nobody sees it. You just apply a policy. You might have a trillion objects but it’s one policy and in the background all this data is moving around and being scrubbed and checked for bit rot and things like that. 

    It’s a very active environment in the background. So this is where we feel that disk drives have stood the test of time because they can deal with the read write endurance, the performance, the bandwidth – performance per terabyte is actually really more important than the IOPS in this space because it’s mostly large objects or large chunks that are moving around. So we see that as continuing. Disk drives are going to continue to be very relevant. There’s some Google papers and there’s a couple of quotes from a distinguished engineer now at Microsoft talking about how important disk drives are and continue to be important for the world. SSDs have their place, they absolutely have their place, and it’s more a question of better together than one versus the other.

    Blocks & Files: How about for video surveillance, smaller network attached storage drives and that kind of thing?

    Ahmed Shihab: If you think about video surveillance, it’s a very write-intensive workload. The endurance is a big deal and it’s also a very cost-sensitive world. So being 6x cheaper than QLC NAND and having practically infinite endurance, it makes a perfect sense for disk drives to be in that world. That’s definitely what we continue to see in that workload. SSDs tend to do well in very small block-based use cases and in caching use cases and high intensity read use cases.

    Blocks & Files: Do you think HDDs will continue to play a role in gaming systems?

    Ahmed Shihab: In some, I would say yes. It’s hard to say. The gaming market changes quite quickly. I don’t really have an opinion just yet on that one.

    Blocks & Files: Disk drives are pretty much in a fixed format; it’s a 3.5-inch drive bay. And that format has a long life ahead of it because you continually are going to be able to increase capacity. And so the cost per terabyte will continue to slowly edge down and your customers will get more value from disk drives than they can get from any alternate technology, whether it be SSDs above them in the performance space or tape drives below them. Is that pretty much it?

    Ahmed Shihab: We actually tried to look at five and a quarter inch drives, things like that. But the three and a half inch, one inch high form factor has really endured; mostly because you have existing infrastructure, you have people who know how to handle it. There’s a whole bunch of operational considerations to do with it. And it wasn’t lack of trying for wanting to change it, but there are practical limitations to do with the rate of spin and the size of the platters and the mechanics about the platters and the vibrations and things like that. So it’s here to stay in my opinion.

    The nice thing is we actually know the physics of the recording technology of HAMR is going to take us for another at least 10, 15, 20 years. There is a whole roadmap ahead of us in that world and that’ll continue to deliver the dollars per terabyte that customers want. And there’s opportunities for us to invent new capabilities. One of the things that we’re very excited about is something new about how we managed to increase the bandwidth per terabyte. So I’m not going to say much more about it, I’m just going to tease it out there. We talked about it publicly also, but it’s something that we’re very excited about.

    Blocks & Files: Do you think there’s a future for NVMe access drives?

    Ahmed Shihab: The only reason I can think is NVMe will become important is when the bandwidth exceeds the capability of SATA. I think it’s going to be a practical thing that changes it. There’s a lot of ideological conversations around NVMe versus SATA versus SAS and, as a company and as a team, we’re very rooted in pragmatism. If there’s no need for it, don’t do it, because it’s disruptive to customers. And that’s something we’re very careful about, in the sense we want to reduce the friction that customers feel when they’re adopting new technology.

    If you think about SMR and what we’ve done with OptiNAND and things like that, we learned a bunch of lessons from that, which is how to make it really super low-friction for customers to get into new drive technology. And we’ve been working with customers for a long time helping them write code, deliver libraries so that they can take better advantage of all the capabilities of drives. So we very much want to work in lockstep with those customers. 

    So just changing the interface for the sake of it; can we do it? Of course we can do it. Doing NVMe now is not really hard. It’s changing the wire and the protocol. It’s not a big deal. The question is, is the market, our customers, ready for it? Is it necessary? And customers will only do it when it’s necessary.

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  • AI is advancing even faster than sci-fi visionaries like Neal Stephenson imagined

    AI is advancing even faster than sci-fi visionaries like Neal Stephenson imagined

    Every time I read about another advance in AI technology, I feel like another figment of science fiction moves closer to reality.

    Lately, I’ve been noticing eerie parallels to Neal Stephenson’s 1995 novel “The Diamond Age: Or, A Young Lady’s Illustrated Primer.”

    “The Diamond Age” depicted a post-cyberpunk sectarian future, in which society is fragmented into tribes, called phyles. In this future world, sophisticated nanotechnology is ubiquitous, and a new type of AI is introduced.

    Though inspired by MIT nanotech pioneer Eric Drexler and Nobel Prize winner Richard Feynman, the advanced nanotechnology depicted in the novel still remains out of reach. However, the AI that’s portrayed, particularly a teaching device called the Young Lady’s Illustrated Primer, isn’t only right in front of us; it also raises serious issues about the role of AI in labor, learning and human behavior.

    In Stephenson’s novel, the Primer looks like a hardcover book, but each of its “pages” is really a screen display that can show animations and text, and it responds to its user in real time via AI. The book also has an audio component, which voices the characters and narrates stories being told by the device.

    It was originally created for the young daughter of an aristocrat, but it accidentally falls into the hands of a girl named Nell who’s living on the streets of a futuristic Shanghai. The Primer provides Nell personalized emotional, social and intellectual support during her journey to adulthood, serving alternatively as an AI companion, a storyteller, a teacher and a surrogate parent.

    The AI is able to weave fairy tales that help a younger Nell cope with past traumas, such as her abusive home and life on the streets. It educates her on everything from math to cryptography to martial arts. In a techno-futuristic homage to George Bernard Shaw’s 1913 play “Pygmalion,” the Primer goes so far as to teach Nell the proper social etiquette to be able to blend into neo-Victorian society, one of the prominent tribes in Stephenson’s balkanized world.

    No need for ‘ractors’

    Three recent developments in AI – in video games, wearable technology and education – reveal that building something like the Primer should no longer be considered the purview of science fiction.

    In May 2025, the hit video game “Fortnite” introduced an AI version of Darth Vader, who speaks with the voice of the late James Earl Jones.

    The estate of James Earl Jones gave Epic Games permission to use the late actor’s voice for an AI Darth Vader.
    Jim Spellman/WireImage via Getty Images

    While it was popular among fans of the game, the Screen Actors Guild lodged a labor complaint with Epic Games, the creator of “Fortnite.” Even though Epic had received permission from the late actor’s estate, the Screen Actors Guild pointed out that actors could have been hired to voice the character, and the company – in refusing to alert the union and negotiate terms – violated existing labor agreements.

    In “The Diamond Age,” while the Primer uses AI to generate the fairy tales that train Nell, for the voices of these archetypal characters, Stephenson concocted a low-tech solution: The characters are played by a network of what he termed “ractors” – real actors working in a studio who are contracted to perform and interact in real time with users.

    The Darth Vader “Fortnite” character shows that a Primer built today wouldn’t need to use actors at all. It could rely almost entirely on AI voice generation and have real-time conversations, showing that today’s technology already exceeds Stephenson’s normally far-sighted vision.

    Recording and guiding in real time

    Synthesizing James Earl Jones’ voice in “Fortnite” wasn’t the only recent AI development heralding the arrival of Primer-like technology.

    I recently witnessed a demonstration of wearable AI that records all of the wearer’s conversations. Their words are then sent to a server so they can be analyzed by AI, providing both summaries and suggestions to the user about future behavior.

    Several startups are making these “always on” AI wearables. In an April 29, 2025, essay titled “I Recorded Everything I Said for Three Months. AI Has Replaced My Memory,” Wall Street Journal technology columnist Joanna Stern describes the experience of using this technology. She concedes that the assistants created useful summaries of her conversations and meetings, along with helpful to-do lists. However, they also recalled “every dumb, private and cringeworthy thing that came out of my mouth.”

    AI wearable devices that continuously record the conversations of their users have recently hit the market.

    These devices also create privacy issues. The people whom the user interacts with don’t always know they are being recorded, even as their words are also sent to a server for the AI to process them. To Stern, the technology’s potential for mass surveillance becomes readily apparent, presenting a “slightly terrifying glimpse of the future.”

    Relying on AI engines such as ChatGPT, Claude and Google’s Gemini, the wearables work only with words, not images. Behavioral suggestions occur only after the fact. However, a key function of the Primer – coaching users in real time in the middle of any situation or social interaction – is the next logical step as the technology advances.

    Education or social engineering?

    In “The Diamond Age,” the Primer doesn’t simply weave interactive fairy tales for Nell. It also assumes the responsibility of educating her on everything from her ABCs when younger to the intricacies of cryptography and politics as she gets older.

    It’s no secret that AI tools, such as ChatGPT, are now being widely used by both teachers and students.

    Several recent studies have shown that AI may be more effective than humans at teaching computer science. One survey found that 85% of students said ChatGPT was more effective than a human tutor. And at least one college, Morehouse College in Atlanta, is introducing an AI teaching assistant for professors.

    There are certainly advantages to AI tutors: Tutoring and college tuition can be exorbitantly expensive, and the technology can offer better access to education to people of all income levels.

    Pulling together these latest AI advances – interactive avatars, behavioral guides, tutors – it’s easy to envision how an AI device like the Young Lady’s Illustrated Primer could be created in the near future. A young person might have a personalized AI character that accompanies them at all times. It can teach them about the world and offer up suggestions for how to act in certain situations. The AI could be tailored to a child’s personality, concocting stories that include AI versions of their favorite TV and movie characters.

    But “The Diamond Age” offers a warning, too.

    Toward the end of the novel, a version of the Primer is handed out to hundreds of thousands of young Chinese girls who, like Nell, didn’t have access to education or mentors. This leads to the education of the masses. But it also opens the door to large-scale social engineering, creating an army of Primer-raised martial arts experts, whom the AI then directs to act on behalf of “Princess Nell,” Nell’s fairy tale name.

    It’s easy to see how this sort of large-scale social engineering could be used to target certain ideologies, crush dissent or build loyalty to a particular regime. The AI’s behavior could also be subject to the whims of the companies or individuals that created it. A ubiquitous, always-on, friendly AI could become the ultimate monitoring and reporting device. Think of a kinder, gentler face for Big Brother that people have trusted since childhood.

    While large-scale deployment of a Primer-like AI could certainly make young people smarter and more efficient, it could also hamper one of the most important parts of education: teaching people to think for themselves.

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  • Circulating Inflammatory Cells Persist in Severe Asthma Despite Biologic Therapy, Study Shows

    Circulating Inflammatory Cells Persist in Severe Asthma Despite Biologic Therapy, Study Shows

    A new study published in Allergy from researchers at Sweden’s Karolinska Institutet reveals that biologic therapies mepolizumab and dupilumab—while clinically effective in reducing exacerbations and improving asthma control—do not fully eliminate type 2 inflammatory lymphocytes in individuals with severe asthma. Paradoxically, treatment is associated with increased frequencies of circulating type 2 innate lymphoid cells (ILC2), type 2 helper T cells (Th2), and cytotoxic T cells (Tc2), alongside phenotypic shifts that may alter their tissue homing and functional properties.

    Lorenz Wirth

    Courtesy of Karolinska Institutet

    These findings suggest that persistent immune activation may continue under the surface, raising questions about the feasibility of biologic-free remission in some patients.

    “We were surprised to find that blood levels of inflammatory cells increased rather than decreased,” Lorenz Wirth, doctoral student at Karolinska Institutet’s Department of Medicine in Huddinge, Sweden, said in a statement. “This could explain why inflammation of the airways often returns when the treatment is tapered or discontinued. It is important that we understand the long-term immunological effects of these drugs.”

    The study addresses a critical gap in understanding how these targeted therapies influence immune cell dynamics beyond blood eosinophils. While biologics targeting interleukin (IL)-5 (eg, mepolizumab) or the IL-4 receptor alpha chain (eg, dupilumab) are now standard therapy for individuals with severe, eosinophilic, or Th2–high asthma, little is known about their impact on circulating type 2 lymphocytes—cells central to asthma pathogenesis. Given that some patients remain symptomatic despite treatment and that long-term remission is an emerging goal, researchers sought to characterize whether these cells persist or resolve with therapy.

    Researchers analyzed peripheral blood samples from 40 participants with severe asthma enrolled in the longitudinal BIOCROSS study. All participants had uncontrolled asthma despite guideline-directed therapy and were treated with mepolizumab (n=33) or dupilumab (n=7). The research team collected blood samples at baseline, 4 months, and 12 months. Flow cytometry, single-cell RNA sequencing, and ex vivo stimulation assays were used to characterize type 2 lymphocyte populations and their transcriptional and functional changes over time.

    FINDINGS

    Clinically, both therapies led to significant improvements. Mepolizumab-treated participants showed reduced annual exacerbation rates (from 3.79 to 0.64; P <.001), decreased oral corticosteroid use, and improved Asthma Control Questionnaire (ACQ-6) and Asthma Quality of Life Questionnaire (AQLQ) scores. Participants treated with dupilumab also improved across similar measures, though the small sample size limited statistical comparisons, authors noted.

    Yasinka and colleagues were surprised that, despite these gains, both treatments were associated with increased frequencies of circulating ILC2s. Mepolizumab also increased Th2 and Tc2 cells—particularly those with a central memory phenotype. These lymphocytes exhibited reduced expression of homing receptors, suggesting the potential for decreased airway trafficking, the researchers said. Notably, CD117^low ILC2s—associated with more active Th2 inflammation—were enriched in circulation, expressing elevated levels of CD62L and KLRG1.

    Transcriptional analyses further revealed that mepolizumab-treated patients had increased expression of activator protein-1 (AP-1) family genes across type 2 lymphocyte subsets; the AP-1 family mediates biologic processes including proliferation and differentiation, authors explained. Functional assays supported these findings: after 1 year of treatment, type 2 lymphocytes produced more IL-5 and IL-13 in response to stimulation, indicating preserved or even enhanced pro-inflammatory potential despite biologic therapy.

    The data put the paradox in context: while biologics reduce clinical symptoms and eosinophilic inflammation, they do not eliminate, and may even enrich, a population of functionally active type 2 lymphocytes with altered trafficking patterns. The authors hypothesize that mepolizumab, in particular, may redirect these cells away from inflamed airways into circulation—a mechanism that reduces local inflammation but does not equate to immune resolution.

    Wirth et al acknowledge several limitations with the study, including the small size of the dupilumab subgroup and the absence of airway tissue samples. Findings are also limited to peripheral blood, which may not fully reflect activity in lung tissue, they wrote.

    The authors conclude that long-term disease control in asthma may not equate to immunologic remission. Persistent inflammatory cell populations could represent a latent risk for disease flare or may influence decisions about tapering biologics, they advised. Further research should investigate whether specific biomarkers can identify patients likely to achieve durable, treatment-free remission or whether additional strategies are needed to suppress the full spectrum of type 2 inflammation.


    References

    Wirth L, Weigel W, Stamper CT, et al. High-dimensional analysis of type 2 lymphocyte dynamics during mepolizumab or dupilumab treatment in severe asthma. Allergy. 2025;0:1–16 doi:10.1111/all.16633

    Inflammatory cells remain in the blood after treatment of severe asthma. News release. Karolinska Institutet. June 26, 2025. Accessed July 2, 2025. https://news.ki.se/inflammatory-cells-remain-in-the-blood-after-treatment-of-severe-asthma

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  • Knowledge, Attitudes, and Practices of Nurses Regarding Needle Stick Injuries, HIV, and Hepatitis B Prevention in a Tertiary Care Center in Nagpur, India: A Cross-Sectional Study

    Knowledge, Attitudes, and Practices of Nurses Regarding Needle Stick Injuries, HIV, and Hepatitis B Prevention in a Tertiary Care Center in Nagpur, India: A Cross-Sectional Study


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  • Tech Preview 222 Released With Fixes

    Tech Preview 222 Released With Fixes

    A new version of Apple’s experimental Safari Technology Preview browser has been released. The browser, which was first released in 2016, allows users to test features that will be included in later Safari editions. Version 222 of the Apple Safari browser update brings a number of compatibility and performance enhancements. Notably, improvements focus on topics including the Web API, accessibility, CSS, media, rendering, and scrolling. The purpose of these modifications is to increase browser dependability and get features ready for future mainstream Safari releases.

    At the moment, macOS Sequoia and macOS Tahoe are compatible with Safari Technology Preview 222. These are the most recent macOS versions from Apple, which should be released later this year. As a result, the upgraded experimental browser is immediately useful for those using more recent versions of macOS.

    apple-technology-preview

    The Apple Safari browser update can be found under Software Update in System Preferences or System Settings. The updated version will only be visible to people who have already downloaded the browser from Apple’s website. Apple has posted release notes on its Safari Technology Preview website with all the information.

    Despite being designed for developers, this version can be used without an Apple developer account. Furthermore, there are no system problems when using the preview version in conjunction with the standard Safari browser. With this release, Apple keeps gathering user and developer input to improve Safari’s essential functionalities.

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  • SpaceX rocket sets reuse record on 500th Falcon 9 launch

    SpaceX rocket sets reuse record on 500th Falcon 9 launch

    SpaceX launched its 500th Falcon 9 rocket on early this morning (July 2) and broke its own reuse record in the process.

    The milestone mission lifted off with 27 Starlink satellites at 2:28 a.m. EDT (0628 GMT) on Wednesday from Space Launch Complex 40 at the Cape Canaveral Space Force Station in Florida. The rocket entered space about nine minutes after leaving the ground and deployed the new units for SpaceX’s broadband internet network 55 minutes later.

    SpaceX’s 500th Falcon 9 launch included another milestone: the 29th reuse of the rocket’s first stage, four more than any other booster in the fleet, on Wednesday, July 2, 2025. (Image credit: SpaceX)

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  • Negative thermal expansion alloy to enable stable lenses to hunt for exoplanets

    02 Jul 2025

    Company Allvar working with NASA on NTE space telescope optics; other applications are possible.

    A new material that shrinks when it is heated and expands when it is cooled could help enable the ultra-stable space telescopes that future NASA missions require to search for habitable worlds; planets beyond our solar system (exoplanets) that could support life. Over the past two decades, scientists have developed ways to detect atmospheres on exoplanets by closely observing stars through advanced telescopes. As light passes through a planet’s atmosphere or is reflected or emitted from a planet’s surface, telescopes can measure the intensity and spectra of the light, and can detect various shifts in the light caused by gases in the planetary atmosphere.

    To successfully detect habitable exoplanets, NASA’s future Habitable Worlds Observatory (HWO) will need a contrast ratio of one to one billion. This in turn will require a telescope that is 1,000 times more stable than state-of-the-art space-based observatories like NASA’s James Webb Space Telescope and its forthcoming Nancy Grace Roman Space Telescope. New sensors, system architectures, and materials must be integrated and work in concert for future mission success.

    A team from Allvar Alloys, College Station, TX, and Syracuse, NY, is collaborating with NASA’s Marshall Space Flight Center and NASA’s Jet Propulsion Laboratory to demonstrate how integration of a new material with “unique negative thermal expansion characteristics” can help enable ultra-stable telescope structures.

    The materials currently used for telescope mirrors and struts have drastically improved the dimensional stability of the great observatories like Webb and Roman, but as indicated in the Decadal Survey on Astronomy and Astrophysics 2020 developed by the National Academies of Sciences, Engineering, and Medicine, they still fall short of the 10 picometer level stability over several hours that will be required for the HWO.

    Funding from NASA and other sources has enabled this material to transition from the laboratory to the commercial scale. Allvar received NASA Small Business Innovative Research funding to scale and integrate a new alloy material into telescope structure demonstrations for potential use on future NASA missions like the Habitable Worlds Observatory.

    This alloy shrinks when heated and expands when cooled – a property known as negative thermal expansion. For example, Allvar’s Alloy 30 exhibits a -30 ppm/°C coefficient of thermal expansion at room temperature. This means that a 1-meter long piece of this NTE alloy will shrink 0.003 mm for every 1 °C increase in temperature. In contrast, aluminum expands at +23 ppm/°C.

    Because it shrinks when other materials expand, Allvar Alloy 30 can be used to strategically compensate for the expansion and contraction of other materials. The alloy’s unique NTE property and lack of moisture expansion could enable optic designers to address the stability needs of future telescope structures.

    Thermal stability ‘improved up to 200 times’

    Calculations have indicated that integrating Alloy 30 into certain telescope designs could improve thermal stability up to 200 times compared to only using traditional materials like aluminum, titanium, carbon fiber reinforced polymers, and the nickel–iron alloy, Invar.

    To demonstrate that negative thermal expansion alloys can enable ultra-stable structures, the Allvar team developed a hexapod structure to separate two mirrors made of a commercially-available glass ceramic material with ultra-low thermal expansion properties. Invar was bonded to the mirrors and flexures made of Ti6Al4V—a titanium alloy commonly used in aerospace applications—were attached to the Invar.

    To compensate for the positive CTEs of the Invar and Ti6Al4V components, an NTE Allvar Alloy 30 tube was used between the Ti6Al4V flexures to create the struts separating the two mirrors. The natural positive thermal expansion of the Invar and Ti6Al4V components is offset by the negative thermal expansion of the NTE alloy struts, resulting in a structure with an effective zero thermal expansion.

    The stability of the structure was evaluated at the University of Florida Institute for High Energy Physics and Astrophysics. The hexapod structure exhibited stability well below the 100 pm/√Hz target and achieved 11 pm/√Hz. This first iteration is close to the 10 pm stability required for the HWO. A paper and presentation made at the August 2021 Society of Photo-Optical Instrumentation Engineers conference provides details about this analysis.

    Furthermore, a series of tests run by NASA Marshall showed that the ultra-stable struts were able to achieve a near-zero thermal expansion that matched the mirrors in the above analysis. This result translates into less than a 5 nm root mean square change in the mirror’s shape across a 28K temperature change.

    Beyond ultra-stable structures, the NTE alloy technology has enabled enhanced passive thermal switch performance and has been used to remove the detrimental effects of temperature changes on bolted joints and infrared optics. These applications could impact technologies used in other NASA missions. For example, these new alloys have been integrated into the cryogenic sub-assembly of Roman’s coronagraph technology demonstration.

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  • Heavy rains expected in KP, AJK, Punjab from Saturday – RADIO PAKISTAN

    1. Heavy rains expected in KP, AJK, Punjab from Saturday  RADIO PAKISTAN
    2. Pakistan slams climate ‘injustice’ as deadly floods hit country again  Al Jazeera
    3. 22 killed, 11 injured in KP rain and floods since June 25: PDMA  Dawn
    4. Mounting monsoon toll  The Express Tribune
    5. CM expresses sorrow over loss of lives due to accidents  Business Recorder

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  • ‘Dora the Explorer’ live-action movie premieres on Nickleodeon and Paramount+

    ‘Dora the Explorer’ live-action movie premieres on Nickleodeon and Paramount+

    Millions of children in more than 150 countries have watched a 7-year-old Latina with her trademark purple backpack take friends on fun television adventures.

    Now, Nickelodeon’s animated series “Dora the Explorer” is celebrating its 25th anniversary with a live-action movie, premiering on Nickelodeon and Paramount+ on Wednesday, ahead of the July 4 holiday weekend.

    “Dora and the Search for Sol Dorado” tells the story of 16-year-old Dora (played by Samantha Lorraine) who is budding into a skilled treasure hunter.

    The movie follows Dora and her friend Diego (Jacob Rodriguez) as they trek through a jungle to find an ancient treasure that could grant a magical wish.

    This teenage version of Dora, Mexican director Alberto Belli says, is like Indiana Jones and Lara Croft, but with a spunky “lo hicimos” (“We did it”) attitude that makes her uniquely Latina.

    Dora played by Samantha Lorainne and Diego played by Jacob Rodriguez in “Dora and the Search for Sol Dorado.”Pablo Arellano Spataro / Nickelodeon/Paramount+

    But according to Belli, Dora is more interested in the adventure because it can help her figure out who she is and what other people are like.

    Developing this larger sense of finding her place became a guiding theme for the movie.

    “When you’re taking a cartoon character into a live action, you need to go a little bit deeper. So we tried to create some more problems,” Belli said in an interview, accompanied by actress Samantha Lorraine. “She (Dora) loses her bag, which is a spoiler, but it’s also in the trailer. So now she needs to find who she really is. And I think right now, more than ever, people feel a little lost.”

    Dora’s backpack typically contains specific items, including a map, which she will need on her adventures. And Belli says that when “you don’t know exactly where you need to go,” you have to look inside yourself to figure it out.

    Lorraine says that “Sol Dorado” (“Golden Sun”) is more about finding an internal space — “who you are as a person.”

    “When she (Dora) finds Sol Dorado, to me, it was this full circle moment that we had finally finished this character arc,” the young actress said.

    Many iconic action-adventure characters “usually go and explore someone else’s culture. They never explore their own culture,” Belli said. “What’s really exciting about Dora is she loves history. She’s exploring her own culture.”

    Dora played by Samantha Lorraine and Boots voiced by Gabriel “Fluffy” Iglesias in "Dora and the Search for Sol Dorado."
    Dora played by Samantha Lorraine and Boots voiced by Gabriel “Fluffy” Iglesias in “Dora and the Search for Sol Dorado.”Pablo Arellano Spataro / Nickelodeon/Paramount+

    The movie incorporates Indigenous Latino traditions that influence Dora’s identity.

    One such tradition was based on “ayllu,” which is the Andean way of organizing communities to support each other through shared land, resources and responsibilities.

    “When it comes to ayllu, friendship and connection is so important, and I think Dora is the epitome of that. She’s the connection through most cultures of the world,” Lorraine said, adding that “Dora the Explorer” has been translated into more than 30 languages.

    Belli said that they had an expert on set to guide them through different Indigenous traditions, including quipus, which are knotted cords that were used by the Incas to record information.

    They also had two consultants to work on pronunciation for when Dora had to speak in Quechua, which is an Indigenous language spoken by people in parts of Perú, Bolivia and Ecuador.

    Lorraine, who identifies as Cuban American, says that playing Dora was a privilege because she offers many Latino children visibility.

    “I kept thinking to myself, what do I want my little cousins to see when they watch this movie?,” she said.

    Lorraine wants “Dora and the Search for Sol Dorado” to help viewers — regardless of their age — keep their sense of adventure and curiosity alive.

    Dora has “always been part of pop culture,” Belli said, adding that he has a 5-year-old who’s a big fan.

    “When I got the job, he got more excited than I did,” the director said with a laugh. “What I love about Dora is she’s a positive influence in people; she teaches you how to be positive, energetic and adventurous — and at the same time she teaches Spanish in a fun way, which I think is very cool.”

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