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  • Bestselling Salt Path authors under fire amid allegations of untruths and unpaid debts – The Irish Times

    Bestselling Salt Path authors under fire amid allegations of untruths and unpaid debts – The Irish Times

    Shortly before the release of The Salt Path, the recent cinematic adaptation of a bestselling memoir by Raynor Winn, Gillian Anderson, star of the film, was asked her impressions of the author.

    “I was surprised at how guarded she was,” the actor told the Guardian. “It was interesting to encounter a certain steeliness. It was informative for me to see that.”

    A report by Chloe Hadjimatheou in last weekend’s Observer offered suggestions as to why the writer may have seemed so reticent. Published in 2018, The Salt Path tells us how, after losing their home following an unwise investment, Winn and her husband Moth, who had recently been diagnosed with a terminal illness, tramped the 630 miles of the South West Coast Path in the English West Country. As so often happens on such literary journeys, they gained a sort of wisdom and found new depths in their relationship. The book sold more than two million copies. The film was a decent hit in the early summer – perfect counterprogramming to the first rush of superheroes.

    It would take a very naive reader not to suspect that such volumes are at home to a degree of creative embellishment. But the Observer story argues Winn may have exceeded industry-standard levels of creative licence.

    Book and film tell us the Winns lost their home after a childhood friend persuaded them to invest in what turned out to be a failing business. But Hadjimatheou claims the Winns – whose real names are Sally and Tim Walker – had embezzled money from a former employer. “In the end, I think it was around £64,000 she’d nicked over the previous few years,” Ros Hemmings, for whose now-late husband Winn had worked as book-keeper, told the Observer. The financial crash it was reported came when the couple failed to pay back a loan a relative had made them to cover the Hemmings’ losses. “According to Winn, the couple lost their home simply because their own generosity was turned against them,” Hadjimatheou notes before paddling into those murkier waters.

    The Observer piece also raises a sceptical eyebrow about the diagnosis of corticobasal degeneration that Moth received in 2013. Hadjimatheou explains that the life expectancy of those with the condition, which is related to Parkinson’s disease, typically runs from six to eight years and that “patients suffer debilitating symptoms significantly before that”. It is 12 years since Moth got the news. Two follow-up volumes to The Salt Path relate further lengthy walks the couple completed. Hadjimatheou does, however, cautiously say that “There is nothing I have seen to contradict his diagnosis or Sally Walker’s account of it.”

    On Sunday night, a spokesperson for the “Winns” (actually, the Walkers) told the Daily Mail the allegations were “highly misleading”. The statement continued: “The Salt Path lays bare the physical and spiritual journey Moth and I shared, an experience that transformed us completely and altered the course of our lives. This is the true story of our journey.” When pressed as to which of the allegations were untrue, the couple’s representative failed to expand, but noted they were taking legal advice.

    It’s possible that more will emerge. The Observer story lists further allegations about unpaid debts in Wales and mysterious cottages in the South of France.

    What becomes of a memoir after debunking? Well, The Salt Path is part of a weirdly unstoppable – and precisely defined – genre that is viewed more as self-help allegory than biographical record. There are endless film adaptations of allegedly true stories concerning walks that brought the characters enlightenment: Wild (Reese Witherspoon walks the Pacific Coast Trail), Tracks (Mia Wasikowska walks across Australia), The Great Escaper (elderly veteran Michael Caine walks to France), The Last Rifleman (elderly veteran Pierce Brosnan walks to France). Would any of these stories be less helpful as life guides for being a little less true?

    There was a colossal row in 2006 when it was revealed that James Frey’s A Million Little Pieces, a supposed addiction memoir much touted by Oprah Winfrey, turned out to be largely fictionalised. Frey’s former champion had him back on her show and showed no mercy. Maureen Dowd, writing in the New York Times, went into high fulmination. “It was a huge relief, after our long national slide into untruth and no consequences into swiftboating and swift bucks, into W’s delusion and denial, to see the Empress of Empathy icily hold someone accountable for lying,” she bellowed. Yet A Million Little Pieces remained in print and, a full 12 years after the Oprah controversy, became a feature film with Aaron Taylor-Johnson.

    Back in the 1970s, concerned parents used to leave a supposed anonymous teenage diary called Go Ask Alice on the beds of any youngster who once arrived home bleary eyed. Few readers believed this tragic yarn of drug abuse to be anything other than a crudely composed admonitory fiction. Sure enough, it eventually proved to be the work of a Mormon youth counsellor – born as far back as the first World War – called Beatrice Sparks. The book has never gone out of print in the 54 years since its first publication.

    None of this may be of relevance to Raynor Winn. We have yet to see where her defence will lead. But, whatever happens, don’t rule out The Salt Path hanging around.

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  • Former MP ‘had no clue’ he had glaucoma before routine eye test

    Former MP ‘had no clue’ he had glaucoma before routine eye test

    Sarah Jones

    BBC News, West of England

    Association of Optometrists Headshot of an elderly man, with white hair and wearing a blue shirt and standing in front of a fireplace in a sitting roomAssociation of Optometrists

    Paul Tyler, 83, from Gloucestershire, found out he had the condition during a routine eye test in 2001

    A former MP who has been living with glaucoma for 25 years said he had “absolutely no clue” anything was wrong with his sight until the condition was picked up at a routine eye test.

    Paul Tyler, 83, who found out he had glaucoma during an eye test in Cornwall in 2001, said he was “lucky to live” somewhere where screening was available.

    The Association of Optometrists (AOP) has said more than half of high street optometrists have witnessed patients going blind from the condition because of late detection or delays in treatment.

    Mr Tyler, who now lives in Gloucestershire, added: “I dread to think what would have happened if I hadn’t had that diagnosis at that time.”

    “I had absolutely no clue that there was anything wrong,” Mr Tyler said.

    Described as the “silent thief of sight”, glaucoma affects about 700,000 people in the UK.

    It is usually caused by fluid building up in the front part of the eye, leading to the optic nerve, which connects the eye to the brain, becoming damaged.

    The condition does not usually cause any symptoms to begin with and can develop slowly over many years.

    Mr Tyler, the former Liberal Democrats rural affairs spokesperson who became a life peer in 2005, said he remembers the day when he discovered he had glaucoma “precisely”.

    “It was the day of the [Twin] towers 9/11 in New York – when I went for my usual sight check,” he said.

    “I was an MP in rural Cornwall. I knew nothing about glaucoma. My eyes seemed to be fine.

    “Like many people, I think you sort of take these things for granted. It is literally out of sight, isn’t it. So, I was completely taken aback.”

    Association of Optometrists Close up image of an elderly man having his eyes tested by an optometristAssociation of Optometrists

    Mr Tyler said he thanks his “lucky stars” that he was seen by “right people at the right place at the right time”.

    Since then he has has moved to Gloucestershire, where he said he can access an “enhanced glaucoma service”.

    As a result, the condition has had a minimal impact on his day-to-day life, he said.

    “Glaucoma is the most extraordinary invisible illness – you have no notion whether there’s something going wrong until probably it’s too late,” he said.

    “In a matter of a couple of years, if I hadn’t had that early diagnosis, I would have had to have given up my job, which would have been really devastating for me.

    “I was very lucky – and thank my lucky stars that I had the right people at the right place at the right time.”

    ‘Failing the public’

    A report by the Royal College of Ophthalmologists suggests cases could rise by 22% by 2035.

    The AOP has also called for the government to commit to a national glaucoma pathway for England, working with high street opticians to ensure patients have equal access to treatment.

    Adam Sampson, AOP chief executive, said the current approach to glaucoma in England was “failing the public”.

    “Each year, people are faced with the reality of permanent sight loss as a direct result of delays to care and inconsistencies in eye care provision,” he said.

    “But glaucoma services led by optometrists show that it does not need to be this way.

    “We must ensure high street optometrists can protect the public by detecting, monitoring and treating glaucoma, and ease the burden on hospital eye services.”

    The Department of Health and Social Care, said regular sight tests “play a crucial role in the early detection of glaucoma”.

    “We want to make it as easy as possible for people to access eye care by expanding the NHS services offered by high street opticians, as we shift healthcare into the community,” a spokesperson said.

    “Free NHS sight tests are available for many, including individuals diagnosed with glaucoma or aged 40 and over with a close family history of glaucoma.”

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  • Samsung Issues Critical Update For All Galaxy Smartphones

    Samsung Issues Critical Update For All Galaxy Smartphones

    Samsung’s game of catch-up with Pixel continues, as speculation builds that One UI 8’s general release is getting closer — albeit July seems a stretch. The Galaxy interpretation of Android 16 includes major privacy and security enhancements for eligible phones.

    Meanwhile, the company has just issued a critical security update for Galaxy users in its July monthly release. This is a stark contract to Google, whose Android and Pixel July security bulletins (1,2) will surprise the millions of users now at risk.

    ForbesIf You Get This Message, An App On Your Phone Is Spying On You

    Samsung has patched one critical and 21 high-severity vulnerabilities, which it attributes to Android’s July security package. It has also patched 17 vulnerabilities of its own, and high-severity exposures affecting its chipsets.

    Google has drawn a surprising blank for July. The Android security bulletin says “there are no Android security patches in the July 2025 Android Security Bulletin,” while Pixel users are also told “there are no Pixel security patches in the July 2025 Pixel Update Bulletin,” given that the latest Android 16 update carries a July security flag.

    No sign yet of the Qualcomm fixes from last month which triggered a U.S. government update mandate for federal staff, with a deadline that was impossible to hit. Similarly, the empty Android monthly update highlights the current disparity between Pixel and Samsung, with one racing ahead with Android 16 and the other falling further behind.

    At the beginning of each month, Samsung’s more complex update process versus Pixel in particular is always highlighted. This includes the lack of seamless updates for all but the latest flagships and the multiple weeks it takes to reach all device models, regions and carriers. This in addition to the delays in OS upgrades is becoming more serious.

    ForbesGoogle Starts Checking If You Can Upgrade To Windows 11

    All Galaxy owners are urged to update their phones as soon as the latest release is available to them. There are plenty of patches to address, despite what Google’s notification to the wider Android community might suggest.

    The other focus at the moment is on Android phones that can’t move beyond Android 12, given that Google no longer provides updates for those phones and its latest Play Integrity API also means some apps will cease to function properly. If your Galaxy can’t run Android 13 or newer, it’s time to consider an upgrade.

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  • Chloé Resort 2026 Ready-to-Wear Runway, Fashion Show & Collection Review

    Chloé Resort 2026 Ready-to-Wear Runway, Fashion Show & Collection Review

    You could get lost in Chemena Kamali’s fascinating, dense mood boards for Chloé, which typically stretch across several boards, and for resort 2026 span Hollywood movies, indie films, avant-garde German photography and Karl Lagerfeld-era runway images — all culled from the early ‘80s.

    The styles depicted dovetail with Kamali’s instincts and current personal penchant for wearing more pronounced, rounded shoulders, Spencer jackets and cropped leather bombers, pleated trousers and stronger, Guy Bourdin-esque colors.

    She’s eased up on the free-flowing garments that are so typically Chloé, sensing the same shift in the fashion mood that compelled Lagerfeld to sketch a coat with an inverted triangle shape that signaled a new era of power dressing.

    “Variety,” a 1983 indie film by Bette Gordon that Kamali recently rewatched, similarly exemplifies a shift in the sociology of women in film, when “she becomes the subject and controls the narrative,” the designer related during a preview.

    Kamali ruminated on all of that, yielding a more streamlined, structured collection that elaborated on the don’t-mess-with-me shoulders she debuted on the runway for fall 2025, showing different facets of the Chloé girl.

    Her blouses and sweaters for resort also incorporate pronounced shoulder padding, while still telegraphing the fluid, feminine spirit of the brand via silky fabrics, polka dots and floral prints.

    Like most collections labeled resort or spring and delivered in November, the collection skews wintry in palette and styles, incorporating shearling chubbies, woolen peacoats and puffer styles in squishy plongé leather.

    Kamali also eased up on the size and scale of charms dangling from her bags, including a fetching take on the bowling shape and some industrial-strength clogs that fit the retro mood. She conscripted photographer Johnny Dufort for the look book shoot, which mirrors her mood board’s cinematic leanings.

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  • Global Energy Security: Western Dependence on Gulf Oil and the Role of Regional Mediation in Middle Eastern Conflicts

    Global Energy Security: Western Dependence on Gulf Oil and the Role of Regional Mediation in Middle Eastern Conflicts

    Introduction

    The 1973 Oil Embargo first revealed the deep interconnection between Middle Eastern stability and global energy security. In response to US military support to Israel during the Yom Kippur war against Egypt and Syria, the Organization of Arab Petroleum Exporting Countries (now OPEC) imposed a total oil embargo against any country that had supported Israel militarily during the aforementioned conflict. This triggered a global recession and a fourfold increase in oil prices. By that time, the world economy had become heavily dependent on oil supplies from the Middle East, with nearly 85% of US crude oil imports coming from OPEC nations

    Although the embargo was lifted by March of 1974, two following Middle Eastern crises would disrupt global energy markets. In late 1978, the Iranian Revolution resulted in a significant drop in Iranian crude oil production and average loss of 3.9 million barrels per day. Neighboring Gulf producers restored the supply gap. Then, in August 1990, Iraq’s invasion of Kuwait disrupted oil exports from both countries, causing another sudden rise in crude oil prices. These crises underscored how regional instability in the Gulf can rapidly escalate into global economic crises.

    This article argues that Western reliance on Gulf energy necessitates a proactive role in Middle East conflict mediation. As such, Western powers must recognize energy mediation as a core security function. As regional actors like Qatar, Egypt, and Oman increasingly assume key roles in facilitating dialogue, Western powers should pursue deeper partnerships with these mediators to ensure long-term stability in global energy markets.

    Global Supply Growth and Contemporary Energy Security Challenges

    Since these major disruptions, the oil market has changed in terms of global supply growth. Four countries in the Americas—the United States, Guyana, Canada, and Brazil—have the capacity to partially offset near-term voluntary production cuts from OPEC+ nations. In 2018, the United States became the world’s greatest oil producer. Concurrently, US imports of Gulf oil have fallen by 1.29 million barrels per day (56.8% reduction) in the last 20 years, while imports from Canada have increased by 2.4 million barrels per day (121.8% increase) over the same time period.

    Table 1: Contributions of Gulf Countries to U.S. and EU Oil Imports

    Although US dependence on Gulf oil has declined, the region remains critical for global energy stability and Western interests. For instance, the European Union has continued to depend heavily on Gulf oil, particularly from Iraq, Saudi Arabia, and Qatar, as alternatives to Russian energy sources. . Moreover, the region remains relevant due to its strategic export role and control over key trade routes. In early 2024, global oil prices increased amid growing tensions in the Middle East. Although the Israel-Hamas conflict did not directly impact supply, it raised fears of broader disruption. Houthi attacks in the Red Sea rerouted oil tankers, and concerns over potential escalation between Israel and Iran heightened fears about the Strait of Hormuz, which in 2022 carried roughly 21% of global petroleum liquids. These risks underscore the Gulf’s enduring influence on energy markets.

    Middle East Mediation as an Essential Process for Global Energy Security

    To prevent supply disruptions and a wider regional war, mediation has become a vital tool for Western powers. This is not only to advance peace but also to protect the stability of global energy markets, which remain vulnerable to Gulf-based conflicts and chokepoint disruptions. Because access to secure, continuous energy flows is a strategic necessity, Western powers are compelled to engage either directly or through partners when conflicts threaten this stability.

    As a rule, the objective of mediation is for a neutral third party to help disputants reach an agreement on their own, rather than impose a solution. Mediators work with parties, sometimes together and sometimes separately, to assist in finding a voluntary and sustainable resolution. However, Western powers are often seen as lacking neutrality due to their strategic and political ties in the region. For example, the United States is frequently viewed as a biased actor due to its close alliance with Israel. Even when Western statements appear neutral and peace-oriented, they are often interpreted through the lens of underlying power dynamics and economic interests, particularly around energy.

    This means that Western powers are pressed to act in partnership with a more diverse set of countries to achieve success in Middle East mediation. This is part of a broader trend in global peacemaking away from the United Nations and the group of traditional mediation countries—such as the United States, United Kingdom, Switzerland, Norway and Finland—that took the lead on international mediation for decades after World War II toward a more diverse set of peacemakers in partnership with traditional mediators. On one hand, traditional mediators are searching for trusted third parties to convey communications with the other side, as when the U.S. leans on Gulf states to communicate messages to Iran. On the other hand, states are increasingly taking on peace-facilitation roles as critical components of their foreign policy for both political prestige and national and regional security.

    Looking Forward: Regional Mediation Partnerships and the Role of Qatar, Egypt, and Oman

    This trend puts a new group of countries—such as Qatar, Egypt, and Oman—as a better conduit between Western powers and Middle East disputants. Qatar and Oman have confidentially mediated discussions for years between the United States and Iran that resulted in a 2023 deal involving the release of prisoners and the unfreezing of $6 billion in Iranian oil revenue. Additionally, since the Gaza war began in 2023, Qatar and Egypt, have emerged as central mediators between Israel and Hamas.. Qatar have initiated ideas for solutions, settled deadlines for replies, reminded both sides of the gravity of the situation, and intervened when it appeared that cease-first talks were stuck. These events demonstrated that Western powers should explore partnerships with this new group of countries to safeguard global energy security.

    Should Western powers seek to ensure short- and long-term security in global energy markets, the role of Gulf state energy and mediation in Middle Eastern conflicts must not go unrecognized. Despite growth in the Americas, Western powers still retain significant reliance on Gulf energy, particularly for its strategic advantages. To mitigate future conflict-related disruptions in global energy markets, Western powers should intensify mediations in partnership with countries that hold regional credentials to achieve success. This includes formalizing mediation partnerships with states like Qatar and Egypt through multilateral agreements or frameworks that go beyond ad hoc collaboration. It also requires investing in capacity-building for regional mediators to strengthen their role in early-warning systems and de-escalation diplomacy. With support and collaboration from traditional mediators, Qatar appears ready, together with other Arab countries, to consolidate its position as a mediator that seeks both regional peace and global energy security.

    . . .

    Dr. Talal Abdulla Al-Emadi is the Energy Law Professor & Fourth Dean of the College of Law at Qatar University (QU). He holds a doctorate degree in law (DPhil) from the University of Oxford, where he wrote about joint ventures in the gas industry. He also holds an LLM from Harvard and an LLB from QU. The author would like to extend thanks to his RAs, Leandro Alves and Eduardo Pereira, for the research help provided, and Prof. Francis Botchway and Dr. Ezieddin Elmahjub for reading the drafts and invaluable comments.

    Image Credit: Odile, Unsplash Content License, Unsplash.

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  • TfL seeks sponsor to ‘own’ branding of line

    TfL seeks sponsor to ‘own’ branding of line

    Getty Images People sit in the carriage of a Tube train. It has a disctinctive light green and blue colour scheme. Getty Images

    The Waterloo & City is a two-stop, three-minute shuttle service

    Transport for London (TfL) is offering a new partnership to an organisation or company willing to pay to sponsor the Waterloo & City line.

    The line – which runs on weekdays between Bank and Waterloo Underground stations – was opened in July 1898 and is colloquially known as The Drain.

    The two-stop, three-minute shuttle service is one of only two Tube lines that runs completely underground, the other being the Victoria line.

    On a post on professional networking site LinkedIn, TfL said the sponsorship offer “goes far beyond a typical media opportunity”, although previous temporary brand “takeovers” of Tube stations have sparked complaints.

    Getty Images People stand on an underground platform at Waterloo. There are adverts on both walls. The train indicator says "all trains go to Bank".Getty Images

    The line only runs on weekdays between Bank and Waterloo

    TfL said: “It’s full-line branding, from moquette seat fabric and signage to maps and experiential spaces, all right in the heart of London’s business district.”

    Moquette fabric is the durable, woollen seating material that is used in upholstery on Tube carriage seats, while an experiential space is described by TfL as a “pop-up presence for sampling and distribution in a pre-approved station space”.

    TfL said: “Millions of professionals and decision-makers travel this route every year. Now, your brand can own the journey.”

    Previous money-making marketing schemes on London Underground have created controversy.

    The exterior of a Tube station - the signage says Burberry Street station in white letters on a blue background.

    Bond Street was renamed Burberry Street in 2023, making TfL £200,000

    PA Media A Tube sign above a 1930s brick station - it says Gareth Southgate.PA Media

    Southgate Tube station was rebranded Gareth Southgate station in 2018

    In 2018, Southgate Tube station was rebranded Gareth Southgate station for 48 hours, after the England men’s football squad he managed finished fourth in the World Cup.

    In 2023, Bond Street was briefly renamed Burberry Street by the fashion brand to mark London Fashion, which raised £200,000 for the transport company.

    That led to more than 50 complaints to TfL with some passengers confused by the new temporary signage.

    Transport for All, a transport advocacy group led by disabled people, warned last year that “thoughtless PR stunts being used to plug holes in TfL funding cannot be at the expense of accessibility and safety for disabled passengers”.

    The group also said that “messing around with station names… stops many disabled people being able to travel confidently”.

    Transport for London A close up of a poster advertising a BBC nature programme above a Tube station sign that reads Green Planet.Transport for London

    The BBC formed a partnership with TfL in January 2022

    TfL documents state that brand sponsorship on its network can cost up to £7.5m.

    IFS Cloud’s sponsorship of the cable car that links North Greenwich and Custom House in east London is worth £2.1m.

    While brands have previously “taken over” one or more Underground stations for several days, if successful this initiative would be the first time an entire Tube line would get a sponsor, albeit one with just two stations.

    The BBC formed a partnership with TfL in January 2022, rebranding Green Park station for 48 hours as Green Planet to promote Sir David Attenborough’s five-part series.

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  • ‘Within four weeks, the vision in his eyes had doubled’ – The Irish Times

    ‘Within four weeks, the vision in his eyes had doubled’ – The Irish Times

    This year may prove to be an important year for advances in gene editing and gene therapies.

    But what does that really mean, and how have we got to this point?

    In what is claimed as a world first, doctors in the United States recently treated a baby with a rare genetic disease using a highly specific and personalised gene-editing technique.

    What did this involve and how is the baby doing?

    Baby boy KJ was born with a rare metabolic disease known as CPSI deficiency. This prevented his body from getting rid of ammonia during the metabolism of protein. And while he was put on a highly restricted protein diet and given drugs to remove protein from his blood, he remained at high risk of brain damage or even death.

    Following the early diagnosis of KJ’s condition, gene-editing researchers at the University of Philadelphia worked with colleagues throughout the US to quickly develop a personalised gene-editing infusion to correct a genetic variant that led to the disorder.

    KJ responded well to the three-dose regimen and is now reaching his developmental milestones. “Ultimately, we hope this has set a precedent where we have firmly entered a world of genetic cures on demand,” said Fyodor Urnov, scientific director of the Innovative Genomic Institute in the University of California, Berkeley, a member of the treatment team.

    Have similar gene-editing techniques been used on patients in Ireland too and how do they differ from gene therapy?

    The gene-editing platform known as Crispr is widely used by researchers in scientific laboratories in their search for new therapies for cancer and other diseases. Essentially, Crispr – whose inventors won the Nobel Prize in chemistry in 2020 – is a cheap and efficient way of finding and altering specific pieces of DNA within cells.

    Clinical trials of gene therapies for inherited eye conditions are desperately needed for the treatment of an estimated 5,000 patients on the island of Ireland affected by these diseases

    —  Dr Emma Duignan

    Gene therapy is slightly different in that it introduces new DNA materials into cells to replace or correct a gene or inactivate a target gene in the treatment of a specific disease.

    Earlier this year, ophthalmologic surgeon Dr Max Treacy treated 20-year-old Maros Tomko, who had severe visual loss since birth, with gene therapy at the Royal Victoria Eye and Ear Hospital in Dublin. The once-off treatment replaced the faulty gene RPE65 with a healthy copy. This was done via a viral vector which carried the healthy copy of the gene into the cells of the eye.

    “Within four weeks, the vision in his eyes had doubled. From not being able to see any letters, he could read the first and second lines. His visual field [the total area seen] also doubled in size,” explains ophthalmologist Dr Emma Duignan. Tomko adds that he is very grateful to the doctors for this opportunity to have surgery. “I can see people’s faces now and I can read the numbers on my bank card for the first time. It’s only three months since the surgery so it will take longer to get better,” he says.

    Ophthalmologist Dr Emma Duignan

    A 31-year-old Sligo man with a similar congenital blindness got his sight back after being treated with ocular gene therapy at the Mater hospital in Dublin in 2024.

    Gene therapies, however, remain very expensive and the Royal Victoria Eye and Ear Hospital treatment, which was paid for by the Health Service Executive, cost close to €800,000.

    Dr Duignan says it took years for the team to get the funding in place, but such treatments now mean that Dublin will have two potential centres for gene therapy clinical trials. “Clinical trials of gene therapies for inherited eye conditions are desperately needed for the treatment of an estimated 5,000 patients on the island of Ireland affected by these diseases,” says Dr Duignan. Drugs used in clinical trials are made available free of charge.

    Manipulating human DNA – the genetic material responsible for life – is like the stuff of science fiction. How is it even possible?

    Research into gene therapy goes back to the 1940s and 1950s. The first studies began to recognise that DNA was a transforming substance capable of changing the living characteristics of individuals through a biochemical process. Later, studies identified that human stem cells (mainly found in the bone marrow) could be genetically modified to carry therapeutic DNA which could then differentiate into various cell types to correct genetic defects.

    In the 1980s, researchers at Boston Children’s Hospital published a paper to show a virus could be used to insert genes into blood-forming stem cells. These so-called viral vectors later became an established way to deliver specific genetic material to human cells. In the meantime, the Human Genome Project was completed in 2003, paving the way for gene therapy to become a reality for multiple diseases, especially those caused by mutations in a single gene.

    What specific diseases are we talking about?

    The painful and life-threatening sickle cell disease, a rare genetic immune deficiency disorder called chronic granulomatous disease, and the rare childhood disease adrenoleukodystrophy have all been treated with gene therapy. Genetic diseases including cystic fibrosis, muscular dystrophy, sickle-cell anaemia and haemophilia could potentially be treated with gene therapy.

    But are there risks to making such precise changes to the basic building blocks of life?

    Yes, there are huge risks, which is why it has taken so long for gene therapy to reach clinical settings. In 1990, four-year-old Ashanthi de Silva became the first patient to be successfully treated with gene therapy. She was given a healthy adenosine deaminase (ADA) enzyme to cure the severe immunodeficiency disorder caused by the absence of ADA. Although she continues to take a drug to keep her condition under control, she leads an active life to this day.

    Delving into the power of DNA for patientsOpens in new window ]

    Throughout the 1990s, European researchers focused on other forms of severe immunodeficiency disorders, reporting the first cures in 2000. However, some years later, five of the 20 treated children developed cancer. The viral vector which had delivered the gene to their T cells (immune cells in the body) had also activated an oncogene, triggering leukaemia. Also in the US, an 18-year-old boy died after receiving gene therapy for a rare metabolic disorder.

    These incidents delayed research into gene therapy for almost 10 years. But in the early 2010s, scientists developed better viral vectors that could more precisely target expressions of genes in specific cell types which don’t go astray in the body and don’t trigger an immune response. This spurred further developments in genetic therapies and several gene therapy drugs were approved for use.

    The use of messenger RNAs (mRNAs) – as was used in Covid-19 vaccines – also represents a form of gene therapy. In this case, the mRNA vaccine introduces information that cells then use to make the coronavirus spike protein, which then stimulates the person’s immune system to develop antibodies to the virus.

    What are the next steps for gene editing and gene therapy?

    There are now hundreds of active gene therapy studies around the world and more than a dozen gene therapy drugs on the market, according to researchers at Boston Children’s Hospital.

    A more finely tuned approach called base-editing, which uses Crispr technology to chemically change one “letter” of a gene’s code at a time, is deemed to be the next technological advance in genetic therapies. The small changes of base-editing can correct a “spelling error” mutation, silence a disease-causing gene or help activate a specific gene. However, while this approach hasn’t yet been tested in clinical trials, places such as Boston Children’s Hospital have several base-editing projects under way.

    Dr Duignan adds that new so-called gene agnostic therapies, which will treat diseases caused by different gene mutations without having to develop a specific infusion for each mutation, represent the next frontier in gene therapy.

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  • Iron Maiden 50th anniversary marked with new coin

    Iron Maiden 50th anniversary marked with new coin

    Heavy metal legends Iron Maiden has been commemorated on a UK coin to mark 50 years since its formation.

    Designed by artist Albert “Akirant” Quirantes, the coin features mascot Eddie and has hidden references to the band’s career, albums and tours.

    Manager Rod Smallwood said: “Having Eddie on an official UK coin is a continuation of his incredible odyssey since we unearthed him back in 1980. We’ve been on stamps, beer bottles, plane tails and now legal tender.”

    Rebecca Morgan, from The Royal Mint, in Llantrisant, south Wales, said the coin was a “perfect fusion of metal on metal”, adding: “We expect it will prove to be a collector’s piece that’s highly sought after.”

    The coin is the first official collectable product to bear the band’s 50th anniversary logo.

    Quirantes said designing the coin had been “one of the most thrilling projects” of his career.

    He added: “As a lifelong fan of the band, and Derek Riggs’ original creations in the ’80s, I wanted to capture not just their iconic imagery, but also the rebellious spirit that has defined their music for decades.

    “I’ve hidden several references within the design that true fans will enjoy discovering, including subtle nods to classic album artwork and their most beloved songs.”

    The coin is available in several editions, with prices from £18.50.

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  • LGBTQ+ mental health website honours Strictly’s Robin Windsor

    LGBTQ+ mental health website honours Strictly’s Robin Windsor

    Thomas Magill

    BBC News, London

    Davide Cini Robin Windsor and his ex-partner and best friend Davide Cini Davide Cini

    Robin Windsor (left) and his ex-partner and best friend Davide Cini

    A free online directory aimed at supporting LGBTQ+ people struggling with their mental health is being launched in honour of former Strictly Come Dancing professional Robin Windsor.

    The dancer died suddenly in February 2024 at the age of 44. An inquest into the cause of death will take place in January 2026.

    Windsor appeared on the show from 2010-2013, where he partnered with Patsy Kensit, Anita Dobson, Lisa Riley and Deborah Meaden.

    Robin’s best friend and ex-partner Davide Cini helped create the Ask Bobby directory and said he hoped it would become a “one-stop-shop” of mental health charities, community groups and sporting organisations that people could contact for help.

    Robin Windsor

    Robin Windsor moved to London from Ipswich at just 15 years old to pursue his dancing career

    Davide hopes the directory will honour Robin’s legacy and all he did to support the mental health community before his death.

    “Helping others, including children and those with disabilities, to dance helped (Robin) during some of his darkest days,” he said.

    Davide added Robin’s work as an ambassador for the mental health charity Sane had also been very important to him.

    Marc Svensson, Founder of youare-loved.com, stands outside a busy pub in London and looks off camera

    Marc Svensson created You Are Loved, which hosts Ask Bobby, and says loneliness and isolation is “rampant” in the LGBTQ+ community

    Davide said the idea to call the new directory had come to him “in the middle of the night”.

    The organisation We Are Loved created the directory Ask Bobby and offers advice and support for the LGBTQ+ community.

    Its founder, Marc Svensson, said the idea had come after he heard about many people from within the community dying “prematurely”.

    “In the last two years, I know of 22 people who have died from either suicide or drugs,” he said.

    “LGBTQ+ people are much more likely to die from suicide and certain drug related deaths.”

    As a social psychologist, Marc is currently doing a PhD in LGBTQ+ mental health and said research showed people were dying “suddenly and prematurely”.

    “Signposting people to their community or group of people that might share the same interests or hobbies might be a really good way to combat loneliness and isolation which is rampant in the LGBTQ+ community,” he said.

    About 15 people perform push-ups on the floor of a gym

    The Weekending is a gym in south London that aims to build friendships for those within LGBTQ+ community

    One of the first businesses to join the directory is The Weekending, a gym in Elephant & Castle, south London, aimed at bringing together the LGBTQ+ community and friends.

    Its founder, Fabio Pozzetto, said: “The LGBTQ+ community used to get together in the clubs at night – but now we’re trying to get healthier alternatives.”

    He said the club was a perfect match for the Ask Bobby directory.

    “There are many people who suffer discrimination and isolation and this is a place where everyone feels very welcome,” he added.

    ‘Beginning to spiral’

    It is a sentiment that Matty Lamy, who attends the gym, agrees with.

    He described it as his “second home” since the Covid lockdowns, which he said had been a “really difficult time”.

    “Feeling isolated was my biggest challenge and I could feel myself beginning to spiral,” he said.

    Since joining the gym, he said it had “changed my mentality, my thinking and my thoughts”.

    “It’s a win-win because of the connections you make through the community here is amazing,” he added.

    Matty bench presses some weights

    Matty says the directory will help others who suffer with feelings of isolation

    Reflecting on the Ask Bobby resource, Davide said: “I think it’s the legacy that myself, Robin’s family and friends would like for him, so he can keep shining a light and help people within our community who are struggling.”

    “Robin would be really proud that we are doing this in his name.”

    • If you have been affected by any of the issues raised in this story, you can find information and support at BBC Action Line.

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  • Dior Lady Art Project Marks 10 Years With New Artist Collaborations

    Dior Lady Art Project Marks 10 Years With New Artist Collaborations

    PARIS — The Dior Lady Art project is turning 10.

    The French fashion house is celebrating the anniversary with a book, due to be published by Rizzoli in October, showcasing 99 artists’ interpretations of its signature Lady Dior bag. 

    For the 10th edition, Dior has invited 10 artists to take part, including Marc Quinn, who kicked off the series in 2016 with a capsule collection commemorating the opening of Dior’s store on London’s New Bond Street.

    “It was such a success that we decided to do it every year-end with around 10 artists for each edition,” said Olivier Bialobos, Dior’s deputy managing director in charge of global communication and image.

    Joining Quinn this time around are fellow U.K. artist Lakwena; U.S. artists Jessica Cannon and Patrick Eugène; Eva Jospin and Inès Longevial from France; China’s Ju Ting; South Korean artist Lee Ufan; Alymamah Rashed from Kuwait, and Sophia Loeb from Brazil.

    Ufan’s designs were unveiled in April as part of the “Christian Dior: Designer of Dreams” exhibition in Seoul. The others will be rolled out from late October exclusively at the Dior flagships on Avenue Montaigne in Paris and at Shanghai luxury shopping mall Plaza 66.

    Other locations will receive a selection of designs from mid-November to mid-December, and participating artists will be featured on the Dior Talks podcast.

    Jessica Cannon’s designs for the Dior Lady Art project.

    Joe Perri/Courtesy of Dior

    Bialobos noted that Dior has a long-standing relationship with the art world. “It’s linked to the history of the house, because before being a couturier, Mr. Dior was a gallery owner,” he said.

    From John Galliano’s 60th anniversary show titled “Le Bal des Artistes,” in which each look was inspired by a painter, to Maria Grazia Chiuri’s work with a cadre of feminist artists, each creative director of the house has brought their own spin to the tradition.

    Jonathan Anderson, who last month became Dior’s eighth couturier, is no exception. His debut collection for the house, shown during Paris men’s fashion week, included a tasseled Lady Dior bag designed by Sheila Hicks. 

    “Jonathan loves the project,” said Bialobos. “He’s already given me a list of artists with whom he would like to collaborate for next year.”

    With artists from every region of the world, the Dior Lady Art project casts a wide net, with both established and emerging artists flocking to put their spin on the pillar handbag style. 

    “Very few have turned us down,” Bialobos said. “Even those who were skeptical to begin with got really caught up in the project.”

    Hidden Meanings

    Judy Chicago, Faith Ringgold, Lee Bul and Joana Vasconcelos are among the art world luminaries who have taken part. 

    Patrick Eugène with his designs for the Dior Lady Art project

    Patrick Eugène with his designs for the Dior Lady Art project.

    Heather Sten/Courtesy of Dior

    “We don’t just pick superstars. Every year, we also try to provide a platform for emerging talents and we have a sort of mix,” Bialobos said. “You might have a little-known young artist next to someone like John Giorno or Gilbert & George. That’s what’s nice about it.”

    Cannon was intrigued by the idea of translating her cosmic landscapes laced with iridescent pigments into objects. Each of her three designs features a pearlescent shell-like ornament at its center, evoking a sun, moon or planet. 

    “This is actually the first time I’ve seen my paintings translated into another medium and so it sparked all of these questions and ideas about how some of that could come back into the paintings, and maybe how the paintings can live in the world in ways that I hadn’t considered,” she told WWD.

    Details like tulle ruffles, pearls and rhinestones echo the ornate embellishments of a couture gown, but are full of hidden meaning.

    “One way that I felt like I really connected with fashion in this project is understanding that it’s a public expression that can come from a very intimate place, and I think paintings are also that way,” Cannon said. 

    “There’s a public dimension to them when they’re finished, but the ideas behind them and the process of making them is much more about this interiority,” she said. “My hope is that people who wear the bags or view them will connect with that interiority a bit as well.”

    Patrick Eugène's sketches for the Dior Lady Art project

    Patrick Eugène with his sketches for the Dior Lady Art project.

    Heather Sten/Courtesy of Dior

    Eugène also embraced embellishment, though in his case, the use of pearls was a way of paying tribute to his Haitian heritage. 

    “I’m inspired by the past, both personal and ancestral, the resilience of Haitians, and the ways culture is preserved and reinterpreted across generations,” he said in a statement. 

    He approached his three reinterpretations of the Lady Dior as if they were accessories that might be carried by the subjects of his portraits. His leather and textile patchworks incorporate elements like wooden beads, macramé, raffia embroidery and straw weaving.

    On one of the medium-sized bags, woven leather side panels are studded with small pearls — a nod to Haiti’s historic nickname as the “Pearl of the Antilles.”

    “Pearls have long symbolized purity and refinement in fashion, especially at Dior. I wanted to take that symbol and infuse it with a deeper meaning — one that speaks to strength, endurance, and legacy. The women in my paintings wear pearls as quiet emblems of grace and survival,” explained Eugène.

    He views the bag as a powerful canvas for artists. “It’s about expanding the definition of art. Art doesn’t have to be confined to gallery walls; it can move, it can be worn, it can engage with everyday life. Dior Lady Art celebrates that idea,” he said.

    New horizons

    Cannon liked the idea of the bag outliving its wearer.

    “I love the fact that this is an invitation to touch the art and to perhaps have it be touched, maybe not just by one generation, but by multiple generations of people who might carry the bag, hold on to it, share it with others — because that’s definitely my relationship with things from my mom or my grandmother,” she said. 

    Jessica Cannon with one of her Lady Dior bag designs

    Jessica Cannon with one of her Lady Dior bag designs.

    Joe Perri/Courtesy of Dior

    She traveled to Paris twice, once to visit La Galerie Dior, the exhibition space at the brand’s historic flagship, for her initial research, and again in March to see the final prototypes at the Dior workshop. 

    “I feel very inspired by just the breadth and depth of technical research that they did, and how carefully and thoughtfully the imagery was translated into those materials,” Cannon said. 

    “This experience has been just an absolute dream, and for it to be the first experience, it just initiated me into all of these possibilities that I would be very open to exploring if other opportunities were to come up,” she added. 

    Bialobos said that once artists have had a taste of working with Dior’s artisans, they often come back for more. 

    Chicago, for example, started by designing a set for one of Chiuri’s shows, then took part in the Dior Lady Art project. Her latest creation for the house is a special trunk for its Miss Dior perfume.

    “Artists arrive either with ideas, drawings — sometimes very precise, depending on the artist — or even prototypes, and it challenges the studio and the workshops to push creativity to its peak,” said Bialobos. 

    “For instance, Korean artist Lee Bul wanted her bag to be made of stone. That might seem a little crazy or even impossible, because a bag made of stone would weigh a ton, but the workshop found a way to laser cut the stone so that it was finer than leather,” he recalled. 

    Each bag is produced in a limited edition of 100. “We don’t always produce all 100 pieces, either for technical reasons, or because we want to keep some for later. But there are some which are sold out and which are unfortunately no longer made,” he said.

    Some collectors have been known to snap up six or seven bags at a time. “At our annual cocktail at Frieze in Seoul, we see a lot of women arriving with bags from previous editions,” Bialobos said. “To me, that’s the best reward.”

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