Physicists from Hebrew University and Cornell University have developed a laser-based method to protect atomic spins from environmental noise, significantly improving their stability and enabling more precise quantum sensing technologies.
The technique uses a single, tuned laser to synchronize the spin precession of cesium atoms, achieving a ninefold improvement in spin coherence even under frequent atomic collisions and without the need for extreme cooling.
This advancement could enhance the performance of quantum sensors, magnetometers, and navigation systems, offering a practical approach for real-world deployment of spin-based quantum devices.
PRESS RELEASE — A team of physicists from the Hebrew University’s Department of Applied Physics and Center for Nanoscience and Nanotechnology, in collaboration with the School of Applied and Engineering Physics at Cornell University, has unveiled a powerful new method to shield atomic spins from environmental “noise”—a major step toward improving the precision and durability of technologies like quantum sensors and navigation systems.
The study, “Optical Protection of Alkali-Metal Atoms from Spin Relaxation,” by Avraham Berrebi, Mark Dikopoltsev, Prof. Ori Katz (Hebrew University), and Prof. Or Katz (Cornell University), has been published in Physical Review Letters and can potentially revolutionize fields that depend on magnetic sensing and atomic coherence.
Why This Matters
Atoms with unpaired electrons—such as those in cesium vapor—have a property of “spin”, strongly interact with magnetic fields and therefore be used for ultra-sensitive measurements of magnetic fields, gravity, and even brain activity. But these spins are notoriously fragile. Even the tiniest disturbance from surrounding atoms or container walls can cause them to lose their orientation, a process known as spin relaxation. Until now, protecting these spins from such interference has required complicated setups or worked only under very specific conditions.
The new method changes that.
Laser Light as a Shield
The researchers developed a technique that uses a single, precisely tuned laser beam to synchronize the precession of atomic spins in magnetic field—even as the atoms constantly collide with one another and their surroundings.
Imagine a scenario where hundreds of tiny spinning tops are confined within a box. Typically, the interactions between these tops can disrupt their spin configurations, causing the entire system to fall out of sync. This effect become much more dominate at high magnetic fields, as the tops process and change their orientation much more rapidly. However, a specific method utilizes light to maintain synchronization within the system, by addressing the differences in the various spin configuration, the light effectively keeps all the tops spinning in harmony, preventing disorder and enabling cooperative behaviour among the spinning entities even at high magnetic fields. This approach highlights the fascinating interplay between light and atomic spin dynamics.
The researchers achieved a ninefold improvement in how long cesium atoms maintained their spin orientation. Remarkably, this protection works even when the atoms are bouncing off special anti-relaxation-coated cell walls and experiencing frequent internal collisions.
Real-World Potential
This technique could significantly enhance devices that rely on atomic spins, including:
Quantum sensors and magnetometers used in medical imaging, archaeology, and space exploration
Precision navigation systems that don’t rely on GPS
Quantum information platforms where spin stability is key to storing and processing information
Because the method works in “warm” environments and doesn’t require extreme cooling or complicated field tuning, it could be more practical for real-world applications than existing approaches.
A New Frontier in Atomic Physics
“This approach opens a new chapter in protecting quantum systems from noise,” said the researchers. “By harnessing the natural motion of atoms and using light as a stabilizer, we can now preserve coherence across a broader range of conditions than ever before.”
The research builds on decades of work in atomic physics, but this simple, elegant solution—using light to coordinate atoms—is a leap forward. It may pave the way for more robust, accurate, and accessible quantum technologies in the near future.
The research paper titled “Optical Protection of Alkali-Metal Atoms from Spin Relaxation” is now published in Physical Review Letters and can be accessed at https://doi.org/10.1103/fncz-b3yy
Researchers:
Avraham Berrebi1, Mark Dikopoltsev1,2, Ori Katz1, and Or Katz3
Institutions:
Department of Applied Physics, The Faculty of Science, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem
Refael Ltd.
School of Applied and Engineering Physics, Cornell University
The UK faces a “rising” and unpredictable threat from Iran and the government must do more to counter it, Parliament’s intelligence and security committee has warned.
The call comes as it publishes the results of a major inquiry which examined Iranian state assassinations and kidnap, espionage, cyber attacks and the country’s nuclear programme.
The committee, which is tasked with overseeing Britain’s spy agencies, has raised particular concern over the “sharp increase” in physical threats posedagainst opponents of the Iranian regime in the UK.
“Iran poses a wide-ranging, persistent and unpredictable threat to the UK, UK nationals and UK interests,” said Lord Beamish, committee chair.
“Iran has a high appetite for risk when conducting offensive activity and its intelligence services are ferociously well-resourced with significant areas of asymmetric strength.”
He added: “Iran is there across the full spectrum of all the kinds of threats we have to be concerned with.”
The committee accuses the government of focusing on “crisis management” and “fire-fighting” with Iran, as well as on its nuclear programme, at the expense of other threats.
It says the national security threat from Iran requires more resourcing and a longer-term approach.
“Whilst Iran’s activity appears to be less strategic and on a smaller scale than Russia and China, Iran poses a wide-ranging threat to UK national security, which should not be underestimated: it is persistent and – crucially – unpredictable.”
On the physical threat to people living in the UK, the committee said it has significantly increased in pace and in number since the start of 2022.
It is focused at dissidents and other opponents of the Iranian regime, it said, adding there is also an increased threat “against Jewish and Israeli interests in the UK”.
There have been at least 15 attempts at murder or kidnap against British nationals or UK-based individuals since the beginning of 2022, the report found.
“The Homeland Security Group told us that the threat of physical attack on individuals in the UK is now ‘the greatest level of threat we currently face from Iran’, and comparable with the threat posed by Russia.”
But, the committee said, Iran does not view attacks on dissident, Jewish and Israeli targets in the UK as attacks on the UK. The report continues: “It rather sees the UK as collateral in its handling of internal matters – i.e. removing perceived enemies of the regime – on UK soil”.
The committee examines the policies, expenditure, administration and operations of UK intelligence organisations including MI5, MI6, and GCHQ.
Its 260-page report was published on Thursday as part of the committee’s inquiry into national security issues relating to Iran. It covers events up to August 2023, when the committee finished taking evidence.
It has previously been read by Prime Minister Sir Keir Starmer, who was sent a copy in March, and circulated among UK intelligence organisations to give them the opportunity to check accuracy and request redactions on national security grounds.
According to the committee, the government is required to provide its response within 60 days of publication.
A UK government spokesperson said the report “demonstrates the vital work” by security and intelligence agencies countering threats posed by states such as Iran.
“This government will take action wherever necessary to protect national security, which is a foundation of our Plan for Change.
“We have already placed Iran on the enhanced tier of the foreign influence registration scheme and introduced further sanctions against individuals and entities linked to Iran, bringing the total number of sanctions to 450.”
They thanked the committee and said the government will be responding fully.
CHENNAI: Swiss-pharma major Novartis AG said early this week that its pediatric malaria treatment, Coartem Baby, received regulatory approval from Swissmedic, Switzerland’s national medicines regulatory authority. This marks a milestone in global health, as this Novartis drug is the world’s first malaria treatment specifically developed for newborns and infants weighing between 2 and 5 kilograms.
Coartem Baby is a reformulation of the existing Coartem (artemether-lumefantrine) combination therapy. The new formulation was developed through a collaboration between Novartis and the Medicines for Malaria Venture (MMV), with support from the PAMAfrica consortium.
The clinical development program was co-funded by the European & Developing Countries Clinical Trials Partnership and the Swedish International Development Cooperation Agency. The approval was based on positive data from the Phase II/III CALINA study, which demonstrated that Coartem Baby has a pharmacokinetic profile suitable for infants under 5 kilograms and exhibits good efficacy and safety.
Global Health Impact
Malaria remains one of the world’s deadliest diseases, particularly among children under five years old in Africa. In 2023, there were an estimated 36 million pregnancies in 33 African countries where malaria is widespread, with about one in three mothers infected with malaria during pregnancy, raising the risk of transmission to their newborns.
It seems as if Dexter Morgan just cannot die. Remember the first Dexter finale 12 years ago? It climaxed with Morgan sailing his boat into an unsurvivable storm, a sure sign that our favourite serial-killing blood spatter analyst had finally met his end. But then the show lost its nerve and he somehow ended up in a postscript with a new job (lumberjack) and a new beard (unconvincing).
Next came 2021’s Dexter: New Blood, a series that was conceived as a definitive full stop for the character. That run ended with – spoiler alert – Dexter being shot dead by his son Harrison. However, now Morgan finds himself back yet again in Dexter: Resurrection, in which we quickly learn that this apparently fatal injury was merely a flesh wound.
“Well, you know, he didn’t get shot in the head,” shrugs Michael C Hall, who plays the titular character. Hall is attempting to explain Dexter’s latest miraculous comeback to me over Zoom – and if he’s getting tired of people like me telling him that they thought he was dead, he’s doing a pretty good job of hiding it.
Michael C Hall, Ntare Guma Mbaho Mwine, Jill Marie Lawrence and Sharon Hope in Dexter: Resurrection. Photograph: Zach Dilgard/Paramount+ with Showtime
This might be because it was his idea to bring Dexter back. “The conversation started as a result of my saying, ‘What if he didn’t die?’” he says breezily. “I can’t take credit for the whole scope of what we’re up to, but it was a notion that I casually floated. What if the end of New Blood was something that enabled Dexter to relinquish some burden that he’d been carrying for a long time?”
What changed his mind? “Time passing, perspective shifting, recognising what a wonderful thing it is to collaborate with this family,” he says. “And realising that how New Blood seemingly ended could be a way to move the character into a place he hadn’t quite earned until then.”
How well the character moves into that place remains to be seen. As we speak, the show is still in production, and only the first episode has been made available to view. Its early scenes might creak with tortured exposition – hardly surprising, given the near-impossible task of bringing someone back from the dead – but happily, the old Dexter magic is still present. There are callbacks and cameos and grisly scenes of dismemberment. Better yet, the season promises all kinds of warped bonding between Dexter (a serial killer) and Harrison (his son and, until quite recently, murderer).
“Harrison has been through a lot, and has a sense of maturity that he didn’t have when we first met him in New Blood,” says Hall. “Dexter initially is very much compelled to check in on his son, but is also daunted by the proposition of making contact, because he’s afraid his son will reject him, or won’t want him, or will wish he’d stayed dead. But I think finding themselves on the other side of this traumatic event will result in both Dexter and his son growing up a little bit.”
Uma Thurman as Charley in Dexter: Resurrection. Photograph: Zach Dilgard/Paramount+ with Showtime
We also have a new fleet of faces to look forward to. Peter Dinklage and Uma Thurman are there, respectively playing a billionaire venture capitalist and his head of security, plus Neil Patrick Harris, Eric Stonestreet, Krysten Ritter and David Dastmalchian will all appear as villains invited to what sounds an awful lot like an international murder convention. “Dexter sort of trips into a literal and figurative invitation to a gathering of unsavoury …” teases Hall of this year’s plot, before trailing off for fear of spoiling anything. “Actually, I’m not sure how much I can say. But it’s really validating and gratifying, the fact that the show remains compelling to the kinds of actors who’ve agreed to join us.”
Perhaps another reason for Hall’s willingness to return was this year’s Dexter: Original Sin. A prequel series that took the form of Dexter’s life flashing before his eyes post-shooting, Original Sin didn’t star Hall (although he provided the voiceover), instead casting Shadow and Bone’s Patrick Gibson as Morgan.
I had wondered if the simple envy of seeing someone else do his job drove Hall back to Dexter, but apparently this wasn’t the case. “I thought it was interesting, once all those blanks had been filled in, to find the character on the other side of it,” he says. “But it was weird to see Patrick embody some of what had evolved as Dexter’s characteristic ways of being. Yes, it’s very strange. In fact, at one point I was like, when I go back to work, I gotta make sure I’m not just doing a Patrick Gibson impression.”
Peter Dinklage in Dexter: Resurrection. Photograph: Zach Dilgard/Paramount+ with Showtime
There will be more Original Sin (a second season was greenlit this spring): another sign of what looks like an ever-expanding Dexterverse. There’s likely to be continued Resurrection – more about that shortly – plus there are rumours of a spin-off focused on John Lithgow’s Trinity Killer. All of which perhaps underlines how much better television as a whole was in Dexter’s heyday.
The original Dexter came out in 2006 at the height of the golden age of TV, with its focus on anguished male antiheroes. Much has been made lately of the demons that plagued James Gandolfini before his death, some attributed to the burden of having to play a character as dark as Tony Soprano for so many years. As Dexter, though, Hall played a serial killer who had to murder and dismember countless people. Did the darkness of the role ever get to him?
Michael C Hall on satellite radio station Sirius XM in New York this week. Photograph: Cindy Ord/Getty Images for SiriusXM
“I think Dexter exists in a world that is, to some degree, dialled away from reality,” he explains. “It’s fantastic in its way and, because of that fantastical element, maybe it doesn’t play the same trick on me that it might otherwise. And you know, as intense as it might be to convey someone who’s wrestling with such formidable darkness, it’s maybe therapeutic. You can endow these victims with whatever it is you’d like to do away with in your own world. Maybe I’m a healthier person for having done all this.”
There is also the question of how comfortable Hall is with returning to the same character over and over again. After all, Dexter aside, his stock in trade is playing a dizzying breadth of characters – he was JFK in The Crown, the Emcee in Cabaret, the lead in David Bowie’s Lazarus musical, a professional bowler in a Tim Robinson-written episode of Documentary Now!. Yet he keeps being drawn back to Dexter. Surely he must be aware that this will be the first line of his obituary.
“I mean, what are you going to do?” he shrugs. “That’s the way it’s unfolded. Whether I were to do more of this or not, I think that would remain the case, and it’s OK. None of it fundamentally matters anyway. But it’s been really fun. Being able to work as an actor feels like getting away with something. Being able to work as an actor while playing a character like Dexter feels exponentially so. I feel very lucky to have gotten away with this.”
A knottier question to bring up is the internet. As well as the initial finale routinely being brought up as one of the worst in television history, a Hollywood Reporter interview with showrunner Clyde Phillips last year suggested that fans weren’t exactly happy with how New Blood ended, either. “The internet hated it,” Phillips said bluntly. With this in mind, I ask Hall if he keeps up with the ins and outs of reactions to the show.
“No, that would make me crazy,” he replies. “But some fans found the notion of Dexter surviving more plausible than him dying. There’s something about the character that people just don’t want to see him die. They don’t want to see his agency extinguished.”
Watch a trailer for Dexter: Resurrection
The good news for these fans is that Dexter: Resurrection is intended to be a long-running affair. The introduction of so many guest stars this season is designed to trickle out across several years, or, as Phillips put it to USA Today, the duration of the comeback is “up to Michael”.
“Well, I guess it’s hard for Dexter to happen if I’m not there,” Hall sighs when I mention this to him. Does this mean he would like Resurrection to run and run? Is there a world where it could end up rivalling the length of the original series? “That sounds insane,” he laughs. “All I can say is that I don’t think we resolve things at the end of this season, and we’ve done it with the reasonable expectation that there will be more to come.”
So you don’t get shot at the end of this one? “We still have two and a half weeks left of filming, and I suppose someone could present some new pages to me,” he smiles. But what would be the point? After all, Dexter Morgan cannot die. And we should all be thankful for that.
“The Salt Path is an unflinchingly honest, inspiring and life-affirming true story,” reads the description of Raynor Winn’s bestselling memoir on its publisher Penguin Random House’s website.
Which is unfortunate wording if accusations made at the weekend turn out to be true: an investigation by the Observer alleged that the 2018 book – which has recently been adapted into a film starring Gillian Anderson and Jason Isaacs – is not all that it seems. Winn writes in The Salt Path that she and her husband, Moth, had their home repossessed due to an investment in a friend’s company that went on to fail. With nowhere to live, as she tells it, the couple decided to walk the length of the South West Coast Path, wild camping along the way and relying on the kindness of strangers. The Observer piece suggests Winn’s account of becoming homeless is untruthful, and reports that she took £64,000 from her former employer. It also questions the legitimacy of Moth’s diagnosis with the neurological condition corticobasal degeneration (CBD), a core part of the memoir.
Winn’s immediate response called the article “highly misleading”, adding: “We are taking legal advice and won’t be making any further comment at this time.” She stood by her book being “the true story of our journey”. Still, after the report, PSPA, a charity that supports people with CBD and formerly worked with Winn and her husband, terminated its relationship with the couple.
On Wednesday, Winn published a more detailed statement, defending her book’s truthfulness and giving more detail about the events that led to the couple losing their home. She also provided medical letters addressed to her husband in defence of allegations relating to his illness.
This is not the first time a much-hyped memoir has come up against accusations of lying. Belgium-born Misha Defonseca’s 1997 book about how she was raised by wolves during the second world war turned out to be completely fabricated. Love and Consequences by Margaret B Jones, which was sold on release in 2008 as the true story of the author’s experience growing up as a mixed-race foster child in South Central Los Angeles, turned out to have been written by Margaret Seltzer, a white, privately educated woman who grew up with her biological family.
James Frey at the Union Chapel, London, in 2011. Photograph: David Levene/The Guardian
Perhaps the most famous instance is James Frey’s A Million Little Pieces, a 2003 memoir of drug addiction and alcoholism that, after being championed by Oprah Winfrey in 2005, shot to the top of the New York Times bestseller list and remained there for 15 weeks. It was billed as “brutally honest”, but later it came to light that chunks of the book had been made up. Winfrey in particular was furious with Frey, telling him it was difficult to talk to him when he came on her TV show to explain himself in 2006. “I feel duped,” she said. “But more importantly, I feel that you betrayed millions of readers.”
“How could they lie?” is a question many readers ask when a memoir they love is proved to be untrue. But there’s another question that needs to be answered, too: how could the author get awaywith it? How did they manage to get their lies past an agent and multiple editors, all the way into a published book labelled as a true story?
The short answer is that if someone is lying about their own life, it is often very difficult for others to tell. Dr Pragya Agarwal, the author of books including the 2021 memoir (M)otherhood and a teacher of memoir writing, says that a big part of writing nonfiction “is about trust between the writer and the reader. I am not really sure how someone’s life story can be factchecked in its entirety.”
Others say it is not the publisher’s role to investigate whether an author is telling the truth or not. Grace Pengelly is a freelance writer and editor who formerly worked as a nonfiction commissioning editor at HarperCollins. An editor’s role “is to help the author craft their story as compellingly and accurately as possible”, she says, and that requires believing in the writer. “Without a certain degree of trust from the outset, it is difficult for an editor and author to work with each other effectively.”
That doesn’t mean that memoirs are not fact-checked. “Prior to acquiring a memoir, a publisher would look into the background of the author and their story to see if it checks out,” says Pengelly. Any “question marks around the veracity of an author’s story would definitely be a reason why a publisher wouldn’t offer on a book”. But the research undertaken at this stage wouldn’t tend to involve checking whether someone was actually incarcerated for as long as they said they were (one of the major falsities in A Million Little Pieces), or whether a couple who claimed to be homeless actually owned a property in the south of France, as was alleged by the Observer regarding Winn and her husband (a property Winn has since described as an “uninhabitable ruin”).
Raynor and Moth Winn. Photograph: Jim Wileman/The Guardian
Finding out that kind of information might be possible only if publishers had specific teams dedicated to it. The publishing consultant and editor Katy Loftus, who previously worked for Penguin Random House, says she isn’t aware of any publishing houses with a factchecking department. “Other than top executive salaries, publishing is run on a shoestring. Books make much less money than people think,” she says. The big publishers have legal departments, “who will give an opinion on something flagged up to them by a commissioning editor, and occasionally do a complete legal read if requested”, she adds. But the main factchecking responsibility tends to fall to the commissioning editors, who are “responsible for hundreds of tasks” – from briefing book cover designers, to negotiating deals with authors, to managing teams of people. The editing itself “is often at the bottom of the list, and factchecking is only part of the editing process.”
Even when it comes to legal checks, the main concern is that a book doesn’t contain anything that might lead to the publisher being sued, rather than actually analysing the factual content, says Ian Bloom, a media lawyer who has worked in publishing. “To some extent, nobody much cares if they’ve got dates wrong and facts wrong, as long as there’s no legal implications.”
Bloom suspects that a number of celebrity memoirs in particular contain omissions or embellishments. “There’s no real harm done if they gloss over certain things in their lives,” he says, as long as it’s not defamatory to anyone else.
Aside from rare exceptions – such as when a group of readers successfully sued Frey’s publisher, claiming they were defrauded as they bought his book under the impression that it was true, and were refunded the cover price – publishers do not face serious material repercussions for lies told in memoirs. Reputational damage, meanwhile, is usually put on the author. “When an author signs a contract with a publisher, there are usually author covenants that include clauses about the truthfulness and integrity of the material to the best of the author’s knowledge and belief,” Bloom says. The publisher is then entitled to cancel that author’s contract, should a book’s veracity be called into question.
Of course, authors can get around this by writing “autobiographical fiction” rather than memoir: books such as the actor Carrie Fisher’s Postcards From the Edge, based on her own life but categorised as a novel, or the Booker-winning autofictional novel Shuggie Bain by Douglas Stuart, don’t come under fire for being made up, because we all know that’s what fiction is. So why didn’t authors like Frey turn their stories into novels? Perhaps the books wouldn’t have done as well marketed in that way – in a true-crime-obsessed world, we’re all familiar with the strength of desire for real stories.“Autofiction isn’t as well-established a genre as memoir,” Pengelly says. “So marketing teams face discrete challenges in framing and taking these stories to the public. A ‘true story’ has historically proved easier to build a campaign around.”
Once a book is out in the world, any inaccuracies tend to be spotted by journalists or academics – there is no regulator of the publishing industry equivalent to the Independent Press Standards Organisationand Ofcom for the media in the UK. With approximately 200,000 books published annually in the UK alone, “There’s no regulator on Earth who can read them all … it’s impossible,” Bloom says.
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So how do we stop fake memoirs from being published? In light of the Salt Path allegations, Pengelly is sure publishers will be considering ways to avoid such a scenario coming up again. “If a narrative arc seems too neat and tidy to be true, perhaps it’s worth considering why, and employing a freelance factchecker to investigate,” she says.
Winn on her travels in south-west England.
The trouble is, neat and tidy narrative arcs are often exactly what many readers – and viewers of film adaptations – want. A memoir Pengelly worked on, Zig-Zag Boy by Tanya Frank, is about a mother coming to terms with her son’s experiences of psychosis. That book was a more modest commercial success than The Salt Path, but could it have been more of a hit if Frank had ended it with her son being “healed”, rather than with her accepting his altered state? Quite possibly. Triumph in the face of medical adversity is a seductive concept, as readers of Winn’s books will know from their stories of Moth’s ability to overcome the symptoms of his illness and undertake long walks.
Nic Wilson, whose memoir Land Beneath the Waves is about how the natural world helped her to navigate and accept her chronic illness, is disparaging of the “nature cure” trope we often see in popular books about health. It creates an unrealistic expectation that the order of events should be “diagnosis, illness, recovery. And I think readers come to expect that,” she says.
Clearly, authors may have something to gain by bowing to such expectations and embellishing or omitting certain facts of their life stories. But they also have the most to lose if lies in their books are exposed: they could have their publishing deal dropped, which might mean having to pay back their advance, and they risk no publisher wanting to be associated with them again.
Frey’s publisher, Nan Talese, was particularly aggrieved by the way her author’s reputation was attacked. Winfrey displayed “fiercely bad manners – you don’t stone someone in public, which is just what she did”, she told the Dallas Morning News at the time.
“Scandal has stalked memoir since the genre was invented,” Loftus says – an early example being the 1836 memoir Awful Disclosures of Maria Monk, a 20-year-old woman’s story of life in a Montreal convent, which was vilified as a hoax. “In practice the publicity rarely does more harm than good to the publisher, whereas an author’s life can be left in tatters.”
That’s not to say that they won’t continue to make money: A Million Little Pieces kept selling even in its second iteration, which had passages rewritten and contained a “note to the reader” addressing its inaccuracies. And whatever happens after the allegations made against Winn, having already sold more than 2m copies of The Salt Path, she has been made rich by this book and its sequels, and will continue to receive royalties for as long as people keep buying them.
The fact that there is money to be made – with very few legal repercussions – by telling the most marketable version of a story, rather than the true one, makes it difficult to believe that this controversy will be the last of its kind. After all, no memoir can be completely true. “Memories are fallible and selective; we always remember half-truths, and the story an author chooses to tell is only ever one story of a particular situation,” Agarwal says. “But what any reader wants to believe is that the story they have put their faith in is closest to the writer’s truth, that they have not been deliberately misled, that they have not been manipulated. This is essential.”
ISLAMABAD, Jul 10 (APP): Prime Minister Shehbaz Sharif on Thursday directed the relevant authorities to formulate a comprehensive plan to transform the Pakistan National Shipping Corporation (PNSC) into a shipping company of international standard.
The prime minister, chairing a meeting to review the restructuring, reforms, and performance of the PNSC, said that Pakistan’s shipping sector held vast potential for investment.
He directed that a comprehensive plan be prepared to encourage private investment in the shipping sector.
He called for steps to increase the number of ships and promote the competitive use of PNSC vessels for cargo movement to and from Pakistan.
Prime Minister Shehbaz advised to acquire the services of shipping experts and consultants to elevate PNSC to an international standard shipping company.
He expressed the hope that the reforms in the PNSC would not only save valuable foreign exchange currently being paid to international companies for shipping services but also create more employment opportunities for local seafarers.
The participants of the meeting were briefed on the PNSC’s operations, the current number of vessels in the PNSC, the annual cargo movement in Pakistan, and the future expansion plans for the organisation.
Federal ministers Ahad Khan Cheema, and Junaid Anwar Chaudhry, and relevant senior officials attended the meeting.
Ishtiaq Ahmed, APP’s Foreign Editor, leads coverage of the Prime Minister, President and Foreign Office, bringing over 20 years of journalism experience from local and international publications – Reach out at 03335293238/ ishtiaqrao@gmail.com/ X: ishtiaqrao
Triple-negative breast cancer (TNBC), an aggressive and hard-to-treat form of breast cancer, has long challenged researchers due to the absence of effective targeted therapies. Now, findings from Cold Spring Harbor Laboratory in New York State have revealed a potentially significant contributor to TNBC biology: a little-studied long non-coding RNA (lncRNA) known as LINC01235.
Breast cancer is among the most common malignancies in women worldwide, and TNBC accounts for approximately 10 to 15 percent of cases. It is disproportionately diagnosed in younger women and those of African American descent. While many forms of breast cancer benefit from targeted treatments, TNBC lacks such options, making basic research crucial.
The study was led by Professor David Spector and graduate student Wenbo Xu. They discovered that LINC01235, previously associated with gastric cancer, also plays a role in TNBC by regulating a gene called NFIB, which is already linked to this cancer subtype.
Using CRISPR gene-editing and antisense knockdown techniques in tumour organoids and cancer cells, the researchers showed that lowering LINC01235 levels suppressed NFIB expression and inhibited TNBC organoid growth. Further analysis suggested that this interaction affects the NOTCH signalling pathway, known to be involved in cancer cell proliferation.
The NOTCH signalling pathway is a fundamental cell communication system that regulates how cells develop, differentiate, and interact with their environment. It is evolutionarily conserved and plays a crucial role in embryonic development, tissue homeostasis, and cell fate decisions. In TNBC aberrant NOTCH signalling can lead to uncontrolled cell proliferation, resistance to apoptosis and enhanced tumour invasiveness.
Very little is known about NFIB’s function in this context and even less about LINC01235.
“The goal here is to understand mechanisms by which the cell functions and how disease states take over those functions, perhaps by up-regulating or down-regulating an RNA molecule,” Spector noted.
While these results are at a preliminary stage, the work points to the promise of lncRNAs as potential therapeutic targets. LINC01235 may yet prove to be a vital step towards effective treatment options for TNBC.
For further reading please visit: 10.1158/1541-7786.MCR-24-1143