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  • Dietary inflammatory index and its association with hematological inflammatory markers: a cross-sectional analysis in healthy and depressed individuals | BMC Nutrition

    Dietary inflammatory index and its association with hematological inflammatory markers: a cross-sectional analysis in healthy and depressed individuals | BMC Nutrition

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  • ‘June was hottest on record in western Europe’

    ‘June was hottest on record in western Europe’


    PARIS:

    Western Europe sweltered through its hottest June on record last month, as “extreme” temperatures blasted the region in punishing back-to-back heatwaves, the EU climate monitor Copernicus said Wednesday.

    Globally, this past June was the third warmest on record, continuing a blistering heat streak in recent years as the planet warms as a result of humanity’s emissions of greenhouse gases.

    The previous hottest June was in 2024 and the second hottest was in 2023, the Copernicus Climate Change Service (C3S) said.

    Sweltering extremes were particularly pronounced in Europe, which is warming several times faster than the global average.

    Millions of people were exposed to high heat stress across parts of the continent as daily average temperatures in western Europe climbed to levels rarely seen before — and never so early in the summer.

    Several countries recorded surface temperatures above 40 degrees Celsius, with heat of up to 46 degrees Celsius in Spain and Portugal, Copernicus said.

    Samantha Burgess, the EU monitor’s Strategic Lead for Climate, said the impact of the heatwaves in Europe was “exceptional”, intensified by record sea surface temperatures in the western Mediterranean — which hit an all-time daily maximum in June.

    “In a warming world, heatwaves are likely to become more frequent, more intense and impact more people across Europe,” she said.

    The two heatwaves — from June 17 to 22, and again from June 30 to July 2 — were linked to heat domes trapping warm air over affected regions, prolonging the stifling weather, and worsening pollution and wildfire conditions.

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  • Seoul’s runaway property market puts Korean central bank in a bind – Financial Times

    Seoul’s runaway property market puts Korean central bank in a bind – Financial Times

    1. Seoul’s runaway property market puts Korean central bank in a bind  Financial Times
    2. Bank of Korea expectedly keeps rates steady at an almost three-year low  CNBC
    3. South Korean court approves arrest of former President Yoon Suk Yeol over martial law decree  financialexpress.com
    4. Bank of Korea Maintains Base Interest Rate at 2.50% per Annum  bloomingbit
    5. Bank of Korea to pause easing in July amid household debt surge: Reuters poll  104.1 WIKY

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  • Asian shares up on Nvidia high, investors unfazed by Trump’s tariff moves

    Asian shares up on Nvidia high, investors unfazed by Trump’s tariff moves

    By Rae Wee

    SINGAPORE (Reuters) -Asian stocks rose slightly on Thursday, riding on optimism from Nvidia’s brief rise to a world-record $4 trillion valuation and as investors largely shrugged off U.S. President Donald Trump’s latest tariff salvos.

    U.S. copper futures widened their premium to the London benchmark overnight after Trump announced plans to impose a 50% tariff on copper. He later said on Wednesday the levies would come into effect on August 1.

    Trump also turned his trade ire against Brazil on Wednesday as he threatened a punitive 50% tariff on exports to the U.S. and issued tariff notices to seven minor trading partners.

    The latest moves did little to rattle markets, leaving MSCI’s broadest index of Asia-Pacific shares outside Japan up 0.4%.

    The Nikkei fell 0.6%, while China’s CSI300 blue-chip index rose 0.4% and Hong Kong’s Hang Seng Index added 0.1%.

    EUROSTOXX 50 futures gained 0.18% and FTSE futures advanced 0.4%.

    Artificial intelligence chip designer Nvidia became the world’s first company to hit a $4 trillion market value on Wednesday, solidifying its position as one of Wall Street’s most favoured stocks. In Japan, chipmaker supplier Disco was the top gainer with a 4.3% surge.

    U.S. stock futures eased slightly in Asia on Thursday, with Nasdaq futures and S&P 500 futures both down about 0.2% each, after both indexes closed higher in the cash session overnight.

    The market reaction to Trump’s tariff developments this week has been much less severe than the post “Liberation Day” selloff in April, with Jeff Ng, SMBC’s head of Asia macro strategy, saying investors have grown somewhat “numb” to the ever-changing situation.

    “They know that there is still room for negotiation. A lot of these announcements, they start off with eye-catching numbers, but they are not totally final, and they are still subject to changes. Even if they are implemented, they could also be reversed in the coming few months to year,” he said.

    Also keeping stocks supported were expectations of Federal Reserve rate cuts later this year.

    Minutes released on Wednesday showed “most participants” at the Fed’s meeting last month anticipated rate cuts would be appropriate later this year, with any price shock from tariffs expected to be “temporary or modest”.

    “Right now, markets are not pricing in a high chance of a full-blown recession at this stage, given that the labour market continues to be quite resilient, but they know that there’s a lot of pressure to push policy rates lower, so that could lower the opportunity cost of holding equities,” Ng said.

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  • “My heart stopped for 20 seconds”: UFC star Ben Askren opens up on life-changing story after lung transplant in Wisconsin hospital | International Sports News

    “My heart stopped for 20 seconds”: UFC star Ben Askren opens up on life-changing story after lung transplant in Wisconsin hospital | International Sports News

    UFC star Ben Askren opens up on life-changing story after lung transplant in Wisconsin hospital (Image via Getty)

    Fans of MMA fighter Ben Askren were surprised this week after the former UFC star shared a very personal and emotional message from his hospital bed. His face was worn down, his voice was cool, and his words were hard to forget. What happened to him was serious, so serious that even he doesn’t remember an entire month of his life. He only found out later by reading what his wife wrote in her journal. The truth? Ben Askren nearly died,multiple times and now he’s finally talking about it.

    What happened to Ben Askren during his lung failure in June 2025

    Wednesday, July 9, 2025, Ben Askren posted a video from his hospital room to his verified Instagram account. In the video, the 40-year-old described how he was fighting for his life last month after coming down with a horrible case of pneumonia. It deteriorated so badly that he ended up needing a double lung transplant to survive.He also said he does not remember anything from the entire month of June. It wasn’t until he read the notes that his wife Amy wrote that he realized how close to death he really was. “I basically died four times,” Ben Askren said in the video. “My heart stopped for 20 seconds. Not ideal, I don’t know if you guys know that.”Doctors were able to save him, but it took major surgery. The lung transplant was done in late June at a hospital in Wisconsin, where he’s still recovering.

    Also Read:

    UFC Fighter Ben Askren’s Wife Shares Terrifying Health Status Before Emergency Lung Transplant

    How Ben Askren’s weight dropped to high school level after 45 days in hospital

    Ben Askren also mentioned that he dropped 50 pounds while he was in the hospital. He had not weighed 147 pounds since he was 15 years old when he stepped on the scale again this week.He joked, “I haven’t been this light since high school wrestling. That’s kind of crazy.”Now in recovery, Ben Askren is slowly regaining his strength. He thanked his fans, his doctors, and most of all, his wife Amy for being by his side through the entire fight. The former Bellator and UFC star’s health update has drawn love and support from the entire MMA community across the U.S.


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  • India's equity benchmarks open flat as IT offsets broader gains – Reuters

    1. India’s equity benchmarks open flat as IT offsets broader gains  Reuters
    2. Indian stock benchmarks set to open flat as Trump threatens pharma tariffs  Business Recorder
    3. India Stocks Extend Fall  TradingView
    4. Stock market today: Nifty50 opens flat; BSE Sensex near 83,550  Times of India
    5. Calm Prevails as India Markets Brush Off Jane Street, Trade Risk  Bloomberg.com

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  • Uncovering how a key inflammatory molecule causes esophageal smooth muscle contractions

    Uncovering how a key inflammatory molecule causes esophageal smooth muscle contractions

    A research group led by Dr. Keisuke Obara, Dr. Kento Yoshioka, and Professor Yoshio Tanaka from the Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, has uncovered important details about how platelet-activating factor (PAF)-a powerful molecule involved in inflammation and allergic reactions-triggers contractions in the smooth muscles of the esophagus. Their findings could pave the way for new treatments targeting gastrointestinal symptoms associated with allergies, asthma, and anaphylaxis.

    What is PAF?

    PAF (platelet-activating factor) is a bioactive lipid molecule produced by various cells in the body, including immune cells, during inflammatory responses. It plays a major role in processes such as blood clotting, immune cell recruitment, and the onset of severe allergic reactions, including anaphylaxis, by making blood vessels more permeable and stimulating smooth muscle contraction in tissues like the lungs, intestines, and esophagus.

    Although PAF is essential for immune defense, excessive or misdirected PAF activity is linked to pathological conditions such as asthma, inflammatory bowel disease, and allergic reactions that affect breathing and digestion.

    Study highlights

    In their study, the researchers investigated how PAF causes contractions in the esophageal smooth muscle of rats-a process that contributes to symptoms like chest tightness and difficulty swallowing during allergic episodes.

    They discovered that PAF triggers calcium entry into muscle cells through three distinct types of calcium channels:

    • L-type voltage-dependent calcium channels (VDCCs),

    • Receptor-operated calcium channels (ROCCs),

    • Store-operated calcium channels (SOCCs).

    Importantly, the study revealed that non-VDCC channels-particularly a protein called Orai1 that forms SOCCs-are the main drivers of PAF-induced muscle contraction in the esophagus. This challenges the traditional focus on VDCCs in smooth muscle pharmacology.

    Our findings suggest that targeting these non-traditional calcium channels could offer more effective treatments for esophageal and gastrointestinal symptoms seen in allergic conditions.”


    Dr. Keisuke Obara, lead researcher

    Implications for future therapies

    By better understanding which calcium channels PAF uses to trigger muscle contraction, the study lays the groundwork for developing new drugs that can more precisely block unwanted muscle activity without affecting normal muscle function elsewhere.

    Source:

    Journal reference:

    Obara, K., et al. (2025). Pharmacological Characteristics of Extracellular Ca2+ Influx Pathways Responsible for Platelet-Activating Factor-Induced Contractions in Rat Esophagus Smooth Muscle: Involvement of L-Type, Receptor-Operated, and Store-Operated Ca2+ Channels. Biological and Pharmaceutical Bulletin. doi.org/10.1248/bpb.b25-00233.

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  • BD recordings suggest ex-PM ordered deadly crackdown

    BD recordings suggest ex-PM ordered deadly crackdown


    DHAKA:

    Audio recordings analysed by the BBC suggest Bangladesh’s fugitive ex-prime minister Sheikh Hasina ordered a deadly crackdown on protests last year, allegations for which she is on trial.

    Up to 1,400 people were killed between July and August 2024, according to the United Nations, when Hasina’s government ordered a crackdown on protesters in a failed bid to cling to power.

    Hasina, 77, fled to India at the culmination of the student-led uprising and has defied orders to return to Dhaka, where her trial in absentia for charges amounting to crimes against humanity opened on June 1.

    The BBC Eye Investigations team analysed audio alleged to be of Hasina — and which forms a key plank of the evidence for the prosecution — which was leaked online.

    In the recording, dated July 18, 2024, a voice alleged to be Hasina is heard authorising security forces to “use lethal weapons” against protesters and that “wherever they find (them), they will shoot”.

    The BBC said audio forensics experts had found no evidence that the speech had been edited or manipulated, and that it was “highly unlikely to have been synthetically generated”.

    Bangladesh police have also matched the audio with verified recordings of Hasina.

    Protests began on July 1, 2024 with university students calling for reforms to a quota system for public sector jobs.

    Student ambitions to topple Hasina’s iron-fisted rule seemed a fantasy, just months after she won her fourth consecutive election in a vote without genuine opposition.

    But protests gathered pace, and a fuse was lit when police launched a deadly crackdown on July 16.

    Hasina’s state-appointed lawyer — who says they have not been in contact with her — have sought to throw out the charges.

    Her now-banned Awami League party said it “categorically denies the charges that its senior leaders, and the prime minister personally, directed the use of lethal force against crowds during the protests of last summer”.

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  • Visa free access: Pakistan passport improves global ranking – Gulf News

    Visa free access: Pakistan passport improves global ranking – Gulf News

    1. Visa free access: Pakistan passport improves global ranking  Gulf News
    2. Interior Minister Mohsin Naqvi discusses visa issues, security cooperation with UAE counterpart  Ptv.com.pk
    3. Naqvi to take up visa rejection issue with UAE interior minister  Dawn
    4. Pakistan aims to improve passport ranking amid business community concerns  Gulf News
    5. UAE Visa Crackdown on Pakistanis: What’s Behind the Rising Rejections?  Times Now

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  • Jail trial conducted in three May 9 cases

    Jail trial conducted in three May 9 cases

    LAHORE  –  The jail trial of three cases, including the arson attack on Shadman Police Station and torching of police vehicles, during the May 9 riots, continued on Wednesday at Kot Lakhpat Jail under tight security. Administrative Judge of the Anti-Terrorism Court (ATC), Manzer Ali Gill, presided over the proceedings which lasted until 6:30 PM. During the hearing, eight prosecution witnesses recorded their statements against the accused while defence counsel completed cross-examination of five witnesses. The trial proceedings were adjourned until tomorrow for further evidence. Prominent PTI leaders on bail, including Aliya Hamza and Khadija Shah, appeared before the court, while the attendance of detained leaders such as Shah Mahmood Qureshi and Dr. Yasmin Rashid was also marked.


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